GREMLIN Database
GPDA - Glycerol-3-phosphate dehydrogenase [NAD(P)+]
UniProt: P0A6S7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20091
Length: 339 (326)
Sequences: 4286 (2751)
Seq/√Len: 152.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_R127_A3.4451.00
230_G240_F3.3411.00
66_E72_A3.2161.00
49_C56_D3.1861.00
35_G41_I3.1081.00
118_R126_E2.8931.00
312_Q316_C2.8201.00
141_T154_I2.8161.00
38_P42_A2.6811.00
7_S30_E2.6381.00
138_S188_V2.6151.00
82_V108_A2.5611.00
9_T76_S2.5451.00
42_A46_R2.5061.00
22_I60_P2.4091.00
201_G310_I2.3941.00
68_D71_T2.3801.00
194_V293_V2.3161.00
266_M271_M2.3071.00
45_E65_L2.2901.00
89_G113_E2.2631.00
271_M279_K2.2601.00
274_Q278_E2.2221.00
149_G176_S2.1851.00
20_L108_A2.1521.00
16_Y146_L2.1251.00
298_H308_E2.1121.00
49_C58_P2.0661.00
319_N322_E2.0631.00
26_R149_G2.0231.00
9_T72_A1.9981.00
125_R159_T1.9761.00
43_T51_A1.9721.00
154_I177_F1.9701.00
142_F251_L1.9521.00
309_E323_A1.9301.00
272_D275_S1.9251.00
13_A35_G1.8601.00
41_I65_L1.8071.00
263_F284_V1.8061.00
206_D215_R1.8041.00
158_S164_A1.8021.00
92_L124_A1.7761.00
294_R311_Y1.7521.00
172_H332_R1.7391.00
294_R298_H1.7341.00
44_L65_L1.6981.00
312_Q318_K1.6861.00
311_Y315_Y1.6801.00
318_K323_A1.6701.00
261_R265_M1.6671.00
43_T47_D1.6651.00
25_A63_L1.6631.00
304_M307_T1.6561.00
191_G244_A1.6471.00
297_A304_M1.6361.00
135_A158_S1.6291.00
78_N167_L1.6281.00
161_Q165_D1.6171.00
59_F63_L1.6131.00
15_S282_Q1.6111.00
89_G118_R1.6081.00
318_K326_T1.6071.00
135_A163_F1.6061.00
78_N104_R1.5941.00
265_M269_Q1.5901.00
290_T310_I1.5831.00
85_S120_L1.5801.00
43_T49_C1.5551.00
233_L300_F1.5541.00
204_M313_V1.5401.00
141_T152_T1.5301.00
230_G235_A1.5211.00
90_E94_Q1.5131.00
20_L80_L1.4741.00
271_M275_S1.4721.00
294_R308_E1.4691.00
30_E64_H1.4661.00
145_E213_N1.4571.00
183_P236_D1.4421.00
70_A98_L1.4401.00
78_N170_L1.4331.00
73_L95_I1.4281.00
219_I250_V1.4261.00
38_P67_S1.4191.00
294_R307_T1.4171.00
57_V148_A1.4061.00
50_N53_F1.4011.00
198_I222_G1.3931.00
89_G126_E1.3911.00
24_L171_L1.3871.00
23_T177_F1.3811.00
37_D52_A1.3771.00
256_N265_M1.3641.00
135_A167_L1.3621.00
88_F120_L1.3601.00
227_S231_A1.3441.00
104_R163_F1.3421.00
124_A134_L1.3301.00
25_A62_T1.3071.00
26_R176_S1.3071.00
106_V167_L1.3001.00
66_E71_T1.2991.00
280_I284_V1.2951.00
223_L246_L1.2901.00
208_I320_A1.2901.00
48_R61_D1.2761.00
113_E116_T1.2741.00
13_A33_L1.2681.00
291_K315_Y1.2681.00
47_D51_A1.2611.00
119_L122_D1.2601.00
80_L171_L1.2581.00
266_M276_A1.2551.00
32_V66_E1.2541.00
156_L167_L1.2491.00
208_I321_R1.2491.00
57_V147_A1.2351.00
229_L296_L1.2351.00
45_E48_R1.2191.00
206_D261_R1.2161.00
7_S32_V1.2151.00
120_L123_V1.2101.00
142_F257_Q1.2081.00
266_M269_Q1.2061.00
58_P61_D1.2051.00
262_R281_G1.2001.00
48_R65_L1.1911.00
81_V124_A1.1881.00
41_I67_S1.1811.00
136_V185_F1.1771.00
144_K257_Q1.1731.00
90_E93_R1.1701.00
229_L233_L1.1631.00
89_G127_A1.1521.00
105_L128_L1.1511.00
133_P160_D1.1511.00
22_I149_G1.1471.00
273_V287_Y1.1471.00
144_K148_A1.1451.00
232_A300_F1.1391.00
22_I26_R1.1371.00
118_R122_D1.1361.00
229_L304_M1.1261.00
21_A63_L1.1150.99
309_E326_T1.1120.99
263_F276_A1.1090.99
81_V92_L1.1000.99
295_E298_H1.0940.99
79_I103_A1.0930.99
88_F109_T1.0920.99
263_F287_Y1.0900.99
85_S289_N1.0880.99
157_A188_V1.0860.99
78_N106_V1.0820.99
69_L95_I1.0810.99
45_E64_H1.0650.99
40_H44_L1.0630.99
18_T59_F1.0580.99
276_A280_I1.0530.99
263_F273_V1.0440.99
322_E325_L1.0430.99
162_T165_D1.0290.99
117_G299_R1.0280.99
80_L108_A1.0270.99
309_E318_K1.0200.99
18_T50_N1.0170.99
32_V75_A1.0110.99
311_Y316_C1.0070.99
115_E295_E1.0030.99
34_W69_L1.0010.99
86_H288_R1.0000.99
41_I45_E1.0000.99
7_S75_A0.9970.99
86_H114_A0.9960.99
155_S182_N0.9880.99
303_E330_R0.9820.99
44_L59_F0.9740.99
212_A255_D0.9690.99
266_M279_K0.9690.99
73_L79_I0.9670.99
161_Q183_P0.9660.99
156_L179_V0.9650.99
150_L214_A0.9640.98
40_H43_T0.9640.98
54_L147_A0.9630.98
36_H87_V0.9630.98
190_L194_V0.9610.98
272_D276_A0.9590.98
212_A257_Q0.9580.98
37_D53_F0.9470.98
39_E42_A0.9440.98
119_L186_I0.9440.98
154_I179_V0.9440.98
107_W124_A0.9430.98
200_I263_F0.9420.98
198_I226_M0.9410.98
91_V94_Q0.9400.98
273_V314_L0.9400.98
164_A181_S0.9360.98
312_Q317_G0.9350.98
231_A237_P0.9350.98
32_V64_H0.9280.98
81_V95_I0.9280.98
262_R266_M0.9270.98
224_A228_R0.9250.98
291_K295_E0.9240.98
113_E123_V0.9180.98
23_T27_N0.9160.98
31_V63_L0.9090.98
198_I307_T0.9010.98
96_K128_L0.9010.98
89_G123_V0.8970.98
169_Q332_R0.8950.98
104_R166_D0.8950.98
100_R103_A0.8870.97
201_G218_L0.8780.97
121_Q134_L0.8770.97
37_D40_H0.8760.97
35_G40_H0.8730.97
64_H71_T0.8680.97
325_L329_G0.8630.97
275_S279_K0.8610.97
8_M170_L0.8590.97
51_A56_D0.8590.97
290_T314_L0.8540.97
291_K316_C0.8530.97
33_L65_L0.8460.97
308_E312_Q0.8440.97
160_D163_F0.8440.97
20_L171_L0.8430.96
11_I95_I0.8410.96
70_A74_A0.8380.96
117_G295_E0.8330.96
52_A281_G0.8320.96
11_I34_W0.8310.96
330_R333_K0.8260.96
256_N262_R0.8260.96
9_T32_V0.8240.96
85_S109_T0.8210.96
43_T52_A0.8190.96
312_Q326_T0.8180.96
113_E118_R0.8170.96
81_V109_T0.8160.96
303_E308_E0.8130.96
197_V293_V0.8120.96
156_L171_L0.8110.96
309_E312_Q0.8100.96
73_L76_S0.8060.95
212_A215_R0.8050.95
121_Q189_Q0.8040.95
81_V88_F0.8030.95
180_Y221_R0.8010.95
15_S53_F0.7980.95
269_Q279_K0.7940.95
22_I59_F0.7910.95
251_L257_Q0.7890.95
194_V226_M0.7890.95
133_P163_F0.7880.95
114_A291_K0.7860.95
75_A100_R0.7840.95
99_M103_A0.7810.95
251_L255_D0.7740.94
274_Q317_G0.7710.94
32_V76_S0.7700.94
106_V135_A0.7690.94
112_L292_E0.7680.94
271_M276_A0.7660.94
10_V63_L0.7640.94
10_V21_A0.7630.94
42_A45_E0.7610.94
165_D169_Q0.7600.94
263_F280_I0.7600.94
114_A292_E0.7570.94
219_I253_C0.7530.94
122_D125_R0.7490.93
246_L250_V0.7470.93
275_S278_E0.7460.93
22_I57_V0.7460.93
210_F324_A0.7450.93
294_R316_C0.7400.93
202_A261_R0.7400.93
284_V287_Y0.7370.93
232_A302_V0.7360.93
8_M29_H0.7330.93
229_L297_A0.7310.92
142_F212_A0.7270.92
22_I147_A0.7260.92
93_R96_K0.7250.92
295_E299_R0.7250.92
266_M280_I0.7230.92
107_W134_L0.7230.92
135_A156_L0.7210.92
25_A60_P0.7190.92
142_F255_D0.7170.92
77_R102_D0.7140.92
303_E333_K0.7130.92
106_V137_I0.7120.91
322_E326_T0.7120.91
227_S237_P0.7110.91
273_V276_A0.7090.91
60_P63_L0.7070.91
84_P87_V0.7050.91
78_N166_D0.7050.91
157_A185_F0.6950.90
168_Q181_S0.6950.90
273_V277_Q0.6880.90
33_L48_R0.6860.90
22_I63_L0.6850.90
112_L190_L0.6820.90
296_L299_R0.6810.90
22_I176_S0.6800.90
7_S77_R0.6780.89
233_L296_L0.6770.89
104_R167_L0.6740.89
153_A217_A0.6740.89
161_Q164_A0.6730.89
125_R185_F0.6730.89
11_I81_V0.6720.89
9_T79_I0.6710.89
202_A215_R0.6710.89
99_M105_L0.6690.89
11_I91_V0.6680.89
293_V307_T0.6680.89
164_A168_Q0.6620.88
209_G269_Q0.6620.88
37_D41_I0.6610.88
8_M78_N0.6590.88
262_R265_M0.6590.88
321_R325_L0.6580.88
296_L300_F0.6570.88
227_S240_F0.6550.88
141_T251_L0.6540.88
267_L273_V0.6530.88
226_M249_L0.6510.87
88_F124_A0.6500.87
194_V304_M0.6460.87
191_G246_L0.6450.87
227_S238_A0.6420.87
19_A54_L0.6420.87
18_T33_L0.6390.86
144_K251_L0.6390.86
24_L27_N0.6360.86
49_C55_P0.6360.86
276_A284_V0.6350.86
11_I79_I0.6320.86
215_R254_T0.6320.86
69_L91_V0.6310.86
118_R127_A0.6300.86
168_Q332_R0.6290.86
102_D133_P0.6280.85
161_Q334_D0.6280.85
92_L127_A0.6280.85
163_F166_D0.6240.85
182_N188_V0.6240.85
37_D87_V0.6230.85
312_Q323_A0.6230.85
89_G116_T0.6210.85
13_A40_H0.6180.85
255_D261_R0.6140.84
132_I160_D0.6130.84
219_I254_T0.6090.84
23_T26_R0.6090.84
137_I156_L0.6080.84
114_A288_R0.6080.84
165_D334_D0.6070.84
231_A238_A0.6040.83
53_F84_P0.6040.83
69_L94_Q0.6040.83
180_Y330_R0.6030.83
262_R280_I0.6030.83
36_H40_H0.6010.83
188_V244_A0.6000.83
214_A217_A0.6000.83
144_K212_A0.6000.83
196_N252_T0.5990.83
9_T75_A0.5960.82
193_A289_N0.5930.82
87_V90_E0.5930.82
296_L302_V0.5930.82
124_A128_L0.5900.82
92_L128_L0.5890.82
235_A240_F0.5890.82
92_L96_K0.5880.82
11_I69_L0.5870.81
119_L189_Q0.5860.81
87_V91_V0.5850.81
137_I179_V0.5850.81
157_A182_N0.5840.81
95_I98_L0.5820.81
30_E62_T0.5820.81
277_Q287_Y0.5810.81
267_L276_A0.5810.81
137_I177_F0.5810.81
276_A279_K0.5800.81
86_H109_T0.5770.80
256_N261_R0.5760.80
24_L80_L0.5750.80
71_T74_A0.5740.80
184_D239_T0.5730.80
19_A142_F0.5730.80
125_R134_L0.5730.80
73_L103_A0.5730.80
112_L193_A0.5720.80
263_F277_Q0.5720.80
72_A76_S0.5720.80
268_G276_A0.5720.80
191_G240_F0.5710.80
83_V87_V0.5710.80
331_A334_D0.5700.80
183_P334_D0.5680.79
85_S292_E0.5680.79
48_R59_F0.5670.79
15_S144_K0.5650.79
251_L256_N0.5650.79
48_R64_H0.5640.79
250_V263_F0.5620.79
77_R100_R0.5610.78
129_G132_I0.5610.78
107_W119_L0.5610.78
184_D187_G0.5600.78
70_A97_P0.5590.78
287_Y314_L0.5570.78
202_A250_V0.5560.78
168_Q179_V0.5550.78
12_G83_V0.5530.77
161_Q181_S0.5530.77
221_R243_M0.5510.77
155_S244_A0.5500.77
76_S79_I0.5480.77
122_D186_I0.5480.77
273_V284_V0.5460.77
318_K322_E0.5460.77
208_I218_L0.5450.76
175_K325_L0.5450.76
123_V127_A0.5450.76
287_Y315_Y0.5450.76
216_T251_L0.5440.76
262_R282_Q0.5400.76
141_T146_L0.5400.76
36_H53_F0.5390.76
196_N248_D0.5370.75
138_S192_G0.5360.75
96_K127_A0.5350.75
297_A302_V0.5350.75
21_A33_L0.5340.75
121_Q185_F0.5320.75
181_S334_D0.5320.75
19_A147_A0.5310.75
205_S218_L0.5300.74
86_H289_N0.5300.74
146_L154_I0.5290.74
18_T53_F0.5280.74
204_M265_M0.5280.74
15_S83_V0.5270.74
80_L106_V0.5260.74
180_Y228_R0.5240.74
158_S163_F0.5240.74
247_G285_E0.5240.74
229_L300_F0.5230.74
48_R58_P0.5230.74
178_R330_R0.5220.73
313_V320_A0.5190.73
225_E305_P0.5180.73
92_L95_I0.5180.73
107_W121_Q0.5180.73
48_R62_T0.5180.73
11_I73_L0.5140.72
142_F256_N0.5120.72
106_V171_L0.5120.72
94_Q97_P0.5120.72
315_Y318_K0.5110.72
74_A100_R0.5100.72
142_F154_I0.5080.71
88_F92_L0.5080.71
133_P158_S0.5080.71
40_H52_A0.5070.71
153_A243_M0.5070.71
141_T213_N0.5070.71
7_S29_H0.5050.71
140_P247_G0.5050.71
8_M24_L0.5030.71
75_A322_E0.5020.70
210_F214_A0.5020.70
190_L233_L0.5020.70
291_K311_Y0.5000.70
289_N293_V0.5000.70
241_M246_L0.5000.70
135_A164_A0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yj8A 2 0.9646 100 0.515 Contact Map
1evyA 2 0.9853 100 0.516 Contact Map
3k96A 2 0.9617 100 0.517 Contact Map
1z82A 2 0.9233 100 0.546 Contact Map
1txgA 2 0.944 100 0.547 Contact Map
1x0vA 2 0.9646 100 0.549 Contact Map
4fgwA 2 0.9469 100 0.571 Contact Map
1np3A 4 0.8466 100 0.643 Contact Map
2p4qA 2 0.8702 100 0.645 Contact Map
4tskA 3 0.8555 100 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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