DEOC - ECOLI - GREMLIN Contacts

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DEOC - Deoxyribose-phosphate aldolase

UniProt:	P0A6L0	Sequences: MTDLKASSLRALKLMDLTTLNDDDTDEKVIALCHQAKTPVGNTAAICIYPRFIPIARKTLKEQGTPEIRIATVTNFPHGNDDIDIALAETRAAIAYGADEVDVVFPYRALMAGNEQVGFDLVKACKEACAAANVLLKVIIETGELKDEALIRKASEISIKAGADFIKTSTGKVAVNATPESARIMMEVIRDMGVEKTVGFKPAGGVRTAEDAQKYLAIADELFGADWADARHYRFGASSLLASLLKALGHGDGKSASSY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10221
Length:	259 (212)
Sequences:	3206 (2118)
Seq/√Len:	145.5

ECOLI - DEOC
BACSU - DEOC
HALSA - DEOC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
208_T	211_D	3.783	1.00
119_F	160_K	3.005	1.00
92_A	96_Y	2.907	1.00
114_N	117_V	2.828	1.00
115_E	153_K	2.754	1.00
126_K	136_L	2.747	1.00
159_I	198_V	2.656	1.00
111_M	149_A	2.643	1.00
199_G	221_E	2.535	1.00
14_L	216_L	2.449	1.00
119_F	123_K	2.310	1.00
144_E	173_V	2.282	1.00
110_L	115_E	2.281	1.00
30_I	55_I	2.166	1.00
109_A	117_V	2.146	1.00
183_R	187_E	2.125	1.00
109_A	114_N	2.111	1.00
45_A	71_A	2.109	1.00
150_L	181_S	2.047	1.00
83_I	87_L	1.965	1.00
19_T	24_D	1.904	1.00
103_V	122_V	1.896	1.00
69_R	99_D	1.869	1.00
30_I	59_T	1.867	1.00
153_K	156_E	1.859	1.00
105_F	110_L	1.853	1.00
179_P	214_K	1.767	1.00
19_T	29_V	1.758	1.00
34_H	38_T	1.734	1.00
209_A	213_Q	1.719	1.00
82_D	92_A	1.695	1.00
90_T	129_C	1.675	1.00
159_I	195_E	1.647	1.00
91_R	95_A	1.640	1.00
123_K	127_E	1.622	1.00
212_A	223_F	1.617	1.00
44_A	69_R	1.582	1.00
121_L	125_C	1.582	1.00
213_Q	217_A	1.571	1.00
34_H	59_T	1.566	1.00
99_D	134_V	1.541	1.00
126_K	130_A	1.515	1.00
147_D	180_E	1.498	1.00
49_Y	78_H	1.469	1.00
143_G	173_V	1.468	1.00
54_P	96_Y	1.462	1.00
138_V	163_A	1.461	1.00
186_M	196_K	1.446	1.00
26_D	112_A	1.444	1.00
30_I	34_H	1.438	1.00
84_D	92_A	1.438	1.00
82_D	96_Y	1.429	1.00
85_I	88_A	1.424	1.00
57_R	99_D	1.416	1.00
110_L	157_I	1.416	1.00
110_L	154_A	1.413	1.00
90_T	101_V	1.410	1.00
92_A	95_A	1.390	1.00
49_Y	80_N	1.366	1.00
53_I	70_I	1.363	1.00
143_G	174_A	1.332	1.00
105_F	154_A	1.319	1.00
94_I	128_A	1.318	1.00
146_K	149_A	1.311	1.00
15_M	228_A	1.306	1.00
182_A	200_F	1.304	1.00
81_D	85_I	1.303	1.00
155_S	185_M	1.300	1.00
207_R	211_D	1.296	1.00
211_D	215_Y	1.282	1.00
211_D	214_K	1.277	1.00
51_R	106_P	1.273	1.00
179_P	218_I	1.270	1.00
142_T	203_A	1.268	1.00
175_V	178_T	1.251	1.00
119_F	157_I	1.246	1.00
129_C	136_L	1.239	1.00
25_T	28_K	1.218	1.00
26_D	55_I	1.200	1.00
50_P	81_D	1.195	1.00
27_E	30_I	1.191	1.00
159_I	197_T	1.189	1.00
155_S	189_I	1.180	1.00
26_D	52_F	1.178	1.00
55_I	59_T	1.174	1.00
63_Q	68_I	1.170	1.00
43_T	228_A	1.156	1.00
50_P	72_T	1.155	1.00
37_K	63_Q	1.151	1.00
19_T	28_K	1.148	1.00
140_I	166_I	1.145	0.99
210_E	214_K	1.122	0.99
151_I	188_V	1.120	0.99
53_I	72_T	1.114	0.99
186_M	199_G	1.113	0.99
45_A	69_R	1.104	0.99
207_R	227_W	1.099	0.99
28_K	31_A	1.090	0.99
83_I	121_L	1.089	0.99
120_D	124_A	1.088	0.99
81_D	89_E	1.088	0.99
56_A	70_I	1.082	0.99
147_D	150_L	1.078	0.99
17_L	228_A	1.070	0.99
13_K	42_N	1.053	0.99
142_T	181_S	1.043	0.99
42_N	67_E	1.039	0.99
38_T	41_G	1.026	0.99
189_I	200_F	1.024	0.99
33_C	46_I	1.023	0.99
74_T	101_V	1.022	0.99
179_P	215_Y	0.995	0.99
13_K	67_E	0.992	0.99
126_K	164_D	0.988	0.98
26_D	30_I	0.987	0.98
130_A	164_D	0.982	0.98
126_K	129_C	0.980	0.98
60_L	68_I	0.978	0.98
210_E	213_Q	0.968	0.98
57_R	61_K	0.961	0.98
23_D	144_E	0.960	0.98
155_S	166_I	0.957	0.98
12_L	42_N	0.951	0.98
229_D	232_H	0.946	0.98
180_E	183_R	0.939	0.98
47_C	73_V	0.938	0.98
135_L	164_D	0.938	0.98
106_P	121_L	0.936	0.98
186_M	221_E	0.936	0.98
124_A	127_E	0.935	0.98
120_D	123_K	0.932	0.98
86_A	121_L	0.931	0.98
140_I	154_A	0.923	0.98
47_C	71_A	0.922	0.98
118_G	121_L	0.918	0.98
22_D	78_H	0.918	0.98
57_R	70_I	0.915	0.98
33_C	59_T	0.912	0.97
158_S	163_A	0.909	0.97
26_D	114_N	0.908	0.97
158_S	161_A	0.904	0.97
41_G	229_D	0.901	0.97
87_L	128_A	0.900	0.97
50_P	82_D	0.900	0.97
94_I	134_V	0.888	0.97
115_E	157_I	0.887	0.97
119_F	161_A	0.885	0.97
54_P	58_K	0.883	0.97
75_N	81_D	0.880	0.97
116_Q	119_F	0.870	0.97
116_Q	120_D	0.869	0.97
11_A	14_L	0.866	0.97
53_I	96_Y	0.856	0.96
34_H	37_K	0.852	0.96
16_D	45_A	0.849	0.96
166_I	185_M	0.833	0.96
11_A	212_A	0.833	0.96
29_V	52_F	0.832	0.96
179_P	183_R	0.831	0.96
158_S	185_M	0.824	0.95
18_T	32_L	0.819	0.95
88_A	91_R	0.818	0.95
122_V	158_S	0.809	0.95
136_L	164_D	0.806	0.95
166_I	189_I	0.805	0.95
185_M	200_F	0.804	0.95
214_K	218_I	0.802	0.95
78_H	172_K	0.798	0.95
43_T	229_D	0.798	0.95
175_V	181_S	0.797	0.95
189_I	195_E	0.795	0.94
17_L	35_Q	0.791	0.94
214_K	217_A	0.784	0.94
165_F	199_G	0.782	0.94
48_I	56_A	0.777	0.94
87_L	125_C	0.776	0.94
82_D	85_I	0.775	0.94
19_T	32_L	0.771	0.93
169_S	176_N	0.770	0.93
156_E	188_V	0.769	0.93
140_I	150_L	0.769	0.93
140_I	158_S	0.768	0.93
31_A	35_Q	0.762	0.93
122_V	163_A	0.759	0.93
143_G	169_S	0.759	0.93
52_F	112_A	0.756	0.93
188_V	195_E	0.753	0.93
131_A	134_V	0.752	0.93
144_E	174_A	0.743	0.92
58_K	61_K	0.740	0.92
103_V	125_C	0.737	0.92
48_I	53_I	0.728	0.91
109_A	112_A	0.725	0.91
150_L	184_I	0.719	0.91
225_A	228_A	0.717	0.91
159_I	166_I	0.712	0.90
101_V	129_C	0.711	0.90
87_L	91_R	0.708	0.90
106_P	109_A	0.705	0.90
87_L	124_A	0.705	0.90
230_A	233_Y	0.699	0.90
13_K	44_A	0.698	0.90
228_A	232_H	0.698	0.90
51_R	109_A	0.693	0.89
72_T	93_A	0.692	0.89
130_A	134_V	0.690	0.89
51_R	117_V	0.689	0.89
10_R	13_K	0.685	0.89
75_N	89_E	0.683	0.89
93_A	98_A	0.683	0.89
183_R	217_A	0.683	0.89
225_A	231_R	0.683	0.89
159_I	189_I	0.676	0.88
93_A	96_Y	0.675	0.88
30_I	33_C	0.675	0.88
29_V	32_L	0.675	0.88
169_S	177_A	0.673	0.88
84_D	88_A	0.669	0.88
37_K	62_E	0.668	0.87
157_I	161_A	0.666	0.87
206_V	227_W	0.663	0.87
31_A	34_H	0.659	0.87
126_K	131_A	0.657	0.87
37_K	59_T	0.655	0.86
142_T	175_V	0.654	0.86
111_M	146_K	0.654	0.86
16_D	71_A	0.650	0.86
212_A	232_H	0.650	0.86
159_I	188_V	0.649	0.86
156_E	160_K	0.647	0.86
43_T	232_H	0.643	0.85
14_L	221_E	0.642	0.85
103_V	163_A	0.642	0.85
38_T	233_Y	0.637	0.85
140_I	151_I	0.636	0.85
140_I	185_M	0.635	0.85
212_A	216_L	0.634	0.85
11_A	209_A	0.632	0.84
90_T	125_C	0.629	0.84
48_I	72_T	0.627	0.84
88_A	92_A	0.625	0.84
153_K	157_I	0.624	0.84
74_T	93_A	0.623	0.84
41_G	232_H	0.622	0.84
103_V	121_L	0.622	0.84
53_I	56_A	0.621	0.83
41_G	233_Y	0.614	0.83
117_V	120_D	0.613	0.83
78_H	81_D	0.611	0.82
27_E	31_A	0.606	0.82
33_C	60_L	0.604	0.82
125_C	136_L	0.600	0.81
186_M	200_F	0.599	0.81
84_D	96_Y	0.597	0.81
94_I	101_V	0.596	0.81
227_W	230_A	0.595	0.81
90_T	94_I	0.593	0.81
83_I	117_V	0.591	0.80
83_I	120_D	0.587	0.80
105_F	118_G	0.586	0.80
30_I	58_K	0.586	0.80
22_D	174_A	0.586	0.80
91_R	127_E	0.584	0.80
25_T	112_A	0.584	0.80
102_D	167_K	0.578	0.79
103_V	138_V	0.576	0.79
202_P	206_V	0.572	0.78
75_N	86_A	0.571	0.78
50_P	85_I	0.571	0.78
122_V	138_V	0.567	0.78
113_G	118_G	0.567	0.78
130_A	136_L	0.566	0.77
108_R	112_A	0.564	0.77
113_G	149_A	0.562	0.77
182_A	220_D	0.558	0.76
11_A	232_H	0.554	0.76
181_S	184_I	0.554	0.76
24_D	28_K	0.552	0.76
14_L	165_F	0.546	0.75
50_P	74_T	0.543	0.74
23_D	28_K	0.543	0.74
159_I	196_K	0.540	0.74
107_Y	110_L	0.538	0.74
33_C	56_A	0.537	0.74
87_L	121_L	0.535	0.73
84_D	124_A	0.533	0.73
103_V	136_L	0.533	0.73
101_V	136_L	0.532	0.73
20_L	172_K	0.531	0.73
157_I	160_K	0.528	0.72
36_A	68_I	0.526	0.72
12_L	15_M	0.524	0.72
10_R	42_N	0.523	0.72
80_N	106_P	0.523	0.72
143_G	175_V	0.523	0.72
69_R	135_L	0.522	0.72
154_A	161_A	0.521	0.71
156_E	159_I	0.520	0.71
94_I	129_C	0.519	0.71
9_L	42_N	0.519	0.71
20_L	73_V	0.516	0.71
52_F	55_I	0.516	0.71
140_I	155_S	0.513	0.70
125_C	128_A	0.513	0.70
107_Y	144_E	0.512	0.70
151_I	181_S	0.510	0.70
37_K	58_K	0.509	0.70
206_V	215_Y	0.508	0.70
150_L	175_V	0.507	0.69
176_N	203_A	0.506	0.69
186_M	195_E	0.505	0.69
10_R	14_L	0.503	0.69
15_M	43_T	0.503	0.69
110_L	153_K	0.502	0.69
182_A	215_Y	0.502	0.69
105_F	138_V	0.502	0.69
155_S	158_S	0.501	0.69
70_I	99_D	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1p1xA	1	0.9653	100	0.237	Contact Map
4eivA	2	0.9421	100	0.237	Contact Map
2a4aA	2	0.9112	100	0.238	Contact Map
3r12A	2	0.8764	100	0.308	Contact Map
1vcvA	2	0.8069	100	0.313	Contact Map
3oa3A	2	0.8687	100	0.314	Contact Map
3ngjA	4	0.8571	100	0.325	Contact Map
3ndoA	2	0.8494	100	0.353	Contact Map
1ub3A	3	0.8185	100	0.404	Contact Map
1n7kA	3	0.8571	100	0.436	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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