GREMLIN Database
DAPA - 4-hydroxy-tetrahydrodipicolinate synthase
UniProt: P0A6L2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10205
Length: 292 (285)
Sequences: 10351 (6869)
Seq/√Len: 406.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_H228_E3.8841.00
29_D66_L3.3631.00
14_D18_N3.2401.00
116_Y150_R3.1631.00
258_E283_R2.8871.00
25_K66_L2.7831.00
93_N127_D2.6951.00
21_R58_D2.6911.00
21_R62_M2.6211.00
77_T89_T2.6121.00
194_F199_G2.5491.00
25_K62_M2.5061.00
57_A91_R2.4241.00
220_L228_E2.4201.00
89_T100_C2.2971.00
228_E231_V2.2191.00
29_D70_R2.1631.00
112_Q147_T2.0861.00
195_M221_A2.0631.00
82_T118_H2.0551.00
6_I38_A2.0531.00
124_E154_V2.0101.00
112_Q144_L2.0091.00
219_K223_E1.9981.00
220_L225_H1.9951.00
215_A219_K1.9661.00
120_K154_V1.9601.00
30_Y34_S1.9591.00
37_S219_K1.9221.00
142_D169_R1.9191.00
149_G176_L1.8921.00
283_R287_K1.8851.00
58_D61_M1.8811.00
29_D33_A1.8671.00
120_K124_E1.8481.00
113_E117_Q1.8451.00
25_K65_D1.8351.00
20_C23_S1.8171.00
53_H84_E1.8161.00
254_W279_R1.7861.00
113_E150_R1.7661.00
116_Y120_K1.7411.00
61_M65_D1.7251.00
28_I63_T1.7241.00
213_D235_R1.7221.00
131_I159_G1.7131.00
7_V207_A1.7021.00
55_E268_R1.6811.00
34_S212_R1.6751.00
24_L63_T1.6661.00
64_L73_V1.6631.00
58_D62_M1.6531.00
123_A154_V1.6341.00
117_Q120_K1.6091.00
257_K265_D1.6001.00
12_P24_L1.5861.00
280_E283_R1.5761.00
144_L147_T1.5671.00
102_T122_I1.5631.00
23_S26_K1.5361.00
89_T126_T1.5221.00
41_S63_T1.5211.00
231_V235_R1.5111.00
60_V75_A1.4841.00
24_L59_V1.4791.00
148_V160_I1.4711.00
62_M66_L1.4571.00
32_V71_I1.4551.00
93_N126_T1.3791.00
216_Q228_E1.3741.00
85_A122_I1.3681.00
216_Q220_L1.3571.00
276_D280_E1.3571.00
37_S215_A1.3501.00
276_D279_R1.3361.00
262_V265_D1.3361.00
117_Q121_A1.3251.00
6_I40_V1.3121.00
93_N128_L1.3111.00
10_V256_C1.3041.00
174_K183_L1.3041.00
131_I203_I1.2961.00
53_H87_S1.2881.00
280_E284_A1.2871.00
91_R94_D1.2851.00
47_E253_K1.2851.00
79_A85_A1.2731.00
257_K262_V1.2711.00
5_S36_T1.2641.00
245_V281_T1.2621.00
275_T278_G1.2581.00
254_W258_E1.2581.00
57_A87_S1.2481.00
74_I99_G1.2391.00
172_Q176_L1.2341.00
212_R216_Q1.2331.00
3_T222_A1.2311.00
62_M65_D1.2301.00
100_C126_T1.2271.00
86_I121_A1.2251.00
81_A84_E1.2151.00
60_V92_F1.2121.00
42_V59_V1.2081.00
57_A61_M1.2061.00
192_L229_A1.1931.00
221_A226_F1.1831.00
284_A288_H1.1761.00
54_D58_D1.1761.00
30_Y261_L1.1701.00
53_H91_R1.1671.00
32_V70_R1.1651.00
90_Q94_D1.1621.00
123_A156_N1.1611.00
40_V101_L1.1511.00
64_L98_V1.1371.00
18_N83_A1.1271.00
216_Q219_K1.1221.00
28_I67_A1.1211.00
7_V31_H1.1201.00
61_M91_R1.1151.00
227_A230_R1.1121.00
22_A25_K1.1121.00
226_F230_R1.1101.00
28_I66_L1.1061.00
121_A124_E1.0951.00
14_D20_C1.0941.00
254_W283_R1.0911.00
146_E176_L1.0851.00
121_A269_L1.0831.00
218_C222_A1.0821.00
67_A73_V1.0771.00
150_R153_K1.0761.00
77_T92_F1.0751.00
254_W257_K1.0741.00
13_M51_L1.0641.00
57_A94_D1.0611.00
23_S263_A1.0581.00
121_A125_H1.0571.00
255_A286_L1.0561.00
182_V200_H1.0491.00
74_I131_I1.0461.00
21_R25_K1.0401.00
100_C128_L1.0261.00
113_E275_T1.0251.00
284_A287_K1.0231.00
274_I282_V1.0061.00
90_Q125_H1.0061.00
3_T200_H1.0041.00
113_E116_Y1.0021.00
7_V36_T0.9991.00
78_G103_V0.9981.00
15_E266_T0.9981.00
86_I90_Q0.9941.00
91_R95_S0.9931.00
132_L148_V0.9881.00
149_G177_V0.9851.00
61_M95_S0.9791.00
172_Q241_N0.9751.00
75_A97_I0.9721.00
274_I278_G0.9711.00
25_K29_D0.9701.00
53_H88_L0.9621.00
228_E232_I0.9611.00
5_S215_A0.9551.00
152_A181_F0.9471.00
64_L97_I0.9411.00
281_T284_A0.9391.00
86_I125_H0.9361.00
279_R283_R0.9331.00
116_Y147_T0.9311.00
54_D87_S0.9301.00
56_H88_L0.9301.00
170_V194_F0.9301.00
27_L256_C0.9301.00
79_A84_E0.9291.00
9_I31_H0.9291.00
196_Q226_F0.9241.00
257_K279_R0.9231.00
230_R234_Q0.9191.00
37_S218_C0.9161.00
17_G83_A0.9151.00
220_L232_I0.9121.00
73_V97_I0.9111.00
77_T100_C0.9091.00
123_A130_Q0.9091.00
278_G281_T0.9081.00
134_N142_D0.9061.00
23_S262_V0.9061.00
206_T240_H0.9021.00
13_M268_R0.9001.00
115_L141_C0.9001.00
100_C130_Q0.8991.00
112_Q150_R0.8981.00
41_S59_V0.8961.00
210_A239_L0.8961.00
28_I62_M0.8931.00
145_P176_L0.8921.00
64_L95_S0.8831.00
238_P288_H0.8801.00
87_S91_R0.8781.00
242_K285_A0.8771.00
104_T141_C0.8721.00
151_L157_I0.8691.00
17_G269_L0.8681.00
195_M218_C0.8631.00
117_Q272_T0.8601.00
149_G153_K0.8601.00
32_V67_A0.8591.00
184_L201_G0.8581.00
87_S90_Q0.8581.00
44_T107_Y0.8541.00
227_A231_V0.8511.00
116_Y154_V0.8491.00
191_A202_V0.8461.00
196_Q230_R0.8431.00
204_S207_A0.8421.00
217_M232_I0.8371.00
5_S207_A0.8371.00
196_Q221_A0.8371.00
277_S280_E0.8321.00
90_Q93_N0.8321.00
36_T211_A0.8281.00
102_T130_Q0.8251.00
123_A157_I0.8191.00
82_T86_I0.8181.00
9_I39_I0.8061.00
42_V75_A0.8061.00
154_V157_I0.8041.00
258_E287_K0.8011.00
60_V97_I0.8011.00
210_A236_L0.7961.00
60_V95_S0.7941.00
5_S202_V0.7901.00
285_A288_H0.7881.00
20_C262_V0.7851.00
265_D279_R0.7831.00
277_S281_T0.7821.00
145_P169_R0.7751.00
185_S194_F0.7731.00
22_A26_K0.7691.00
26_K261_L0.7641.00
224_G227_A0.7631.00
92_F97_I0.7621.00
17_G266_T0.7611.00
34_S211_A0.7601.00
24_L28_I0.7561.00
258_E279_R0.7531.00
104_T143_L0.7491.00
145_P172_Q0.7471.00
257_K263_A0.7461.00
193_D196_Q0.7451.00
145_P149_G0.7451.00
265_D273_P0.7441.00
54_D57_A0.7421.00
9_I24_L0.7391.00
83_A87_S0.7391.00
28_I39_I0.7381.00
72_P98_V0.7381.00
38_A74_I0.7371.00
67_A70_R0.7371.00
14_D266_T0.7361.00
85_A102_T0.7351.00
135_V139_T0.7331.00
210_A213_D0.7311.00
32_V66_L0.7261.00
96_G128_L0.7261.00
143_L148_V0.7251.00
233_N237_M0.7231.00
51_L59_V0.7151.00
5_S218_C0.7151.00
133_Y161_K0.7071.00
14_D22_A0.7041.00
48_S76_G0.7031.00
250_I267_L0.6951.00
134_N162_E0.6951.00
237_M241_N0.6941.00
148_V173_I0.6941.00
153_K180_D0.6911.00
39_I67_A0.6881.00
31_H36_T0.6861.00
19_V24_L0.6831.00
146_E172_Q0.6821.00
170_V183_L0.6821.00
213_D216_Q0.6811.00
217_M221_A0.6811.00
42_V51_L0.6801.00
61_M94_D0.6770.99
57_A88_L0.6770.99
172_Q175_E0.6770.99
216_Q232_I0.6760.99
192_L221_A0.6760.99
117_Q269_L0.6720.99
132_L143_L0.6710.99
177_V200_H0.6710.99
57_A92_F0.6700.99
111_S250_I0.6670.99
212_R259_L0.6660.99
112_Q146_E0.6660.99
77_T102_T0.6660.99
57_A95_S0.6650.99
31_H34_S0.6630.99
14_D17_G0.6570.99
120_K150_R0.6550.99
142_D166_N0.6540.99
174_K177_V0.6540.99
9_I63_T0.6540.99
245_V278_G0.6500.99
82_T121_A0.6500.99
30_Y259_L0.6490.99
60_V64_L0.6450.99
256_C259_L0.6440.99
53_H57_A0.6440.99
19_V59_V0.6420.99
44_T133_Y0.6410.99
267_L271_M0.6400.99
256_C261_L0.6380.99
192_L226_F0.6360.99
193_D197_L0.6350.99
258_E286_L0.6340.99
168_T189_A0.6340.99
170_V174_K0.6330.99
274_I279_R0.6330.99
6_I74_I0.6310.99
114_G272_T0.6290.99
193_D233_N0.6290.99
250_I274_I0.6280.99
27_L31_H0.6270.99
67_A71_I0.6270.99
49_A108_N0.6240.99
223_E228_E0.6220.99
191_A217_M0.6220.99
280_E287_K0.6210.99
266_T273_P0.6210.99
174_K200_H0.6200.99
175_E234_Q0.6180.99
84_E87_S0.6140.99
178_S181_F0.6130.99
40_V74_I0.6120.99
127_D156_N0.6110.99
41_S73_V0.6070.99
171_N175_E0.6020.99
52_N83_A0.6010.99
247_P251_P0.6000.99
152_A177_V0.5990.99
42_V56_H0.5940.99
8_A205_V0.5930.99
171_N197_L0.5910.99
166_N169_R0.5870.99
13_M55_E0.5860.99
29_D32_V0.5860.99
281_T285_A0.5850.99
146_E149_G0.5830.98
8_A188_D0.5780.98
147_T150_R0.5720.98
220_L223_E0.5710.98
246_E278_G0.5710.98
5_S31_H0.5690.98
158_I182_V0.5680.98
8_A204_S0.5670.98
133_Y163_A0.5670.98
162_E170_V0.5650.98
171_N233_N0.5650.98
209_V255_A0.5650.98
219_K222_A0.5640.98
15_E263_A0.5640.98
19_V62_M0.5640.98
208_N211_A0.5630.98
231_V234_Q0.5610.98
131_I158_I0.5610.98
69_G98_V0.5610.98
111_S114_G0.5600.98
195_M222_A0.5590.98
192_L233_N0.5570.98
152_A178_S0.5570.98
267_L272_T0.5570.98
104_T119_F0.5550.98
21_R66_L0.5550.98
76_G101_L0.5540.98
97_I128_L0.5530.98
109_R137_S0.5500.98
171_N193_D0.5480.98
149_G178_S0.5470.98
111_S246_E0.5470.98
177_V180_D0.5450.98
175_E238_P0.5440.98
263_A266_T0.5420.98
74_I101_L0.5410.98
254_W267_L0.5410.98
192_L196_Q0.5390.97
124_E156_N0.5340.97
93_N125_H0.5330.97
159_G182_V0.5330.97
64_L70_R0.5310.97
39_I71_I0.5310.97
276_D283_R0.5310.97
153_K178_S0.5300.97
143_L147_T0.5300.97
36_T215_A0.5300.97
220_L229_A0.5300.97
183_L194_F0.5270.97
35_G215_A0.5270.97
18_N58_D0.5270.97
187_D190_S0.5270.97
65_D68_D0.5270.97
54_D91_R0.5240.97
159_G181_F0.5230.97
10_V252_V0.5230.97
186_G203_I0.5200.97
113_E272_T0.5200.97
205_V252_V0.5190.97
191_A214_M0.5170.97
50_T82_T0.5150.97
75_A92_F0.5150.97
102_T119_F0.5110.97
27_L262_V0.5100.97
209_V256_C0.5100.97
173_I183_L0.5080.96
42_V60_V0.5080.96
31_H207_A0.5070.96
131_I182_V0.5070.96
246_E275_T0.5050.96
209_V252_V0.5050.96
64_L68_D0.5050.96
151_L154_V0.5040.96
167_L190_S0.5030.96
86_I122_I0.5030.96
251_P274_I0.5000.96
56_H91_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ojpA 2 0.9932 100 0.03 Contact Map
3si9A 3 0.9966 100 0.031 Contact Map
3takA 2 0.9966 100 0.034 Contact Map
3qzeA 2 0.9932 100 0.035 Contact Map
3fluA 3 0.9966 100 0.035 Contact Map
3a5fA 3 0.9897 100 0.036 Contact Map
4pfmA 2 0.9966 100 0.036 Contact Map
1o5kA 3 0.9897 100 0.038 Contact Map
2ehhA 3 0.9932 100 0.038 Contact Map
4i7wA 3 0.9897 100 0.038 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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