GREMLIN Database
ENO - Enolase
UniProt: P0A6P9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10258
Length: 432 (416)
Sequences: 3438 (1540)
Seq/√Len: 75.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_E333_K4.0301.00
11_E58_R3.6531.00
12_I36_A3.6061.00
338_S365_T3.4601.00
23_A113_A3.3821.00
271_E303_Y3.1901.00
101_E325_K3.1831.00
86_D89_G3.0761.00
278_E307_V3.0571.00
172_Q244_A3.0461.00
74_P105_K2.9701.00
328_K332_E2.9691.00
269_T272_E2.8711.00
46_R326_I2.8411.00
189_V241_I2.6951.00
176_A185_M2.6721.00
358_M362_A2.6401.00
69_A73_G2.6211.00
183_I410_I2.6041.00
153_I226_I2.5411.00
199_A232_A2.5361.00
220_A283_Q2.5361.00
382_D408_Q2.5191.00
29_G125_A2.5041.00
90_I118_N2.4991.00
217_G221_E2.4891.00
236_E239_K2.3931.00
327_L339_I2.3281.00
174_V242_T2.2861.00
116_L349_L2.2761.00
190_F398_S2.2581.00
223_L227_A2.2491.00
408_Q411_R2.2461.00
302_A306_K2.2351.00
179_V183_I2.2321.00
88_A354_A2.1981.00
200_K228_E2.1951.00
231_K236_E2.1561.00
353_L387_T2.1341.00
45_S296_S2.1121.00
82_K93_I2.0711.00
320_F336_A2.0671.00
46_R296_S2.0671.00
368_I389_A2.0641.00
313_Q391_Q2.0461.00
92_K96_D2.0301.00
73_G77_Q2.0101.00
320_F330_G1.9831.00
120_K379_T1.9761.00
276_F280_L1.9631.00
131_Y415_A1.9611.00
275_H307_V1.9461.00
27_L84_A1.9061.00
10_R414_E1.9031.00
75_I97_L1.8961.00
227_A237_L1.8731.00
151_M186_G1.8671.00
224_A284_Y1.8631.00
22_E411_R1.8561.00
296_S326_I1.8281.00
181_E184_R1.8261.00
34_M408_Q1.8001.00
274_T293_L1.7991.00
274_T303_Y1.7841.00
259_V267_A1.7821.00
7_I79_L1.7651.00
190_F396_S1.7451.00
24_E34_M1.7251.00
60_L192_H1.7091.00
10_R22_E1.7071.00
282_K311_K1.6941.00
230_V243_L1.6691.00
247_C277_L1.6541.00
279_E283_Q1.6541.00
190_F397_M1.6491.00
185_M241_I1.6471.00
200_K225_V1.6251.00
292_G304_Q1.6171.00
257_K267_A1.6081.00
179_V410_I1.6081.00
49_L104_S1.5940.99
8_I414_E1.5880.99
45_S250_S1.5600.99
356_I368_I1.5580.99
228_E231_K1.5550.99
273_F277_L1.5530.99
278_E282_K1.5320.99
244_A288_S1.5310.99
356_I387_T1.5190.99
327_L355_A1.5110.99
242_T287_V1.4930.99
270_S300_G1.4880.99
357_K361_D1.4880.99
268_F273_F1.4810.99
97_L106_F1.4810.99
119_A349_L1.4600.99
82_K89_G1.4590.99
11_E180_K1.4430.99
66_K69_A1.4260.99
260_L268_F1.4200.99
302_A335_I1.4180.99
36_A375_T1.4160.99
22_E408_Q1.4080.99
88_A350_T1.4050.99
184_R188_E1.3850.99
134_I386_G1.3830.99
195_K198_K1.3820.98
376_E404_A1.3790.98
368_I384_A1.3720.98
357_K360_K1.3630.98
24_E411_R1.3590.98
379_T383_L1.3500.98
194_A212_Y1.3460.98
11_E63_G1.3410.98
51_L66_K1.3360.98
75_I114_V1.3330.98
275_H278_E1.3290.98
272_E275_H1.3140.98
74_P77_Q1.3120.98
292_G314_L1.3100.98
230_V237_L1.3090.98
89_G93_I1.3070.98
134_I353_L1.2950.98
304_Q308_L1.2890.98
177_K185_M1.2850.98
328_K358_M1.2830.98
220_A224_A1.2750.97
335_I364_Y1.2660.97
111_I348_S1.2570.97
37_A113_A1.2530.97
25_V118_N1.2480.97
343_F349_L1.2450.97
169_F222_A1.2440.97
3_K28_E1.2410.97
150_M172_Q1.2340.97
70_A74_P1.2330.97
206_V398_S1.2290.97
129_P132_E1.2200.97
75_I106_F1.2180.97
94_M348_S1.2170.97
400_S403_V1.2160.97
12_I375_T1.2090.96
324_T355_A1.2080.96
308_L312_I1.2010.96
10_R24_E1.1990.96
320_F364_Y1.1940.96
341_I356_I1.1930.96
26_H32_V1.1920.96
297_D300_G1.1870.96
34_M411_R1.1690.96
88_A144_Y1.1690.96
396_S403_V1.1670.96
301_F314_L1.1660.96
195_K199_A1.1650.96
324_T358_M1.1600.96
225_V228_E1.1590.96
88_A92_K1.1540.95
343_F383_L1.1540.95
250_S294_D1.1500.95
299_D333_K1.1490.95
150_M367_V1.1480.95
13_I59_F1.1480.95
84_A118_N1.1410.95
162_N215_N1.1380.95
6_K76_A1.1350.95
353_L383_L1.1340.95
85_K126_K1.1330.95
196_V225_V1.1330.95
334_G364_Y1.1330.95
27_L31_F1.1280.95
119_A134_I1.1230.95
79_L82_K1.1230.95
260_L264_G1.1220.95
273_F293_L1.1070.94
304_Q314_L1.1060.94
228_E232_A1.1060.94
71_V113_A1.1050.94
24_E414_E1.0960.94
22_E34_M1.0900.94
51_L70_A1.0860.94
103_K351_E1.0790.93
136_E143_K1.0720.93
76_A80_I1.0710.93
262_G265_N1.0690.93
302_A333_K1.0630.93
84_A122_A1.0630.93
163_N219_N1.0620.93
275_H279_E1.0600.93
279_E282_K1.0590.93
31_F125_A1.0570.93
87_Q133_H1.0540.93
166_I247_C1.0540.93
265_N268_F1.0530.93
417_G420_A1.0530.93
260_L273_F1.0500.92
303_Y306_K1.0440.92
182_A422_Y1.0410.92
177_K181_E1.0360.92
298_W335_I1.0350.92
58_R63_G1.0250.92
185_M235_Y1.0190.91
306_K334_G1.0180.91
231_K237_L1.0180.91
78_A97_L1.0150.91
288_S313_Q1.0130.91
93_I96_D1.0130.91
192_H195_K1.0100.91
10_R411_R1.0050.91
356_I360_K1.0030.91
195_K232_A1.0030.91
260_L263_E1.0000.91
94_M111_I1.0000.91
281_T308_L0.9990.90
128_M133_H0.9990.90
128_M136_E0.9980.90
192_H232_A0.9970.90
293_L300_G0.9920.90
305_T364_Y0.9840.90
326_I335_I0.9830.90
68_V72_N0.9820.90
166_I280_L0.9810.90
324_T354_A0.9800.90
145_S423_N0.9770.89
8_I26_H0.9740.89
135_A143_K0.9700.89
200_K221_E0.9690.89
35_A116_L0.9640.89
366_A389_A0.9630.89
326_I329_E0.9610.89
79_L118_N0.9590.89
327_L364_Y0.9580.89
411_R414_E0.9560.88
55_D58_R0.9520.88
154_I164_V0.9510.88
172_Q367_V0.9500.88
360_K366_A0.9440.88
397_M403_V0.9430.88
303_Y307_V0.9360.87
27_L30_G0.9320.87
120_K378_A0.9300.87
100_T105_K0.9250.87
31_F124_A0.9230.87
356_I366_A0.9220.87
9_G71_V0.9190.86
163_N216_L0.9190.86
126_K136_E0.9180.86
49_L102_N0.9170.86
129_P415_A0.9160.86
220_A279_E0.9150.86
188_E235_Y0.9130.86
10_R34_M0.9110.86
116_L353_L0.9110.86
219_N280_L0.9080.86
336_A364_Y0.9070.86
376_E400_S0.9040.86
255_D267_A0.9020.85
74_P78_A0.8990.85
23_A71_V0.8920.85
185_M240_D0.8900.85
281_T312_I0.8870.84
330_G336_A0.8820.84
164_V219_N0.8800.84
92_K354_A0.8780.84
176_A240_D0.8760.84
249_A252_F0.8710.83
196_V228_E0.8700.83
166_I276_F0.8680.83
25_V33_G0.8680.83
65_T180_K0.8640.83
182_A186_G0.8620.83
257_K269_T0.8610.83
134_I137_L0.8590.82
134_I379_T0.8580.82
331_I362_A0.8580.82
161_D198_K0.8570.82
319_L326_I0.8560.82
46_R329_E0.8550.82
271_E274_T0.8530.82
163_N215_N0.8520.82
254_K259_V0.8510.82
144_Y388_A0.8510.82
6_K26_H0.8450.81
78_A93_I0.8440.81
280_L286_I0.8420.81
288_S391_Q0.8410.81
161_D194_A0.8330.80
327_L359_A0.8320.80
277_L289_I0.8290.80
258_Y262_G0.8270.80
172_Q242_T0.8260.80
5_V28_E0.8220.80
339_I359_A0.8160.79
24_E32_V0.8160.79
218_S221_E0.8140.79
178_T413_E0.8140.79
10_R408_Q0.8140.79
55_D65_T0.8130.79
178_T181_E0.8120.79
271_E275_H0.8100.79
293_L304_Q0.8090.79
254_K257_K0.8020.78
85_K125_A0.8010.78
255_D259_V0.7990.78
196_V232_A0.7980.78
202_M205_A0.7980.78
378_A400_S0.7950.77
341_I352_T0.7950.77
72_N77_Q0.7950.77
148_V422_Y0.7940.77
180_K413_E0.7930.77
254_K258_Y0.7910.77
349_L379_T0.7880.77
116_L120_K0.7880.77
216_L222_A0.7870.77
138_N354_A0.7870.77
384_A392_I0.7850.76
227_A230_V0.7840.76
116_L379_T0.7820.76
133_H136_E0.7820.76
170_M315_V0.7800.76
378_A403_V0.7790.76
8_I72_N0.7790.76
101_E104_S0.7790.76
18_N191_H0.7780.76
177_K184_R0.7780.76
223_L245_M0.7740.75
13_I183_I0.7710.75
224_A227_A0.7660.75
138_N144_Y0.7660.75
70_A106_F0.7650.75
163_N166_I0.7640.74
202_M217_G0.7620.74
323_N346_I0.7600.74
353_L389_A0.7580.74
274_T304_Q0.7540.73
166_I219_N0.7530.73
158_E251_E0.7490.73
132_E415_A0.7480.73
135_A144_Y0.7450.73
329_E332_E0.7440.72
216_L225_V0.7430.72
137_L353_L0.7430.72
82_K90_I0.7400.72
278_E281_T0.7390.72
58_R184_R0.7370.72
108_A112_L0.7340.71
236_E240_D0.7330.71
93_I97_L0.7320.71
221_E224_A0.7310.71
339_I355_A0.7270.71
49_L95_I0.7270.71
274_T307_V0.7270.71
247_C289_I0.7260.71
153_I189_V0.7260.71
163_N218_S0.7240.70
408_Q414_E0.7230.70
349_L383_L0.7230.70
164_V215_N0.7230.70
95_I348_S0.7230.70
7_I76_A0.7210.70
144_Y354_A0.7200.70
293_L308_L0.7180.70
360_K388_A0.7180.70
27_L32_V0.7170.70
148_V424_G0.7170.70
190_F206_V0.7160.70
163_N217_G0.7160.70
180_K414_E0.7140.69
24_E408_Q0.7140.69
120_K124_A0.7110.69
262_G280_L0.7100.69
158_E247_C0.7080.69
247_C252_F0.7070.69
79_L90_I0.7070.69
278_E311_K0.7070.69
187_S397_M0.7070.69
161_D164_V0.7040.68
252_F277_L0.7030.68
166_I245_M0.7030.68
183_I187_S0.7020.68
145_S388_A0.6990.68
158_E198_K0.6980.68
270_S293_L0.6980.68
24_E36_A0.6970.68
7_I25_V0.6960.67
13_I184_R0.6950.67
247_C294_D0.6950.67
366_A387_T0.6930.67
27_L125_A0.6890.67
226_I243_L0.6870.66
21_V71_V0.6860.66
37_A112_L0.6860.66
11_E65_T0.6850.66
171_I189_V0.6810.66
355_A366_A0.6770.65
154_I226_I0.6770.65
134_I368_I0.6740.65
276_F279_E0.6740.65
220_A284_Y0.6730.65
237_L243_L0.6730.65
161_D203_N0.6730.65
171_I241_I0.6730.65
277_L304_Q0.6720.65
343_F352_T0.6710.65
227_A284_Y0.6700.64
33_G124_A0.6700.64
189_V192_H0.6690.64
79_L93_I0.6690.64
45_S326_I0.6670.64
180_K183_I0.6670.64
45_S294_D0.6660.64
60_L187_S0.6650.64
270_S274_T0.6640.64
136_E388_A0.6620.64
281_T304_Q0.6620.64
292_G301_F0.6610.63
338_S367_V0.6610.63
249_A294_D0.6610.63
274_T308_L0.6590.63
253_Y294_D0.6580.63
171_I226_I0.6570.63
6_K80_I0.6560.63
59_F191_H0.6520.62
45_S295_E0.6510.62
247_C273_F0.6460.62
153_I171_I0.6460.62
243_L247_C0.6420.61
325_K329_E0.6410.61
145_S421_P0.6380.61
302_A334_G0.6380.61
299_D302_A0.6370.61
33_G121_A0.6350.60
105_K348_S0.6340.60
85_K122_A0.6340.60
324_T328_K0.6340.60
128_M132_E0.6340.60
28_E84_A0.6340.60
166_I222_A0.6330.60
331_I358_M0.6320.60
314_L335_I0.6300.60
119_A379_T0.6280.59
85_K118_N0.6280.59
202_M221_E0.6270.59
251_E394_T0.6270.59
249_A277_L0.6260.59
275_H303_Y0.6250.59
21_V113_A0.6250.59
8_I24_E0.6240.59
90_I95_I0.6240.59
58_R180_K0.6240.59
29_G84_A0.6230.59
168_E370_H0.6230.59
368_I383_L0.6230.59
122_A133_H0.6220.59
186_G241_I0.6220.59
227_A243_L0.6210.59
95_I103_K0.6190.58
161_D197_L0.6190.58
165_D259_V0.6190.58
118_N122_A0.6160.58
207_G370_H0.6140.58
305_T334_G0.6130.58
89_G92_K0.6130.58
11_E187_S0.6110.57
151_M397_M0.6110.57
354_A357_K0.6090.57
29_G32_V0.6090.57
368_I387_T0.6080.57
84_A90_I0.6060.57
12_I34_M0.6060.57
31_F84_A0.6030.56
9_G21_V0.6030.56
144_Y357_K0.6030.56
92_K350_T0.6020.56
103_K111_I0.6010.56
46_R294_D0.6010.56
332_E358_M0.6000.56
313_Q390_G0.6000.56
268_F272_E0.6000.56
170_M244_A0.5990.56
83_D122_A0.5980.56
68_V71_V0.5970.56
313_Q367_V0.5940.55
216_L219_N0.5940.55
158_E294_D0.5940.55
184_R235_Y0.5920.55
27_L121_A0.5910.55
252_F260_L0.5910.55
25_V117_A0.5900.55
78_A82_K0.5890.55
12_I21_V0.5890.55
319_L335_I0.5880.55
271_E299_D0.5870.54
320_F335_I0.5870.54
40_G44_G0.5850.54
22_E414_E0.5790.53
29_G127_G0.5780.53
278_E308_L0.5780.53
333_K364_Y0.5760.53
169_F216_L0.5760.53
70_A110_A0.5750.53
144_Y421_P0.5740.53
176_A182_A0.5740.53
197_L225_V0.5730.53
150_M244_A0.5730.53
296_S329_E0.5730.53
3_K127_G0.5720.53
13_I397_M0.5700.52
154_I225_V0.5690.52
72_N76_A0.5690.52
176_A183_I0.5690.52
180_K410_I0.5690.52
162_N212_Y0.5670.52
298_W329_E0.5670.52
36_A414_E0.5660.52
172_Q186_G0.5650.52
128_M137_L0.5650.52
136_E144_Y0.5650.52
124_A127_G0.5640.52
263_E268_F0.5630.51
376_E392_I0.5620.51
65_T69_A0.5620.51
152_N155_N0.5620.51
164_V182_A0.5590.51
143_K388_A0.5580.51
35_A117_A0.5570.51
219_N260_L0.5570.51
154_I166_I0.5550.50
138_N388_A0.5550.50
301_F336_A0.5540.50
84_A125_A0.5530.50
356_I389_A0.5530.50
58_R65_T0.5520.50
143_K146_M0.5510.50
161_D205_A0.5510.50
341_I368_I0.5490.50
339_I364_Y0.5480.50
23_A114_V0.5480.50
163_N202_M0.5480.50
292_G335_I0.5470.49
7_I24_E0.5470.49
196_V200_K0.5460.49
406_Y409_L0.5460.49
32_V124_A0.5450.49
42_S47_E0.5450.49
159_H370_H0.5450.49
353_L357_K0.5440.49
277_L280_L0.5440.49
12_I376_E0.5430.49
202_M225_V0.5430.49
418_E421_P0.5410.49
243_L286_I0.5410.49
22_E36_A0.5410.49
251_E321_V0.5410.49
193_L207_G0.5400.49
83_D86_D0.5400.49
5_V26_H0.5390.48
94_M106_F0.5390.48
162_N221_E0.5370.48
88_A419_K0.5370.48
11_E59_F0.5330.48
155_N168_E0.5330.48
132_E136_E0.5330.48
163_N205_A0.5320.47
196_V229_A0.5320.47
83_D125_A0.5310.47
119_A386_G0.5310.47
175_G185_M0.5310.47
163_N262_G0.5300.47
23_A118_N0.5300.47
21_V376_E0.5290.47
275_H282_K0.5290.47
132_E419_K0.5280.47
380_I383_L0.5280.47
221_E225_V0.5270.47
3_K83_D0.5270.47
219_N247_C0.5270.47
172_Q247_C0.5260.47
137_L361_D0.5250.47
88_A138_N0.5240.46
163_N225_V0.5220.46
199_A228_E0.5220.46
13_I187_S0.5210.46
281_T311_K0.5210.46
327_L341_I0.5210.46
88_A357_K0.5190.46
416_L420_A0.5190.46
251_E383_L0.5180.46
383_L389_A0.5180.46
74_P106_F0.5180.46
324_T327_L0.5170.46
159_H209_E0.5160.45
28_E83_D0.5150.45
162_N262_G0.5140.45
144_Y350_T0.5120.45
261_A265_N0.5120.45
215_N219_N0.5120.45
305_T309_G0.5120.45
149_P182_A0.5110.45
162_N204_T0.5110.45
28_E80_I0.5110.45
132_E145_S0.5110.45
343_F368_I0.5110.45
155_N207_G0.5090.45
155_N370_H0.5090.45
168_E207_G0.5090.45
189_V242_T0.5080.44
301_F304_Q0.5080.44
34_M414_E0.5080.44
5_V9_G0.5070.44
176_A181_E0.5070.44
219_N252_F0.5070.44
252_F262_G0.5060.44
67_A110_A0.5050.44
137_L386_G0.5050.44
26_H31_F0.5050.44
300_G308_L0.5020.44
158_E252_F0.5020.44
150_M243_L0.5020.44
126_K137_L0.5010.44
277_L293_L0.5010.44
203_N215_N0.5000.44
172_Q287_V0.5000.44
7_I94_M0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mksA 3 0.919 100 0.284 Contact Map
1w6tA 3 0.9815 100 0.309 Contact Map
3tqpA 2 0.9653 100 0.321 Contact Map
3otrA 2 0.9931 100 0.324 Contact Map
2akzA 2 0.9815 100 0.326 Contact Map
4ywsA 2 0.9491 100 0.346 Contact Map
2fymA 3 0.9977 100 0.349 Contact Map
4ropA 3 0.9792 100 0.35 Contact Map
2pa6A 5 0.9676 100 0.352 Contact Map
3uj2A 3 0.9722 100 0.353 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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