FABH - ECOLI - GREMLIN Contacts

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FABH - 3-oxoacyl-[acyl-carrier-protein] synthase 3

UniProt:	P0A6R0	Sequences: MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10277
Length:	317 (296)
Sequences:	40797 (25078)
Seq/√Len:	1457.6

ECOLI - FABH FABF FABB
BACSU - FABH1 FABH2 BCSA PKSG PKSF FABF
SULSO - Y535

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_T	21_D	3.228	1.00
287_A	299_V	2.711	1.00
59_A	135_L	2.659	1.00
123_D	127_K	2.512	1.00
60_T	64_E	2.502	1.00
234_D	237_Q	2.463	1.00
131_V	134_A	2.446	1.00
120_S	195_D	2.435	1.00
119_L	284_L	2.405	1.00
24_K	28_T	2.405	1.00
56_F	97_M	2.402	1.00
178_H	182_D	2.316	1.00
233_L	298_L	2.309	1.00
190_T	288_V	2.285	1.00
180_H	183_G	2.277	1.00
106_F	121_V	2.249	1.00
124_Q	130_A	2.249	1.00
177_T	180_H	2.243	1.00
124_Q	128_S	2.214	1.00
180_H	184_S	2.183	1.00
122_A	134_A	2.174	1.00
74_G	77_V	2.153	1.00
69_E	72_Q	2.140	1.00
221_A	225_D	2.131	1.00
77_V	81_T	2.118	1.00
58_A	170_E	2.103	1.00
62_A	174_I	2.100	1.00
25_M	30_D	2.069	1.00
237_Q	298_L	2.069	1.00
261_S	264_N	2.035	1.00
55_G	94_I	2.022	1.00
156_I	270_D	1.956	1.00
157_F	243_P	1.947	1.00
284_L	315_V	1.929	1.00
145_T	149_T	1.905	1.00
17_R	21_D	1.903	1.00
77_V	80_T	1.893	1.00
10_S	285_D	1.850	1.00
227_T	231_N	1.842	1.00
285_D	289_R	1.762	1.00
125_Y	131_V	1.759	1.00
260_M	265_V	1.755	1.00
176_S	186_G	1.710	1.00
61_R	64_E	1.704	1.00
65_M	189_L	1.663	1.00
171_E	281_P	1.655	1.00
76_I	81_T	1.652	1.00
225_D	229_A	1.650	1.00
275_T	282_C	1.633	1.00
12_L	282_C	1.626	1.00
126_V	177_T	1.600	1.00
58_A	172_P	1.596	1.00
8_T	285_D	1.595	1.00
59_A	94_I	1.574	1.00
284_L	301_L	1.557	1.00
53_T	97_M	1.546	1.00
9_G	58_A	1.543	1.00
239_D	297_Q	1.542	1.00
32_W	36_R	1.538	1.00
39_I	48_N	1.521	1.00
62_A	66_A	1.500	1.00
124_Q	127_K	1.495	1.00
33_I	36_R	1.477	1.00
21_D	24_K	1.456	1.00
255_A	262_M	1.453	1.00
176_S	184_S	1.442	1.00
137_V	172_P	1.434	1.00
60_T	97_M	1.431	1.00
132_K	180_H	1.426	1.00
179_L	183_G	1.423	1.00
260_M	264_N	1.415	1.00
51_V	139_S	1.407	1.00
222_H	226_E	1.404	1.00
34_V	40_R	1.403	1.00
74_G	78_V	1.393	1.00
118_A	136_V	1.387	1.00
263_D	266_V	1.387	1.00
50_T	54_M	1.383	1.00
55_G	78_V	1.372	1.00
145_T	148_P	1.368	1.00
61_R	65_M	1.359	1.00
122_A	136_V	1.339	1.00
75_L	134_A	1.333	1.00
75_L	78_V	1.327	1.00
125_Y	130_A	1.324	1.00
91_A	107_D	1.305	1.00
8_T	19_N	1.292	1.00
120_S	124_Q	1.282	1.00
268_T	282_C	1.277	1.00
146_C	149_T	1.275	1.00
300_L	312_S	1.256	1.00
155_I	160_G	1.256	1.00
176_S	180_H	1.246	1.00
92_C	307_G	1.240	1.00
117_Y	311_G	1.238	1.00
121_V	124_Q	1.236	1.00
173_G	281_P	1.235	1.00
74_G	81_T	1.234	1.00
9_G	62_A	1.230	1.00
193_N	298_L	1.226	1.00
9_G	61_R	1.226	1.00
60_T	98_L	1.218	1.00
133_Y	176_S	1.211	1.00
24_K	27_D	1.209	1.00
302_E	312_S	1.207	1.00
22_L	286_E	1.193	1.00
123_D	192_P	1.193	1.00
132_K	177_T	1.191	1.00
300_L	314_L	1.188	1.00
57_E	60_T	1.186	1.00
226_E	230_A	1.182	1.00
226_E	229_A	1.179	1.00
222_H	225_D	1.170	1.00
22_L	268_T	1.165	1.00
133_Y	167_A	1.164	1.00
56_F	60_T	1.159	1.00
57_E	61_R	1.158	1.00
227_T	314_L	1.157	1.00
110_A	113_A	1.151	1.00
41_E	271_R	1.137	1.00
24_K	30_D	1.135	1.00
272_H	282_C	1.132	1.00
176_S	181_A	1.130	1.00
77_V	125_Y	1.129	1.00
74_G	133_Y	1.128	1.00
58_A	61_R	1.127	1.00
50_T	53_T	1.119	1.00
11_Y	54_M	1.117	1.00
228_L	238_L	1.116	1.00
228_L	233_L	1.113	1.00
239_D	298_L	1.113	1.00
233_L	237_Q	1.111	1.00
95_Q	105_A	1.110	1.00
59_A	98_L	1.106	1.00
223_I	227_T	1.105	1.00
116_T	311_G	1.103	1.00
206_T	310_W	1.094	1.00
110_A	117_Y	1.088	1.00
68_I	133_Y	1.087	1.00
238_L	298_L	1.080	1.00
233_L	238_L	1.079	1.00
117_Y	309_T	1.073	1.00
225_D	235_R	1.072	1.00
290_D	293_I	1.071	1.00
253_A	257_K	1.071	1.00
233_L	314_L	1.067	1.00
167_A	275_T	1.060	1.00
260_M	263_D	1.059	1.00
261_S	265_V	1.056	1.00
55_G	172_P	1.055	1.00
171_E	285_D	1.049	1.00
56_F	94_I	1.041	1.00
173_G	284_L	1.040	1.00
240_W	287_A	1.039	1.00
223_I	312_S	1.038	1.00
55_G	137_V	1.037	1.00
133_Y	174_I	1.036	1.00
135_L	174_I	1.033	1.00
224_V	300_L	1.028	1.00
117_Y	121_V	1.028	1.00
116_T	313_A	1.026	1.00
20_A	24_K	1.020	1.00
130_A	230_A	1.019	1.00
228_L	235_R	1.017	1.00
291_G	295_P	1.008	1.00
231_N	314_L	1.004	1.00
78_V	137_V	1.002	1.00
141_V	144_R	0.998	1.00
268_T	272_H	0.996	1.00
151_R	155_I	0.991	1.00
179_L	182_D	0.989	1.00
74_G	80_T	0.989	1.00
126_V	175_I	0.987	1.00
76_I	80_T	0.987	1.00
261_S	266_V	0.985	1.00
10_S	19_N	0.983	1.00
115_F	281_P	0.981	1.00
235_R	241_L	0.978	1.00
271_R	286_E	0.974	1.00
151_R	162_G	0.972	1.00
227_T	312_S	0.966	1.00
60_T	70_K	0.966	1.00
259_G	263_D	0.963	1.00
15_Q	25_M	0.962	1.00
119_L	136_V	0.958	1.00
62_A	135_L	0.955	1.00
242_V	283_A	0.954	1.00
268_T	286_E	0.953	1.00
108_V	121_V	0.953	1.00
169_S	275_T	0.952	1.00
72_Q	133_Y	0.952	1.00
65_M	187_E	0.949	1.00
40_R	270_D	0.945	1.00
192_P	195_D	0.940	1.00
255_A	265_V	0.936	1.00
138_G	281_P	0.933	1.00
40_R	43_H	0.931	1.00
120_S	130_A	0.923	1.00
11_Y	57_E	0.921	1.00
178_H	191_L	0.921	1.00
56_F	98_L	0.904	1.00
8_T	288_V	0.893	1.00
267_V	270_D	0.891	1.00
155_I	162_G	0.888	1.00
31_E	34_V	0.887	1.00
23_E	27_D	0.885	1.00
31_E	36_R	0.884	1.00
262_M	266_V	0.879	1.00
20_A	23_E	0.874	1.00
224_V	258_L	0.868	1.00
121_V	125_Y	0.868	1.00
133_Y	180_H	0.867	1.00
218_T	221_A	0.867	1.00
75_L	80_T	0.865	1.00
21_D	25_M	0.864	1.00
166_L	276_S	0.863	1.00
62_A	172_P	0.863	1.00
275_T	278_A	0.855	1.00
194_A	227_T	0.855	1.00
32_W	35_T	0.854	1.00
94_I	137_V	0.854	1.00
288_V	315_V	0.849	1.00
160_G	163_A	0.842	1.00
75_L	125_Y	0.838	1.00
150_D	162_G	0.838	1.00
117_Y	205_L	0.836	1.00
173_G	285_D	0.836	1.00
294_K	297_Q	0.834	1.00
260_M	266_V	0.831	1.00
224_V	302_E	0.829	1.00
65_M	289_R	0.828	1.00
238_L	241_L	0.826	1.00
195_D	313_A	0.824	1.00
52_S	90_A	0.817	1.00
80_T	90_A	0.813	1.00
59_A	62_A	0.812	1.00
101_K	222_H	0.812	1.00
206_T	223_I	0.809	1.00
89_S	212_V	0.804	1.00
262_M	265_V	0.800	1.00
77_V	132_K	0.795	1.00
77_V	122_A	0.792	1.00
204_H	223_I	0.791	1.00
11_Y	61_R	0.788	1.00
92_C	105_A	0.787	1.00
208_A	211_E	0.787	1.00
292_R	295_P	0.785	1.00
74_G	132_K	0.785	1.00
78_V	172_P	0.782	1.00
189_L	288_V	0.781	1.00
10_S	22_L	0.781	1.00
238_L	314_L	0.780	1.00
8_T	189_L	0.773	1.00
79_A	114_G	0.773	1.00
42_R	46_A	0.772	1.00
177_T	182_D	0.771	1.00
59_A	137_V	0.771	1.00
74_G	79_A	0.764	1.00
55_G	139_S	0.764	1.00
55_G	90_A	0.762	1.00
12_L	171_E	0.759	1.00
105_A	207_M	0.759	1.00
119_L	175_I	0.758	1.00
218_T	222_H	0.756	1.00
189_L	193_N	0.753	1.00
237_Q	295_P	0.751	1.00
213_F	217_V	0.749	1.00
122_A	175_I	0.748	1.00
8_T	65_M	0.744	1.00
63_I	70_K	0.743	1.00
126_V	129_G	0.742	1.00
90_A	139_S	0.742	1.00
219_E	222_H	0.742	1.00
59_A	172_P	0.740	1.00
72_Q	132_K	0.738	1.00
194_A	230_A	0.736	1.00
248_L	252_S	0.735	1.00
194_A	231_N	0.733	1.00
63_I	135_L	0.729	1.00
63_I	98_L	0.727	1.00
228_L	231_N	0.725	1.00
124_Q	230_A	0.725	1.00
210_N	214_K	0.721	1.00
65_M	288_V	0.720	1.00
14_E	25_M	0.719	1.00
293_I	296_G	0.719	1.00
38_G	42_R	0.718	1.00
77_V	106_F	0.717	1.00
140_D	277_A	0.716	1.00
133_Y	136_V	0.711	1.00
259_G	262_M	0.710	1.00
111_A	306_G	0.709	1.00
54_M	141_V	0.709	1.00
127_K	230_A	0.709	1.00
52_S	93_Q	0.706	1.00
239_D	294_K	0.703	1.00
181_A	188_L	0.693	1.00
26_V	286_E	0.691	1.00
272_H	286_E	0.689	1.00
282_C	286_E	0.687	1.00
116_T	303_A	0.685	1.00
155_I	158_G	0.684	1.00
241_L	300_L	0.683	1.00
39_I	46_A	0.682	1.00
77_V	134_A	0.682	1.00
291_G	294_K	0.680	1.00
158_G	162_G	0.676	1.00
25_M	28_T	0.676	1.00
116_T	280_V	0.672	1.00
252_S	255_A	0.671	1.00
15_Q	21_D	0.670	1.00
156_I	163_A	0.667	1.00
51_V	90_A	0.666	1.00
217_V	257_K	0.665	1.00
283_A	301_L	0.663	1.00
238_L	300_L	0.663	1.00
88_P	111_A	0.661	1.00
250_I	254_T	0.659	1.00
43_H	46_A	0.656	1.00
42_R	45_A	0.655	1.00
123_D	230_A	0.655	1.00
287_A	301_L	0.650	1.00
252_S	256_K	0.650	1.00
116_T	301_L	0.647	1.00
78_V	81_T	0.645	1.00
91_A	105_A	0.642	1.00
158_G	161_A	0.642	1.00
75_L	81_T	0.641	1.00
125_Y	128_S	0.641	1.00
49_E	53_T	0.640	1.00
49_E	57_E	0.639	1.00
228_L	314_L	0.639	1.00
140_D	276_S	0.639	1.00
75_L	79_A	0.639	1.00
79_A	118_A	0.636	1.00
239_D	296_G	0.635	1.00
95_Q	207_M	0.631	1.00
119_L	173_G	0.627	1.00
119_L	313_A	0.626	1.00
27_D	30_D	0.626	1.00
245_Q	251_I	0.624	1.00
182_D	188_L	0.623	1.00
55_G	59_A	0.620	1.00
31_E	35_T	0.618	1.00
100_I	135_L	0.616	1.00
171_E	278_A	0.616	1.00
12_L	272_H	0.616	1.00
138_G	278_A	0.616	1.00
37_T	42_R	0.615	1.00
75_L	131_V	0.611	1.00
154_I	165_V	0.610	1.00
290_D	295_P	0.610	1.00
291_G	296_G	0.607	1.00
301_L	315_V	0.604	1.00
76_I	79_A	0.602	1.00
53_T	57_E	0.602	1.00
113_A	308_F	0.600	1.00
153_T	165_V	0.600	1.00
11_Y	58_A	0.600	1.00
73_I	133_Y	0.598	1.00
292_R	296_G	0.598	1.00
89_S	306_G	0.598	1.00
19_N	22_L	0.597	1.00
18_T	41_E	0.595	1.00
150_D	153_T	0.594	1.00
10_S	282_C	0.594	1.00
39_I	42_R	0.593	1.00
178_H	188_L	0.593	1.00
86_A	89_S	0.592	1.00
206_T	226_E	0.591	1.00
8_T	289_R	0.590	1.00
104_P	131_V	0.590	1.00
206_T	222_H	0.589	1.00
224_V	228_L	0.588	1.00
12_L	285_D	0.587	1.00
41_E	45_A	0.587	1.00
252_S	262_M	0.585	1.00
39_I	43_H	0.582	1.00
76_I	95_Q	0.580	1.00
33_I	37_T	0.579	1.00
119_L	281_P	0.574	1.00
177_T	181_A	0.574	1.00
244_H	274_N	0.573	1.00
211_E	214_K	0.573	1.00
153_T	157_F	0.571	1.00
244_H	248_L	0.570	1.00
245_Q	267_V	0.568	1.00
115_F	138_G	0.567	1.00
239_D	291_G	0.566	1.00
54_M	170_E	0.565	1.00
248_L	267_V	0.563	1.00
114_G	118_A	0.561	1.00
37_T	44_I	0.560	1.00
153_T	156_I	0.559	1.00
44_I	148_P	0.558	1.00
66_A	174_I	0.555	1.00
290_D	294_K	0.554	1.00
74_G	131_V	0.553	1.00
161_A	165_V	0.552	1.00
123_D	195_D	0.551	1.00
190_T	194_A	0.551	1.00
93_Q	97_M	0.550	1.00
72_Q	184_S	0.547	1.00
178_H	181_A	0.547	1.00
22_L	26_V	0.547	1.00
205_L	208_A	0.547	1.00
259_G	264_N	0.545	1.00
236_S	259_G	0.545	1.00
63_I	100_I	0.543	1.00
154_I	164_A	0.542	1.00
139_S	170_E	0.541	1.00
241_L	260_M	0.540	1.00
158_G	163_A	0.538	1.00
156_I	159_D	0.537	1.00
293_I	297_Q	0.536	1.00
248_L	270_D	0.534	1.00
189_L	192_P	0.533	1.00
193_N	233_L	0.533	1.00
23_E	289_R	0.533	1.00
251_I	254_T	0.529	1.00
162_G	165_V	0.528	1.00
249_R	253_A	0.528	1.00
242_V	287_A	0.528	1.00
18_T	61_R	0.526	1.00
220_L	304_F	0.525	1.00
217_V	254_T	0.523	1.00
251_I	265_V	0.517	1.00
236_S	264_N	0.516	1.00
298_L	314_L	0.514	1.00
188_L	192_P	0.512	1.00
116_T	284_L	0.511	1.00
112_C	274_N	0.511	1.00
93_Q	96_S	0.510	1.00
251_I	255_A	0.510	1.00
61_R	285_D	0.508	1.00
164_A	276_S	0.508	1.00
32_W	37_T	0.508	1.00
51_V	141_V	0.507	1.00
218_T	257_K	0.505	1.00
269_L	279_S	0.504	1.00
148_P	166_L	0.504	1.00
182_D	185_Y	0.501	1.00
157_F	163_A	0.501	1.00
142_L	276_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3s21A	2	0.9779	100	0.185	Contact Map
1hnjA	2	0.9558	100	0.21	Contact Map
3gwaA	2	0.9621	100	0.211	Contact Map
1zowA	2	0.959	100	0.216	Contact Map
3il3A	2	0.9527	100	0.221	Contact Map
1mzjA	2	0.9558	100	0.221	Contact Map
2ebdA	2	0.9558	100	0.222	Contact Map
4rybA	2	0.9527	100	0.225	Contact Map
4ewpA	2	0.9716	100	0.225	Contact Map
4x9kA	2	0.9527	100	0.229	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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