GREMLIN Database
FIS - DNA-binding protein Fis
UniProt: P0A6R3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10317
Length: 98 (78)
Sequences: 486 (318)
Seq/√Len: 36.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_M92_L3.6801.00
63_L92_L3.5251.00
51_Y55_L3.1861.00
50_L62_L2.6451.00
72_G83_I2.3571.00
35_L39_F2.2080.99
92_L97_M2.1710.99
63_L97_M2.0120.98
55_L58_V1.8010.97
36_K40_A1.7610.96
36_K65_M1.6490.95
54_V58_V1.6280.94
67_M90_K1.5210.92
51_Y61_P1.4480.90
65_M83_I1.4390.90
72_G78_A1.4370.90
39_F65_M1.4090.89
42_L47_V1.3800.88
67_M97_M1.3490.86
74_Q91_K1.3440.86
28_R60_Q1.3080.85
64_D68_Q1.3070.85
76_R79_L1.2780.83
69_Y83_I1.2490.82
50_L54_V1.2460.82
67_M93_K1.2430.81
51_Y84_N1.2390.81
39_F42_L1.2330.81
69_Y93_K1.2050.79
57_E96_G1.2040.79
27_L31_V1.1660.77
26_P83_I1.1600.77
44_G81_M1.1420.76
36_K68_Q1.1270.75
28_R67_M1.0990.73
42_L53_L1.0900.72
86_G94_K1.0750.71
60_Q95_Y1.0470.69
65_M86_G1.0400.68
28_R57_E1.0360.68
31_V57_E1.0330.68
72_G84_N1.0070.66
46_D76_R0.9740.63
67_M72_G0.9560.62
30_S44_G0.9520.61
57_E69_Y0.9360.60
23_T33_Q0.8750.55
71_R75_T0.8660.54
54_V77_A0.8430.52
52_E94_K0.8380.52
60_Q92_L0.8350.52
66_V80_M0.8250.51
53_L58_V0.8130.50
27_L34_A0.8060.49
32_K64_D0.7990.48
35_L83_I0.7950.48
26_P70_T0.7930.48
49_D56_A0.7810.47
79_L97_M0.7790.47
37_N41_Q0.7780.47
25_K33_Q0.7690.46
41_Q53_L0.7660.46
46_D95_Y0.7600.45
33_Q67_M0.7590.45
35_L46_D0.7580.45
45_Q67_M0.7560.45
42_L69_Y0.7540.45
70_T93_K0.7460.44
25_K40_A0.7400.43
92_L95_Y0.7260.42
90_K93_K0.7180.41
60_Q65_M0.7150.41
49_D52_E0.7120.41
47_V53_L0.7100.41
24_Q33_Q0.7100.41
28_R86_G0.7010.40
39_F53_L0.6980.40
40_A43_N0.6900.39
26_P78_A0.6900.39
23_T40_A0.6850.39
33_Q71_R0.6820.38
63_L95_Y0.6770.38
72_G96_G0.6760.38
68_Q76_R0.6700.37
52_E56_A0.6670.37
37_N45_Q0.6630.37
32_K86_G0.6630.37
83_I90_K0.6430.35
32_K48_N0.6310.34
35_L65_M0.6270.34
29_D71_R0.6260.34
60_Q86_G0.6090.33
55_L91_K0.6050.32
55_L96_G0.6040.32
30_S58_V0.5930.31
35_L60_Q0.5890.31
21_Q58_V0.5890.31
32_K65_M0.5850.31
70_T80_M0.5820.31
57_E62_L0.5810.31
51_Y62_L0.5740.30
34_A57_E0.5710.30
20_D63_L0.5640.29
45_Q48_N0.5620.29
61_P73_N0.5520.28
34_A55_L0.5510.28
27_L57_E0.5440.28
29_D37_N0.5430.28
67_M77_A0.5420.28
41_Q47_V0.5320.27
29_D96_G0.5260.27
51_Y57_E0.5260.27
45_Q86_G0.5200.26
25_K71_R0.5200.26
29_D79_L0.5170.26
39_F47_V0.5030.25
34_A92_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1etoA 2 0.9694 99.9 0.426 Contact Map
4l4uA 2 0.4286 99.1 0.674 Contact Map
1ntcA 2 0.9184 99.1 0.674 Contact Map
3e7lA 2 0.602 98.9 0.693 Contact Map
2m8gX 1 0.6735 98.8 0.701 Contact Map
1umqA 1 0.6122 98.7 0.71 Contact Map
1g2hA 1 0.6122 98.7 0.718 Contact Map
1ojlA 3 0.9388 98.6 0.726 Contact Map
4l5eA 2 0.4694 98 0.769 Contact Map
3vw4A 1 0.8265 97 0.806 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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