EFTS - ECOLI - GREMLIN Contacts

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EFTS - Elongation factor Ts

UniProt:	P0A6P1	Sequences: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11033
Length:	283 (261)
Sequences:	2632 (1446)
Seq/√Len:	89.5

ECOLI - EFTS
BACSU - EFTS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_D	110_V	3.384	1.00
240_K	248_E	3.268	1.00
159_K	252_E	3.197	1.00
168_H	236_M	3.144	1.00
182_K	185_D	3.073	1.00
203_M	212_A	3.072	1.00
188_A	192_E	3.048	1.00
39_E	193_K	2.586	1.00
195_Y	217_E	2.536	1.00
65_K	98_D	2.436	1.00
10_K	14_E	2.420	1.00
183_P	221_K	2.338	1.00
193_K	196_Q	2.316	1.00
168_H	234_F	2.236	1.00
30_A	40_N	2.223	1.00
33_D	36_L	2.216	1.00
244_Q	247_K	2.189	1.00
165_L	245_L	2.156	1.00
157_A	255_G	2.065	1.00
70_Y	104_K	2.039	1.00
88_G	125_K	2.008	1.00
199_L	213_E	1.998	1.00
183_P	231_G	1.953	1.00
76_V	93_A	1.935	1.00
8_L	34_I	1.926	1.00
87_A	91_A	1.909	1.00
237_E	240_K	1.884	1.00
6_A	9_V	1.876	1.00
182_K	230_T	1.875	1.00
201_I	219_R	1.864	1.00
74_L	96_V	1.857	1.00
8_L	11_E	1.844	1.00
231_G	243_G	1.816	1.00
91_A	95_K	1.800	1.00
55_N	79_Q	1.754	1.00
203_M	209_K	1.738	1.00
63_K	93_A	1.710	1.00
99_A	103_G	1.704	1.00
65_K	101_V	1.702	1.00
196_Q	200_D	1.692	1.00
31_N	36_L	1.692	1.00
123_V	129_N	1.687	1.00
198_Q	201_I	1.659	1.00
92_F	122_L	1.649	1.00
158_A	166_V	1.630	1.00
104_K	137_A	1.611	1.00
98_D	102_A	1.603	1.00
200_D	204_Q	1.596	1.00
70_Y	137_A	1.585	1.00
92_F	119_R	1.572	1.00
214_K	217_E	1.564	1.00
119_R	132_I	1.564	1.00
161_A	251_A	1.561	1.00
159_K	254_T	1.559	1.00
192_E	196_Q	1.549	1.00
62_I	153_G	1.542	1.00
243_G	247_K	1.534	1.00
144_G	166_V	1.526	1.00
192_E	195_Y	1.503	1.00
77_N	133_R	1.500	1.00
75_E	134_R	1.474	1.00
138_L	255_G	1.460	0.99
70_Y	139_E	1.455	0.99
114_Q	117_E	1.436	0.99
140_G	159_K	1.432	0.99
202_A	219_R	1.428	0.99
199_L	203_M	1.417	0.99
16_T	38_I	1.417	0.99
237_E	248_E	1.401	0.99
94_D	98_D	1.397	0.99
200_D	203_M	1.381	0.99
15_R	38_I	1.377	0.99
96_V	115_F	1.376	0.99
221_K	225_G	1.371	0.99
177_K	260_E	1.371	0.99
241_T	244_Q	1.364	0.99
36_L	43_K	1.362	0.99
138_L	157_A	1.343	0.99
138_L	257_I	1.338	0.99
113_A	116_E	1.335	0.99
29_E	40_N	1.305	0.99
116_E	120_V	1.301	0.99
228_S	231_G	1.296	0.99
179_E	190_V	1.291	0.99
154_V	174_A	1.285	0.99
246_L	251_A	1.272	0.99
217_E	221_K	1.257	0.98
92_F	96_V	1.252	0.98
191_V	224_T	1.242	0.98
180_F	186_V	1.239	0.98
71_G	155_L	1.238	0.98
11_E	15_R	1.234	0.98
183_P	228_S	1.230	0.98
195_Y	199_L	1.224	0.98
74_L	97_L	1.214	0.98
225_G	241_T	1.207	0.98
35_E	193_K	1.205	0.98
36_L	39_E	1.204	0.98
190_V	223_F	1.190	0.98
202_A	205_S	1.188	0.98
105_I	135_V	1.185	0.98
106_T	110_V	1.182	0.98
66_I	71_G	1.177	0.98
108_V	112_K	1.171	0.97
136_A	257_I	1.170	0.97
90_Q	94_D	1.170	0.97
181_I	256_F	1.152	0.97
198_Q	220_M	1.149	0.97
145_S	155_L	1.135	0.97
76_V	92_F	1.134	0.97
141_D	157_A	1.132	0.97
66_I	145_S	1.128	0.97
224_T	228_S	1.128	0.97
88_G	122_L	1.114	0.97
104_K	139_E	1.113	0.97
165_L	246_L	1.109	0.97
240_K	244_Q	1.104	0.96
233_P	238_P	1.093	0.96
42_R	194_E	1.090	0.96
162_D	249_H	1.076	0.96
210_E	214_K	1.073	0.96
92_F	132_I	1.067	0.96
211_I	215_M	1.057	0.95
156_V	170_A	1.057	0.95
213_E	217_E	1.056	0.95
215_M	219_R	1.056	0.95
11_E	34_I	1.056	0.95
157_A	254_T	1.047	0.95
181_I	185_D	1.046	0.95
244_Q	248_E	1.035	0.95
136_A	255_G	1.033	0.95
95_K	118_E	1.032	0.95
61_V	93_A	1.029	0.95
57_A	77_N	1.028	0.95
202_A	215_M	1.028	0.95
196_Q	199_L	1.025	0.95
136_A	259_F	1.022	0.94
63_K	97_L	1.019	0.94
18_A	124_A	1.014	0.94
182_K	252_E	1.014	0.94
180_F	190_V	1.013	0.94
36_L	40_N	1.002	0.94
97_L	101_V	0.990	0.93
246_L	253_V	0.989	0.93
73_I	153_G	0.982	0.93
164_E	168_H	0.976	0.93
63_K	94_D	0.972	0.93
140_G	157_A	0.968	0.93
241_T	245_L	0.963	0.93
180_F	187_S	0.959	0.92
123_V	130_I	0.954	0.92
111_L	132_I	0.951	0.92
165_L	169_I	0.950	0.92
199_L	212_A	0.943	0.92
141_D	159_K	0.939	0.92
112_K	116_E	0.933	0.91
187_S	190_V	0.931	0.91
88_G	91_A	0.927	0.91
76_V	132_I	0.922	0.91
225_G	233_P	0.921	0.91
30_A	36_L	0.917	0.91
220_M	224_T	0.916	0.91
7_S	10_K	0.915	0.90
73_I	136_A	0.913	0.90
202_A	212_A	0.911	0.90
209_K	212_A	0.908	0.90
35_E	38_I	0.906	0.90
208_P	215_M	0.904	0.90
109_E	112_K	0.902	0.90
161_A	250_N	0.896	0.90
169_I	245_L	0.892	0.89
173_V	256_F	0.892	0.89
160_G	250_N	0.892	0.89
167_K	171_M	0.891	0.89
50_A	120_V	0.884	0.89
67_D	102_A	0.883	0.89
192_E	199_L	0.882	0.89
64_T	73_I	0.875	0.88
95_K	98_D	0.871	0.88
9_V	23_C	0.867	0.88
100_A	135_V	0.867	0.88
39_E	43_K	0.866	0.88
160_G	251_A	0.862	0.88
211_I	214_K	0.858	0.87
242_V	245_L	0.857	0.87
58_A	133_R	0.856	0.87
240_K	245_L	0.850	0.87
70_Y	101_V	0.844	0.87
43_K	200_D	0.844	0.87
201_I	204_Q	0.837	0.86
22_D	44_S	0.836	0.86
30_A	37_A	0.835	0.86
126_I	130_I	0.832	0.86
72_I	100_A	0.819	0.85
205_S	215_M	0.819	0.85
151_R	260_E	0.819	0.85
165_L	251_A	0.812	0.84
3_E	31_N	0.810	0.84
108_V	132_I	0.808	0.84
99_A	115_F	0.805	0.84
186_V	227_V	0.803	0.84
64_T	145_S	0.802	0.84
72_I	137_A	0.802	0.84
43_K	46_A	0.801	0.84
119_R	123_V	0.801	0.84
25_K	28_T	0.798	0.83
72_I	101_V	0.797	0.83
193_K	197_V	0.794	0.83
28_T	31_N	0.793	0.83
73_I	257_I	0.791	0.83
171_M	175_A	0.787	0.83
198_Q	219_R	0.784	0.82
208_P	211_I	0.783	0.82
156_V	169_I	0.782	0.82
117_E	120_V	0.782	0.82
207_K	215_M	0.780	0.82
199_L	209_K	0.774	0.81
65_K	94_D	0.774	0.81
3_E	28_T	0.773	0.81
147_Q	153_G	0.770	0.81
120_V	123_V	0.767	0.81
188_A	191_V	0.765	0.81
43_K	204_Q	0.759	0.80
75_E	133_R	0.759	0.80
4_I	8_L	0.753	0.80
4_I	28_T	0.750	0.79
152_I	174_A	0.746	0.79
144_G	167_K	0.745	0.79
177_K	258_R	0.744	0.79
4_I	9_V	0.743	0.79
15_R	34_I	0.742	0.79
206_G	212_A	0.738	0.78
210_E	213_E	0.738	0.78
75_E	262_G	0.734	0.78
180_F	185_D	0.728	0.77
87_A	90_Q	0.726	0.77
39_E	197_V	0.723	0.77
201_I	215_M	0.720	0.77
216_V	219_R	0.719	0.76
202_A	211_I	0.718	0.76
64_T	71_G	0.710	0.76
158_A	165_L	0.710	0.76
49_A	127_G	0.710	0.76
134_R	259_F	0.709	0.75
67_D	98_D	0.707	0.75
183_P	230_T	0.706	0.75
198_Q	202_A	0.706	0.75
3_E	8_L	0.700	0.75
4_I	32_G	0.698	0.74
109_E	113_A	0.694	0.74
122_L	125_K	0.692	0.74
77_N	134_R	0.692	0.74
143_L	155_L	0.692	0.74
38_I	50_A	0.690	0.73
179_E	227_V	0.690	0.73
6_A	21_M	0.689	0.73
100_A	111_L	0.689	0.73
135_V	259_F	0.688	0.73
229_L	253_V	0.683	0.73
15_R	35_E	0.682	0.73
105_I	110_V	0.681	0.72
100_A	105_I	0.680	0.72
189_E	192_E	0.680	0.72
106_T	135_V	0.677	0.72
191_V	220_M	0.675	0.72
194_E	198_Q	0.674	0.72
107_D	112_K	0.673	0.72
105_I	137_A	0.672	0.71
247_K	250_N	0.671	0.71
195_Y	216_V	0.670	0.71
73_I	259_F	0.668	0.71
142_V	163_E	0.659	0.70
183_P	243_G	0.658	0.70
99_A	102_A	0.655	0.70
65_K	97_L	0.655	0.70
4_I	11_E	0.654	0.69
202_A	216_V	0.654	0.69
42_R	197_V	0.654	0.69
212_A	215_M	0.648	0.69
219_R	222_K	0.647	0.69
69_N	140_G	0.646	0.69
206_G	213_E	0.642	0.68
5_T	8_L	0.642	0.68
104_K	135_V	0.642	0.68
172_H	238_P	0.640	0.68
40_N	44_S	0.639	0.68
247_K	252_E	0.637	0.67
144_G	158_A	0.637	0.67
191_V	223_F	0.633	0.67
134_R	262_G	0.632	0.67
49_A	123_V	0.630	0.67
105_I	111_L	0.626	0.66
185_D	255_G	0.625	0.66
78_C	86_D	0.623	0.66
96_V	99_A	0.623	0.66
147_Q	150_A	0.620	0.65
55_N	81_D	0.618	0.65
6_A	20_M	0.617	0.65
218_G	222_K	0.616	0.65
43_K	196_Q	0.611	0.64
194_E	223_F	0.611	0.64
54_G	129_N	0.610	0.64
181_I	253_V	0.610	0.64
14_E	23_C	0.609	0.64
233_P	239_S	0.608	0.64
205_S	212_A	0.605	0.63
152_I	260_E	0.601	0.63
7_S	14_E	0.598	0.63
86_D	126_I	0.596	0.62
199_L	206_G	0.594	0.62
179_E	223_F	0.591	0.62
182_K	231_G	0.590	0.62
217_E	220_M	0.589	0.61
172_H	235_V	0.588	0.61
71_G	145_S	0.586	0.61
117_E	121_A	0.586	0.61
78_C	93_A	0.586	0.61
207_K	214_K	0.585	0.61
96_V	119_R	0.583	0.61
234_F	237_E	0.581	0.60
67_D	101_V	0.581	0.60
69_N	141_D	0.579	0.60
29_E	44_S	0.576	0.60
18_A	22_D	0.575	0.60
110_V	113_A	0.574	0.59
191_V	195_Y	0.574	0.59
74_L	177_K	0.574	0.59
152_I	258_R	0.572	0.59
172_H	175_A	0.572	0.59
194_E	197_V	0.571	0.59
90_Q	93_A	0.571	0.59
199_L	220_M	0.569	0.59
209_K	213_E	0.568	0.59
58_A	77_N	0.567	0.59
211_I	216_V	0.567	0.59
118_E	122_L	0.566	0.58
9_V	21_M	0.566	0.58
144_G	163_E	0.565	0.58
34_I	38_I	0.564	0.58
175_A	235_V	0.564	0.58
195_Y	213_E	0.562	0.58
142_V	158_A	0.559	0.57
122_L	130_I	0.556	0.57
63_K	74_L	0.556	0.57
71_G	143_L	0.555	0.57
172_H	261_V	0.555	0.57
245_L	248_E	0.552	0.56
78_C	130_I	0.550	0.56
7_S	11_E	0.549	0.56
182_K	228_S	0.549	0.56
39_E	196_Q	0.549	0.56
85_K	90_Q	0.548	0.56
180_F	228_S	0.544	0.55
161_A	246_L	0.542	0.55
133_R	259_F	0.542	0.55
186_V	224_T	0.542	0.55
230_T	252_E	0.542	0.55
118_E	121_A	0.540	0.55
19_G	22_D	0.539	0.55
140_G	161_A	0.539	0.55
22_D	45_G	0.536	0.54
66_I	143_L	0.533	0.54
103_G	137_A	0.533	0.54
108_V	135_V	0.533	0.54
168_H	172_H	0.532	0.54
43_K	205_S	0.530	0.54
123_V	127_G	0.529	0.53
18_A	45_G	0.529	0.53
122_L	126_I	0.529	0.53
224_T	231_G	0.526	0.53
198_Q	239_S	0.526	0.53
116_E	119_R	0.525	0.53
55_N	82_F	0.525	0.53
205_S	216_V	0.525	0.53
184_E	230_T	0.524	0.53
205_S	211_I	0.523	0.53
172_H	176_S	0.521	0.52
120_V	124_A	0.521	0.52
168_H	245_L	0.519	0.52
181_I	230_T	0.518	0.52
161_A	165_L	0.518	0.52
158_A	169_I	0.516	0.52
114_Q	118_E	0.514	0.51
92_F	118_E	0.514	0.51
181_I	246_L	0.511	0.51
190_V	227_V	0.510	0.51
183_P	224_T	0.509	0.51
212_A	216_V	0.506	0.50
85_K	180_F	0.506	0.50
171_M	242_V	0.505	0.50
23_C	28_T	0.500	0.49
74_L	132_I	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pc3C	1	0.9859	100	0.001	Contact Map
3avxA	1	0.9965	100	0.057	Contact Map
1xb2B	1	0.8127	100	0.226	Contact Map
1aipC	2	0.6608	100	0.292	Contact Map
1tfeA	2	0.4735	100	0.564	Contact Map
2cp9A	1	0.1979	99.8	0.799	Contact Map
1wj7A	1	0.2261	98.4	0.901	Contact Map
2g3qA	1	0.1519	98.1	0.91	Contact Map
2mr9A	1	0.1519	97.8	0.915	Contact Map
2dahA	1	0.1661	97.4	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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