GREMLIN Database
EFPL - Elongation factor P-like protein
UniProt: P0A6N8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12035
Length: 190 (183)
Sequences: 2787 (1323)
Seq/√Len: 97.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E175_K3.7971.00
71_Y114_D3.0551.00
70_R86_D2.7301.00
18_K45_D2.5831.00
157_T163_V2.4961.00
28_Q38_L2.4921.00
106_F183_R2.4711.00
140_T156_A2.4451.00
75_S92_P2.4161.00
171_S174_E2.3681.00
47_R123_Q2.3581.00
164_I176_I2.3311.00
136_E159_S2.3041.00
30_P33_R2.2371.00
177_R187_G2.2111.00
134_D175_K2.1991.00
137_I176_I2.1691.00
105_L162_L2.1691.00
14_N63_D2.1421.00
138_V157_T2.0521.00
139_E172_P1.9791.00
4_A59_D1.9501.00
83_V94_T1.9221.00
134_D177_R1.8831.00
156_A166_V1.8781.00
135_L158_L1.8451.00
136_E172_P1.8351.00
81_E94_T1.8321.00
136_E173_G1.7621.00
73_D87_K1.7581.00
108_P159_S1.7271.00
16_N54_E1.7261.00
72_V117_V1.7111.00
71_Y116_Q1.6781.00
77_V97_K1.6661.00
139_E157_T1.6561.00
15_Y54_E1.6531.00
73_D114_D1.5901.00
87_K114_D1.5871.00
74_F77_V1.5791.00
117_V124_L1.5531.00
14_N121_D1.5421.00
7_I22_V1.5071.00
137_I170_L1.5051.00
138_V158_L1.4661.00
28_Q33_R1.4641.00
57_K60_D1.4541.00
169_Y185_Y1.4411.00
72_V93_Y1.4381.00
77_V80_N1.4341.00
78_D81_E1.3890.99
106_F162_L1.3700.99
152_R168_E1.3620.99
132_T186_M1.3410.99
96_T99_Q1.3310.99
145_K148_S1.3060.99
78_D94_T1.3010.99
135_L159_S1.2980.99
30_P34_G1.2800.99
41_M56_F1.2670.99
13_L62_V1.2650.99
45_D48_T1.2610.99
7_I62_V1.2520.99
76_Y83_V1.2410.99
85_M92_P1.2400.99
131_Q181_E1.2310.99
97_K104_L1.2200.99
13_L43_F1.2120.99
108_P111_G1.2110.99
30_P38_L1.1960.98
82_Y104_L1.1850.98
33_R38_L1.1830.98
170_L174_E1.1630.98
143_G168_E1.1630.98
158_L176_I1.1500.98
135_L160_T1.1440.98
132_T177_R1.1260.98
158_L178_I1.1170.97
105_L183_R1.1050.97
9_K24_D1.0880.97
84_F100_I1.0760.97
19_L120_W1.0670.97
20_L52_V1.0580.96
137_I172_P1.0560.96
77_V82_Y1.0470.96
81_E96_T1.0450.96
137_I156_A1.0420.96
138_V159_S1.0350.96
15_Y56_F1.0250.96
12_V19_L1.0200.96
14_N120_W1.0180.96
25_I39_Y1.0130.95
108_P175_K1.0130.95
4_A58_G1.0110.95
18_K47_R1.0050.95
40_K55_R0.9910.95
4_A22_V0.9840.95
132_T179_H0.9800.95
169_Y174_E0.9770.95
23_K44_S0.9760.94
177_R186_M0.9750.94
140_T155_P0.9700.94
84_F127_L0.9690.94
134_D189_A0.9510.94
164_I178_I0.9460.94
158_L162_L0.9450.93
42_R53_E0.9370.93
119_T124_L0.9330.93
69_R128_E0.9280.93
19_L65_V0.9270.93
179_H182_E0.9070.92
73_D110_G0.9000.92
27_I39_Y0.8940.91
177_R189_A0.8890.91
153_N165_Q0.8840.91
147_A168_E0.8830.91
28_Q40_K0.8750.91
9_K25_I0.8550.90
80_N97_K0.8550.90
77_V83_V0.8530.89
82_Y97_K0.8520.89
19_L66_T0.8510.89
45_D50_L0.8510.89
101_E104_L0.8500.89
14_N17_G0.8420.89
12_V69_R0.8360.88
39_Y58_G0.8280.88
5_N22_V0.8260.88
12_V65_V0.8250.88
70_R119_T0.8230.88
107_M111_G0.8140.87
4_A7_I0.8140.87
144_I147_A0.8060.87
7_I11_M0.8050.87
35_A53_E0.8030.86
95_F99_Q0.7980.86
140_T144_I0.7960.86
82_Y100_I0.7960.86
132_T189_A0.7950.86
100_I127_L0.7820.85
153_N163_V0.7810.85
14_N65_V0.7800.85
19_L46_V0.7800.85
68_T122_G0.7790.85
95_F124_L0.7760.84
147_A152_R0.7730.84
99_Q123_Q0.7730.84
19_L47_R0.7720.84
167_P185_Y0.7670.84
7_I41_M0.7660.84
144_I168_E0.7580.83
78_D83_V0.7500.82
20_L43_F0.7500.82
155_P165_Q0.7460.82
158_L163_V0.7450.82
145_K149_A0.7400.82
65_V120_W0.7400.82
77_V104_L0.7370.81
140_T172_P0.7340.81
29_S33_R0.7330.81
86_D89_D0.7330.81
139_E163_V0.7270.80
174_E188_R0.7200.80
40_K53_E0.7170.79
93_Y119_T0.7160.79
138_V160_T0.7160.79
69_R118_L0.7110.79
72_V115_M0.7060.78
84_F95_F0.7060.78
143_G156_A0.7050.78
119_T122_G0.7010.78
33_R36_A0.6980.78
103_E126_A0.6980.78
13_L22_V0.6960.77
11_M22_V0.6950.77
80_N95_F0.6900.77
24_D42_R0.6820.76
100_I103_E0.6720.75
5_N9_K0.6710.75
67_L118_L0.6700.75
140_T166_V0.6600.74
32_A36_A0.6590.74
25_I41_M0.6580.73
32_A38_L0.6500.72
11_M64_T0.6500.72
46_V118_L0.6480.72
28_Q36_A0.6410.71
3_R6_E0.6390.71
29_S55_R0.6370.71
87_K90_Y0.6360.71
73_D92_P0.6320.70
14_N19_L0.6300.70
141_A155_P0.6290.70
155_P163_V0.6260.70
84_F115_M0.6240.69
108_P135_L0.6210.69
179_H186_M0.6170.69
34_G40_K0.6150.68
19_L125_L0.6150.68
34_G55_R0.6140.68
36_A58_G0.6130.68
42_R51_K0.6120.68
74_F83_V0.6100.68
4_A62_V0.6070.67
5_N39_Y0.6030.67
116_Q128_E0.6010.67
152_R155_P0.6000.66
74_F104_L0.6000.66
27_I32_A0.5990.66
18_K48_T0.5970.66
13_L54_E0.5960.66
4_A60_D0.5960.66
133_V180_I0.5870.65
56_F95_F0.5840.64
54_E62_V0.5830.64
35_A38_L0.5790.64
28_Q34_G0.5790.64
86_D93_Y0.5770.63
28_Q32_A0.5770.63
66_T122_G0.5760.63
105_L160_T0.5760.63
22_V25_I0.5760.63
169_Y188_R0.5740.63
44_S51_K0.5690.62
143_G155_P0.5690.62
69_R116_Q0.5690.62
29_S34_G0.5670.62
46_V126_A0.5660.62
55_R151_A0.5660.62
142_P149_A0.5630.62
26_D41_M0.5620.61
29_S35_A0.5580.61
7_I59_D0.5570.61
85_M90_Y0.5570.61
34_G38_L0.5550.60
19_L121_D0.5540.60
21_L69_R0.5530.60
111_G130_P0.5510.60
29_S44_S0.5500.60
28_Q35_A0.5470.59
118_L126_A0.5460.59
80_N96_T0.5460.59
5_N62_V0.5460.59
141_A152_R0.5440.59
45_D123_Q0.5440.59
143_G152_R0.5420.59
142_P171_S0.5390.58
142_P156_A0.5380.58
73_D85_M0.5370.58
115_M127_L0.5360.58
137_I174_E0.5360.58
133_V160_T0.5350.58
132_T181_E0.5340.58
143_G147_A0.5330.57
150_S153_N0.5310.57
79_G83_V0.5290.57
141_A153_N0.5290.57
111_G133_V0.5250.56
136_E174_E0.5210.56
80_N98_D0.5210.56
20_L60_D0.5190.55
158_L164_I0.5160.55
35_A57_K0.5140.55
13_L52_V0.5130.55
7_I13_L0.5100.54
139_E189_A0.5090.54
102_E105_L0.5070.54
32_A58_G0.5060.54
71_Y128_E0.5060.54
70_R122_G0.5050.53
105_L163_V0.5040.53
86_D90_Y0.5020.53
141_A171_S0.5010.53
75_S110_G0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3treA 1 0.6789 100 0.06 Contact Map
1ybyA 2 0.9526 100 0.061 Contact Map
3a5zB 1 0.7053 100 0.062 Contact Map
1uebA 1 0.9684 100 0.063 Contact Map
3oyyA 1 0.9684 100 0.063 Contact Map
1bkbA 3 0.6684 100 0.504 Contact Map
1iz6A 1 0.6789 100 0.512 Contact Map
2eifA 1 0.6474 100 0.515 Contact Map
3er0A 1 0.7053 100 0.521 Contact Map
3hksA 1 0.7053 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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