GREMLIN Database
ENGB - Probable GTP-binding protein EngB
UniProt: P0A6P7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11203
Length: 210 (165)
Sequences: 27241 (17064)
Seq/√Len: 1328.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_T183_K2.9071.00
176_E192_K2.8891.00
113_V143_L2.6651.00
192_K195_T2.5251.00
174_Q192_K2.2411.00
118_I144_L2.2381.00
67_L75_R2.2101.00
192_K196_W2.1891.00
147_A177_T2.1081.00
41_S180_S2.0781.00
116_M142_V1.9411.00
28_E75_R1.9261.00
44_N55_T1.9101.00
30_A109_L1.8951.00
72_D194_D1.8761.00
45_T186_V1.7981.00
111_G141_L1.7861.00
113_V193_L1.7711.00
143_L178_F1.7271.00
115_L145_T1.7161.00
69_E73_G1.6761.00
141_L192_K1.6741.00
159_L177_T1.6611.00
144_L177_T1.6511.00
42_A115_L1.6451.00
161_M165_A1.6231.00
130_I134_V1.5471.00
143_L189_L1.5431.00
31_F113_V1.5281.00
69_E75_R1.4861.00
103_L132_W1.4791.00
160_N164_E1.4331.00
47_T68_F1.4291.00
159_L163_R1.4211.00
158_Q161_M1.4161.00
67_L77_V1.4061.00
53_A66_N1.4021.00
113_V141_L1.3991.00
31_F43_L1.3911.00
132_W135_D1.3801.00
114_V130_I1.3741.00
145_T180_S1.3621.00
42_A189_L1.3581.00
27_I197_F1.3271.00
152_S155_R1.3261.00
43_L53_A1.3231.00
160_N163_R1.3141.00
144_L175_V1.3091.00
74_K194_D1.2941.00
114_V140_V1.2881.00
117_D120_H1.2761.00
131_E135_D1.2691.00
34_R126_D1.2691.00
40_S53_A1.2551.00
95_W98_A1.2501.00
26_G75_R1.2471.00
120_H123_K1.2431.00
146_K149_K1.2411.00
72_D198_S1.2391.00
97_R100_G1.2281.00
127_Q165_A1.2281.00
185_G188_K1.2171.00
158_Q162_V1.2141.00
142_V175_V1.2101.00
141_L176_E1.2091.00
91_M94_K1.2021.00
119_R149_K1.1921.00
29_V193_L1.1911.00
128_Q132_W1.1861.00
129_M133_A1.1801.00
186_V190_R1.1731.00
187_D191_Q1.1581.00
139_A196_W1.1581.00
42_A46_L1.1551.00
65_I77_V1.1441.00
26_G69_E1.1411.00
194_D198_S1.1401.00
188_K191_Q1.1381.00
29_V111_G1.1171.00
151_A154_A1.1161.00
56_S61_R1.1161.00
174_Q196_W1.1121.00
131_E134_V1.1041.00
111_G196_W1.0931.00
161_M164_E1.0861.00
92_K95_W1.0741.00
36_N57_K1.0741.00
128_Q131_E1.0711.00
130_I133_A1.0611.00
93_R97_R1.0511.00
188_K192_K1.0491.00
93_R96_Q1.0431.00
53_A68_F1.0431.00
46_L190_R1.0411.00
178_F189_L1.0411.00
191_Q195_T1.0351.00
100_G104_E1.0151.00
190_R194_D1.0071.00
190_R193_L0.9841.00
54_R61_R0.9831.00
118_I147_A0.9751.00
44_N53_A0.9601.00
174_Q177_T0.9591.00
95_W99_L0.9511.00
46_L76_L0.9501.00
42_A178_F0.9501.00
26_G73_G0.9461.00
101_E104_E0.9451.00
187_D190_R0.9371.00
35_S59_P0.9361.00
182_K185_G0.9341.00
150_L155_R0.9221.00
125_L128_Q0.9211.00
124_D128_Q0.9191.00
124_D127_Q0.9161.00
109_L112_L0.9141.00
97_R101_E0.9061.00
159_L162_V0.8981.00
189_L193_L0.8961.00
116_M144_L0.8961.00
141_L196_W0.8901.00
31_F42_A0.8871.00
94_K98_A0.8831.00
43_L68_F0.8821.00
122_L127_Q0.8791.00
99_L102_Y0.8791.00
129_M132_W0.8771.00
96_Q99_L0.8661.00
127_Q131_E0.8611.00
147_A184_Q0.8591.00
90_E95_W0.8511.00
29_V76_L0.8381.00
29_V74_K0.8371.00
120_H126_D0.8331.00
183_K186_V0.8311.00
65_I105_K0.8271.00
94_K97_R0.8231.00
176_E188_K0.8211.00
126_D130_I0.8191.00
117_D146_K0.8181.00
70_V190_R0.8171.00
30_A79_L0.8141.00
141_L174_Q0.8141.00
191_Q194_D0.8131.00
96_Q100_G0.8121.00
82_Y102_Y0.8081.00
118_I150_L0.8051.00
34_R125_L0.8021.00
28_E110_Q0.7901.00
42_A143_L0.7881.00
32_A106_R0.7841.00
107_Q136_S0.7841.00
126_D129_M0.7791.00
28_E77_V0.7761.00
99_L103_L0.7651.00
140_V173_V0.7621.00
111_G139_A0.7601.00
113_V189_L0.7571.00
34_R120_H0.7531.00
41_S55_T0.7511.00
45_T180_S0.7451.00
45_T178_F0.7421.00
147_A155_R0.7381.00
114_V133_A0.7351.00
114_V142_V0.7351.00
178_F186_V0.7321.00
42_A186_V0.7311.00
196_W199_E0.7301.00
117_D145_T0.7251.00
67_L108_S0.7251.00
70_V74_K0.7221.00
28_E108_S0.7221.00
101_E105_K0.7131.00
83_G95_W0.7071.00
133_A140_V0.7051.00
130_I140_V0.7031.00
104_E107_Q0.6931.00
92_K96_Q0.6931.00
111_G193_L0.6901.00
32_A112_L0.6821.00
151_A177_T0.6811.00
47_T70_V0.6751.00
143_L176_E0.6741.00
142_V173_V0.6731.00
42_A180_S0.6711.00
163_R175_V0.6701.00
122_L126_D0.6671.00
49_Q68_F0.6561.00
122_L125_L0.6521.00
70_V76_L0.6511.00
41_S178_F0.6431.00
174_Q195_T0.6411.00
28_E67_L0.6391.00
195_T198_S0.6361.00
155_R177_T0.6291.00
123_K127_Q0.6261.00
98_A101_E0.6191.00
92_K97_R0.6191.00
89_E92_K0.6181.00
90_E93_R0.6181.00
83_G99_L0.6171.00
89_E93_R0.6071.00
31_F53_A0.6061.00
90_E94_K0.6021.00
45_T181_L0.6011.00
95_W102_Y0.5921.00
112_L138_I0.5911.00
77_V105_K0.5791.00
185_G189_L0.5781.00
181_L184_Q0.5771.00
91_M95_W0.5761.00
23_S26_G0.5761.00
165_A170_N0.5731.00
43_L47_T0.5701.00
151_A155_R0.5641.00
62_T65_I0.5631.00
149_K152_S0.5611.00
48_N190_R0.5611.00
195_T199_E0.5561.00
162_V166_V0.5541.00
136_S139_A0.5541.00
129_M134_V0.5521.00
172_D175_V0.5441.00
37_A117_D0.5401.00
115_L178_F0.5401.00
92_K102_Y0.5391.00
37_A40_S0.5351.00
176_E185_G0.5351.00
115_L180_S0.5331.00
65_I79_L0.5331.00
53_A56_S0.5331.00
43_L76_L0.5301.00
64_L80_P0.5281.00
34_R123_K0.5281.00
82_Y99_L0.5261.00
30_A112_L0.5221.00
80_P98_A0.5211.00
54_R58_T0.5201.00
54_R66_N0.5191.00
74_K197_F0.5161.00
106_R112_L0.5141.00
63_Q91_M0.5141.00
178_F181_L0.5141.00
97_R104_E0.5131.00
147_A150_L0.5021.00
78_D81_G0.5021.00
40_S55_T0.5021.00
112_L133_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1puiA 1 0.8095 100 0.336 Contact Map
1sviA 1 0.8667 100 0.363 Contact Map
3ievA 1 0.8619 100 0.367 Contact Map
1mkyA 1 0.7571 100 0.371 Contact Map
3j65o 1 0.9381 100 0.378 Contact Map
1egaA 2 0.8524 100 0.38 Contact Map
3j8gX 1 0.9095 100 0.38 Contact Map
3pqcA 1 0.9238 100 0.383 Contact Map
2j69A 1 0.9429 100 0.388 Contact Map
4dcuA 1 0.9429 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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