GREMLIN Database
EFTS - Elongation factor Ts
UniProt: P0A6P1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11033
Length: 283 (261)
Sequences: 2632 (1446)
Seq/√Len: 89.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_D110_V3.3841.00
240_K248_E3.2681.00
159_K252_E3.1971.00
168_H236_M3.1441.00
182_K185_D3.0731.00
203_M212_A3.0721.00
188_A192_E3.0481.00
39_E193_K2.5861.00
195_Y217_E2.5361.00
65_K98_D2.4361.00
10_K14_E2.4201.00
183_P221_K2.3381.00
193_K196_Q2.3161.00
168_H234_F2.2361.00
30_A40_N2.2231.00
33_D36_L2.2161.00
244_Q247_K2.1891.00
165_L245_L2.1561.00
157_A255_G2.0651.00
70_Y104_K2.0391.00
88_G125_K2.0081.00
199_L213_E1.9981.00
183_P231_G1.9531.00
76_V93_A1.9351.00
8_L34_I1.9261.00
87_A91_A1.9091.00
237_E240_K1.8841.00
6_A9_V1.8761.00
182_K230_T1.8751.00
201_I219_R1.8641.00
74_L96_V1.8571.00
8_L11_E1.8441.00
231_G243_G1.8161.00
91_A95_K1.8001.00
55_N79_Q1.7541.00
203_M209_K1.7381.00
63_K93_A1.7101.00
99_A103_G1.7041.00
65_K101_V1.7021.00
196_Q200_D1.6921.00
31_N36_L1.6921.00
123_V129_N1.6871.00
198_Q201_I1.6591.00
92_F122_L1.6491.00
158_A166_V1.6301.00
104_K137_A1.6111.00
98_D102_A1.6031.00
200_D204_Q1.5961.00
70_Y137_A1.5851.00
92_F119_R1.5721.00
214_K217_E1.5641.00
119_R132_I1.5641.00
161_A251_A1.5611.00
159_K254_T1.5591.00
192_E196_Q1.5491.00
62_I153_G1.5421.00
243_G247_K1.5341.00
144_G166_V1.5261.00
192_E195_Y1.5031.00
77_N133_R1.5001.00
75_E134_R1.4741.00
138_L255_G1.4600.99
70_Y139_E1.4550.99
114_Q117_E1.4360.99
140_G159_K1.4320.99
202_A219_R1.4280.99
199_L203_M1.4170.99
16_T38_I1.4170.99
237_E248_E1.4010.99
94_D98_D1.3970.99
200_D203_M1.3810.99
15_R38_I1.3770.99
96_V115_F1.3760.99
221_K225_G1.3710.99
177_K260_E1.3710.99
241_T244_Q1.3640.99
36_L43_K1.3620.99
138_L157_A1.3430.99
138_L257_I1.3380.99
113_A116_E1.3350.99
29_E40_N1.3050.99
116_E120_V1.3010.99
228_S231_G1.2960.99
179_E190_V1.2910.99
154_V174_A1.2850.99
246_L251_A1.2720.99
217_E221_K1.2570.98
92_F96_V1.2520.98
191_V224_T1.2420.98
180_F186_V1.2390.98
71_G155_L1.2380.98
11_E15_R1.2340.98
183_P228_S1.2300.98
195_Y199_L1.2240.98
74_L97_L1.2140.98
225_G241_T1.2070.98
35_E193_K1.2050.98
36_L39_E1.2040.98
190_V223_F1.1900.98
202_A205_S1.1880.98
105_I135_V1.1850.98
106_T110_V1.1820.98
66_I71_G1.1770.98
108_V112_K1.1710.97
136_A257_I1.1700.97
90_Q94_D1.1700.97
181_I256_F1.1520.97
198_Q220_M1.1490.97
145_S155_L1.1350.97
76_V92_F1.1340.97
141_D157_A1.1320.97
66_I145_S1.1280.97
224_T228_S1.1280.97
88_G122_L1.1140.97
104_K139_E1.1130.97
165_L246_L1.1090.97
240_K244_Q1.1040.96
233_P238_P1.0930.96
42_R194_E1.0900.96
162_D249_H1.0760.96
210_E214_K1.0730.96
92_F132_I1.0670.96
211_I215_M1.0570.95
156_V170_A1.0570.95
213_E217_E1.0560.95
215_M219_R1.0560.95
11_E34_I1.0560.95
157_A254_T1.0470.95
181_I185_D1.0460.95
244_Q248_E1.0350.95
136_A255_G1.0330.95
95_K118_E1.0320.95
61_V93_A1.0290.95
57_A77_N1.0280.95
202_A215_M1.0280.95
196_Q199_L1.0250.95
136_A259_F1.0220.94
63_K97_L1.0190.94
18_A124_A1.0140.94
182_K252_E1.0140.94
180_F190_V1.0130.94
36_L40_N1.0020.94
97_L101_V0.9900.93
246_L253_V0.9890.93
73_I153_G0.9820.93
164_E168_H0.9760.93
63_K94_D0.9720.93
140_G157_A0.9680.93
241_T245_L0.9630.93
180_F187_S0.9590.92
123_V130_I0.9540.92
111_L132_I0.9510.92
165_L169_I0.9500.92
199_L212_A0.9430.92
141_D159_K0.9390.92
112_K116_E0.9330.91
187_S190_V0.9310.91
88_G91_A0.9270.91
76_V132_I0.9220.91
225_G233_P0.9210.91
30_A36_L0.9170.91
220_M224_T0.9160.91
7_S10_K0.9150.90
73_I136_A0.9130.90
202_A212_A0.9110.90
209_K212_A0.9080.90
35_E38_I0.9060.90
208_P215_M0.9040.90
109_E112_K0.9020.90
161_A250_N0.8960.90
169_I245_L0.8920.89
173_V256_F0.8920.89
160_G250_N0.8920.89
167_K171_M0.8910.89
50_A120_V0.8840.89
67_D102_A0.8830.89
192_E199_L0.8820.89
64_T73_I0.8750.88
95_K98_D0.8710.88
9_V23_C0.8670.88
100_A135_V0.8670.88
39_E43_K0.8660.88
160_G251_A0.8620.88
211_I214_K0.8580.87
242_V245_L0.8570.87
58_A133_R0.8560.87
240_K245_L0.8500.87
70_Y101_V0.8440.87
43_K200_D0.8440.87
201_I204_Q0.8370.86
22_D44_S0.8360.86
30_A37_A0.8350.86
126_I130_I0.8320.86
72_I100_A0.8190.85
205_S215_M0.8190.85
151_R260_E0.8190.85
165_L251_A0.8120.84
3_E31_N0.8100.84
108_V132_I0.8080.84
99_A115_F0.8050.84
186_V227_V0.8030.84
64_T145_S0.8020.84
72_I137_A0.8020.84
43_K46_A0.8010.84
119_R123_V0.8010.84
25_K28_T0.7980.83
72_I101_V0.7970.83
193_K197_V0.7940.83
28_T31_N0.7930.83
73_I257_I0.7910.83
171_M175_A0.7870.83
198_Q219_R0.7840.82
208_P211_I0.7830.82
156_V169_I0.7820.82
117_E120_V0.7820.82
207_K215_M0.7800.82
199_L209_K0.7740.81
65_K94_D0.7740.81
3_E28_T0.7730.81
147_Q153_G0.7700.81
120_V123_V0.7670.81
188_A191_V0.7650.81
43_K204_Q0.7590.80
75_E133_R0.7590.80
4_I8_L0.7530.80
4_I28_T0.7500.79
152_I174_A0.7460.79
144_G167_K0.7450.79
177_K258_R0.7440.79
4_I9_V0.7430.79
15_R34_I0.7420.79
206_G212_A0.7380.78
210_E213_E0.7380.78
75_E262_G0.7340.78
180_F185_D0.7280.77
87_A90_Q0.7260.77
39_E197_V0.7230.77
201_I215_M0.7200.77
216_V219_R0.7190.76
202_A211_I0.7180.76
64_T71_G0.7100.76
158_A165_L0.7100.76
49_A127_G0.7100.76
134_R259_F0.7090.75
67_D98_D0.7070.75
183_P230_T0.7060.75
198_Q202_A0.7060.75
3_E8_L0.7000.75
4_I32_G0.6980.74
109_E113_A0.6940.74
122_L125_K0.6920.74
77_N134_R0.6920.74
143_L155_L0.6920.74
38_I50_A0.6900.73
179_E227_V0.6900.73
6_A21_M0.6890.73
100_A111_L0.6890.73
135_V259_F0.6880.73
229_L253_V0.6830.73
15_R35_E0.6820.73
105_I110_V0.6810.72
100_A105_I0.6800.72
189_E192_E0.6800.72
106_T135_V0.6770.72
191_V220_M0.6750.72
194_E198_Q0.6740.72
107_D112_K0.6730.72
105_I137_A0.6720.71
247_K250_N0.6710.71
195_Y216_V0.6700.71
73_I259_F0.6680.71
142_V163_E0.6590.70
183_P243_G0.6580.70
99_A102_A0.6550.70
65_K97_L0.6550.70
4_I11_E0.6540.69
202_A216_V0.6540.69
42_R197_V0.6540.69
212_A215_M0.6480.69
219_R222_K0.6470.69
69_N140_G0.6460.69
206_G213_E0.6420.68
5_T8_L0.6420.68
104_K135_V0.6420.68
172_H238_P0.6400.68
40_N44_S0.6390.68
247_K252_E0.6370.67
144_G158_A0.6370.67
191_V223_F0.6330.67
134_R262_G0.6320.67
49_A123_V0.6300.67
105_I111_L0.6260.66
185_D255_G0.6250.66
78_C86_D0.6230.66
96_V99_A0.6230.66
147_Q150_A0.6200.65
55_N81_D0.6180.65
6_A20_M0.6170.65
218_G222_K0.6160.65
43_K196_Q0.6110.64
194_E223_F0.6110.64
54_G129_N0.6100.64
181_I253_V0.6100.64
14_E23_C0.6090.64
233_P239_S0.6080.64
205_S212_A0.6050.63
152_I260_E0.6010.63
7_S14_E0.5980.63
86_D126_I0.5960.62
199_L206_G0.5940.62
179_E223_F0.5910.62
182_K231_G0.5900.62
217_E220_M0.5890.61
172_H235_V0.5880.61
71_G145_S0.5860.61
117_E121_A0.5860.61
78_C93_A0.5860.61
207_K214_K0.5850.61
96_V119_R0.5830.61
234_F237_E0.5810.60
67_D101_V0.5810.60
69_N141_D0.5790.60
29_E44_S0.5760.60
18_A22_D0.5750.60
110_V113_A0.5740.59
191_V195_Y0.5740.59
74_L177_K0.5740.59
152_I258_R0.5720.59
172_H175_A0.5720.59
194_E197_V0.5710.59
90_Q93_A0.5710.59
199_L220_M0.5690.59
209_K213_E0.5680.59
58_A77_N0.5670.59
211_I216_V0.5670.59
118_E122_L0.5660.58
9_V21_M0.5660.58
144_G163_E0.5650.58
34_I38_I0.5640.58
175_A235_V0.5640.58
195_Y213_E0.5620.58
142_V158_A0.5590.57
122_L130_I0.5560.57
63_K74_L0.5560.57
71_G143_L0.5550.57
172_H261_V0.5550.57
245_L248_E0.5520.56
78_C130_I0.5500.56
7_S11_E0.5490.56
182_K228_S0.5490.56
39_E196_Q0.5490.56
85_K90_Q0.5480.56
180_F228_S0.5440.55
161_A246_L0.5420.55
133_R259_F0.5420.55
186_V224_T0.5420.55
230_T252_E0.5420.55
118_E121_A0.5400.55
19_G22_D0.5390.55
140_G161_A0.5390.55
22_D45_G0.5360.54
66_I143_L0.5330.54
103_G137_A0.5330.54
108_V135_V0.5330.54
168_H172_H0.5320.54
43_K205_S0.5300.54
123_V127_G0.5290.53
18_A45_G0.5290.53
122_L126_I0.5290.53
224_T231_G0.5260.53
198_Q239_S0.5260.53
116_E119_R0.5250.53
55_N82_F0.5250.53
205_S216_V0.5250.53
184_E230_T0.5240.53
205_S211_I0.5230.53
172_H176_S0.5210.52
120_V124_A0.5210.52
168_H245_L0.5190.52
181_I230_T0.5180.52
161_A165_L0.5180.52
158_A169_I0.5160.52
114_Q118_E0.5140.51
92_F118_E0.5140.51
181_I246_L0.5110.51
190_V227_V0.5100.51
183_P224_T0.5090.51
212_A216_V0.5060.50
85_K180_F0.5060.50
171_M242_V0.5050.50
23_C28_T0.5000.49
74_L132_I0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pc3C 1 0.9859 100 0.001 Contact Map
3avxA 1 0.9965 100 0.057 Contact Map
1xb2B 1 0.8127 100 0.226 Contact Map
1aipC 2 0.6608 100 0.292 Contact Map
1tfeA 2 0.4735 100 0.564 Contact Map
2cp9A 1 0.1979 99.8 0.799 Contact Map
1wj7A 1 0.2261 98.4 0.901 Contact Map
2g3qA 1 0.1519 98.1 0.91 Contact Map
2mr9A 1 0.1519 97.8 0.915 Contact Map
2dahA 1 0.1661 97.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.