GREMLIN Database
HSCB - Co-chaperone protein HscB
UniProt: P0A6L9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12131
Length: 171 (161)
Sequences: 1089 (758)
Seq/√Len: 59.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_D11_A3.6841.00
14_Q133_V3.6671.00
135_Q147_T3.5431.00
140_T143_A3.5231.00
2_D5_T3.1431.00
40_S43_E3.1391.00
99_R160_S2.9571.00
101_E120_R2.7911.00
114_L161_A2.7791.00
31_Y54_I2.6741.00
63_H155_D2.4021.00
26_D29_R2.3811.00
3_Y53_T2.3121.00
68_A148_V2.2891.00
3_Y70_Y2.2281.00
63_H66_M2.1841.00
60_T70_Y2.1431.00
94_E124_M2.1411.00
39_G43_E2.1341.00
25_Q29_R2.0611.00
27_L54_I2.0261.00
28_Q151_L1.9491.00
134_E138_N1.9431.00
132_M136_L1.8841.00
95_Q153_F1.8501.00
105_I117_F1.8081.00
59_Q66_M1.7440.99
75_H139_E1.7010.99
71_L136_L1.6780.99
48_V52_A1.6560.99
8_G23_R1.6540.99
19_A23_R1.6490.99
93_M100_E1.5720.99
75_H141_W1.5600.99
50_Q53_T1.5590.99
11_A74_L1.5140.98
53_T56_Q1.3930.97
41_Q44_Q1.3900.97
23_R27_L1.3860.97
95_Q98_L1.3800.97
98_L124_M1.3770.97
149_R153_F1.3750.97
68_A151_L1.3530.96
69_E152_R1.3530.96
51_S58_W1.3180.96
153_F156_K1.3160.96
16_D19_A1.3130.96
99_R156_K1.2990.95
73_S78_D1.2920.95
133_V137_D1.2660.95
126_D130_Q1.2660.95
122_K158_R1.2450.94
118_I161_A1.2330.94
156_K160_S1.2260.94
136_L141_W1.2230.94
158_R162_E1.2230.94
121_V157_L1.1910.93
132_M151_L1.1470.91
69_E81_S1.1430.91
131_L147_T1.1400.91
11_A75_H1.1300.91
88_D150_K1.1210.90
102_L157_L1.1190.90
125_F158_R1.1170.90
2_D74_L1.1130.90
24_F60_T1.0870.89
31_Y50_Q1.0830.89
104_E107_Q1.0700.88
25_Q152_R1.0530.87
72_L152_R1.0460.87
101_E113_R1.0400.87
36_F43_E1.0260.86
11_A71_L1.0150.85
23_R26_D1.0040.85
7_F20_L0.9900.84
101_E104_E0.9850.83
27_L47_A0.9820.83
68_A144_A0.9790.83
121_V124_M0.9780.83
98_L153_F0.9780.83
131_L134_E0.9690.82
57_A67_R0.9690.82
135_Q143_A0.9680.82
12_R137_D0.9650.82
125_F151_L0.9400.80
36_F47_A0.9400.80
159_S163_Q0.9350.80
31_Y47_A0.9340.80
42_A46_A0.9320.80
135_Q140_T0.9210.79
72_L157_L0.9190.79
69_E151_L0.9170.79
89_T93_M0.9120.78
14_Q17_T0.9030.78
125_F154_L0.9000.77
131_L135_Q0.8860.76
50_Q56_Q0.8720.75
94_E120_R0.8590.74
68_A99_R0.8440.73
90_A119_K0.8250.71
53_T73_S0.8240.71
6_L52_A0.8230.71
128_R147_T0.8190.70
84_H87_R0.8120.70
102_L114_L0.8110.70
122_K126_D0.8060.69
69_E79_L0.8050.69
24_F28_Q0.8050.69
150_K165_E0.8010.69
124_M154_L0.7970.68
7_F23_R0.7960.68
93_M96_L0.7960.68
107_Q112_A0.7950.68
68_A136_L0.7900.68
116_S120_R0.7810.67
105_I114_L0.7810.67
72_L150_K0.7750.66
31_Y157_L0.7640.65
57_A70_Y0.7580.64
117_F161_A0.7570.64
33_P55_N0.7550.64
111_E115_E0.7540.64
85_T149_R0.7490.64
39_G44_Q0.7430.63
4_F11_A0.7340.62
118_I158_R0.7290.61
146_D158_R0.7260.61
14_Q116_S0.7240.61
162_E165_E0.7160.60
79_L114_L0.7120.60
84_H145_A0.7100.59
42_A45_L0.7090.59
121_V161_A0.7050.59
127_T131_L0.7030.59
24_F54_I0.7020.59
29_R102_L0.6990.58
91_F99_R0.6920.57
70_Y73_S0.6920.57
95_Q99_R0.6900.57
16_D143_A0.6890.57
90_A165_E0.6880.57
51_S113_R0.6870.57
4_F10_P0.6800.56
4_F12_R0.6780.56
13_Y67_R0.6780.56
49_Q95_Q0.6770.56
103_D163_Q0.6760.56
51_S54_I0.6750.56
123_K126_D0.6720.55
77_F132_M0.6630.54
106_E127_T0.6590.54
58_W70_Y0.6570.54
13_Y71_L0.6570.54
15_L113_R0.6570.54
111_E165_E0.6560.53
50_Q161_A0.6530.53
31_Y46_A0.6520.53
102_L165_E0.6460.52
41_Q124_M0.6450.52
58_W65_L0.6440.52
123_K131_L0.6430.52
25_Q48_V0.6390.52
44_Q51_S0.6380.51
88_D165_E0.6350.51
121_V158_R0.6320.51
112_A116_S0.6310.51
90_A126_D0.6270.50
12_R24_F0.6220.50
135_Q144_A0.6200.49
77_F80_A0.6190.49
32_H55_N0.6180.49
94_E150_K0.6180.49
91_F95_Q0.6180.49
118_I122_K0.6170.49
160_S163_Q0.6160.49
119_K131_L0.6160.49
113_R125_F0.6160.49
145_A149_R0.6150.49
24_F72_L0.6150.49
107_Q113_R0.6020.47
117_F164_L0.5980.47
13_Y136_L0.5920.46
15_L20_L0.5910.46
28_Q51_S0.5910.46
145_A152_R0.5900.46
116_S138_N0.5890.46
28_Q49_Q0.5880.46
53_T148_V0.5880.46
15_L115_E0.5860.46
54_I158_R0.5860.46
131_L150_K0.5840.45
154_L160_S0.5810.45
142_D146_D0.5800.45
115_E119_K0.5800.45
150_K162_E0.5770.45
65_L132_M0.5770.45
104_E140_T0.5740.44
14_Q130_Q0.5720.44
18_Q138_N0.5700.44
69_E80_A0.5680.44
95_Q121_V0.5670.44
45_L49_Q0.5640.43
98_L120_R0.5630.43
65_L69_E0.5600.43
129_H151_L0.5590.43
19_A26_D0.5590.43
97_E138_N0.5590.43
72_L136_L0.5580.43
28_Q32_H0.5540.42
148_V151_L0.5530.42
19_A22_L0.5520.42
131_L139_E0.5510.42
98_L117_F0.5470.41
71_L74_L0.5450.41
127_T138_N0.5450.41
94_E98_L0.5440.41
103_D149_R0.5430.41
47_A99_R0.5370.40
69_E78_D0.5350.40
35_K153_F0.5330.40
130_Q138_N0.5320.40
4_F156_K0.5320.40
28_Q33_P0.5290.39
15_L63_H0.5260.39
127_T130_Q0.5240.39
7_F151_L0.5220.39
116_S139_E0.5220.39
128_R153_F0.5210.39
45_L48_V0.5210.39
21_S165_E0.5170.38
28_Q54_I0.5170.38
6_L54_I0.5130.38
96_L152_R0.5110.38
137_D140_T0.5110.38
77_F145_A0.5100.37
93_M111_E0.5100.37
121_V135_Q0.5030.37
160_S164_L0.5030.37
2_D21_S0.5020.37
27_L31_Y0.5010.36
21_S60_T0.5010.36
133_V138_N0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fpoA 3 1 100 0.232 Contact Map
4it5A 4 0.9883 100 0.234 Contact Map
3bvoA 1 0.9649 100 0.258 Contact Map
3uo3A 1 0.9357 100 0.323 Contact Map
2l6lA 1 0.8187 99.8 0.621 Contact Map
1wjzA 1 0.4561 99.4 0.712 Contact Map
1n4cA 1 0.386 99.3 0.725 Contact Map
1fafA 1 0.4035 99.3 0.728 Contact Map
2cugA 1 0.4211 99.3 0.734 Contact Map
2yuaA 1 0.4854 99.2 0.737 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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