GREMLIN Database
DER - GTPase Der
UniProt: P0A6P5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14207
Length: 490 (431)
Sequences: 2871 (1481)
Seq/√Len: 71.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
289_M319_V4.4541.00
252_Y369_R3.8411.00
157_H160_L3.7611.00
86_L116_V3.5851.00
250_R369_R3.4381.00
208_V309_I3.3151.00
246_E251_E3.1831.00
206_A285_A3.1281.00
441_Y444_K3.0321.00
221_R358_G2.9921.00
207_I219_T2.9321.00
335_K339_D2.8631.00
260_V278_T2.8291.00
285_A288_V2.8061.00
246_E249_G2.8061.00
100_E134_S2.7271.00
91_A120_T2.7241.00
91_A117_A2.6861.00
388_M410_A2.6721.00
86_L158_V2.6361.00
21_R148_G2.5601.00
67_V71_M2.4931.00
219_T228_V2.4931.00
419_I456_Q2.4481.00
365_F368_V2.4371.00
23_T27_D2.4341.00
23_T43_G2.4321.00
202_P253_V2.3991.00
427_V459_E2.3771.00
317_V371_A2.3531.00
6_A82_A2.3471.00
254_L368_V2.3021.00
255_I284_D2.2111.00
435_K457_F2.1871.00
309_I316_L2.1761.00
205_L368_V2.1511.00
419_I454_R2.1051.00
303_L341_R2.1021.00
430_L457_F2.0781.00
204_K255_I2.0631.00
315_S371_A2.0521.00
260_V275_V2.0351.00
115_L140_I2.0261.00
336_E340_F2.0071.00
5_V158_V1.9931.00
89_V115_L1.9871.00
242_Y284_D1.9711.00
46_E49_G1.9671.00
319_V351_H1.9581.00
320_V352_F1.9571.00
374_S447_D1.9441.00
40_R74_Q1.9391.00
332_E336_E1.9281.00
387_I446_L1.9031.00
410_A422_I1.8931.00
88_M143_I1.8861.00
290_L306_L1.8831.00
84_V158_V1.8791.00
22_L45_A1.8671.00
240_S281_A1.8351.00
44_R51_E1.8341.00
5_V84_V1.8201.00
376_T416_N1.7881.00
282_I288_V1.7531.00
283_E312_S1.7461.00
315_S375_S1.7331.00
18_L145_A1.7281.00
411_H423_H1.7001.00
261_R271_E1.7001.00
313_G454_R1.7001.00
387_I445_S1.6991.00
319_V364_L1.6981.00
121_D149_R1.6971.00
377_R447_D1.6951.00
306_L345_I1.6951.00
208_V282_I1.6901.00
358_G361_V1.6821.00
413_G421_V1.6721.00
364_L368_V1.6541.00
351_H367_S1.6450.99
422_I457_F1.6400.99
79_I109_R1.6380.99
408_K460_G1.6330.99
28_A41_K1.6310.99
349_R371_A1.6300.99
157_H161_P1.6260.99
244_P253_V1.6220.99
84_V114_F1.5960.99
47_I155_L1.5910.99
333_Q337_T1.5730.99
221_R361_V1.5640.99
332_E335_K1.5510.99
372_Y376_T1.5310.99
387_I391_A1.5310.99
381_T385_T1.5240.99
79_I85_V1.5190.99
279_L308_F1.5030.99
410_A420_V1.5000.99
18_L88_M1.4830.99
31_A36_L1.4790.99
260_V305_L1.4630.99
73_E226_E1.4580.99
137_L140_I1.4470.99
319_V353_I1.4460.99
205_L254_L1.4440.99
316_L345_I1.4370.99
204_K253_V1.4360.99
50_R163_M1.4360.99
70_R73_E1.4340.99
141_Y157_H1.4270.99
5_V45_A1.4220.98
152_L156_E1.4210.98
407_L422_I1.4180.98
84_V162_W1.4140.98
294_A326_L1.4130.98
223_L245_M1.4110.98
203_I372_Y1.4000.98
290_L309_I1.3960.98
289_M368_V1.3940.98
391_A441_Y1.3930.98
290_L316_L1.3900.98
50_R164_E1.3790.98
381_T409_Y1.3750.98
218_L361_V1.3750.98
367_S370_E1.3710.98
203_I252_Y1.3590.98
290_L318_I1.3470.98
391_A438_L1.3430.98
218_L291_V1.3300.98
42_Y81_E1.3290.98
370_E447_D1.3240.98
40_R78_A1.3090.97
328_Q331_K1.3080.97
90_D93_A1.3060.97
45_A52_F1.3010.97
349_R370_E1.2990.97
114_F141_Y1.2830.97
384_L410_A1.2820.97
353_I364_L1.2780.97
289_M364_L1.2780.97
244_P251_E1.2730.97
47_I156_E1.2700.97
317_V351_H1.2610.97
5_V52_F1.2510.97
148_G151_V1.2470.97
23_T54_C1.2390.96
405_V424_G1.2180.96
67_V70_R1.2150.96
379_V448_V1.2150.96
27_D43_G1.2120.96
248_D366_E1.2080.96
202_P244_P1.2030.96
84_V161_P1.2020.96
92_R125_P1.1970.96
397_P434_Y1.1930.96
129_V142_P1.1880.95
223_L228_V1.1830.95
339_D350_V1.1830.95
44_R53_I1.1780.95
94_G131_D1.1760.95
375_S416_N1.1720.95
391_A437_Y1.1720.95
5_V159_L1.1720.95
74_Q78_A1.1660.95
388_M407_L1.1620.95
17_T145_A1.1570.95
374_S377_R1.1550.95
207_I228_V1.1550.95
371_A451_S1.1530.95
424_G427_V1.1530.95
47_I152_L1.1480.94
377_R448_V1.1360.94
320_V334_V1.1330.94
116_V143_I1.1310.94
104_K107_R1.1250.94
100_E104_K1.1220.94
298_I342_L1.1210.94
334_V338_L1.1210.94
307_G348_A1.1200.94
104_K108_S1.1160.94
247_R365_F1.1100.93
4_V53_I1.1030.93
218_L353_I1.1010.93
50_R159_L1.0970.93
294_A320_V1.0900.93
321_N355_A1.0880.93
310_L347_F1.0850.93
337_T341_R1.0800.92
295_R325_G1.0790.92
114_F157_H1.0790.92
61_D71_M1.0760.92
22_L52_F1.0730.92
79_I105_H1.0730.92
250_R373_D1.0700.92
363_N366_E1.0670.92
81_E382_S1.0630.92
333_Q336_E1.0590.92
405_V430_L1.0580.92
300_D304_S1.0570.92
440_N444_K1.0570.92
379_V446_L1.0540.92
252_Y365_F1.0510.91
374_S450_G1.0500.91
139_E157_H1.0450.91
231_Y236_T1.0390.91
208_V305_L1.0360.91
370_E374_S1.0290.90
91_A128_A1.0290.90
77_L80_E1.0260.90
378_R411_H1.0200.90
378_R415_Y1.0200.90
403_R426_Q1.0200.90
71_M75_S1.0160.90
407_L430_L1.0150.90
395_H437_Y1.0150.90
89_V132_F1.0140.90
349_R449_M1.0130.90
114_F161_P1.0100.90
198_P253_V1.0090.90
405_V426_Q1.0070.90
286_N416_N0.9960.89
266_I275_V0.9950.89
18_L151_V0.9930.89
296_E299_S0.9910.89
114_F158_V0.9830.88
36_L270_V0.9790.88
116_V154_L0.9780.88
248_D369_R0.9770.88
359_S363_N0.9760.88
245_M365_F0.9720.88
61_D68_E0.9700.88
307_G311_N0.9640.87
307_G344_F0.9620.87
222_I365_F0.9500.87
399_L402_G0.9490.87
45_A54_C0.9480.86
68_E71_M0.9460.86
122_G125_P0.9420.86
150_G303_L0.9350.86
394_D441_Y0.9300.85
337_T340_F0.9280.85
7_L86_L0.9270.85
414_G419_I0.9250.85
42_Y74_Q0.9220.85
203_I369_R0.9210.85
70_R229_V0.9190.85
403_R429_D0.9190.85
131_D134_S0.9180.85
10_R13_V0.9170.85
95_L134_S0.9140.84
81_E280_Q0.9120.84
247_R252_Y0.9120.84
388_M442_F0.9090.84
383_M386_R0.9070.84
46_E51_E0.9060.84
68_E98_A0.9050.84
292_I297_G0.9040.84
426_Q429_D0.8990.83
313_G417_P0.8970.83
275_V278_T0.8900.83
377_R383_M0.8880.83
273_F277_K0.8860.83
432_D435_K0.8850.82
113_T137_L0.8850.82
398_P402_G0.8810.82
421_V456_Q0.8730.82
282_I309_I0.8730.82
275_V279_L0.8720.82
5_V86_L0.8690.81
103_A137_L0.8680.81
390_M445_S0.8640.81
314_R375_S0.8640.81
400_V429_D0.8630.81
318_I342_L0.8610.81
240_S255_I0.8600.81
95_L115_L0.8590.81
126_D149_R0.8550.80
329_E332_E0.8550.80
200_S251_E0.8540.80
289_M353_I0.8530.80
247_R250_R0.8520.80
291_V319_V0.8510.80
25_T43_G0.8510.80
245_M254_L0.8510.80
373_D377_R0.8510.80
420_V442_F0.8500.80
390_M393_E0.8500.80
213_V296_E0.8470.80
387_I442_F0.8440.79
42_Y53_I0.8420.79
52_F155_L0.8400.79
405_V429_D0.8380.79
117_A132_F0.8330.78
335_K352_F0.8300.78
18_L154_L0.8300.78
219_T254_L0.8290.78
9_G14_G0.8280.78
318_I350_V0.8280.78
264_G304_S0.8280.78
421_V458_K0.8250.78
115_L135_L0.8250.78
336_E341_R0.8220.78
103_A138_G0.8190.77
351_H364_L0.8180.77
9_G15_K0.8180.77
121_D144_A0.8160.77
58_G71_M0.8150.77
222_I245_M0.8150.77
435_K439_M0.8110.77
97_P100_E0.8060.76
160_L163_M0.8060.76
29_L277_K0.8030.76
254_L282_I0.8030.76
22_L54_C0.7990.76
93_A97_P0.7990.76
369_R373_D0.7990.76
76_L79_I0.7980.75
219_T243_I0.7970.75
372_Y375_S0.7950.75
117_A138_G0.7940.75
210_R299_S0.7940.75
66_G233_M0.7900.75
392_V397_P0.7900.75
158_V161_P0.7880.75
215_K256_D0.7880.75
49_G104_K0.7870.74
33_F270_V0.7860.74
252_Y368_V0.7850.74
60_I75_S0.7830.74
63_T98_A0.7830.74
254_L365_F0.7780.74
336_E350_V0.7710.73
261_R266_I0.7710.73
76_L80_E0.7700.73
370_E449_M0.7690.73
385_T409_Y0.7670.73
295_R320_V0.7630.72
63_T66_G0.7620.72
434_Y437_Y0.7600.72
348_A451_S0.7590.72
378_R458_K0.7580.72
117_A140_I0.7580.72
263_R279_L0.7550.71
8_V85_V0.7520.71
380_G383_M0.7520.71
40_R81_E0.7470.71
6_A55_I0.7470.71
287_V315_S0.7460.70
245_M345_I0.7430.70
106_L113_T0.7430.70
402_G405_V0.7410.70
219_T223_L0.7410.70
242_Y253_V0.7400.70
113_T164_E0.7390.70
76_L105_H0.7390.70
264_G275_V0.7380.70
353_I356_L0.7380.70
57_T78_A0.7370.70
228_V243_I0.7350.69
33_F36_L0.7340.69
89_V95_L0.7300.69
412_A415_Y0.7300.69
121_D126_D0.7300.69
205_L245_M0.7300.69
201_L251_E0.7270.68
261_R301_Q0.7250.68
222_I361_V0.7240.68
221_R291_V0.7240.68
133_Y320_V0.7220.68
371_A374_S0.7220.68
95_L131_D0.7220.68
22_L43_G0.7210.68
367_S371_A0.7210.68
132_F135_L0.7170.67
293_D296_E0.7120.67
152_L155_L0.7110.67
26_R30_V0.7100.67
287_V375_S0.7100.67
214_G256_D0.7100.67
219_T260_V0.7090.67
298_I338_L0.7070.66
49_G155_L0.7070.66
418_P451_S0.7010.66
264_G342_L0.7000.66
313_G375_S0.6990.65
10_R96_M0.6980.65
275_V301_Q0.6960.65
203_I368_V0.6940.65
117_A142_P0.6930.65
282_I312_S0.6910.65
401_R429_D0.6910.65
123_L149_R0.6910.65
318_I345_I0.6900.64
317_V367_S0.6880.64
72_A76_L0.6860.64
9_G12_N0.6850.64
442_F446_L0.6820.64
320_V338_L0.6810.63
327_S330_V0.6800.63
45_A162_W0.6800.63
40_R57_T0.6790.63
329_E333_Q0.6790.63
6_A78_A0.6760.63
92_R122_G0.6730.62
238_R270_V0.6730.62
223_L243_I0.6720.62
153_S156_E0.6720.62
52_F156_E0.6720.62
291_V355_A0.6690.62
104_K134_S0.6680.62
382_S386_R0.6680.62
120_T128_A0.6670.62
221_R357_H0.6670.62
308_F311_N0.6660.62
75_S231_Y0.6640.61
310_L345_I0.6630.61
34_P299_S0.6630.61
412_A418_P0.6610.61
164_E195_D0.6600.61
48_E159_L0.6580.61
40_R77_L0.6570.61
130_V133_Y0.6570.61
30_V282_I0.6570.61
142_P263_R0.6560.61
40_R55_I0.6560.61
398_P431_P0.6550.60
75_S79_I0.6540.60
247_R369_R0.6520.60
26_R283_E0.6510.60
329_E360_G0.6500.60
228_V241_I0.6490.60
61_D72_A0.6480.60
203_I250_R0.6480.60
144_A149_R0.6470.59
9_G16_S0.6450.59
431_P440_N0.6420.59
221_R355_A0.6410.59
141_Y150_G0.6390.59
31_A269_A0.6390.59
43_G54_C0.6390.59
28_A43_G0.6380.58
424_G457_F0.6370.58
323_W360_G0.6360.58
409_Y423_H0.6360.58
334_V352_F0.6360.58
422_I430_L0.6350.58
216_S220_N0.6340.58
342_L345_I0.6330.58
391_A445_S0.6310.58
204_K286_N0.6310.58
266_I301_Q0.6300.57
269_A272_K0.6290.57
112_P161_P0.6280.57
7_L88_M0.6280.57
295_R326_L0.6280.57
57_T74_Q0.6280.57
328_Q359_S0.6280.57
49_G159_L0.6270.57
114_F130_V0.6250.57
62_G382_S0.6240.57
218_L364_L0.6230.57
210_R280_Q0.6220.56
360_G386_R0.6220.56
216_S237_T0.6210.56
418_P452_P0.6200.56
68_E72_A0.6170.56
60_I82_A0.6170.56
7_L19_F0.6150.56
198_P201_L0.6110.55
237_T259_G0.6110.55
374_S449_M0.6110.55
155_L158_V0.6090.55
148_G152_L0.6090.55
16_S20_N0.6080.55
378_R382_S0.6070.55
289_M317_V0.6070.55
101_A205_L0.6060.55
384_L420_V0.6060.55
432_D440_N0.6050.54
422_I455_I0.6040.54
443_R452_P0.6030.54
6_A57_T0.6030.54
396_Q434_Y0.6020.54
393_E432_D0.6020.54
288_V314_R0.6010.54
217_T353_I0.6010.54
61_D234_P0.6010.54
330_V360_G0.6010.54
115_L138_G0.6010.54
60_I230_V0.6000.54
438_L457_F0.6000.54
19_F43_G0.5990.54
21_R147_H0.5990.54
213_V338_L0.5990.54
27_D41_K0.5980.54
10_R99_D0.5980.54
381_T411_H0.5970.53
143_I151_V0.5970.53
328_Q360_G0.5960.53
8_V348_A0.5960.53
24_R377_R0.5940.53
12_N20_N0.5900.53
346_D349_R0.5900.53
334_V339_D0.5890.52
275_V451_S0.5890.52
109_R326_L0.5890.52
278_T282_I0.5880.52
47_I52_F0.5830.52
272_K276_I0.5830.52
26_R280_Q0.5810.51
116_V129_V0.5810.51
219_T404_R0.5800.51
47_I153_S0.5790.51
269_A273_F0.5780.51
120_T149_R0.5780.51
87_F106_L0.5770.51
97_P101_A0.5760.51
410_A438_L0.5760.51
419_I424_G0.5750.51
270_V274_S0.5750.51
362_G366_E0.5720.50
344_F375_S0.5710.50
392_V437_Y0.5710.50
385_T411_H0.5710.50
217_T355_A0.5700.50
6_A79_I0.5690.50
94_G103_A0.5690.50
399_L403_R0.5690.50
54_C158_V0.5690.50
73_E225_E0.5680.50
21_R151_V0.5650.50
114_F154_L0.5650.50
165_D195_D0.5650.50
417_P454_R0.5650.50
288_V406_K0.5640.49
47_I159_L0.5640.49
298_I380_G0.5630.49
307_G431_P0.5630.49
277_K280_Q0.5620.49
6_A40_R0.5590.49
393_E458_K0.5580.49
118_N321_N0.5570.49
45_A158_V0.5560.48
286_N385_T0.5560.48
264_G308_F0.5550.48
292_I299_S0.5550.48
297_G365_F0.5540.48
42_Y55_I0.5540.48
151_V394_D0.5540.48
82_A285_A0.5540.48
5_V116_V0.5520.48
432_D436_R0.5500.48
386_R389_T0.5480.47
211_P301_Q0.5470.47
219_T269_A0.5470.47
422_I438_L0.5470.47
396_Q436_R0.5460.47
359_S366_E0.5450.47
361_V367_S0.5450.47
156_E159_L0.5450.47
212_N322_K0.5450.47
92_R97_P0.5430.47
404_R430_L0.5400.46
103_A113_T0.5390.46
63_T69_T0.5390.46
216_S259_G0.5390.46
340_F343_G0.5380.46
358_G441_Y0.5380.46
101_A104_K0.5370.46
12_N16_S0.5360.46
36_L313_G0.5360.46
151_V162_W0.5360.46
219_T365_F0.5350.46
88_M445_S0.5350.46
326_L334_V0.5330.46
303_L307_G0.5330.46
419_I458_K0.5320.45
309_I446_L0.5320.45
146_S151_V0.5320.45
61_D75_S0.5310.45
272_K404_R0.5310.45
378_R385_T0.5310.45
194_D198_P0.5300.45
399_L405_V0.5300.45
220_N237_T0.5300.45
344_F431_P0.5300.45
414_G417_P0.5290.45
141_Y158_V0.5270.45
446_L450_G0.5260.45
230_V277_K0.5250.45
270_V273_F0.5240.45
121_D140_I0.5240.45
303_L343_G0.5240.45
43_G150_G0.5230.44
93_A96_M0.5220.44
47_I148_G0.5220.44
160_L165_D0.5220.44
379_V420_V0.5210.44
94_G132_F0.5200.44
103_A139_E0.5200.44
209_G214_G0.5200.44
6_A75_S0.5190.44
214_G237_T0.5190.44
9_G13_V0.5190.44
83_D207_I0.5170.44
269_A277_K0.5170.44
121_D304_S0.5170.44
42_Y78_A0.5160.44
392_V395_H0.5160.44
250_R253_V0.5160.44
54_C369_R0.5150.43
204_K284_D0.5150.43
7_L145_A0.5140.43
378_R417_P0.5140.43
202_P372_Y0.5130.43
7_L54_C0.5120.43
25_T276_I0.5120.43
26_R146_S0.5120.43
22_L151_V0.5110.43
58_G236_T0.5110.43
62_G303_L0.5110.43
313_G371_A0.5100.43
374_S448_V0.5090.43
286_N372_Y0.5080.43
280_Q289_M0.5080.43
310_L315_S0.5080.43
6_A74_Q0.5080.43
309_I312_S0.5060.42
236_T277_K0.5060.42
271_E301_Q0.5060.42
56_D59_G0.5060.42
216_S256_D0.5050.42
224_G358_G0.5050.42
14_G20_N0.5040.42
111_K228_V0.5040.42
288_V395_H0.5040.42
418_P443_R0.5030.42
240_S397_P0.5030.42
44_R129_V0.5030.42
266_I305_L0.5020.42
228_V245_M0.5020.42
418_P436_R0.5010.42
291_V353_I0.5010.42
114_F160_L0.5010.42
124_D134_S0.5010.42
412_A420_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j8gX 1 0.851 100 0.293 Contact Map
1mkyA 1 0.8184 100 0.306 Contact Map
4dcuA 1 0.8122 100 0.309 Contact Map
3j65o 1 0.6673 100 0.687 Contact Map
4fidA 1 0.5204 100 0.732 Contact Map
4xc8A 2 0.8592 100 0.748 Contact Map
1egaA 2 0.5551 100 0.756 Contact Map
3ec1A 1 0.5939 100 0.76 Contact Map
3zvrA 1 0.6163 100 0.772 Contact Map
3h2yA 1 0.5939 100 0.78 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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