FABA - ECOLI - GREMLIN Contacts

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FABA - 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

UniProt:	P0A6Q3	Sequences: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10273
Length:	172 (162)
Sequences:	962 (519)
Seq/√Len:	40.8

ECOLI - FABA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_T	12_D	4.549	1.00
39_R	60_D	4.174	1.00
15_A	20_E	3.842	1.00
122_A	150_V	3.339	1.00
39_R	58_E	3.242	1.00
31_A	73_I	2.774	1.00
126_T	152_G	2.745	1.00
132_K	145_D	2.668	1.00
149_L	154_L	2.492	1.00
128_R	147_E	2.422	1.00
56_E	128_R	2.366	1.00
147_E	154_L	2.325	1.00
126_T	149_L	2.282	1.00
14_L	18_R	2.159	0.99
17_G	31_A	2.130	0.99
54_Y	128_R	1.966	0.99
111_E	159_S	1.964	0.99
87_M	146_G	1.956	0.99
98_L	136_N	1.930	0.99
50_F	145_D	1.922	0.99
18_R	73_I	1.920	0.99
42_K	56_E	1.919	0.99
56_E	126_T	1.909	0.99
100_G	136_N	1.898	0.99
14_L	32_P	1.876	0.98
10_K	14_L	1.855	0.98
128_R	149_L	1.839	0.98
149_L	152_G	1.817	0.98
118_V	148_V	1.732	0.97
150_V	153_R	1.687	0.97
7_S	11_E	1.687	0.97
119_L	122_A	1.682	0.97
94_Y	98_L	1.650	0.96
15_A	18_R	1.538	0.95
107_L	164_G	1.533	0.95
135_V	141_M	1.528	0.94
123_K	151_D	1.507	0.94
87_M	129_I	1.451	0.93
148_V	156_Y	1.445	0.93
36_M	90_L	1.434	0.92
58_E	124_K	1.424	0.92
27_P	101_E	1.410	0.92
95_L	142_G	1.399	0.91
158_A	161_L	1.393	0.91
54_Y	130_H	1.390	0.91
28_Q	74_G	1.384	0.91
130_H	145_D	1.380	0.91
109_V	112_V	1.339	0.89
83_G	156_Y	1.319	0.89
18_R	31_A	1.278	0.87
98_L	131_F	1.273	0.87
125_V	148_V	1.254	0.86
154_L	157_T	1.235	0.85
49_N	130_H	1.235	0.85
75_D	105_R	1.196	0.83
87_M	158_A	1.190	0.83
115_T	157_T	1.189	0.83
32_P	39_R	1.182	0.82
27_P	33_N	1.162	0.81
41_V	58_E	1.155	0.81
21_L	93_F	1.151	0.81
41_V	56_E	1.146	0.80
45_E	98_L	1.123	0.79
71_H	77_V	1.122	0.79
55_V	131_F	1.088	0.77
83_G	112_V	1.078	0.76
130_H	147_E	1.061	0.75
26_G	96_G	1.059	0.75
40_V	93_F	1.055	0.75
116_G	153_R	1.041	0.74
113_K	159_S	1.028	0.73
10_K	38_D	1.022	0.72
33_N	37_M	1.017	0.72
28_Q	73_I	1.015	0.72
43_M	97_W	1.001	0.71
71_H	80_G	0.994	0.70
70_C	127_Y	0.984	0.69
88_W	92_G	0.984	0.69
88_W	163_V	0.978	0.69
59_L	65_L	0.964	0.68
8_Y	93_F	0.961	0.67
100_G	140_I	0.957	0.67
16_S	21_L	0.955	0.67
88_W	110_G	0.932	0.65
84_L	88_W	0.930	0.65
14_L	20_E	0.927	0.65
100_G	134_I	0.925	0.64
69_G	73_I	0.916	0.64
10_K	13_L	0.914	0.63
8_Y	21_L	0.910	0.63
71_H	75_D	0.907	0.63
131_F	149_L	0.899	0.62
10_K	32_P	0.893	0.62
58_E	126_T	0.891	0.61
91_V	144_A	0.890	0.61
147_E	157_T	0.880	0.60
20_E	24_A	0.877	0.60
47_G	54_Y	0.872	0.60
96_G	142_G	0.871	0.60
42_K	54_Y	0.861	0.59
10_K	62_N	0.860	0.59
57_A	92_G	0.860	0.59
122_A	153_R	0.858	0.59
77_V	117_Q	0.856	0.58
131_F	144_A	0.843	0.57
44_T	54_Y	0.838	0.57
70_C	77_V	0.822	0.55
27_P	168_D	0.818	0.55
119_L	150_V	0.810	0.54
132_K	143_L	0.810	0.54
27_P	100_G	0.805	0.54
10_K	17_G	0.803	0.54
47_G	51_D	0.802	0.53
16_S	96_G	0.784	0.52
30_P	125_V	0.784	0.52
91_V	94_Y	0.769	0.50
84_L	158_A	0.766	0.50
84_L	156_Y	0.766	0.50
27_P	96_G	0.763	0.50
34_M	82_L	0.758	0.49
133_R	143_L	0.758	0.49
10_K	37_M	0.757	0.49
75_D	114_F	0.756	0.49
30_P	92_G	0.756	0.49
85_D	164_G	0.752	0.49
126_T	141_M	0.749	0.49
85_D	88_W	0.747	0.48
136_N	140_I	0.735	0.47
59_L	125_V	0.735	0.47
78_M	110_G	0.730	0.47
64_D	94_Y	0.729	0.47
16_S	93_F	0.729	0.47
66_W	79_P	0.727	0.46
28_Q	92_G	0.717	0.46
77_V	80_G	0.717	0.46
62_N	65_L	0.716	0.45
110_G	134_I	0.714	0.45
90_L	129_I	0.710	0.45
31_A	146_G	0.709	0.45
108_G	164_G	0.701	0.44
76_P	120_P	0.699	0.44
105_R	166_F	0.698	0.44
17_G	89_Q	0.697	0.44
88_W	108_G	0.693	0.43
79_P	84_L	0.689	0.43
50_F	132_K	0.679	0.42
39_R	141_M	0.677	0.42
71_H	117_Q	0.674	0.42
138_R	152_G	0.672	0.41
11_E	15_A	0.671	0.41
49_N	157_T	0.659	0.40
48_G	63_P	0.658	0.40
35_L	95_L	0.656	0.40
91_V	131_F	0.655	0.40
30_P	161_L	0.649	0.39
116_G	151_D	0.649	0.39
11_E	14_L	0.647	0.39
77_V	86_A	0.642	0.39
23_G	26_G	0.640	0.39
10_K	33_N	0.639	0.39
128_R	154_L	0.635	0.38
139_L	164_G	0.634	0.38
40_V	102_G	0.630	0.38
40_V	124_K	0.630	0.38
49_N	145_D	0.627	0.37
107_L	166_F	0.620	0.37
10_K	157_T	0.620	0.37
13_L	116_G	0.619	0.37
64_D	123_K	0.618	0.37
115_T	166_F	0.614	0.36
75_D	80_G	0.614	0.36
100_G	142_G	0.613	0.36
95_L	106_A	0.611	0.36
113_K	158_A	0.611	0.36
37_M	129_I	0.610	0.36
68_F	120_P	0.609	0.36
94_Y	100_G	0.609	0.36
62_N	69_G	0.606	0.36
12_D	56_E	0.606	0.36
20_E	47_G	0.602	0.35
45_E	94_Y	0.599	0.35
129_I	144_A	0.594	0.35
80_G	83_G	0.592	0.35
16_S	26_G	0.591	0.34
132_K	160_D	0.591	0.34
8_Y	137_R	0.591	0.34
114_F	127_Y	0.590	0.34
121_T	126_T	0.584	0.34
101_E	167_Q	0.582	0.34
75_D	116_G	0.582	0.34
104_G	150_V	0.580	0.34
49_N	124_K	0.580	0.34
52_K	134_I	0.578	0.33
82_L	116_G	0.577	0.33
38_D	66_W	0.576	0.33
116_G	155_I	0.576	0.33
86_A	99_G	0.575	0.33
64_D	99_G	0.575	0.33
61_I	84_L	0.574	0.33
10_K	16_S	0.573	0.33
121_T	153_R	0.569	0.33
10_K	24_A	0.566	0.32
36_M	120_P	0.561	0.32
143_L	162_K	0.560	0.32
41_V	124_K	0.560	0.32
28_Q	100_G	0.559	0.32
109_V	168_D	0.558	0.32
42_K	64_D	0.557	0.32
60_D	88_W	0.554	0.31
77_V	112_V	0.552	0.31
71_H	76_P	0.551	0.31
52_K	118_V	0.550	0.31
40_V	111_E	0.545	0.31
81_C	156_Y	0.542	0.30
107_L	163_V	0.541	0.30
37_M	55_V	0.541	0.30
36_M	129_I	0.536	0.30
100_G	138_R	0.536	0.30
72_F	83_G	0.533	0.30
153_R	168_D	0.533	0.30
62_N	98_L	0.530	0.30
45_E	125_V	0.528	0.29
104_G	163_V	0.527	0.29
71_H	82_L	0.527	0.29
25_K	28_Q	0.525	0.29
24_A	46_T	0.522	0.29
86_A	125_V	0.522	0.29
67_F	156_Y	0.521	0.29
33_N	36_M	0.519	0.29
72_F	80_G	0.517	0.29
30_P	34_M	0.517	0.29
74_G	163_V	0.513	0.28
17_G	91_V	0.511	0.28
50_F	143_L	0.510	0.28
48_G	80_G	0.509	0.28
65_L	78_M	0.507	0.28
44_T	145_D	0.503	0.27
94_Y	132_K	0.502	0.27
135_V	139_L	0.502	0.27
81_C	114_F	0.502	0.27
7_S	12_D	0.501	0.27
30_P	85_D	0.501	0.27
47_G	116_G	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cf2C	2	0.9942	100	0.401	Contact Map
3q62A	2	0.9826	100	0.446	Contact Map
4b0bA	2	0.9884	100	0.46	Contact Map
2gllA	3	0.8314	99.8	0.624	Contact Map
1u1zA	3	0.8081	99.8	0.64	Contact Map
1z6bA	3	0.8023	99.7	0.67	Contact Map
3d6xA	3	0.7965	99.6	0.7	Contact Map
4h4gA	3	0.8081	99.6	0.708	Contact Map
4i83A	3	0.8081	99.5	0.718	Contact Map
3esiA	4	0.7093	99.2	0.762	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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