GREMLIN Database
EFP - Elongation factor P
UniProt: P0A6N4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12099
Length: 188 (183)
Sequences: 2794 (1329)
Seq/√Len: 98.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_E173_V3.7291.00
71_N112_E2.8961.00
70_M86_N2.7551.00
20_E45_R2.5881.00
30_V38_F2.4861.00
106_W181_G2.4801.00
155_T161_V2.4721.00
138_T154_A2.4361.00
75_L92_Q2.4031.00
47_L121_Q2.3951.00
169_Q172_E2.3481.00
162_V174_I2.3391.00
134_E157_S2.3111.00
175_K185_S2.2431.00
105_K160_A2.1781.00
132_E173_V2.1721.00
135_I174_I2.1601.00
16_M63_E2.1481.00
136_V155_T2.0841.00
137_D170_I1.9651.00
83_H94_S1.9371.00
6_S59_T1.9251.00
132_E175_K1.8851.00
154_A164_V1.8821.00
134_E170_I1.8791.00
133_L156_L1.8641.00
81_F94_S1.8461.00
71_N114_I1.7891.00
73_T87_N1.7701.00
134_E171_G1.7471.00
108_L157_S1.7131.00
18_D54_K1.7061.00
72_L115_V1.6861.00
17_L54_K1.6631.00
87_N112_E1.6491.00
137_D155_T1.6411.00
73_T112_E1.6371.00
77_N97_A1.6331.00
115_V122_P1.6061.00
16_M119_N1.5651.00
74_Y77_N1.5561.00
30_V34_K1.4991.00
9_F24_V1.4911.00
135_I168_V1.4831.00
167_F183_Y1.4771.00
57_K60_D1.4741.00
77_N80_E1.4711.00
136_V156_L1.4691.00
72_L93_L1.4661.00
106_W160_A1.3860.99
150_G166_L1.3780.99
78_D81_F1.3710.99
133_L157_S1.3360.99
130_F184_V1.3330.99
143_K146_T1.3310.99
15_I62_A1.3130.99
96_D99_A1.3010.99
78_D94_S1.2830.99
45_R48_T1.2720.99
41_V56_F1.2530.99
32_P38_F1.2460.99
108_L111_A1.2430.99
9_F62_A1.2420.99
76_Y83_H1.2410.99
85_M92_Q1.2350.99
97_A104_A1.2340.99
129_N179_R1.2260.99
15_I43_L1.1930.98
34_K38_F1.1860.98
156_L176_V1.1760.98
82_W104_A1.1750.98
168_V172_E1.1730.98
133_L158_T1.1570.98
141_G166_L1.1490.98
156_L174_I1.1470.98
105_K181_G1.1290.98
130_F175_K1.1100.97
136_V157_S1.0900.97
84_F100_I1.0870.97
11_A26_A1.0760.97
16_M118_W1.0740.97
135_I170_I1.0660.97
22_Y52_V1.0630.97
21_P118_W1.0600.97
132_E187_V1.0600.97
81_F96_D1.0430.96
6_S24_V1.0350.96
77_N82_W1.0340.96
135_I154_A1.0330.96
27_S39_A1.0200.96
20_E47_L1.0130.96
6_S58_S1.0020.95
17_L56_F1.0000.95
14_K21_P0.9980.95
130_F177_D0.9920.95
108_L173_V0.9860.95
40_R55_T0.9820.95
32_P35_G0.9790.95
117_L122_P0.9740.94
175_K184_V0.9690.94
25_E44_R0.9660.94
162_V176_V0.9620.94
138_T153_P0.9590.94
84_F125_V0.9490.94
167_F172_E0.9450.94
21_P65_A0.9430.93
69_D126_T0.9420.93
42_K53_E0.9360.93
101_G104_A0.9350.93
73_T110_Q0.9330.93
156_L160_A0.9250.93
177_D180_S0.9090.92
29_F39_A0.8970.92
151_G163_K0.8940.92
6_S9_F0.8930.91
77_N83_H0.8880.91
145_D166_L0.8860.91
45_R50_T0.8820.91
82_W97_A0.8780.91
11_A27_S0.8700.90
70_M117_L0.8680.90
80_E97_A0.8660.90
30_V40_R0.8610.90
21_P66_D0.8590.90
14_K69_D0.8410.89
175_K187_V0.8350.88
9_F13_L0.8320.88
14_K65_A0.8310.88
39_A58_S0.8220.88
82_W100_I0.8200.88
107_L111_A0.8160.87
100_I125_V0.8160.87
95_A99_A0.8160.87
16_M65_A0.8090.87
7_N24_V0.8090.87
33_G37_A0.8050.87
138_T142_L0.8040.87
145_D150_G0.8030.86
142_L145_D0.8020.86
21_P46_L0.7950.86
16_M19_G0.7880.85
99_A121_Q0.7860.85
21_P47_L0.7860.85
151_G161_V0.7760.85
165_P183_Y0.7690.84
93_L117_L0.7640.84
78_D83_H0.7620.83
156_L161_V0.7590.83
9_F41_V0.7580.83
95_A122_P0.7550.83
142_L166_L0.7540.83
69_D116_T0.7530.83
153_P163_K0.7530.83
103_N124_S0.7500.83
84_F95_A0.7470.82
138_T170_I0.7460.82
143_K147_A0.7450.82
31_K34_K0.7440.82
32_P37_A0.7420.82
22_Y43_L0.7380.82
77_N104_A0.7380.82
30_V35_G0.7350.81
137_D161_V0.7320.81
172_E186_R0.7260.80
72_L113_C0.7240.80
86_N89_T0.7240.80
68_V120_G0.7220.80
40_R53_E0.7210.80
130_F187_V0.7170.80
5_Y8_D0.7100.79
26_A42_K0.7100.79
100_I103_N0.7080.79
35_G40_R0.7060.79
65_A118_W0.7030.78
15_I24_V0.6950.77
136_V158_T0.6900.77
117_L120_G0.6890.77
7_N11_A0.6870.77
27_S41_V0.6860.77
13_L24_V0.6850.76
141_G154_A0.6790.76
138_T164_V0.6740.75
30_V37_A0.6730.75
80_E95_A0.6730.75
36_Q53_E0.6710.75
21_P123_I0.6500.73
87_N90_F0.6460.72
33_G38_F0.6450.72
33_G58_S0.6410.72
139_D153_P0.6410.72
34_K37_A0.6390.71
177_D184_V0.6380.71
35_G55_T0.6370.71
35_G38_F0.6370.71
13_L64_G0.6350.71
46_L116_T0.6340.71
16_M21_P0.6330.71
69_D114_I0.6300.70
73_T92_Q0.6250.70
31_K55_T0.6250.70
29_F33_G0.6250.70
74_Y83_H0.6240.70
42_K51_R0.6210.69
7_N39_A0.6160.69
74_Y104_A0.6130.68
84_F115_V0.6120.68
153_P161_V0.6110.68
84_F113_C0.6100.68
108_L133_L0.6040.67
36_Q57_K0.6040.67
150_G153_P0.6030.67
54_K62_A0.6000.67
86_N93_L0.5940.66
24_V27_S0.5920.66
66_D120_G0.5910.65
15_I54_K0.5880.65
6_S62_A0.5850.65
20_E48_T0.5840.65
167_F186_R0.5820.64
67_V116_T0.5790.64
114_I126_T0.5790.64
85_M90_F0.5790.64
111_A128_P0.5780.64
134_E172_E0.5740.63
140_P147_A0.5730.63
131_V178_T0.5730.63
56_F95_A0.5720.63
111_A131_V0.5710.63
23_A69_D0.5700.63
80_E96_D0.5680.62
141_G150_G0.5660.62
140_P154_A0.5660.62
9_F59_T0.5640.62
140_P169_Q0.5630.62
105_K158_T0.5620.62
6_S60_D0.5610.61
31_K35_G0.5590.61
113_C125_V0.5580.61
31_K44_R0.5580.61
46_L124_S0.5570.61
116_T124_S0.5560.61
141_G153_P0.5500.60
75_L110_Q0.5490.60
141_G145_D0.5480.60
156_L162_V0.5470.60
28_E41_V0.5470.60
44_R51_R0.5450.59
98_K101_G0.5450.59
55_T149_T0.5450.59
139_D150_G0.5440.59
21_P119_N0.5430.59
130_F179_R0.5360.58
73_T85_M0.5360.58
70_M120_G0.5350.58
80_E98_K0.5350.58
45_R121_Q0.5340.58
15_I52_V0.5280.57
139_D151_G0.5280.57
131_V158_T0.5250.56
135_I172_E0.5230.56
149_T167_F0.5220.56
14_K23_A0.5210.56
26_A59_T0.5180.55
8_D39_A0.5180.55
22_Y60_D0.5170.55
95_A124_S0.5150.55
105_K161_V0.5090.54
79_G83_H0.5080.54
30_V33_G0.5080.54
7_N62_A0.5070.54
71_N126_T0.5030.53
148_G151_G0.5020.53
58_S73_T0.5010.53
151_G170_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3treA 1 0.6862 100 0.045 Contact Map
3a5zB 1 0.7128 100 0.048 Contact Map
3oyyA 1 0.9894 100 0.051 Contact Map
1ybyA 2 0.9628 100 0.07 Contact Map
1uebA 1 0.9787 100 0.07 Contact Map
1bkbA 3 0.6862 100 0.508 Contact Map
1iz6A 1 0.6915 100 0.515 Contact Map
2eifA 1 0.6649 100 0.516 Contact Map
3er0A 1 0.7234 100 0.519 Contact Map
3hksA 1 0.7234 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.