GREMLIN Database
DSBB - Disulfide bond formation protein B
UniProt: P0A6M2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11393
Length: 176 (154)
Sequences: 1441 (1025)
Seq/√Len: 82.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_W36_M4.8341.00
30_L34_H3.6371.00
32_F142_M3.5091.00
19_A58_A3.2481.00
47_E88_T3.1641.00
92_T144_Q3.1201.00
31_W35_V3.1021.00
92_T96_L3.0361.00
140_L144_Q2.9211.00
19_A62_A2.9051.00
26_E52_F2.6181.00
18_M58_A2.5551.00
26_E30_L2.3821.00
64_A73_A2.3491.00
85_V147_L2.3091.00
91_H143_P2.1711.00
25_L149_I2.0731.00
89_Y147_L1.9181.00
78_L161_V1.9161.00
47_E91_H1.9141.00
23_L55_L1.9031.00
32_F36_M1.8851.00
151_I155_I1.8261.00
84_G150_F1.7371.00
77_W157_A1.7251.00
51_L146_L1.6821.00
133_R141_E1.6111.00
38_L135_W1.5691.00
16_L62_A1.5230.99
50_A87_L1.5190.99
21_T153_Y1.5020.99
96_L144_Q1.4950.99
28_T142_M1.4680.99
47_E146_L1.4390.99
22_A55_L1.4270.99
79_Y83_R1.4050.99
30_L52_F1.3890.99
121_P124_F1.3830.99
138_L145_W1.2890.98
141_E144_Q1.2790.98
115_P118_K1.2470.98
61_G73_A1.2270.98
25_L51_L1.2240.98
83_R86_Q1.2210.97
82_F86_Q1.2180.97
19_A81_A1.2090.97
45_I52_F1.2030.97
28_T32_F1.2000.97
66_K69_L1.1850.97
57_A80_S1.1800.97
85_V89_Y1.1730.97
120_V123_V1.1670.97
24_A28_T1.1650.97
78_L158_V1.1590.97
142_M149_I1.1520.96
95_Q133_R1.1390.96
118_K121_P1.1380.96
91_H94_L1.1320.96
19_A59_L1.1270.96
19_A23_L1.1210.96
50_A83_R1.1150.96
140_L148_G1.1120.96
50_A84_G1.1030.95
159_L163_S1.0770.95
46_Y50_A1.0730.95
133_R136_D1.0590.94
52_F56_G1.0510.94
87_L91_H1.0230.93
20_F62_A1.0010.92
25_L29_A0.9920.92
53_G80_S0.9920.92
64_A69_L0.9890.92
58_A77_W0.9830.92
155_I159_L0.9800.92
16_L59_L0.9790.92
135_W142_M0.9690.91
93_M99_S0.9630.91
107_M129_D0.9570.91
14_A18_M0.9490.90
20_F24_A0.9460.90
71_Y74_M0.9420.90
46_Y87_L0.9410.90
101_F105_D0.9400.90
58_A128_G0.9360.90
90_E93_M0.9240.89
85_V154_L0.9230.89
45_I126_A0.9130.88
95_Q150_F0.8930.87
56_G76_I0.8820.87
22_A27_L0.8750.86
26_E31_W0.8740.86
141_E145_W0.8640.86
18_M74_M0.8610.85
32_F38_L0.8550.85
71_Y164_Q0.8550.85
17_L21_T0.8510.85
105_D109_R0.8480.85
95_Q104_C0.8430.84
95_Q141_E0.8380.84
43_L90_E0.8260.83
97_Y101_F0.8190.82
28_T149_I0.8140.82
18_M91_H0.8130.82
97_Y100_P0.8090.82
32_F135_W0.8090.82
38_L142_M0.8080.82
51_L150_F0.8030.81
75_V158_V0.8020.81
32_F146_L0.8020.81
12_R65_P0.7990.81
117_D123_V0.7840.80
67_T162_I0.7820.79
65_P73_A0.7790.79
126_A129_D0.7700.78
42_V103_T0.7670.78
47_E94_L0.7670.78
111_P119_W0.7640.78
31_W138_L0.7640.78
139_G144_Q0.7630.78
91_H146_L0.7540.77
57_A77_W0.7540.77
121_P125_V0.7530.77
35_V154_L0.7530.77
33_Q87_L0.7520.77
42_V46_Y0.7440.76
32_F149_I0.7410.76
57_A76_I0.7340.75
82_F154_L0.7330.75
108_V117_D0.7270.74
13_G78_L0.7210.74
50_A80_S0.7210.74
95_Q143_P0.7170.73
29_A51_L0.7140.73
148_G152_A0.7080.72
81_A85_V0.7050.72
114_L126_A0.6970.71
95_Q131_A0.6890.70
95_Q98_P0.6870.70
21_T152_A0.6860.70
104_C108_V0.6800.69
15_W61_G0.6790.69
133_R143_P0.6780.69
93_M98_P0.6780.69
81_A157_A0.6750.69
138_L162_I0.6690.68
90_E129_D0.6660.68
78_L154_L0.6610.67
108_V129_D0.6580.67
159_L162_I0.6570.67
105_D143_P0.6560.66
56_G60_I0.6550.66
27_L34_H0.6480.66
97_Y131_A0.6470.65
97_Y102_A0.6470.65
32_F77_W0.6450.65
92_T133_R0.6430.65
50_A133_R0.6410.65
13_G20_F0.6390.64
129_D143_P0.6390.64
56_G68_P0.6330.64
138_L148_G0.6310.63
111_P126_A0.6290.63
50_A53_G0.6280.63
45_I49_C0.6190.62
92_T147_L0.6170.62
98_P150_F0.6170.62
18_M81_A0.6150.61
47_E87_L0.6130.61
133_R144_Q0.6110.61
92_T141_E0.6100.61
133_R145_W0.6100.61
104_C143_P0.6090.61
66_K73_A0.6080.61
71_Y163_S0.6040.60
99_S131_A0.6030.60
13_G17_L0.6020.60
119_W123_V0.6000.60
121_P126_A0.5930.59
101_F113_W0.5870.58
135_W149_I0.5850.58
156_V160_V0.5830.57
118_K125_V0.5800.57
116_L119_W0.5800.57
146_L150_F0.5760.57
81_A84_G0.5740.56
24_A55_L0.5710.56
78_L157_A0.5630.55
145_W148_G0.5580.54
54_V58_A0.5570.54
149_I153_Y0.5540.54
46_Y129_D0.5540.54
24_A164_Q0.5520.53
51_L84_G0.5510.53
92_T140_L0.5510.53
67_T154_L0.5490.53
25_L142_M0.5480.53
87_L124_F0.5470.53
25_L28_T0.5460.53
20_F75_V0.5430.52
154_L158_V0.5410.52
74_M157_A0.5390.52
91_H131_A0.5380.52
40_P44_C0.5370.51
86_Q89_Y0.5320.51
46_Y123_V0.5300.50
158_V161_V0.5300.50
76_I79_Y0.5290.50
82_F158_V0.5290.50
41_C130_C0.5280.50
137_F149_I0.5240.50
13_G16_L0.5230.50
45_I124_F0.5230.50
42_V126_A0.5210.49
114_L122_Q0.5160.49
69_L72_V0.5140.48
137_F152_A0.5130.48
22_A62_A0.5120.48
58_A76_I0.5100.48
23_L27_L0.5100.48
83_R87_L0.5080.48
152_A155_I0.5080.48
75_V79_Y0.5080.48
75_V162_I0.5060.47
119_W124_F0.5040.47
88_T146_L0.5040.47
154_L157_A0.5030.47
56_G164_Q0.5030.47
137_F140_L0.5020.47
100_P131_A0.5010.47
46_Y127_S0.5010.47
22_A30_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi7B 1 0.7614 100 0.154 Contact Map
2l0lA 1 0.1534 94.7 0.877 Contact Map
2l0nA 1 0.1705 87.8 0.898 Contact Map
4nv5A 1 0.4773 48.5 0.926 Contact Map
2ks1B 1 0.2386 45.1 0.927 Contact Map
2jwaA 2 0.2386 14.9 0.943 Contact Map
2l2tA 2 0.2386 14 0.943 Contact Map
2kluA 1 0.2614 5.3 0.953 Contact Map
2z3gA 4 0.3977 4.4 0.955 Contact Map
2m20A 2 0.2273 3.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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