GREMLIN Database
NANA - N-acetylneuraminate lyase
UniProt: P0A6L4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10637
Length: 297 (284)
Sequences: 10371 (6810)
Seq/√Len: 404.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_D231_T3.7511.00
32_Q69_E3.2241.00
17_D21_A3.0841.00
119_C154_T3.0221.00
261_Y286_K2.9351.00
28_R69_E2.7681.00
24_K61_Q2.6901.00
96_K131_G2.5911.00
24_K65_I2.5851.00
28_R65_I2.5621.00
60_E94_S2.4791.00
80_V92_A2.4611.00
223_A231_T2.4311.00
197_G202_A2.3851.00
92_A103_V2.2081.00
231_T234_K2.1201.00
32_Q73_K2.0181.00
223_A228_D2.0081.00
218_Q222_K1.9761.00
9_M41_G1.9741.00
123_R158_L1.9711.00
115_F148_T1.9561.00
222_K226_E1.9531.00
127_D158_L1.9321.00
33_F37_Q1.9311.00
198_L224_L1.9061.00
115_F151_Q1.9051.00
85_T121_H1.8951.00
61_Q64_E1.8711.00
257_T282_L1.8601.00
123_R127_D1.8601.00
40_D222_K1.8501.00
23_D26_S1.8431.00
116_E120_D1.8251.00
56_L87_E1.8021.00
146_K173_Q1.8001.00
32_Q36_Q1.7911.00
216_R238_E1.7711.00
286_K290_Q1.7681.00
116_E154_T1.7671.00
28_R68_E1.7591.00
37_Q215_W1.7511.00
31_V66_V1.7161.00
153_N180_E1.7161.00
119_C123_R1.7021.00
64_E68_E1.6801.00
27_L66_V1.6651.00
67_A76_L1.6591.00
61_Q65_I1.6491.00
135_V163_A1.6461.00
10_A210_Y1.6431.00
126_I158_L1.6221.00
260_H268_P1.6221.00
26_S29_R1.6081.00
120_D123_R1.5951.00
105_A125_I1.5811.00
283_P286_K1.5721.00
44_V66_V1.5561.00
152_I164_L1.5481.00
148_T151_Q1.5201.00
65_I69_E1.5161.00
129_A132_L1.5101.00
63_L78_A1.5071.00
92_A129_A1.4971.00
58_E271_R1.4941.00
234_K238_E1.4831.00
35_I74_I1.4431.00
154_T157_T1.4431.00
27_L62_V1.4211.00
15_P27_L1.4101.00
96_K129_A1.3991.00
88_S125_I1.3791.00
219_G223_A1.3791.00
96_K132_L1.3511.00
13_L259_L1.3481.00
120_D124_A1.3401.00
283_P287_A1.3391.00
248_K284_E1.3381.00
279_E283_P1.3341.00
279_E282_L1.3331.00
40_D218_Q1.3281.00
219_G231_T1.3281.00
94_S97_R1.3261.00
9_M43_Y1.2981.00
65_I68_E1.2961.00
123_R157_T1.2901.00
82_C88_S1.2801.00
257_T261_Y1.2791.00
89_Q124_A1.2711.00
278_D281_Y1.2651.00
56_L90_Q1.2631.00
6_R225_K1.2581.00
60_E90_Q1.2571.00
84_S87_E1.2521.00
135_V206_I1.2391.00
215_W219_G1.2271.00
77_I102_A1.2261.00
224_L229_I1.2221.00
103_V129_A1.2201.00
260_H266_S1.2131.00
60_E64_E1.2061.00
33_F264_V1.2051.00
8_V39_I1.2031.00
56_L94_S1.2031.00
50_E256_K1.1881.00
195_A232_A1.1861.00
57_S61_Q1.1821.00
178_R186_L1.1821.00
35_I73_K1.1681.00
31_V70_A1.1601.00
124_A272_K1.1581.00
229_I233_Q1.1521.00
126_I160_G1.1511.00
185_V203_D1.1461.00
63_L95_A1.1451.00
221_V225_K1.1391.00
258_V289_A1.1291.00
21_A86_A1.1271.00
45_G62_V1.1261.00
230_Q233_Q1.1101.00
64_E94_S1.1101.00
17_D23_D1.1091.00
70_A76_L1.1091.00
67_A101_D1.1071.00
150_D180_E1.1021.00
257_T260_H1.0931.00
93_A97_R1.0931.00
124_A127_D1.0911.00
219_G222_K1.0881.00
176_Q180_E1.0861.00
93_A128_S1.0741.00
24_K28_R1.0731.00
25_A28_R1.0671.00
60_E97_R1.0621.00
64_E98_Y1.0611.00
16_F54_Q1.0591.00
124_A128_S1.0581.00
77_I135_V1.0421.00
18_Q269_L1.0411.00
257_T286_K1.0401.00
199_L229_I1.0341.00
116_E119_C1.0321.00
31_V69_E1.0291.00
89_Q93_A1.0181.00
103_V132_L1.0131.00
287_A290_Q1.0111.00
176_Q244_D1.0111.00
26_S267_V1.0031.00
80_V95_A1.0031.00
116_E278_D1.0031.00
6_R203_D1.0021.00
78_A100_F0.9991.00
277_V285_L0.9981.00
94_S98_Y0.9961.00
8_V218_Q0.9941.00
103_V134_M0.9861.00
10_A34_N0.9841.00
231_T235_L0.9801.00
155_L161_V0.9771.00
282_L286_K0.9731.00
284_E287_A0.9691.00
281_Y284_E0.9681.00
26_S266_S0.9661.00
56_L91_L0.9651.00
277_V281_Y0.9621.00
245_L288_L0.9601.00
28_R32_Q0.9561.00
126_I134_M0.9501.00
43_Y104_S0.9481.00
10_A39_I0.9471.00
199_L233_Q0.9411.00
156_V184_L0.9401.00
209_T243_I0.9361.00
233_Q237_T0.9361.00
223_A235_L0.9331.00
90_Q94_S0.9291.00
67_A100_F0.9261.00
57_S90_Q0.9261.00
119_C151_Q0.9261.00
89_Q128_S0.9231.00
260_H282_L0.9211.00
30_L259_L0.9211.00
107_T145_V0.9201.00
136_V152_I0.9191.00
35_I70_A0.9161.00
81_G106_V0.9121.00
40_D221_V0.9101.00
80_V103_V0.9101.00
118_H145_V0.9101.00
20_Q86_A0.9071.00
115_F154_T0.9041.00
59_R91_L0.9021.00
149_L180_E0.9021.00
67_A98_Y0.9001.00
12_L34_N0.9001.00
82_C87_E0.8951.00
174_M197_G0.8941.00
90_Q93_A0.8931.00
138_N146_K0.8921.00
119_C157_T0.8901.00
76_L100_F0.8901.00
280_K283_P0.8851.00
120_D275_G0.8821.00
16_F271_R0.8711.00
198_L221_V0.8681.00
126_I161_V0.8661.00
31_V65_I0.8651.00
268_P282_L0.8531.00
207_G210_Y0.8511.00
220_I235_L0.8491.00
44_V62_V0.8491.00
230_Q234_K0.8481.00
20_Q272_K0.8471.00
39_I214_G0.8381.00
8_V221_V0.8361.00
194_F205_G0.8321.00
93_A96_K0.8311.00
261_Y290_Q0.8301.00
213_M242_V0.8301.00
12_L42_L0.8301.00
149_L176_Q0.8291.00
199_L224_L0.8291.00
158_L161_V0.8251.00
187_Y204_G0.8231.00
188_N197_G0.8221.00
105_A134_M0.8211.00
280_K284_E0.8151.00
227_G230_Q0.8111.00
268_P276_P0.8101.00
85_T89_Q0.8091.00
261_Y282_L0.8041.00
29_R264_V0.8041.00
8_V205_G0.8011.00
149_L153_N0.7931.00
25_A29_R0.7921.00
63_L100_F0.7901.00
240_N244_D0.7901.00
119_C158_L0.7871.00
20_Q269_L0.7851.00
57_S60_E0.7851.00
95_A100_F0.7801.00
18_Q266_S0.7741.00
70_A73_K0.7671.00
196_S199_L0.7671.00
63_L98_Y0.7671.00
45_G78_A0.7651.00
236_Q240_N0.7611.00
8_V210_Y0.7601.00
54_Q62_V0.7591.00
120_D272_K0.7571.00
86_A90_Q0.7491.00
213_M216_R0.7491.00
47_S110_Y0.7481.00
12_L27_L0.7451.00
27_L31_V0.7451.00
17_D25_A0.7391.00
213_M239_C0.7381.00
37_Q214_G0.7371.00
219_G235_L0.7361.00
42_L70_A0.7301.00
99_G132_L0.7281.00
260_H267_V0.7281.00
41_G77_I0.7261.00
88_S105_A0.7241.00
137_Y165_K0.7231.00
181_H184_L0.7221.00
115_F150_D0.7201.00
175_E179_R0.7171.00
253_R270_C0.7141.00
17_D269_L0.7131.00
107_T147_L0.7131.00
220_I224_L0.7121.00
31_V42_L0.7121.00
75_K101_D0.7101.00
176_Q179_R0.7101.00
248_K281_Y0.7041.00
60_E91_L0.7011.00
149_L173_Q0.7001.00
80_V105_A0.6971.00
269_L276_P0.6961.00
147_L152_I0.6961.00
216_R219_G0.6951.00
270_C274_F0.6941.00
123_R154_T0.6941.00
22_L27_L0.6931.00
146_K170_D0.6921.00
174_M178_R0.6911.00
139_I143_S0.6881.00
196_S200_A0.6851.00
215_W262_M0.6821.00
56_L60_E0.6790.99
45_G54_Q0.6780.99
35_I69_E0.6760.99
22_L62_V0.6740.99
253_R277_V0.6730.99
85_T124_A0.6720.99
60_E98_Y0.6710.99
51_A79_H0.6700.99
34_N39_I0.6700.99
195_A224_L0.6700.99
226_E231_T0.6680.99
259_L262_M0.6670.99
117_E275_G0.6670.99
259_L264_V0.6660.99
136_V147_L0.6620.99
70_A74_I0.6610.99
18_Q267_V0.6580.99
174_M186_L0.6570.99
138_N166_Q0.6560.99
12_L66_V0.6560.99
152_I177_I0.6540.99
283_P290_Q0.6510.99
17_D20_Q0.6510.99
114_S253_R0.6480.99
249_T281_Y0.6480.99
172_Y192_E0.6470.99
63_L67_A0.6460.99
223_A226_E0.6430.99
30_L34_N0.6420.99
55_S86_A0.6400.99
9_M77_I0.6380.99
194_F220_I0.6360.99
277_V282_L0.6350.99
261_Y289_A0.6350.99
195_A229_I0.6350.99
60_E95_A0.6340.99
32_Q35_I0.6330.99
135_V162_G0.6320.99
52_F111_Y0.6290.99
64_E97_R0.6250.99
162_G185_V0.6240.99
34_N37_Q0.6220.99
33_F262_M0.6210.99
284_E288_L0.6210.99
87_E90_Q0.6170.99
170_D173_Q0.6170.99
150_D176_Q0.6140.99
175_E200_A0.6130.99
196_S236_Q0.6110.99
44_V76_L0.6110.99
153_N181_H0.6050.99
131_G160_G0.6040.99
72_G101_D0.6020.99
150_D153_N0.6010.99
114_S117_E0.6010.99
179_R237_T0.6000.99
16_F58_E0.5960.99
250_G254_G0.5940.99
166_Q174_M0.5930.99
257_T270_C0.5910.99
195_A199_L0.5910.99
45_G59_R0.5910.99
195_A236_Q0.5880.99
107_T122_Y0.5850.98
22_L65_I0.5830.98
24_K69_E0.5830.98
212_I258_V0.5830.98
38_G218_Q0.5820.98
147_L151_Q0.5820.98
100_F132_L0.5810.98
222_K225_K0.5810.98
151_Q154_T0.5800.98
173_Q177_I0.5790.98
5_L102_A0.5790.98
270_C275_G0.5780.98
258_V261_Y0.5730.98
163_A185_V0.5730.98
175_E236_Q0.5710.98
43_Y77_I0.5680.98
135_V185_V0.5650.98
77_I104_S0.5640.98
57_S94_S0.5610.98
223_A232_A0.5600.98
234_K237_T0.5600.98
68_E71_K0.5600.98
39_I218_Q0.5560.98
127_D160_G0.5540.98
175_E196_S0.5540.98
224_L232_A0.5530.98
47_S137_Y0.5530.98
258_V285_L0.5520.98
13_L255_L0.5510.98
23_D266_S0.5510.98
155_L158_L0.5510.98
194_F217_Y0.5500.98
179_R241_K0.5490.98
45_G63_L0.5460.98
177_I186_L0.5450.98
78_A95_A0.5440.98
279_E286_K0.5440.98
178_R203_D0.5440.98
121_H124_A0.5430.98
6_R40_D0.5430.98
122_Y161_V0.5420.98
171_L193_I0.5400.97
105_A122_Y0.5360.97
245_L284_E0.5340.97
235_L238_E0.5320.97
11_A208_S0.5320.97
42_L74_I0.5320.97
66_V70_A0.5310.97
89_Q125_I0.5300.97
212_I259_L0.5300.97
212_I255_L0.5290.97
21_A61_Q0.5250.97
67_A71_K0.5250.97
96_K128_S0.5240.97
116_E275_G0.5240.97
33_F214_G0.5220.97
11_A207_G0.5210.97
92_A125_I0.5190.97
30_L33_F0.5180.97
12_L31_V0.5180.97
107_T118_H0.5140.97
254_G277_V0.5110.96
168_S173_Q0.5080.96
86_A124_A0.5080.96
163_A184_L0.5070.96
91_L95_A0.5070.96
53_V85_T0.5060.96
209_T217_Y0.5060.96
257_T277_V0.5040.96
55_S58_E0.5020.96
82_C91_L0.5010.96
122_Y136_V0.5010.96
198_L225_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wkjA 3 0.9899 100 0.06 Contact Map
3na8A 3 0.9731 100 0.062 Contact Map
3eb2A 3 0.9764 100 0.062 Contact Map
4oe7A 3 0.9832 100 0.068 Contact Map
1f6kA 3 0.9798 100 0.072 Contact Map
3cprA 3 0.9798 100 0.074 Contact Map
3l21A 5 0.9832 100 0.074 Contact Map
4n4pA 3 0.9663 100 0.075 Contact Map
1xkyA 3 0.9798 100 0.075 Contact Map
3qzeA 2 0.9731 100 0.077 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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