GREMLIN Database
GCH1 - GTP cyclohydrolase 1
UniProt: P0A6T5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11375
Length: 222 (185)
Sequences: 3014 (1462)
Seq/√Len: 107.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_A65_H3.3861.00
124_V138_I3.0361.00
65_H69_K2.9501.00
37_K73_D2.5671.00
43_H46_E2.5441.00
40_I47_I2.5091.00
79_L149_P2.3991.00
125_A173_A2.3811.00
62_E65_H2.2461.00
107_L178_A2.1861.00
161_I201_G2.1391.00
45_T56_A2.0861.00
129_K170_N2.0271.00
39_L46_E1.9881.00
84_F165_T1.9861.00
75_I116_V1.9731.00
39_L49_Q1.9311.00
71_Y76_F1.9131.00
82_A85_P1.8811.00
122_A176_I1.8521.00
44_M67_I1.8341.00
125_A214_F1.8271.00
173_A200_L1.7831.00
43_H50_L1.7451.00
97_D205_K1.7321.00
53_L57_D1.7211.00
145_F158_Q1.7031.00
99_M204_F1.6921.00
86_K144_F1.6391.00
38_S41_A1.6321.00
160_L201_G1.5961.00
108_T185_A1.5791.00
108_T181_Y1.5591.00
46_E49_Q1.5471.00
209_N212_H1.5401.00
115_F149_P1.5171.00
106_T192_T1.5141.00
170_N203_L1.5111.00
42_G46_E1.5071.00
76_F149_P1.5061.00
99_M214_F1.4871.00
121_K177_D1.4691.00
123_T177_D1.4591.00
179_V184_K1.4441.00
212_H216_R1.4401.00
148_R158_Q1.4161.00
177_D194_A1.3951.00
107_L142_V1.3941.00
124_V142_V1.3801.00
143_Q190_D1.3681.00
203_L207_S1.3611.00
175_S218_V1.3551.00
173_A214_F1.3471.00
77_S81_Y1.3471.00
76_F110_T1.3391.00
164_Q201_G1.3391.00
70_M75_I1.3240.99
127_I203_L1.3200.99
208_Q212_H1.2890.99
40_I68_A1.2790.99
99_M125_A1.2680.99
175_S214_F1.2660.99
36_R39_L1.2650.99
81_Y144_F1.2630.99
104_D121_K1.2630.99
175_S198_T1.2600.99
181_Y185_A1.2500.99
160_L199_S1.2370.99
48_M115_F1.2150.99
74_E189_R1.2130.99
141_I163_L1.2000.99
119_D181_Y1.1920.99
145_F162_A1.1820.99
78_G148_R1.1740.99
129_K168_G1.1740.99
48_M53_L1.1640.99
163_L167_L1.1570.99
142_V159_I1.1380.98
145_F155_L1.1310.98
132_V151_V1.1280.98
133_I138_I1.1270.98
58_D93_K1.1260.98
135_L195_T1.1200.98
38_S42_G1.1090.98
179_V192_T1.1010.98
46_E50_L1.1010.98
156_T197_T1.1000.98
151_V154_R1.0920.98
47_I71_Y1.0870.98
122_A159_I1.0850.98
99_M210_T1.0730.98
45_T55_L1.0720.98
216_R219_R1.0710.98
102_V193_S1.0640.97
107_L176_I1.0630.97
198_T210_T1.0600.97
200_L211_R1.0600.97
137_K140_R1.0580.97
161_I165_T1.0350.97
37_K41_A1.0300.97
122_A142_V1.0250.97
62_E89_L1.0240.97
53_L59_S1.0110.97
87_I133_I1.0060.96
160_L174_V1.0040.96
101_T125_A0.9940.96
155_L159_I0.9900.96
94_M154_R0.9830.96
110_T116_V0.9730.96
108_T119_D0.9670.96
84_F166_L0.9630.95
179_V194_A0.9600.95
123_T175_S0.9480.95
44_M47_I0.9430.95
107_L155_L0.9230.94
83_N144_F0.9200.94
67_I71_Y0.9180.94
44_M71_Y0.9180.94
116_V185_A0.9170.94
36_R50_L0.8990.93
157_Q161_I0.8990.93
81_Y86_K0.8900.93
143_Q147_Q0.8870.93
131_S168_G0.8840.93
102_V195_T0.8770.93
133_I173_A0.8750.92
77_S147_Q0.8670.92
102_V138_I0.8620.92
56_A61_M0.8620.92
51_L71_Y0.8570.92
210_T213_E0.8540.92
55_L60_L0.8490.91
67_I115_F0.8480.91
53_L60_L0.8480.91
45_T49_Q0.8410.91
102_V135_L0.8400.91
146_A155_L0.8380.91
133_I167_L0.8310.90
43_H47_I0.8270.90
164_Q172_V0.8210.90
136_S140_R0.8140.89
59_S112_E0.8140.89
160_L172_V0.8080.89
106_T121_K0.8080.89
101_T217_A0.8060.89
39_L50_L0.8060.89
37_K69_K0.8050.89
57_D60_L0.8040.89
161_I199_S0.8010.89
156_T176_I0.8000.89
184_K191_A0.7980.89
119_D179_V0.7970.88
203_L206_S0.7950.88
75_I110_T0.7950.88
103_R196_T0.7930.88
139_N183_V0.7850.88
86_K141_I0.7840.88
98_E199_S0.7830.88
204_F214_F0.7820.88
91_E131_S0.7820.88
107_L119_D0.7820.88
40_I44_M0.7820.88
87_I141_I0.7770.87
198_T213_E0.7700.87
200_L205_K0.7690.87
118_I181_Y0.7660.86
133_I141_I0.7640.86
71_Y75_I0.7610.86
96_V154_R0.7530.86
214_F218_V0.7500.85
98_E205_K0.7490.85
138_I163_L0.7450.85
155_L176_I0.7430.85
39_L43_H0.7430.85
136_S188_I0.7400.85
164_Q169_T0.7400.85
162_A165_T0.7320.84
181_Y184_K0.7290.84
200_L210_T0.7280.84
139_N190_D0.7120.82
164_Q168_G0.7080.82
200_L215_L0.7070.82
97_D170_N0.7070.82
207_S210_T0.7050.82
133_I139_N0.7050.82
161_I164_Q0.7040.81
123_T218_V0.7040.81
108_T147_Q0.7010.81
75_I185_A0.6990.81
141_I162_A0.6990.81
112_E154_R0.6950.81
173_A198_T0.6940.81
106_T179_V0.6930.80
183_V195_T0.6920.80
37_K65_H0.6870.80
44_M115_F0.6870.80
102_V128_P0.6850.80
137_K188_I0.6800.79
120_G178_A0.6790.79
165_T168_G0.6760.79
79_L145_F0.6740.79
200_L213_E0.6700.78
110_T185_A0.6680.78
79_L115_F0.6680.78
113_H153_E0.6650.78
93_K131_S0.6650.78
162_A166_L0.6640.78
200_L204_F0.6600.77
135_L140_R0.6590.77
106_T191_A0.6550.77
147_Q189_R0.6540.77
92_N132_V0.6500.76
121_K194_A0.6450.76
114_H153_E0.6410.75
90_I93_K0.6360.75
153_E182_C0.6350.74
144_F162_A0.6300.74
175_S210_T0.6280.74
98_E198_T0.6210.73
175_S217_A0.6200.73
83_N87_I0.6160.72
40_I50_L0.6150.72
110_T118_I0.6130.72
135_L180_H0.6050.71
198_T205_K0.6040.71
57_D112_E0.5980.70
151_V195_T0.5970.70
157_Q199_S0.5940.69
40_I71_Y0.5870.69
152_Q182_C0.5860.68
120_G142_V0.5850.68
122_A138_I0.5850.68
94_M157_Q0.5820.68
48_M67_I0.5760.67
84_F88_T0.5710.66
119_D184_K0.5710.66
127_I170_N0.5690.66
171_N203_L0.5630.65
113_H182_C0.5560.64
125_A175_S0.5550.64
44_M48_M0.5540.64
203_L210_T0.5510.64
114_H182_C0.5470.63
107_L120_G0.5460.63
39_L42_G0.5450.63
35_T50_L0.5410.62
212_H215_L0.5400.62
104_D194_A0.5400.62
141_I145_F0.5390.62
187_G195_T0.5380.62
127_I210_T0.5370.62
106_T190_D0.5350.61
86_K90_I0.5330.61
99_M127_I0.5310.61
186_R195_T0.5280.60
104_D123_T0.5250.60
155_L158_Q0.5240.60
86_K89_L0.5240.60
83_N133_I0.5240.60
97_D131_S0.5220.60
200_L214_F0.5210.59
157_Q201_G0.5200.59
42_G45_T0.5190.59
41_A45_T0.5190.59
209_N216_R0.5150.59
102_V183_V0.5140.58
73_D80_D0.5130.58
78_G147_Q0.5120.58
81_Y85_P0.5120.58
98_E210_T0.5110.58
203_L216_R0.5110.58
182_C187_G0.5070.57
99_M218_V0.5060.57
111_C114_H0.5060.57
165_T216_R0.5050.57
67_I75_I0.5040.57
150_Q154_R0.5000.56
205_K208_Q0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a8rA 7 0.9955 100 0.046 Contact Map
1is8A 5 0.8649 100 0.072 Contact Map
4uqfA 5 0.8333 100 0.085 Contact Map
1wurA 6 0.8333 100 0.136 Contact Map
4f8bA 5 0.6171 96 0.919 Contact Map
3uxjA 2 0.8288 52.7 0.954 Contact Map
3lq9A 1 0.4189 15.7 0.965 Contact Map
1w5dA 1 0.6622 12.7 0.966 Contact Map
1nbuA 4 0.4505 10.4 0.968 Contact Map
2q2kA 3 0.1982 9.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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