GREMLIN Database
GCSH - Glycine cleavage system H protein
UniProt: P0A6T9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10371
Length: 129 (121)
Sequences: 3749 (2315)
Seq/√Len: 210.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_D121_A4.0931.00
95_E98_A3.5751.00
77_E106_K3.4711.00
58_C103_F2.9851.00
26_T104_K2.7731.00
80_A104_K2.5961.00
31_E34_Q2.1461.00
19_K25_Y2.0801.00
25_Y107_A2.0211.00
75_S112_E2.0201.00
95_E99_G2.0131.00
119_A123_E1.9051.00
24_T104_K1.9021.00
51_T108_S1.8611.00
51_T77_E1.8611.00
117_L125_L1.8541.00
109_D112_E1.7701.00
88_S91_L1.7221.00
111_S114_E1.7161.00
52_V72_A1.7151.00
8_L18_R1.6231.00
8_L97_Y1.6201.00
18_R26_T1.5851.00
22_D106_K1.5101.00
92_V102_I1.5051.00
59_A70_I1.5001.00
53_S56_D1.4741.00
7_E18_R1.4721.00
74_V107_A1.4711.00
54_A115_S1.4561.00
31_E35_E1.4511.00
84_A88_S1.4361.00
60_V67_A1.4291.00
12_K125_L1.4121.00
47_E50_A1.3781.00
84_A99_G1.3621.00
57_D69_D1.3561.00
24_T106_K1.3391.00
85_L102_I1.3301.00
91_L100_G1.3031.00
17_L25_Y1.2741.00
53_S75_S1.2701.00
58_C70_I1.2691.00
60_V64_V1.2321.00
49_G77_E1.2141.00
45_L81_V1.1981.00
84_A91_L1.1901.00
34_Q93_N1.1841.00
32_H36_L1.1831.00
19_K107_A1.1501.00
52_V58_C1.1431.00
15_E64_V1.0841.00
54_A112_E1.0811.00
24_T79_V1.0731.00
79_V106_K1.0651.00
44_D60_V1.0651.00
83_D86_S1.0651.00
20_E26_T1.0611.00
6_A120_T1.0491.00
27_V103_F1.0491.00
88_S94_S1.0481.00
76_G105_I1.0371.00
9_K113_L1.0021.00
121_A124_A0.9801.00
48_V81_V0.9711.00
41_V64_V0.9571.00
43_V85_L0.9480.99
120_T123_E0.9420.99
74_V105_I0.9400.99
91_L94_S0.9210.99
80_A83_D0.9200.99
20_E104_K0.9170.99
50_A56_D0.9170.99
97_Y119_A0.9140.99
11_S17_L0.9110.99
9_K114_E0.8980.99
45_L102_I0.8960.99
20_E24_T0.8950.99
11_S30_T0.8840.99
6_A123_E0.8770.99
19_K113_L0.8750.99
43_V61_A0.8520.99
29_I61_A0.8490.99
11_S15_E0.8470.99
17_L74_V0.8470.99
70_I103_F0.8380.99
60_V69_D0.8120.98
91_L99_G0.8100.98
109_D113_L0.8060.98
25_Y74_V0.8030.98
13_E71_Y0.8000.98
84_A87_D0.7990.98
72_A105_I0.7960.98
39_D90_E0.7950.98
75_S108_S0.7920.98
19_K110_E0.7800.98
41_V67_A0.7770.98
108_S112_E0.7750.98
31_E97_Y0.7720.98
10_Y97_Y0.7690.98
16_W28_G0.7600.98
85_L91_L0.7580.98
5_P119_A0.7540.97
14_H38_G0.7520.97
48_V80_A0.7350.97
40_M61_A0.7280.97
90_E94_S0.7240.97
13_E66_A0.7140.96
27_V105_I0.7070.96
110_E114_E0.7060.96
5_P10_Y0.6910.96
9_K118_D0.6840.96
34_Q97_Y0.6810.95
107_A110_E0.6800.95
37_L68_S0.6750.95
70_I102_I0.6710.95
52_V78_I0.6660.95
25_Y113_L0.6600.95
21_A24_T0.6560.94
46_P78_I0.6500.94
24_T80_A0.6440.94
46_P81_V0.6420.94
110_E113_L0.6410.94
13_E55_G0.6320.93
10_Y30_T0.6290.93
36_L63_S0.6280.93
5_P30_T0.6250.93
15_E71_Y0.6190.92
83_D87_D0.6170.92
12_K121_A0.6170.92
33_A68_S0.6130.92
120_T124_A0.6130.92
47_E87_D0.6120.92
117_L121_A0.6080.92
65_K68_S0.6060.92
15_E41_V0.6010.91
52_V75_S0.5990.91
94_S99_G0.5980.91
43_V89_P0.5980.91
57_D66_A0.5940.91
40_M59_A0.5930.91
27_V73_P0.5900.91
46_P63_S0.5860.90
18_R21_A0.5780.90
29_I33_A0.5730.89
7_E119_A0.5730.89
32_H126_L0.5710.89
9_K19_K0.5660.89
31_E93_N0.5650.89
63_S66_A0.5640.89
62_E65_K0.5630.88
36_L68_S0.5630.88
48_V83_D0.5590.88
15_E33_A0.5580.88
12_K115_S0.5550.88
57_D60_V0.5530.88
49_G79_V0.5510.87
37_L66_A0.5480.87
25_Y112_E0.5410.86
40_M60_V0.5390.86
24_T107_A0.5390.86
95_E100_G0.5390.86
78_I103_F0.5370.86
40_M93_N0.5360.86
59_A103_F0.5330.86
30_T96_P0.5240.85
9_K39_D0.5240.85
39_D64_V0.5200.84
38_G68_S0.5190.84
41_V62_E0.5170.84
50_A53_S0.5160.84
39_D42_F0.5130.83
68_S71_Y0.5120.83
11_S116_L0.5110.83
109_D114_E0.5080.83
8_L119_A0.5070.83
43_V91_L0.5060.83
42_F62_E0.5030.82
50_A59_A0.5030.82
16_W93_N0.5020.82
78_I105_I0.5000.82
15_E66_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.9845 100 0.132 Contact Map
3mxuA 3 0.969 100 0.199 Contact Map
1hpcA 2 0.9845 100 0.217 Contact Map
3a7lA 1 0.9922 100 0.218 Contact Map
3tzuA 2 0.938 100 0.232 Contact Map
3wdnA 1 0.9535 100 0.255 Contact Map
1onlA 1 0.9767 100 0.268 Contact Map
1zkoA 2 0.9845 100 0.282 Contact Map
5a35A 1 0.8682 100 0.328 Contact Map
2dn8A 1 0.7752 96.2 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.