GREMLIN Database
GAL1 - Galactokinase
UniProt: P0A6T3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10363
Length: 382 (320)
Sequences: 4494 (3304)
Seq/√Len: 184.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_Q51_Q4.6151.00
295_A320_K4.3041.00
197_K283_E3.7481.00
65_R114_D3.7461.00
57_A114_D3.3911.00
286_D289_R3.2731.00
150_D153_Q3.2651.00
52_T132_S3.0231.00
301_M307_I2.8901.00
54_I136_A2.8811.00
329_V342_A2.8801.00
278_A290_M2.8081.00
227_R231_E2.7041.00
273_A277_E2.6841.00
206_A346_E2.6621.00
59_R114_D2.5281.00
291_G328_G2.5231.00
62_R81_D2.4591.00
354_Q358_E2.3771.00
56_C140_V2.3481.00
65_R77_E2.2911.00
280_S284_Q2.2781.00
289_R292_E2.2621.00
63_K77_E2.2281.00
204_G346_E2.1981.00
142_Q148_P2.1461.00
344_I352_V2.1121.00
135_V179_A2.1061.00
233_G265_V2.0821.00
281_A289_R2.0781.00
312_I340_I2.0681.00
138_G154_I2.0121.00
281_A286_D1.9421.00
345_P348_L1.8981.00
279_A283_E1.8881.00
236_F261_V1.8351.00
299_A303_D1.8341.00
20_T58_P1.8221.00
216_R334_G1.8151.00
210_I342_A1.8101.00
23_I143_Q1.7671.00
169_N224_N1.7391.00
267_H300_S1.7381.00
348_L351_A1.7341.00
266_R304_D1.7161.00
317_E321_A1.7051.00
299_A320_K1.7051.00
25_A136_A1.6921.00
232_T236_F1.6881.00
277_E289_R1.6581.00
58_P111_G1.6481.00
259_P263_K1.6341.00
101_K105_L1.6151.00
314_T318_I1.6061.00
358_E362_A1.5901.00
208_V352_V1.5871.00
155_A179_A1.5761.00
111_G145_Y1.5721.00
79_S82_A1.5681.00
350_P354_Q1.5671.00
152_A156_L1.5621.00
318_I322_V1.5601.00
32_I278_A1.5581.00
42_F276_V1.5451.00
292_E296_E1.5421.00
56_C144_L1.5331.00
70_D118_S1.5221.00
316_V329_V1.5161.00
117_I133_L1.5021.00
228_E232_T1.4921.00
349_V353_Q1.4761.00
22_T55_S1.4671.00
322_V355_A1.4331.00
63_K79_S1.4301.00
135_V158_G1.4291.00
106_R160_E1.4291.00
160_E164_Q1.4111.00
214_F309_V1.4111.00
142_Q154_I1.3901.00
302_R313_D1.3751.00
350_P353_Q1.3671.00
56_C113_V1.3571.00
182_K198_A1.3551.00
321_A359_Q1.3461.00
39_N230_C1.3451.00
322_V326_K1.3441.00
210_I340_I1.3441.00
99_V138_G1.3401.00
271_E274_R1.3391.00
35_H38_Y1.3361.00
270_T304_D1.3301.00
206_A349_V1.3271.00
100_V141_L1.3191.00
30_N45_P1.3071.00
318_I359_Q1.2951.00
329_V340_I1.2941.00
355_A359_Q1.2881.00
308_T313_D1.2871.00
188_L279_A1.2831.00
260_I263_K1.2771.00
62_R79_S1.2751.00
64_V112_G1.2581.00
139_T151_G1.2551.00
68_A71_Y1.2521.00
64_V113_V1.2411.00
177_I181_G1.2411.00
298_H316_V1.2391.00
232_T235_R1.2371.00
59_R112_G1.2321.00
69_A116_V1.2181.00
102_H160_E1.1971.00
28_R37_D1.1841.00
229_Q264_R1.1791.00
217_T220_G1.1751.00
96_V137_V1.1721.00
66_V96_V1.1721.00
280_S283_E1.1691.00
312_I331_M1.1611.00
151_G179_A1.1581.00
277_E280_S1.1571.00
308_T331_M1.1571.00
230_C234_A1.1461.00
54_I115_M1.1451.00
119_G132_S1.1431.00
263_K306_E1.1411.00
131_A170_C1.1321.00
142_Q147_L1.1301.00
319_V352_V1.1211.00
34_E301_M1.1191.00
351_A354_Q1.1181.00
225_T229_Q1.1061.00
264_R306_E1.1001.00
262_A266_R1.0991.00
142_Q149_L1.0951.00
288_K345_P1.0941.00
25_A178_S1.0941.00
234_A238_Q1.0911.00
182_K185_H1.0861.00
290_M343_L1.0801.00
27_G121_V1.0751.00
273_A276_V1.0751.00
135_V178_S1.0741.00
351_A355_A1.0721.00
132_S178_S1.0631.00
315_L340_I1.0561.00
36_T272_N1.0561.00
102_H106_R1.0541.00
162_E338_G1.0501.00
29_V341_V1.0501.00
30_N34_E1.0471.00
212_S315_L1.0431.00
64_V78_F1.0431.00
359_Q362_A1.0371.00
210_I315_L1.0351.00
288_K292_E1.0271.00
322_V325_D1.0251.00
266_R270_T1.0181.00
352_V356_V1.0161.00
106_R153_Q1.0150.99
139_T154_I1.0140.99
138_G158_G1.0120.99
55_S116_V1.0050.99
225_T228_E1.0040.99
117_I137_V1.0000.99
299_A302_R0.9950.99
296_E299_A0.9940.99
318_I321_A0.9870.99
67_M116_V0.9820.99
233_G261_V0.9770.99
162_E171_G0.9750.99
115_M137_V0.9710.99
61_D112_G0.9660.99
168_C334_G0.9650.99
58_P144_L0.9650.99
210_I329_V0.9650.99
176_L180_L0.9640.99
92_W95_Y0.9640.99
214_F311_Q0.9620.99
36_T39_N0.9510.99
66_V78_F0.9490.99
229_Q260_I0.9470.99
327_G345_P0.9370.99
232_T261_V0.9320.99
210_I319_V0.9270.99
159_Q172_I0.9140.99
102_H105_L0.9060.99
20_T57_A0.9050.99
326_K348_L0.9020.99
54_I117_I0.9020.99
153_Q157_N0.9010.99
53_V118_S0.8990.99
313_D316_V0.8990.99
226_R230_C0.8970.99
223_Y227_R0.8920.99
172_I176_L0.8920.99
69_A118_S0.8900.99
152_A180_L0.8880.99
44_L199_V0.8820.99
56_C115_M0.8820.99
29_V332_T0.8810.99
281_A293_L0.8800.99
188_L191_C0.8780.99
40_D192_R0.8730.98
94_N97_R0.8720.98
319_V340_I0.8700.98
215_K218_L0.8660.98
37_D175_Q0.8640.98
197_K279_A0.8640.98
29_V46_C0.8630.98
236_F257_L0.8630.98
43_V173_M0.8610.98
319_V329_V0.8610.98
293_L297_S0.8610.98
54_I140_V0.8600.98
310_P314_T0.8580.98
155_A159_Q0.8570.98
45_P177_I0.8540.98
316_V320_K0.8520.98
108_N149_L0.8520.98
275_T279_A0.8520.98
277_E296_E0.8500.98
168_C218_L0.8460.98
294_M328_G0.8450.98
29_V48_I0.8440.98
24_Q53_V0.8440.98
90_Y93_A0.8440.98
221_S336_F0.8380.98
268_I271_E0.8370.98
36_T41_G0.8280.98
204_G345_P0.8270.98
99_V103_L0.8260.98
301_M312_I0.8220.98
99_V161_A0.8220.98
159_Q170_C0.8210.98
275_T278_A0.8190.98
37_D41_G0.8110.98
133_L137_V0.8100.98
184_D202_P0.8070.97
59_R64_V0.8070.97
267_H271_E0.8070.97
355_A358_E0.8070.97
353_Q357_A0.8070.97
86_A89_N0.8070.97
134_E161_A0.8000.97
58_P145_Y0.7970.97
295_A299_A0.7920.97
90_Y94_N0.7900.97
176_L196_T0.7890.97
212_S312_I0.7890.97
309_V312_I0.7880.97
127_L209_I0.7860.97
171_G175_Q0.7850.97
265_V269_L0.7820.97
332_T339_C0.7770.97
153_Q156_L0.7750.97
235_R238_Q0.7730.97
278_A282_L0.7700.97
37_D43_V0.7700.97
314_T317_E0.7690.97
333_G337_G0.7690.97
313_D317_E0.7670.97
26_P47_A0.7640.96
106_R157_N0.7610.96
28_R175_Q0.7590.96
293_L296_E0.7560.96
89_N93_A0.7530.96
319_V356_V0.7530.96
28_R128_S0.7530.96
258_D261_V0.7520.96
162_E175_Q0.7490.96
47_A178_S0.7490.96
90_Y97_R0.7440.96
352_V355_A0.7430.96
286_D292_E0.7430.96
223_Y226_R0.7420.96
163_N166_V0.7400.96
230_C233_G0.7390.96
158_G179_A0.7360.96
278_A294_M0.7360.96
30_N35_H0.7350.96
257_L261_V0.7320.96
135_V154_I0.7310.95
229_Q232_T0.7290.95
30_N332_T0.7280.95
28_R43_V0.7260.95
134_E158_G0.7220.95
226_R229_Q0.7210.95
21_H143_Q0.7210.95
142_Q145_Y0.7200.95
294_M341_V0.7180.95
101_K104_Q0.7160.95
223_Y230_C0.7130.95
318_I355_A0.7100.95
51_Q121_V0.7100.95
176_L189_I0.7100.95
322_V351_A0.7090.95
60_D111_G0.7080.95
138_G157_N0.7030.94
187_L198_A0.7020.94
170_C218_L0.7010.94
262_A265_V0.6940.94
349_V352_V0.6930.94
34_E173_M0.6930.94
136_A140_V0.6910.94
208_V319_V0.6900.94
154_I179_A0.6890.94
161_A166_V0.6890.94
23_I136_A0.6880.94
319_V325_D0.6870.94
227_R230_C0.6830.94
212_S337_G0.6820.94
294_M343_L0.6790.93
274_R293_L0.6780.93
67_M114_D0.6770.93
297_S300_S0.6770.93
42_F272_N0.6750.93
277_E293_L0.6730.93
52_T121_V0.6720.93
62_R80_L0.6720.93
84_I87_H0.6710.93
218_L221_S0.6690.93
130_S338_G0.6640.93
59_R62_R0.6620.92
103_L157_N0.6510.92
229_Q261_V0.6500.92
28_R174_D0.6460.92
322_V352_V0.6440.91
354_Q357_A0.6430.91
295_A328_G0.6420.91
42_F275_T0.6420.91
36_T265_V0.6410.91
200_S283_E0.6390.91
115_M140_V0.6380.91
89_N94_N0.6360.91
27_G35_H0.6350.91
32_I293_L0.6340.91
151_G154_I0.6340.91
199_V279_A0.6340.91
155_A175_Q0.6340.91
48_I127_L0.6310.91
210_I356_V0.6300.91
332_T341_V0.6290.90
270_T273_A0.6290.90
30_N37_D0.6280.90
261_V268_I0.6280.90
132_S136_A0.6280.90
269_L272_N0.6270.90
151_G180_L0.6270.90
88_E94_N0.6260.90
358_E361_E0.6250.90
185_H200_S0.6230.90
163_N170_C0.6230.90
29_V45_P0.6230.90
326_K345_P0.6210.90
139_T142_Q0.6210.90
100_V103_L0.6160.90
298_H331_M0.6160.90
103_L106_R0.6160.90
103_L147_L0.6160.90
59_R65_R0.6140.89
265_V268_I0.6140.89
35_H301_M0.6120.89
216_R221_S0.6070.89
309_V314_T0.6070.89
52_T136_A0.6050.89
206_A347_E0.6050.89
175_Q338_G0.6040.89
298_H302_R0.6020.88
34_E45_P0.6010.88
68_A133_L0.6000.88
30_N128_S0.6000.88
298_H301_M0.5990.88
223_Y233_G0.5990.88
31_L290_M0.5990.88
314_T321_A0.5990.88
35_H45_P0.5980.88
93_A97_R0.5980.88
176_L194_L0.5950.88
34_E341_V0.5920.88
205_V327_G0.5890.87
233_G237_F0.5850.87
105_L160_E0.5840.87
166_V170_C0.5830.87
23_I54_I0.5830.87
314_T320_K0.5830.87
292_E359_Q0.5820.87
96_V117_I0.5810.87
216_R339_C0.5810.87
264_R267_H0.5810.87
152_A195_G0.5790.86
142_Q153_Q0.5790.86
171_G174_D0.5790.86
295_A327_G0.5770.86
295_A316_V0.5760.86
313_D319_V0.5740.86
92_W98_G0.5740.86
228_E231_E0.5740.86
61_D64_V0.5730.86
36_T42_F0.5720.86
103_L108_N0.5720.86
191_C194_L0.5700.86
189_I194_L0.5700.86
139_T179_A0.5680.85
99_V141_L0.5680.85
45_P172_I0.5680.85
180_L196_T0.5670.85
186_A189_I0.5640.85
130_S333_G0.5640.85
302_R317_E0.5630.85
86_A97_R0.5620.85
134_E170_C0.5620.85
95_Y100_V0.5610.85
37_D171_G0.5600.85
226_R233_G0.5600.85
162_E174_D0.5590.85
162_E167_G0.5590.85
43_V172_I0.5570.84
84_I88_E0.5560.84
316_V340_I0.5550.84
134_E175_Q0.5550.84
340_I352_V0.5520.84
149_L153_Q0.5520.84
264_R271_E0.5520.84
271_E275_T0.5510.84
159_Q175_Q0.5480.83
314_T359_Q0.5480.83
128_S173_M0.5440.83
333_G338_G0.5440.83
55_S118_S0.5410.83
28_R36_T0.5390.82
35_H298_H0.5390.82
85_V89_N0.5380.82
142_Q151_G0.5360.82
35_H305_F0.5350.82
185_H279_A0.5340.82
30_N301_M0.5340.82
171_G338_G0.5330.82
154_I157_N0.5320.82
320_K326_K0.5320.82
317_E320_K0.5300.81
28_R223_Y0.5300.81
68_A72_E0.5290.81
44_L278_A0.5280.81
82_A85_V0.5270.81
113_V141_L0.5270.81
57_A116_V0.5270.81
170_C173_M0.5260.81
289_R293_L0.5250.81
268_I272_N0.5240.81
44_L275_T0.5230.80
210_I213_N0.5220.80
96_V133_L0.5210.80
131_A334_G0.5200.80
156_L159_Q0.5200.80
186_A191_C0.5190.80
209_I332_T0.5190.80
212_S340_I0.5180.80
319_V342_A0.5170.80
207_V341_V0.5160.80
109_S321_A0.5160.80
184_D187_L0.5160.80
263_K266_R0.5150.79
86_A90_Y0.5140.79
27_G34_E0.5110.79
113_V145_Y0.5110.79
36_T234_A0.5100.79
91_Q95_Y0.5100.79
208_V344_I0.5090.79
128_S223_Y0.5080.79
78_F97_R0.5070.78
97_R100_V0.5070.78
25_A52_T0.5070.78
25_A135_V0.5050.78
122_P338_G0.5040.78
229_Q258_D0.5020.78
298_H308_T0.5020.78
156_L160_E0.5020.78
313_D328_G0.5020.78
138_G161_A0.5010.78
23_I139_T0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pieA 1 0.9895 100 0.224 Contact Map
2a2cA 1 0.9764 100 0.256 Contact Map
1wuuA 2 0.9791 100 0.26 Contact Map
3v2uC 2 0.9869 100 0.268 Contact Map
2cz9A 1 0.9058 100 0.312 Contact Map
1kvkA 2 0.8586 100 0.416 Contact Map
3k85A 3 0.7539 100 0.437 Contact Map
4n3oA 2 0.8141 100 0.439 Contact Map
1kkhA 1 0.8089 100 0.451 Contact Map
2hfsA 1 0.8403 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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