GAL1 - ECOLI - GREMLIN Contacts

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GAL1 - Galactokinase

UniProt:	P0A6T3	Sequences: MSLKEKTQSLFANAFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRKVRVMAADYENQLDEFSLDAPIVAHENYQWANYVRGVVKHLQLRNNSFGGVDMVISGNVPQGAGLSSSASLEVAVGTVLQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPALRDVTIEEFNAVAHELDPIVAKRVRHILTENARTVEAASALEQGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVIGDKGGVRMTGGGFGGCIVALIPEELVPAVQQAVAEQYEAKTGIKETFYVCKPSQGAGQC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10363
Length:	382 (320)
Sequences:	4494 (3304)
Seq/√Len:	184.7

ECOLI - GAL1 KHSE
BACSU - GAL1
HALSA - Q9HQI6
SULSO - MVK PMK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_Q	51_Q	4.615	1.00
295_A	320_K	4.304	1.00
197_K	283_E	3.748	1.00
65_R	114_D	3.746	1.00
57_A	114_D	3.391	1.00
286_D	289_R	3.273	1.00
150_D	153_Q	3.265	1.00
52_T	132_S	3.023	1.00
301_M	307_I	2.890	1.00
54_I	136_A	2.881	1.00
329_V	342_A	2.880	1.00
278_A	290_M	2.808	1.00
227_R	231_E	2.704	1.00
273_A	277_E	2.684	1.00
206_A	346_E	2.662	1.00
59_R	114_D	2.528	1.00
291_G	328_G	2.523	1.00
62_R	81_D	2.459	1.00
354_Q	358_E	2.377	1.00
56_C	140_V	2.348	1.00
65_R	77_E	2.291	1.00
280_S	284_Q	2.278	1.00
289_R	292_E	2.262	1.00
63_K	77_E	2.228	1.00
204_G	346_E	2.198	1.00
142_Q	148_P	2.146	1.00
344_I	352_V	2.112	1.00
135_V	179_A	2.106	1.00
233_G	265_V	2.082	1.00
281_A	289_R	2.078	1.00
312_I	340_I	2.068	1.00
138_G	154_I	2.012	1.00
281_A	286_D	1.942	1.00
345_P	348_L	1.898	1.00
279_A	283_E	1.888	1.00
236_F	261_V	1.835	1.00
299_A	303_D	1.834	1.00
20_T	58_P	1.822	1.00
216_R	334_G	1.815	1.00
210_I	342_A	1.810	1.00
23_I	143_Q	1.767	1.00
169_N	224_N	1.739	1.00
267_H	300_S	1.738	1.00
348_L	351_A	1.734	1.00
266_R	304_D	1.716	1.00
317_E	321_A	1.705	1.00
299_A	320_K	1.705	1.00
25_A	136_A	1.692	1.00
232_T	236_F	1.688	1.00
277_E	289_R	1.658	1.00
58_P	111_G	1.648	1.00
259_P	263_K	1.634	1.00
101_K	105_L	1.615	1.00
314_T	318_I	1.606	1.00
358_E	362_A	1.590	1.00
208_V	352_V	1.587	1.00
155_A	179_A	1.576	1.00
111_G	145_Y	1.572	1.00
79_S	82_A	1.568	1.00
350_P	354_Q	1.567	1.00
152_A	156_L	1.562	1.00
318_I	322_V	1.560	1.00
32_I	278_A	1.558	1.00
42_F	276_V	1.545	1.00
292_E	296_E	1.542	1.00
56_C	144_L	1.533	1.00
70_D	118_S	1.522	1.00
316_V	329_V	1.516	1.00
117_I	133_L	1.502	1.00
228_E	232_T	1.492	1.00
349_V	353_Q	1.476	1.00
22_T	55_S	1.467	1.00
322_V	355_A	1.433	1.00
63_K	79_S	1.430	1.00
135_V	158_G	1.429	1.00
106_R	160_E	1.429	1.00
160_E	164_Q	1.411	1.00
214_F	309_V	1.411	1.00
142_Q	154_I	1.390	1.00
302_R	313_D	1.375	1.00
350_P	353_Q	1.367	1.00
56_C	113_V	1.357	1.00
182_K	198_A	1.355	1.00
321_A	359_Q	1.346	1.00
39_N	230_C	1.345	1.00
322_V	326_K	1.344	1.00
210_I	340_I	1.344	1.00
99_V	138_G	1.340	1.00
271_E	274_R	1.339	1.00
35_H	38_Y	1.336	1.00
270_T	304_D	1.330	1.00
206_A	349_V	1.327	1.00
100_V	141_L	1.319	1.00
30_N	45_P	1.307	1.00
318_I	359_Q	1.295	1.00
329_V	340_I	1.294	1.00
355_A	359_Q	1.288	1.00
308_T	313_D	1.287	1.00
188_L	279_A	1.283	1.00
260_I	263_K	1.277	1.00
62_R	79_S	1.275	1.00
64_V	112_G	1.258	1.00
139_T	151_G	1.255	1.00
68_A	71_Y	1.252	1.00
64_V	113_V	1.241	1.00
177_I	181_G	1.241	1.00
298_H	316_V	1.239	1.00
232_T	235_R	1.237	1.00
59_R	112_G	1.232	1.00
69_A	116_V	1.218	1.00
102_H	160_E	1.197	1.00
28_R	37_D	1.184	1.00
229_Q	264_R	1.179	1.00
217_T	220_G	1.175	1.00
96_V	137_V	1.172	1.00
66_V	96_V	1.172	1.00
280_S	283_E	1.169	1.00
312_I	331_M	1.161	1.00
151_G	179_A	1.158	1.00
277_E	280_S	1.157	1.00
308_T	331_M	1.157	1.00
230_C	234_A	1.146	1.00
54_I	115_M	1.145	1.00
119_G	132_S	1.143	1.00
263_K	306_E	1.141	1.00
131_A	170_C	1.132	1.00
142_Q	147_L	1.130	1.00
319_V	352_V	1.121	1.00
34_E	301_M	1.119	1.00
351_A	354_Q	1.118	1.00
225_T	229_Q	1.106	1.00
264_R	306_E	1.100	1.00
262_A	266_R	1.099	1.00
142_Q	149_L	1.095	1.00
288_K	345_P	1.094	1.00
25_A	178_S	1.094	1.00
234_A	238_Q	1.091	1.00
182_K	185_H	1.086	1.00
290_M	343_L	1.080	1.00
27_G	121_V	1.075	1.00
273_A	276_V	1.075	1.00
135_V	178_S	1.074	1.00
351_A	355_A	1.072	1.00
132_S	178_S	1.063	1.00
315_L	340_I	1.056	1.00
36_T	272_N	1.056	1.00
102_H	106_R	1.054	1.00
162_E	338_G	1.050	1.00
29_V	341_V	1.050	1.00
30_N	34_E	1.047	1.00
212_S	315_L	1.043	1.00
64_V	78_F	1.043	1.00
359_Q	362_A	1.037	1.00
210_I	315_L	1.035	1.00
288_K	292_E	1.027	1.00
322_V	325_D	1.025	1.00
266_R	270_T	1.018	1.00
352_V	356_V	1.016	1.00
106_R	153_Q	1.015	0.99
139_T	154_I	1.014	0.99
138_G	158_G	1.012	0.99
55_S	116_V	1.005	0.99
225_T	228_E	1.004	0.99
117_I	137_V	1.000	0.99
299_A	302_R	0.995	0.99
296_E	299_A	0.994	0.99
318_I	321_A	0.987	0.99
67_M	116_V	0.982	0.99
233_G	261_V	0.977	0.99
162_E	171_G	0.975	0.99
115_M	137_V	0.971	0.99
61_D	112_G	0.966	0.99
168_C	334_G	0.965	0.99
58_P	144_L	0.965	0.99
210_I	329_V	0.965	0.99
176_L	180_L	0.964	0.99
92_W	95_Y	0.964	0.99
214_F	311_Q	0.962	0.99
36_T	39_N	0.951	0.99
66_V	78_F	0.949	0.99
229_Q	260_I	0.947	0.99
327_G	345_P	0.937	0.99
232_T	261_V	0.932	0.99
210_I	319_V	0.927	0.99
159_Q	172_I	0.914	0.99
102_H	105_L	0.906	0.99
20_T	57_A	0.905	0.99
326_K	348_L	0.902	0.99
54_I	117_I	0.902	0.99
153_Q	157_N	0.901	0.99
53_V	118_S	0.899	0.99
313_D	316_V	0.899	0.99
226_R	230_C	0.897	0.99
223_Y	227_R	0.892	0.99
172_I	176_L	0.892	0.99
69_A	118_S	0.890	0.99
152_A	180_L	0.888	0.99
44_L	199_V	0.882	0.99
56_C	115_M	0.882	0.99
29_V	332_T	0.881	0.99
281_A	293_L	0.880	0.99
188_L	191_C	0.878	0.99
40_D	192_R	0.873	0.98
94_N	97_R	0.872	0.98
319_V	340_I	0.870	0.98
215_K	218_L	0.866	0.98
37_D	175_Q	0.864	0.98
197_K	279_A	0.864	0.98
29_V	46_C	0.863	0.98
236_F	257_L	0.863	0.98
43_V	173_M	0.861	0.98
319_V	329_V	0.861	0.98
293_L	297_S	0.861	0.98
54_I	140_V	0.860	0.98
310_P	314_T	0.858	0.98
155_A	159_Q	0.857	0.98
45_P	177_I	0.854	0.98
316_V	320_K	0.852	0.98
108_N	149_L	0.852	0.98
275_T	279_A	0.852	0.98
277_E	296_E	0.850	0.98
168_C	218_L	0.846	0.98
294_M	328_G	0.845	0.98
29_V	48_I	0.844	0.98
24_Q	53_V	0.844	0.98
90_Y	93_A	0.844	0.98
221_S	336_F	0.838	0.98
268_I	271_E	0.837	0.98
36_T	41_G	0.828	0.98
204_G	345_P	0.827	0.98
99_V	103_L	0.826	0.98
301_M	312_I	0.822	0.98
99_V	161_A	0.822	0.98
159_Q	170_C	0.821	0.98
275_T	278_A	0.819	0.98
37_D	41_G	0.811	0.98
133_L	137_V	0.810	0.98
184_D	202_P	0.807	0.97
59_R	64_V	0.807	0.97
267_H	271_E	0.807	0.97
355_A	358_E	0.807	0.97
353_Q	357_A	0.807	0.97
86_A	89_N	0.807	0.97
134_E	161_A	0.800	0.97
58_P	145_Y	0.797	0.97
295_A	299_A	0.792	0.97
90_Y	94_N	0.790	0.97
176_L	196_T	0.789	0.97
212_S	312_I	0.789	0.97
309_V	312_I	0.788	0.97
127_L	209_I	0.786	0.97
171_G	175_Q	0.785	0.97
265_V	269_L	0.782	0.97
332_T	339_C	0.777	0.97
153_Q	156_L	0.775	0.97
235_R	238_Q	0.773	0.97
278_A	282_L	0.770	0.97
37_D	43_V	0.770	0.97
314_T	317_E	0.769	0.97
333_G	337_G	0.769	0.97
313_D	317_E	0.767	0.97
26_P	47_A	0.764	0.96
106_R	157_N	0.761	0.96
28_R	175_Q	0.759	0.96
293_L	296_E	0.756	0.96
89_N	93_A	0.753	0.96
319_V	356_V	0.753	0.96
28_R	128_S	0.753	0.96
258_D	261_V	0.752	0.96
162_E	175_Q	0.749	0.96
47_A	178_S	0.749	0.96
90_Y	97_R	0.744	0.96
352_V	355_A	0.743	0.96
286_D	292_E	0.743	0.96
223_Y	226_R	0.742	0.96
163_N	166_V	0.740	0.96
230_C	233_G	0.739	0.96
158_G	179_A	0.736	0.96
278_A	294_M	0.736	0.96
30_N	35_H	0.735	0.96
257_L	261_V	0.732	0.96
135_V	154_I	0.731	0.95
229_Q	232_T	0.729	0.95
30_N	332_T	0.728	0.95
28_R	43_V	0.726	0.95
134_E	158_G	0.722	0.95
226_R	229_Q	0.721	0.95
21_H	143_Q	0.721	0.95
142_Q	145_Y	0.720	0.95
294_M	341_V	0.718	0.95
101_K	104_Q	0.716	0.95
223_Y	230_C	0.713	0.95
318_I	355_A	0.710	0.95
51_Q	121_V	0.710	0.95
176_L	189_I	0.710	0.95
322_V	351_A	0.709	0.95
60_D	111_G	0.708	0.95
138_G	157_N	0.703	0.94
187_L	198_A	0.702	0.94
170_C	218_L	0.701	0.94
262_A	265_V	0.694	0.94
349_V	352_V	0.693	0.94
34_E	173_M	0.693	0.94
136_A	140_V	0.691	0.94
208_V	319_V	0.690	0.94
154_I	179_A	0.689	0.94
161_A	166_V	0.689	0.94
23_I	136_A	0.688	0.94
319_V	325_D	0.687	0.94
227_R	230_C	0.683	0.94
212_S	337_G	0.682	0.94
294_M	343_L	0.679	0.93
274_R	293_L	0.678	0.93
67_M	114_D	0.677	0.93
297_S	300_S	0.677	0.93
42_F	272_N	0.675	0.93
277_E	293_L	0.673	0.93
52_T	121_V	0.672	0.93
62_R	80_L	0.672	0.93
84_I	87_H	0.671	0.93
218_L	221_S	0.669	0.93
130_S	338_G	0.664	0.93
59_R	62_R	0.662	0.92
103_L	157_N	0.651	0.92
229_Q	261_V	0.650	0.92
28_R	174_D	0.646	0.92
322_V	352_V	0.644	0.91
354_Q	357_A	0.643	0.91
295_A	328_G	0.642	0.91
42_F	275_T	0.642	0.91
36_T	265_V	0.641	0.91
200_S	283_E	0.639	0.91
115_M	140_V	0.638	0.91
89_N	94_N	0.636	0.91
27_G	35_H	0.635	0.91
32_I	293_L	0.634	0.91
151_G	154_I	0.634	0.91
199_V	279_A	0.634	0.91
155_A	175_Q	0.634	0.91
48_I	127_L	0.631	0.91
210_I	356_V	0.630	0.91
332_T	341_V	0.629	0.90
270_T	273_A	0.629	0.90
30_N	37_D	0.628	0.90
261_V	268_I	0.628	0.90
132_S	136_A	0.628	0.90
269_L	272_N	0.627	0.90
151_G	180_L	0.627	0.90
88_E	94_N	0.626	0.90
358_E	361_E	0.625	0.90
185_H	200_S	0.623	0.90
163_N	170_C	0.623	0.90
29_V	45_P	0.623	0.90
326_K	345_P	0.621	0.90
139_T	142_Q	0.621	0.90
100_V	103_L	0.616	0.90
298_H	331_M	0.616	0.90
103_L	106_R	0.616	0.90
103_L	147_L	0.616	0.90
59_R	65_R	0.614	0.89
265_V	268_I	0.614	0.89
35_H	301_M	0.612	0.89
216_R	221_S	0.607	0.89
309_V	314_T	0.607	0.89
52_T	136_A	0.605	0.89
206_A	347_E	0.605	0.89
175_Q	338_G	0.604	0.89
298_H	302_R	0.602	0.88
34_E	45_P	0.601	0.88
68_A	133_L	0.600	0.88
30_N	128_S	0.600	0.88
298_H	301_M	0.599	0.88
223_Y	233_G	0.599	0.88
31_L	290_M	0.599	0.88
314_T	321_A	0.599	0.88
35_H	45_P	0.598	0.88
93_A	97_R	0.598	0.88
176_L	194_L	0.595	0.88
34_E	341_V	0.592	0.88
205_V	327_G	0.589	0.87
233_G	237_F	0.585	0.87
105_L	160_E	0.584	0.87
166_V	170_C	0.583	0.87
23_I	54_I	0.583	0.87
314_T	320_K	0.583	0.87
292_E	359_Q	0.582	0.87
96_V	117_I	0.581	0.87
216_R	339_C	0.581	0.87
264_R	267_H	0.581	0.87
152_A	195_G	0.579	0.86
142_Q	153_Q	0.579	0.86
171_G	174_D	0.579	0.86
295_A	327_G	0.577	0.86
295_A	316_V	0.576	0.86
313_D	319_V	0.574	0.86
92_W	98_G	0.574	0.86
228_E	231_E	0.574	0.86
61_D	64_V	0.573	0.86
36_T	42_F	0.572	0.86
103_L	108_N	0.572	0.86
191_C	194_L	0.570	0.86
189_I	194_L	0.570	0.86
139_T	179_A	0.568	0.85
99_V	141_L	0.568	0.85
45_P	172_I	0.568	0.85
180_L	196_T	0.567	0.85
186_A	189_I	0.564	0.85
130_S	333_G	0.564	0.85
302_R	317_E	0.563	0.85
86_A	97_R	0.562	0.85
134_E	170_C	0.562	0.85
95_Y	100_V	0.561	0.85
37_D	171_G	0.560	0.85
226_R	233_G	0.560	0.85
162_E	174_D	0.559	0.85
162_E	167_G	0.559	0.85
43_V	172_I	0.557	0.84
84_I	88_E	0.556	0.84
316_V	340_I	0.555	0.84
134_E	175_Q	0.555	0.84
340_I	352_V	0.552	0.84
149_L	153_Q	0.552	0.84
264_R	271_E	0.552	0.84
271_E	275_T	0.551	0.84
159_Q	175_Q	0.548	0.83
314_T	359_Q	0.548	0.83
128_S	173_M	0.544	0.83
333_G	338_G	0.544	0.83
55_S	118_S	0.541	0.83
28_R	36_T	0.539	0.82
35_H	298_H	0.539	0.82
85_V	89_N	0.538	0.82
142_Q	151_G	0.536	0.82
35_H	305_F	0.535	0.82
185_H	279_A	0.534	0.82
30_N	301_M	0.534	0.82
171_G	338_G	0.533	0.82
154_I	157_N	0.532	0.82
320_K	326_K	0.532	0.82
317_E	320_K	0.530	0.81
28_R	223_Y	0.530	0.81
68_A	72_E	0.529	0.81
44_L	278_A	0.528	0.81
82_A	85_V	0.527	0.81
113_V	141_L	0.527	0.81
57_A	116_V	0.527	0.81
170_C	173_M	0.526	0.81
289_R	293_L	0.525	0.81
268_I	272_N	0.524	0.81
44_L	275_T	0.523	0.80
210_I	213_N	0.522	0.80
96_V	133_L	0.521	0.80
131_A	334_G	0.520	0.80
156_L	159_Q	0.520	0.80
186_A	191_C	0.519	0.80
209_I	332_T	0.519	0.80
212_S	340_I	0.518	0.80
319_V	342_A	0.517	0.80
207_V	341_V	0.516	0.80
109_S	321_A	0.516	0.80
184_D	187_L	0.516	0.80
263_K	266_R	0.515	0.79
86_A	90_Y	0.514	0.79
27_G	34_E	0.511	0.79
113_V	145_Y	0.511	0.79
36_T	234_A	0.510	0.79
91_Q	95_Y	0.510	0.79
208_V	344_I	0.509	0.79
128_S	223_Y	0.508	0.79
78_F	97_R	0.507	0.78
97_R	100_V	0.507	0.78
25_A	52_T	0.507	0.78
25_A	135_V	0.505	0.78
122_P	338_G	0.504	0.78
229_Q	258_D	0.502	0.78
298_H	308_T	0.502	0.78
156_L	160_E	0.502	0.78
313_D	328_G	0.502	0.78
138_G	161_A	0.501	0.78
23_I	139_T	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pieA	1	0.9895	100	0.224	Contact Map
2a2cA	1	0.9764	100	0.256	Contact Map
1wuuA	2	0.9791	100	0.26	Contact Map
3v2uC	2	0.9869	100	0.268	Contact Map
2cz9A	1	0.9058	100	0.312	Contact Map
1kvkA	2	0.8586	100	0.416	Contact Map
3k85A	3	0.7539	100	0.437	Contact Map
4n3oA	2	0.8141	100	0.439	Contact Map
1kkhA	1	0.8089	100	0.451	Contact Map
2hfsA	1	0.8403	100	0.468	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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