GREMLIN Database
FABH - 3-oxoacyl-[acyl-carrier-protein] synthase 3
UniProt: P0A6R0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10277
Length: 317 (296)
Sequences: 40797 (25078)
Seq/√Len: 1457.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_T21_D3.2281.00
287_A299_V2.7111.00
59_A135_L2.6591.00
123_D127_K2.5121.00
60_T64_E2.5021.00
234_D237_Q2.4631.00
131_V134_A2.4461.00
120_S195_D2.4351.00
119_L284_L2.4051.00
24_K28_T2.4051.00
56_F97_M2.4021.00
178_H182_D2.3161.00
233_L298_L2.3091.00
190_T288_V2.2851.00
180_H183_G2.2771.00
106_F121_V2.2491.00
124_Q130_A2.2491.00
177_T180_H2.2431.00
124_Q128_S2.2141.00
180_H184_S2.1831.00
122_A134_A2.1741.00
74_G77_V2.1531.00
69_E72_Q2.1401.00
221_A225_D2.1311.00
77_V81_T2.1181.00
58_A170_E2.1031.00
62_A174_I2.1001.00
25_M30_D2.0691.00
237_Q298_L2.0691.00
261_S264_N2.0351.00
55_G94_I2.0221.00
156_I270_D1.9561.00
157_F243_P1.9471.00
284_L315_V1.9291.00
145_T149_T1.9051.00
17_R21_D1.9031.00
77_V80_T1.8931.00
10_S285_D1.8501.00
227_T231_N1.8421.00
285_D289_R1.7621.00
125_Y131_V1.7591.00
260_M265_V1.7551.00
176_S186_G1.7101.00
61_R64_E1.7041.00
65_M189_L1.6631.00
171_E281_P1.6551.00
76_I81_T1.6521.00
225_D229_A1.6501.00
275_T282_C1.6331.00
12_L282_C1.6261.00
126_V177_T1.6001.00
58_A172_P1.5961.00
8_T285_D1.5951.00
59_A94_I1.5741.00
284_L301_L1.5571.00
53_T97_M1.5461.00
9_G58_A1.5431.00
239_D297_Q1.5421.00
32_W36_R1.5381.00
39_I48_N1.5211.00
62_A66_A1.5001.00
124_Q127_K1.4951.00
33_I36_R1.4771.00
21_D24_K1.4561.00
255_A262_M1.4531.00
176_S184_S1.4421.00
137_V172_P1.4341.00
60_T97_M1.4311.00
132_K180_H1.4261.00
179_L183_G1.4231.00
260_M264_N1.4151.00
51_V139_S1.4071.00
222_H226_E1.4041.00
34_V40_R1.4031.00
74_G78_V1.3931.00
118_A136_V1.3871.00
263_D266_V1.3871.00
50_T54_M1.3831.00
55_G78_V1.3721.00
145_T148_P1.3681.00
61_R65_M1.3591.00
122_A136_V1.3391.00
75_L134_A1.3331.00
75_L78_V1.3271.00
125_Y130_A1.3241.00
91_A107_D1.3051.00
8_T19_N1.2921.00
120_S124_Q1.2821.00
268_T282_C1.2771.00
146_C149_T1.2751.00
300_L312_S1.2561.00
155_I160_G1.2561.00
176_S180_H1.2461.00
92_C307_G1.2401.00
117_Y311_G1.2381.00
121_V124_Q1.2361.00
173_G281_P1.2351.00
74_G81_T1.2341.00
9_G62_A1.2301.00
193_N298_L1.2261.00
9_G61_R1.2261.00
60_T98_L1.2181.00
133_Y176_S1.2111.00
24_K27_D1.2091.00
302_E312_S1.2071.00
22_L286_E1.1931.00
123_D192_P1.1931.00
132_K177_T1.1911.00
300_L314_L1.1881.00
57_E60_T1.1861.00
226_E230_A1.1821.00
226_E229_A1.1791.00
222_H225_D1.1701.00
22_L268_T1.1651.00
133_Y167_A1.1641.00
56_F60_T1.1591.00
57_E61_R1.1581.00
227_T314_L1.1571.00
110_A113_A1.1511.00
41_E271_R1.1371.00
24_K30_D1.1351.00
272_H282_C1.1321.00
176_S181_A1.1301.00
77_V125_Y1.1291.00
74_G133_Y1.1281.00
58_A61_R1.1271.00
50_T53_T1.1191.00
11_Y54_M1.1171.00
228_L238_L1.1161.00
228_L233_L1.1131.00
239_D298_L1.1131.00
233_L237_Q1.1111.00
95_Q105_A1.1101.00
59_A98_L1.1061.00
223_I227_T1.1051.00
116_T311_G1.1031.00
206_T310_W1.0941.00
110_A117_Y1.0881.00
68_I133_Y1.0871.00
238_L298_L1.0801.00
233_L238_L1.0791.00
117_Y309_T1.0731.00
225_D235_R1.0721.00
290_D293_I1.0711.00
253_A257_K1.0711.00
233_L314_L1.0671.00
167_A275_T1.0601.00
260_M263_D1.0591.00
261_S265_V1.0561.00
55_G172_P1.0551.00
171_E285_D1.0491.00
56_F94_I1.0411.00
173_G284_L1.0401.00
240_W287_A1.0391.00
223_I312_S1.0381.00
55_G137_V1.0371.00
133_Y174_I1.0361.00
135_L174_I1.0331.00
224_V300_L1.0281.00
117_Y121_V1.0281.00
116_T313_A1.0261.00
20_A24_K1.0201.00
130_A230_A1.0191.00
228_L235_R1.0171.00
291_G295_P1.0081.00
231_N314_L1.0041.00
78_V137_V1.0021.00
141_V144_R0.9981.00
268_T272_H0.9961.00
151_R155_I0.9911.00
179_L182_D0.9891.00
74_G80_T0.9891.00
126_V175_I0.9871.00
76_I80_T0.9871.00
261_S266_V0.9851.00
10_S19_N0.9831.00
115_F281_P0.9811.00
235_R241_L0.9781.00
271_R286_E0.9741.00
151_R162_G0.9721.00
227_T312_S0.9661.00
60_T70_K0.9661.00
259_G263_D0.9631.00
15_Q25_M0.9621.00
119_L136_V0.9581.00
62_A135_L0.9551.00
242_V283_A0.9541.00
268_T286_E0.9531.00
108_V121_V0.9531.00
169_S275_T0.9521.00
72_Q133_Y0.9521.00
65_M187_E0.9491.00
40_R270_D0.9451.00
192_P195_D0.9401.00
255_A265_V0.9361.00
138_G281_P0.9331.00
40_R43_H0.9311.00
120_S130_A0.9231.00
11_Y57_E0.9211.00
178_H191_L0.9211.00
56_F98_L0.9041.00
8_T288_V0.8931.00
267_V270_D0.8911.00
155_I162_G0.8881.00
31_E34_V0.8871.00
23_E27_D0.8851.00
31_E36_R0.8841.00
262_M266_V0.8791.00
20_A23_E0.8741.00
224_V258_L0.8681.00
121_V125_Y0.8681.00
133_Y180_H0.8671.00
218_T221_A0.8671.00
75_L80_T0.8651.00
21_D25_M0.8641.00
166_L276_S0.8631.00
62_A172_P0.8631.00
275_T278_A0.8551.00
194_A227_T0.8551.00
32_W35_T0.8541.00
94_I137_V0.8541.00
288_V315_V0.8491.00
160_G163_A0.8421.00
75_L125_Y0.8381.00
150_D162_G0.8381.00
117_Y205_L0.8361.00
173_G285_D0.8361.00
294_K297_Q0.8341.00
260_M266_V0.8311.00
224_V302_E0.8291.00
65_M289_R0.8281.00
238_L241_L0.8261.00
195_D313_A0.8241.00
52_S90_A0.8171.00
80_T90_A0.8131.00
59_A62_A0.8121.00
101_K222_H0.8121.00
206_T223_I0.8091.00
89_S212_V0.8041.00
262_M265_V0.8001.00
77_V132_K0.7951.00
77_V122_A0.7921.00
204_H223_I0.7911.00
11_Y61_R0.7881.00
92_C105_A0.7871.00
208_A211_E0.7871.00
292_R295_P0.7851.00
74_G132_K0.7851.00
78_V172_P0.7821.00
189_L288_V0.7811.00
10_S22_L0.7811.00
238_L314_L0.7801.00
8_T189_L0.7731.00
79_A114_G0.7731.00
42_R46_A0.7721.00
177_T182_D0.7711.00
59_A137_V0.7711.00
74_G79_A0.7641.00
55_G139_S0.7641.00
55_G90_A0.7621.00
12_L171_E0.7591.00
105_A207_M0.7591.00
119_L175_I0.7581.00
218_T222_H0.7561.00
189_L193_N0.7531.00
237_Q295_P0.7511.00
213_F217_V0.7491.00
122_A175_I0.7481.00
8_T65_M0.7441.00
63_I70_K0.7431.00
126_V129_G0.7421.00
90_A139_S0.7421.00
219_E222_H0.7421.00
59_A172_P0.7401.00
72_Q132_K0.7381.00
194_A230_A0.7361.00
248_L252_S0.7351.00
194_A231_N0.7331.00
63_I135_L0.7291.00
63_I98_L0.7271.00
228_L231_N0.7251.00
124_Q230_A0.7251.00
210_N214_K0.7211.00
65_M288_V0.7201.00
14_E25_M0.7191.00
293_I296_G0.7191.00
38_G42_R0.7181.00
77_V106_F0.7171.00
140_D277_A0.7161.00
133_Y136_V0.7111.00
259_G262_M0.7101.00
111_A306_G0.7091.00
54_M141_V0.7091.00
127_K230_A0.7091.00
52_S93_Q0.7061.00
239_D294_K0.7031.00
181_A188_L0.6931.00
26_V286_E0.6911.00
272_H286_E0.6891.00
282_C286_E0.6871.00
116_T303_A0.6851.00
155_I158_G0.6841.00
241_L300_L0.6831.00
39_I46_A0.6821.00
77_V134_A0.6821.00
291_G294_K0.6801.00
158_G162_G0.6761.00
25_M28_T0.6761.00
116_T280_V0.6721.00
252_S255_A0.6711.00
15_Q21_D0.6701.00
156_I163_A0.6671.00
51_V90_A0.6661.00
217_V257_K0.6651.00
283_A301_L0.6631.00
238_L300_L0.6631.00
88_P111_A0.6611.00
250_I254_T0.6591.00
43_H46_A0.6561.00
42_R45_A0.6551.00
123_D230_A0.6551.00
287_A301_L0.6501.00
252_S256_K0.6501.00
116_T301_L0.6471.00
78_V81_T0.6451.00
91_A105_A0.6421.00
158_G161_A0.6421.00
75_L81_T0.6411.00
125_Y128_S0.6411.00
49_E53_T0.6401.00
49_E57_E0.6391.00
228_L314_L0.6391.00
140_D276_S0.6391.00
75_L79_A0.6391.00
79_A118_A0.6361.00
239_D296_G0.6351.00
95_Q207_M0.6311.00
119_L173_G0.6271.00
119_L313_A0.6261.00
27_D30_D0.6261.00
245_Q251_I0.6241.00
182_D188_L0.6231.00
55_G59_A0.6201.00
31_E35_T0.6181.00
100_I135_L0.6161.00
171_E278_A0.6161.00
12_L272_H0.6161.00
138_G278_A0.6161.00
37_T42_R0.6151.00
75_L131_V0.6111.00
154_I165_V0.6101.00
290_D295_P0.6101.00
291_G296_G0.6071.00
301_L315_V0.6041.00
76_I79_A0.6021.00
53_T57_E0.6021.00
113_A308_F0.6001.00
153_T165_V0.6001.00
11_Y58_A0.6001.00
73_I133_Y0.5981.00
292_R296_G0.5981.00
89_S306_G0.5981.00
19_N22_L0.5971.00
18_T41_E0.5951.00
150_D153_T0.5941.00
10_S282_C0.5941.00
39_I42_R0.5931.00
178_H188_L0.5931.00
86_A89_S0.5921.00
206_T226_E0.5911.00
8_T289_R0.5901.00
104_P131_V0.5901.00
206_T222_H0.5891.00
224_V228_L0.5881.00
12_L285_D0.5871.00
41_E45_A0.5871.00
252_S262_M0.5851.00
39_I43_H0.5821.00
76_I95_Q0.5801.00
33_I37_T0.5791.00
119_L281_P0.5741.00
177_T181_A0.5741.00
244_H274_N0.5731.00
211_E214_K0.5731.00
153_T157_F0.5711.00
244_H248_L0.5701.00
245_Q267_V0.5681.00
115_F138_G0.5671.00
239_D291_G0.5661.00
54_M170_E0.5651.00
248_L267_V0.5631.00
114_G118_A0.5611.00
37_T44_I0.5601.00
153_T156_I0.5591.00
44_I148_P0.5581.00
66_A174_I0.5551.00
290_D294_K0.5541.00
74_G131_V0.5531.00
161_A165_V0.5521.00
123_D195_D0.5511.00
190_T194_A0.5511.00
93_Q97_M0.5501.00
72_Q184_S0.5471.00
178_H181_A0.5471.00
22_L26_V0.5471.00
205_L208_A0.5471.00
259_G264_N0.5451.00
236_S259_G0.5451.00
63_I100_I0.5431.00
154_I164_A0.5421.00
139_S170_E0.5411.00
241_L260_M0.5401.00
158_G163_A0.5381.00
156_I159_D0.5371.00
293_I297_Q0.5361.00
248_L270_D0.5341.00
189_L192_P0.5331.00
193_N233_L0.5331.00
23_E289_R0.5331.00
251_I254_T0.5291.00
162_G165_V0.5281.00
249_R253_A0.5281.00
242_V287_A0.5281.00
18_T61_R0.5261.00
220_L304_F0.5251.00
217_V254_T0.5231.00
251_I265_V0.5171.00
236_S264_N0.5161.00
298_L314_L0.5141.00
188_L192_P0.5121.00
116_T284_L0.5111.00
112_C274_N0.5111.00
93_Q96_S0.5101.00
251_I255_A0.5101.00
61_R285_D0.5081.00
164_A276_S0.5081.00
32_W37_T0.5081.00
51_V141_V0.5071.00
218_T257_K0.5051.00
269_L279_S0.5041.00
148_P166_L0.5041.00
182_D185_Y0.5011.00
157_F163_A0.5011.00
142_L276_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s21A 2 0.9779 100 0.185 Contact Map
1hnjA 2 0.9558 100 0.21 Contact Map
3gwaA 2 0.9621 100 0.211 Contact Map
1zowA 2 0.959 100 0.216 Contact Map
3il3A 2 0.9527 100 0.221 Contact Map
1mzjA 2 0.9558 100 0.221 Contact Map
2ebdA 2 0.9558 100 0.222 Contact Map
4rybA 2 0.9527 100 0.225 Contact Map
4ewpA 2 0.9716 100 0.225 Contact Map
4x9kA 2 0.9527 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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