GREMLIN Database
UXAB - Altronate oxidoreductase
UniProt: P0A6L7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11065
Length: 483 (449)
Sequences: 2391 (1670)
Seq/√Len: 78.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_D87_R4.0621.00
310_D476_R3.9011.00
51_V105_F3.2531.00
301_L310_D3.2231.00
35_I261_L3.1011.00
469_A478_A3.0671.00
16_E49_V3.0381.00
228_E234_H2.9141.00
318_E341_S2.9001.00
221_R224_V2.7861.00
49_V108_L2.7781.00
37_L87_R2.6891.00
94_R108_L2.6791.00
111_N114_M2.6731.00
249_I268_V2.6471.00
103_D156_H2.6461.00
107_K160_A2.5931.00
18_I35_I2.5711.00
181_R185_L2.5611.00
189_Q202_D2.5071.00
178_D209_S2.4321.00
14_Y47_G2.3111.00
319_K323_E2.3031.00
101_E104_E2.2781.00
307_A313_I2.2721.00
376_L452_D2.2471.00
19_I114_M2.2161.00
294_P363_G2.1661.00
165_W205_N2.1561.00
291_A392_A2.1471.00
72_I86_A2.1471.00
206_S254_S2.1391.00
314_C348_R2.1341.00
115_R258_E2.1311.00
354_H358_S2.0981.00
206_S252_P2.0911.00
378_G384_T2.0731.00
109_A153_R2.0561.00
63_S67_G2.0441.00
322_Y340_A2.0441.00
199_Q203_Q2.0161.00
94_R104_E1.9991.00
188_A201_L1.9971.00
184_V207_F1.9841.00
393_L459_L1.9671.00
103_D107_K1.9621.00
34_Q245_Y1.9601.00
152_E156_H1.9391.00
167_I180_L1.9251.00
68_L88_L1.9251.00
27_L31_V1.9241.00
295_V395_A1.9181.00
110_H152_E1.9141.00
47_G93_N1.9001.00
225_A229_E1.9001.00
260_R265_P1.8931.00
73_I241_A1.8601.00
53_P149_L1.8561.00
375_L393_L1.8321.00
288_A317_V1.8261.00
128_Y183_L1.8241.00
189_Q198_I1.8231.00
16_E94_R1.8231.00
305_G309_N1.8181.00
36_D40_E1.8101.00
462_Q466_D1.8101.00
49_V94_R1.7941.00
291_A320_A1.7941.00
71_T89_I1.7901.00
152_E155_S1.7841.00
16_E114_M1.7681.00
284_I321_I1.7661.00
175_Y178_D1.7641.00
297_F409_Y1.7341.00
295_V391_F1.7251.00
296_A307_A1.7181.00
261_L268_V1.7181.00
284_I340_A1.7071.00
397_I442_V1.6951.00
60_P64_T1.6891.00
304_V359_I1.6881.00
403_E407_E1.6871.00
33_W71_T1.6851.00
470_I478_A1.6671.00
15_P113_E1.6661.00
156_H160_A1.6571.00
96_I105_F1.6561.00
326_I340_A1.6501.00
168_I249_I1.6441.00
50_V92_V1.6421.00
166_I254_S1.6281.00
16_E93_N1.6231.00
145_K148_R1.6021.00
314_C318_E1.5981.00
121_T146_L1.5771.00
375_L459_L1.5630.99
457_P461_E1.5490.99
109_A165_W1.5400.99
17_R115_R1.5390.99
150_L184_V1.5270.99
155_S159_G1.5260.99
288_A321_I1.5090.99
117_V165_W1.5020.99
164_G205_N1.4970.99
295_V470_I1.4920.99
377_A380_K1.4880.99
175_Y275_K1.4850.99
335_E338_S1.4800.99
315_A319_K1.4740.99
454_T460_V1.4690.99
185_L202_D1.4680.99
19_I51_V1.4610.99
302_D306_E1.4440.99
133_K186_R1.4410.99
344_T348_R1.4280.99
390_T463_V1.4240.99
49_V114_M1.4180.99
201_L207_F1.4150.99
18_I48_V1.4110.99
444_A454_T1.4110.99
398_A467_L1.4020.99
158_N196_A1.3960.99
401_R425_W1.3960.99
70_T88_L1.3870.99
312_E476_R1.3800.99
302_D355_Q1.3730.99
35_I48_V1.3700.99
391_F478_A1.3650.99
155_S193_L1.3630.99
226_K230_E1.3600.99
322_Y341_S1.3550.99
10_P13_Q1.3540.99
32_D48_V1.3510.98
196_A199_Q1.3510.98
440_A460_V1.3470.98
104_E107_K1.3470.98
398_A471_L1.3390.98
318_E322_Y1.3370.98
446_K455_Q1.3320.98
304_V307_A1.3310.98
379_Q456_V1.3290.98
271_V276_P1.3200.98
151_F188_A1.3170.98
198_I201_L1.3130.98
70_T86_A1.3090.98
219_Y224_V1.3040.98
106_L152_E1.2960.98
119_S146_L1.2880.98
297_F399_F1.2820.98
319_K388_R1.2820.98
106_L156_H1.2750.98
74_R223_E1.2710.98
284_I343_V1.2620.98
189_Q199_Q1.2560.98
199_Q202_D1.2550.98
293_V360_A1.2540.98
39_N44_L1.2530.98
284_I326_I1.2520.98
446_K452_D1.2500.97
37_L41_H1.2460.97
68_L90_R1.2410.97
74_R84_S1.2320.97
338_S342_A1.2310.97
469_A473_K1.2290.97
182_E186_R1.2260.97
151_F201_L1.2240.97
133_K182_E1.2110.97
468_D472_E1.2090.97
155_S194_P1.2070.97
110_H156_H1.2030.97
189_Q195_E1.2010.97
291_A316_F1.1970.97
387_A462_Q1.1880.97
107_K110_H1.1830.96
357_L399_F1.1810.96
283_A377_A1.1810.96
292_L313_I1.1800.96
331_L334_D1.1740.96
152_E193_L1.1700.96
65_Q235_D1.1630.96
219_Y238_L1.1630.96
299_A313_I1.1590.96
124_A365_T1.1580.96
304_V356_L1.1550.96
67_G95_E1.1540.96
308_M314_C1.1500.96
423_Q426_S1.1420.96
115_R257_T1.1370.96
84_S230_E1.1270.95
473_K477_E1.1120.95
23_E50_V1.1110.95
336_L340_A1.1100.95
452_D455_Q1.1020.95
33_W89_I1.0980.95
168_I210_T1.0920.95
59_P63_S1.0870.94
23_E92_V1.0800.94
195_E199_Q1.0780.94
41_H265_P1.0770.94
167_I207_F1.0750.94
290_T366_K1.0740.94
19_I153_R1.0700.94
391_F470_I1.0700.94
21_F109_A1.0650.94
308_M344_T1.0640.94
357_L412_Q1.0620.94
21_F146_L1.0620.94
320_A389_L1.0610.94
460_V464_A1.0610.94
19_I117_V1.0560.93
376_L450_E1.0470.93
440_A444_A1.0450.93
420_R445_E1.0430.93
59_P95_E1.0410.93
440_A464_A1.0410.93
420_R447_D1.0410.93
136_D140_V1.0400.93
165_W254_S1.0330.93
67_G94_R1.0310.93
297_F357_L1.0290.93
357_L409_Y1.0260.92
305_G353_K1.0250.92
273_D276_P1.0240.92
367_F392_A1.0240.92
33_W37_L1.0190.92
10_P14_Y1.0150.92
34_Q266_L1.0110.92
221_R225_A1.0090.92
422_Q426_S1.0080.92
445_E448_H1.0080.92
76_L350_P1.0080.92
326_I336_L1.0060.92
214_R241_A1.0040.92
325_I389_L1.0040.92
178_D181_R1.0030.92
219_Y239_D0.9940.91
163_K255_L0.9940.91
33_W87_R0.9850.91
374_Q389_L0.9840.91
31_V118_F0.9810.91
26_F170_C0.9810.91
134_F186_R0.9800.91
297_F356_L0.9790.91
321_I344_T0.9780.91
364_M448_H0.9740.90
37_L245_Y0.9710.90
419_E423_Q0.9710.90
364_M396_L0.9700.90
73_I85_D0.9690.90
355_Q358_S0.9670.90
299_A310_D0.9660.90
63_S94_R0.9660.90
316_F388_R0.9660.90
474_G478_A0.9650.90
139_A142_Y0.9620.90
86_A231_L0.9590.90
258_E262_D0.9590.90
398_A402_G0.9580.90
154_F196_A0.9550.89
64_T236_G0.9530.89
390_T459_L0.9530.89
399_F411_V0.9470.89
354_H370_R0.9450.89
404_R475_M0.9360.89
438_L444_A0.9340.88
151_F184_V0.9340.88
124_A370_R0.9290.88
49_V93_N0.9270.88
185_L198_I0.9260.88
436_Q464_A0.9260.88
303_T306_E0.9250.88
318_E344_T0.9250.88
118_F210_T0.9200.88
338_S341_S0.9190.88
462_Q465_N0.9150.87
284_I325_I0.9130.87
200_W204_A0.9120.87
301_L306_E0.9120.87
261_L270_I0.9100.87
167_I205_N0.9090.87
36_D91_S0.9070.87
62_L67_G0.9060.87
35_I268_V0.9040.87
166_I253_K0.9040.87
398_A404_R0.9000.86
303_T353_K0.8940.86
107_K156_H0.8940.86
304_V317_V0.8930.86
306_E309_N0.8890.86
56_T60_P0.8870.86
17_R39_N0.8850.86
320_A325_I0.8830.85
308_M317_V0.8830.85
109_A117_V0.8820.85
386_P458_G0.8810.85
222_D225_A0.8790.85
70_T233_Y0.8710.85
393_L463_V0.8690.85
375_L390_T0.8690.85
385_L390_T0.8640.84
361_L412_Q0.8640.84
15_P45_N0.8620.84
116_F258_E0.8610.84
21_F153_R0.8610.84
128_Y179_A0.8600.84
16_E108_L0.8590.84
118_F247_F0.8580.84
354_H359_I0.8580.84
18_I116_F0.8580.84
108_L111_N0.8570.84
342_A345_G0.8550.84
227_L231_L0.8520.83
102_Y149_L0.8510.83
57_S61_S0.8470.83
292_L356_L0.8450.83
17_R46_S0.8440.83
179_A182_E0.8430.83
194_P198_I0.8360.82
118_F168_I0.8350.82
31_V170_C0.8330.82
226_K229_E0.8310.82
321_I340_A0.8310.82
55_E58_F0.8270.81
324_E328_V0.8270.81
322_Y326_I0.8230.81
333_R337_E0.8220.81
371_I392_A0.8210.81
465_N469_A0.8170.81
415_A420_R0.8160.81
358_S412_Q0.8160.81
224_V238_L0.8160.81
297_F302_D0.8120.80
337_E341_S0.8080.80
295_V313_I0.8050.80
154_F157_F0.8030.80
325_I374_Q0.8000.79
117_V167_I0.7990.79
16_E47_G0.7990.79
59_P100_S0.7970.79
262_D270_I0.7960.79
94_R107_K0.7950.79
217_T339_F0.7950.79
40_E87_R0.7950.79
165_W188_A0.7850.78
444_A460_V0.7850.78
48_V91_S0.7840.78
38_L266_L0.7840.78
127_S145_K0.7810.78
170_C244_F0.7790.77
75_G243_H0.7790.77
420_R423_Q0.7780.77
372_L375_L0.7780.77
27_L32_D0.7770.77
397_I463_V0.7770.77
84_S351_Y0.7770.77
137_A140_V0.7760.77
188_A198_I0.7760.77
288_A347_F0.7760.77
443_L459_L0.7750.77
188_A197_F0.7740.77
75_G79_K0.7720.77
390_T462_Q0.7710.77
341_S344_T0.7700.77
150_L180_L0.7690.77
253_K258_E0.7680.76
185_L201_L0.7670.76
119_S169_P0.7630.76
98_V149_L0.7630.76
300_G310_D0.7610.76
88_L233_Y0.7610.76
52_R58_F0.7600.76
321_I343_V0.7590.76
26_F31_V0.7590.76
372_L393_L0.7580.75
304_V366_K0.7570.75
386_P390_T0.7560.75
365_T415_A0.7540.75
43_D260_R0.7510.75
312_E479_V0.7490.75
112_P162_D0.7430.74
35_I38_L0.7430.74
320_A388_R0.7420.74
76_L80_G0.7420.74
290_T363_G0.7420.74
166_I258_E0.7400.74
279_E377_A0.7390.74
254_S257_T0.7380.74
162_D204_A0.7340.73
61_S236_G0.7340.73
283_A328_V0.7340.73
154_F194_P0.7320.73
153_R165_W0.7320.73
130_A133_K0.7310.73
166_I208_C0.7310.73
375_L389_L0.7300.73
299_A312_E0.7290.73
23_E53_P0.7270.72
294_P399_F0.7260.72
475_M479_V0.7260.72
147_T187_Y0.7260.72
318_E340_A0.7250.72
37_L40_E0.7200.72
19_I109_A0.7180.71
306_E356_L0.7150.71
209_S250_Q0.7150.71
147_T184_V0.7130.71
11_G14_Y0.7120.71
403_E406_G0.7110.71
427_Q441_I0.7090.71
16_E113_E0.7080.70
137_A187_Y0.7070.70
290_T294_P0.7070.70
395_A475_M0.7060.70
424_L445_E0.7030.70
461_E465_N0.7010.70
52_R95_E0.6990.69
470_I475_M0.6990.69
324_E388_R0.6970.69
296_A356_L0.6960.69
292_L307_A0.6960.69
110_H153_R0.6950.69
224_V237_F0.6950.69
124_A362_N0.6940.69
262_D268_V0.6930.69
283_A374_Q0.6920.69
71_T352_I0.6920.69
323_E388_R0.6900.68
136_D139_A0.6900.68
280_R331_L0.6890.68
114_M149_L0.6880.68
420_R424_L0.6870.68
154_F200_W0.6870.68
280_R336_L0.6860.68
217_T247_F0.6850.68
33_W245_Y0.6840.68
52_R97_S0.6840.68
387_A465_N0.6830.68
425_W438_L0.6810.67
364_M421_Y0.6800.67
97_S100_S0.6790.67
118_F170_C0.6780.67
206_S255_L0.6770.67
96_I104_E0.6750.67
170_C339_F0.6730.67
475_M478_A0.6700.66
274_I278_K0.6700.66
313_I479_V0.6700.66
111_N162_D0.6650.66
312_E315_A0.6650.66
437_E440_A0.6640.66
181_R202_D0.6640.66
75_G351_Y0.6640.66
393_L449_W0.6630.65
328_V374_Q0.6620.65
217_T239_D0.6600.65
186_R190_E0.6580.65
323_E383_G0.6570.65
96_I101_E0.6520.64
365_T370_R0.6510.64
379_Q459_L0.6480.64
299_A476_R0.6460.63
246_L339_F0.6450.63
324_E329_L0.6440.63
106_L149_L0.6430.63
311_A315_A0.6410.63
223_E226_K0.6380.62
391_F475_M0.6360.62
44_L47_G0.6350.62
365_T369_T0.6350.62
398_A470_I0.6350.62
162_D165_W0.6340.62
402_G409_Y0.6340.62
339_F343_V0.6340.62
26_F241_A0.6330.62
368_R450_E0.6320.62
211_L274_I0.6310.62
294_P307_A0.6300.61
23_E52_R0.6290.61
474_G477_E0.6270.61
401_R471_L0.6270.61
168_I261_L0.6270.61
128_Y132_D0.6260.61
52_R59_P0.6250.61
148_R187_Y0.6250.61
418_L422_Q0.6250.61
123_E361_L0.6240.61
244_F247_F0.6240.61
51_V98_V0.6240.61
141_S152_E0.6230.61
11_G90_R0.6220.60
297_F407_E0.6220.60
112_P163_K0.6210.60
119_S150_L0.6210.60
134_F148_R0.6170.60
379_Q458_G0.6160.60
69_Y214_R0.6130.59
290_T361_L0.6120.59
174_D287_G0.6110.59
187_Y190_E0.6100.59
216_V231_L0.6090.59
303_T352_I0.6090.59
284_I288_A0.6080.59
419_E422_Q0.6080.59
102_Y105_F0.6070.59
214_R245_Y0.6070.59
168_I268_V0.6070.59
324_E372_L0.6050.58
99_Y102_Y0.6050.58
450_E454_T0.6040.58
328_V378_G0.6030.58
373_P376_L0.6000.58
39_N91_S0.5990.58
379_Q386_P0.5980.57
36_D90_R0.5970.57
106_L110_H0.5960.57
54_I97_S0.5950.57
225_A228_E0.5940.57
26_F30_F0.5930.57
158_N197_F0.5920.57
400_Y409_Y0.5900.56
138_P143_P0.5880.56
296_A301_L0.5880.56
158_N194_P0.5880.56
442_V445_E0.5870.56
356_L359_I0.5860.56
27_L30_F0.5860.56
282_V370_R0.5850.56
227_L230_E0.5850.56
424_L438_L0.5850.56
120_N171_E0.5850.56
216_V352_I0.5830.56
165_W255_L0.5820.55
229_E457_P0.5820.55
290_T359_I0.5800.55
178_D444_A0.5800.55
23_E54_I0.5790.55
442_V448_H0.5780.55
391_F466_D0.5780.55
276_P329_L0.5770.55
199_Q455_Q0.5750.55
185_L352_I0.5750.55
377_A382_N0.5750.55
27_L48_V0.5740.54
35_I270_I0.5730.54
409_Y475_M0.5730.54
54_I57_S0.5720.54
313_I475_M0.5710.54
217_T267_N0.5670.54
300_G403_E0.5670.54
157_F161_L0.5660.53
61_S237_F0.5660.53
397_I449_W0.5660.53
174_D278_K0.5650.53
124_A358_S0.5640.53
371_I389_L0.5630.53
98_V102_Y0.5630.53
290_T358_S0.5620.53
33_W375_L0.5620.53
70_T235_D0.5610.53
211_L248_V0.5610.53
153_R157_F0.5600.53
461_E473_K0.5580.52
57_S60_P0.5580.52
38_L44_L0.5580.52
291_A325_I0.5570.52
11_G68_L0.5560.52
62_L170_C0.5540.52
324_E378_G0.5530.52
146_L167_I0.5530.52
154_F167_I0.5530.52
208_C251_G0.5510.51
373_P377_A0.5510.51
96_I108_L0.5510.51
56_T59_P0.5490.51
71_T216_V0.5490.51
439_V464_A0.5480.51
37_L266_L0.5480.51
163_K206_S0.5470.51
21_F150_L0.5460.51
365_T374_Q0.5460.51
323_E385_L0.5450.51
21_F105_F0.5450.51
408_T455_Q0.5450.51
15_P44_L0.5450.51
54_I121_T0.5450.51
378_G386_P0.5430.50
360_A399_F0.5430.50
219_Y237_F0.5430.50
159_G162_D0.5430.50
59_P219_Y0.5430.50
184_V201_L0.5430.50
73_I245_Y0.5420.50
225_A234_H0.5410.50
123_E362_N0.5410.50
458_G462_Q0.5400.50
461_E469_A0.5400.50
116_F257_T0.5400.50
411_V418_L0.5390.50
295_V475_M0.5390.50
189_Q201_L0.5380.50
371_I374_Q0.5380.50
117_V150_L0.5360.50
120_N278_K0.5360.50
160_A163_K0.5350.49
52_R55_E0.5350.49
219_Y223_E0.5340.49
75_G350_P0.5340.49
195_E230_E0.5340.49
157_F204_A0.5330.49
367_F371_I0.5330.49
376_L380_K0.5330.49
37_L311_A0.5320.49
86_A227_L0.5320.49
324_E389_L0.5320.49
423_Q477_E0.5300.49
38_L43_D0.5300.49
220_P223_E0.5300.49
321_I325_I0.5300.49
287_G374_Q0.5290.49
139_A144_A0.5290.49
20_Q118_F0.5290.49
436_Q468_D0.5280.49
370_R463_V0.5270.48
210_T275_K0.5270.48
358_S370_R0.5260.48
151_F187_Y0.5230.48
436_Q440_A0.5220.48
253_K257_T0.5220.48
222_D353_K0.5220.48
421_Y445_E0.5220.48
146_L184_V0.5210.48
156_H162_D0.5210.48
303_T359_I0.5200.47
71_T241_A0.5190.47
400_Y411_V0.5190.47
136_D143_P0.5190.47
151_F154_F0.5180.47
287_G324_E0.5180.47
345_G350_P0.5180.47
292_L317_V0.5170.47
157_F163_K0.5170.47
30_F170_C0.5170.47
203_Q225_A0.5170.47
358_S365_T0.5160.47
31_V247_F0.5150.47
391_F395_A0.5140.47
14_Y90_R0.5140.47
14_Y93_N0.5130.47
198_I202_D0.5130.47
150_L154_F0.5130.47
62_L237_F0.5130.47
128_Y190_E0.5130.47
280_R399_F0.5120.46
151_F155_S0.5120.46
374_Q377_A0.5110.46
41_H455_Q0.5100.46
186_R189_Q0.5100.46
25_N240_T0.5090.46
360_A365_T0.5080.46
359_I370_R0.5080.46
304_V347_F0.5060.46
362_N414_D0.5060.46
65_Q68_L0.5050.46
161_L199_Q0.5040.45
65_Q237_F0.5040.45
129_H135_D0.5030.45
366_K370_R0.5030.45
41_H266_L0.5030.45
411_V422_Q0.5020.45
74_R214_R0.5020.45
181_R252_P0.5020.45
442_V449_W0.5010.45
287_G371_I0.5010.45
139_A148_R0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4im7A 1 0.9648 100 0.112 Contact Map
1lj8A 1 0.9607 100 0.117 Contact Map
3h2zA 2 0.766 100 0.355 Contact Map
3hn2A 2 0.619 88.6 0.965 Contact Map
2ew2A 2 0.6356 86.8 0.966 Contact Map
3wfiA 2 0.6273 82.6 0.968 Contact Map
2qytA 1 0.5756 79.2 0.969 Contact Map
3i83A 2 0.6377 75.2 0.97 Contact Map
3hwrA 2 0.6108 74.6 0.97 Contact Map
1z9bA 1 0.1615 52.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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