GREMLIN Database
FABZ - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
UniProt: P0A6Q6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11284
Length: 151 (137)
Sequences: 3765 (2091)
Seq/√Len: 178.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_R136_K2.9721.00
33_E36_R2.8791.00
40_A73_A2.7471.00
69_A113_M2.4771.00
39_R112_I2.3991.00
70_M113_M2.3771.00
96_I99_A2.3701.00
41_V110_Q2.3671.00
98_E142_T2.3601.00
9_Q12_E2.3401.00
66_I111_M2.1811.00
116_T128_K2.1741.00
50_F61_F2.1351.00
132_L137_V2.1351.00
130_V137_V2.1341.00
114_E132_L2.0281.00
99_A141_A1.9611.00
39_R114_E1.9061.00
128_K142_T1.8751.00
118_E128_K1.7771.00
41_V112_I1.7301.00
74_T127_F1.6911.00
66_I139_C1.6791.00
12_E15_E1.6691.00
58_K104_P1.6551.00
30_L41_V1.6521.00
49_P52_Q1.6481.00
132_L135_G1.6451.00
28_R41_V1.6171.00
43_N110_Q1.6011.00
114_E130_V1.5951.00
31_D39_R1.5891.00
36_R116_T1.5091.00
38_L77_L1.4821.00
115_V129_G1.4781.00
37_F114_E1.4701.00
42_K48_E1.4471.00
29_V76_I1.4171.00
33_E37_F1.3701.00
112_I132_L1.3321.00
37_F116_T1.3251.00
31_D37_F1.2811.00
92_Y104_P1.2511.00
21_F52_Q1.2361.00
125_T145_C1.2241.00
29_V40_A1.2091.00
113_M131_A1.1921.00
11_E14_L1.1741.00
61_F65_L1.1621.00
103_R138_V1.1581.00
129_G143_M1.1551.00
26_V73_A1.1481.00
58_K106_V1.1431.00
131_A139_C1.1321.00
102_K140_E1.1261.00
38_L73_A1.1231.00
44_V61_F1.1161.00
11_E15_E1.1081.00
35_G81_S1.0791.00
60_I92_Y1.0741.00
111_M131_A1.0641.00
55_F63_G1.0601.00
94_A144_M1.0471.00
109_D133_V1.0461.00
61_F69_A1.0411.00
67_L96_I1.0391.00
14_L57_G1.0371.00
58_K90_L1.0361.00
74_T115_V1.0290.99
95_G144_M1.0210.99
93_F96_I1.0190.99
105_V138_V1.0170.99
66_I131_A1.0160.99
112_I135_G1.0090.99
30_L112_I0.9960.99
14_L46_V0.9940.99
10_I46_V0.9930.99
30_L39_R0.9790.99
137_V140_E0.9770.99
70_M141_A0.9710.99
58_K92_Y0.9580.99
12_E80_K0.9570.99
11_E58_K0.9540.99
21_F47_N0.9340.99
67_L99_A0.9290.99
116_T130_V0.9160.99
117_F125_T0.9040.99
16_L79_F0.8990.99
14_L24_L0.8990.99
110_Q134_D0.8880.98
94_A146_A0.8850.98
28_R43_N0.8830.98
120_T125_T0.8810.98
21_F46_V0.8800.98
17_L75_G0.8750.98
97_D126_R0.8740.98
38_L76_I0.8730.98
91_Y145_C0.8730.98
54_H63_G0.8690.98
10_I14_L0.8670.98
130_V140_E0.8620.98
77_L81_S0.8590.98
70_M139_C0.8440.98
118_E126_R0.8280.98
45_S48_E0.8270.98
16_L76_I0.8260.98
94_A124_L0.8080.97
11_E106_V0.8030.97
32_F38_L0.8000.97
86_E89_E0.7990.97
119_K122_R0.7900.97
127_F145_C0.7840.97
97_D142_T0.7780.97
21_F43_N0.7770.96
100_R144_M0.7730.96
32_F80_K0.7630.96
99_A139_C0.7620.96
42_K45_S0.7560.96
54_H60_I0.7530.96
126_R144_M0.7430.95
118_E142_T0.7400.95
105_V111_M0.7360.95
28_R110_Q0.7320.95
79_F125_T0.7310.95
19_H25_L0.7290.95
26_V76_I0.7260.95
25_L65_L0.7140.94
12_E16_L0.7040.94
78_A125_T0.6950.94
44_V105_V0.6920.93
79_F82_V0.6900.93
20_R56_P0.6890.93
102_K137_V0.6890.93
94_A145_C0.6780.93
50_F65_L0.6770.93
14_L59_P0.6750.93
128_K140_E0.6710.92
29_V73_A0.6640.92
44_V50_F0.6580.92
10_I28_R0.6540.91
17_L20_R0.6530.91
54_H64_V0.6480.91
96_I101_F0.6410.91
73_A77_L0.6290.90
55_F91_Y0.6280.90
46_V50_F0.6270.90
19_H75_G0.6260.89
106_V109_D0.6210.89
38_L74_T0.6200.89
53_G56_P0.6130.89
100_R140_E0.6110.88
74_T129_G0.6100.88
34_E81_S0.6100.88
42_K47_N0.6100.88
45_S108_G0.6080.88
120_T123_G0.6080.88
19_H23_F0.6050.88
119_K126_R0.6030.88
86_E147_R0.6020.88
95_G100_R0.6000.87
73_A113_M0.5990.87
67_L141_A0.5990.87
103_R106_V0.5970.87
83_G87_P0.5960.87
77_L127_F0.5940.87
91_Y127_F0.5940.87
53_G64_V0.5890.86
28_R134_D0.5820.86
11_E57_G0.5810.86
46_V49_P0.5780.85
70_M129_G0.5760.85
82_V86_E0.5750.85
47_N50_F0.5730.85
21_F45_S0.5700.85
124_L144_M0.5660.84
55_F60_I0.5640.84
46_V52_Q0.5560.83
53_G63_G0.5560.83
43_N46_V0.5540.83
26_V113_M0.5520.83
16_L89_E0.5500.83
83_G86_E0.5480.82
26_V40_A0.5430.82
78_A127_F0.5400.81
79_F147_R0.5340.81
51_F107_P0.5310.80
10_I21_F0.5300.80
93_F97_D0.5280.80
15_E57_G0.5220.79
112_I134_D0.5210.79
14_L21_F0.5200.79
11_E59_P0.5200.79
117_F127_F0.5190.79
35_G117_F0.5180.79
10_I59_P0.5170.79
43_N47_N0.5140.78
16_L80_K0.5140.78
54_H59_P0.5130.78
27_D43_N0.5090.77
70_M131_A0.5090.77
23_F64_V0.5080.77
61_F111_M0.5070.77
117_F123_G0.5070.77
21_F28_R0.5020.77
32_F37_F0.5010.76
29_V38_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gllA 3 0.9801 100 0.194 Contact Map
1u1zA 3 0.947 100 0.211 Contact Map
2cf2C 2 0.9669 100 0.235 Contact Map
3q62A 2 0.9669 100 0.25 Contact Map
1z6bA 3 0.9272 100 0.26 Contact Map
3d6xA 3 0.9338 100 0.268 Contact Map
4h4gA 3 0.9338 100 0.291 Contact Map
4b0bA 2 0.9536 100 0.305 Contact Map
4i83A 3 0.9536 100 0.311 Contact Map
3esiA 4 0.7947 99.9 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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