GREMLIN Database
DEOC - Deoxyribose-phosphate aldolase
UniProt: P0A6L0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10221
Length: 259 (212)
Sequences: 3206 (2118)
Seq/√Len: 145.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_T211_D3.7831.00
119_F160_K3.0051.00
92_A96_Y2.9071.00
114_N117_V2.8281.00
115_E153_K2.7541.00
126_K136_L2.7471.00
159_I198_V2.6561.00
111_M149_A2.6431.00
199_G221_E2.5351.00
14_L216_L2.4491.00
119_F123_K2.3101.00
144_E173_V2.2821.00
110_L115_E2.2811.00
30_I55_I2.1661.00
109_A117_V2.1461.00
183_R187_E2.1251.00
109_A114_N2.1111.00
45_A71_A2.1091.00
150_L181_S2.0471.00
83_I87_L1.9651.00
19_T24_D1.9041.00
103_V122_V1.8961.00
69_R99_D1.8691.00
30_I59_T1.8671.00
153_K156_E1.8591.00
105_F110_L1.8531.00
179_P214_K1.7671.00
19_T29_V1.7581.00
34_H38_T1.7341.00
209_A213_Q1.7191.00
82_D92_A1.6951.00
90_T129_C1.6751.00
159_I195_E1.6471.00
91_R95_A1.6401.00
123_K127_E1.6221.00
212_A223_F1.6171.00
44_A69_R1.5821.00
121_L125_C1.5821.00
213_Q217_A1.5711.00
34_H59_T1.5661.00
99_D134_V1.5411.00
126_K130_A1.5151.00
147_D180_E1.4981.00
49_Y78_H1.4691.00
143_G173_V1.4681.00
54_P96_Y1.4621.00
138_V163_A1.4611.00
186_M196_K1.4461.00
26_D112_A1.4441.00
30_I34_H1.4381.00
84_D92_A1.4381.00
82_D96_Y1.4291.00
85_I88_A1.4241.00
57_R99_D1.4161.00
110_L157_I1.4161.00
110_L154_A1.4131.00
90_T101_V1.4101.00
92_A95_A1.3901.00
49_Y80_N1.3661.00
53_I70_I1.3631.00
143_G174_A1.3321.00
105_F154_A1.3191.00
94_I128_A1.3181.00
146_K149_A1.3111.00
15_M228_A1.3061.00
182_A200_F1.3041.00
81_D85_I1.3031.00
155_S185_M1.3001.00
207_R211_D1.2961.00
211_D215_Y1.2821.00
211_D214_K1.2771.00
51_R106_P1.2731.00
179_P218_I1.2701.00
142_T203_A1.2681.00
175_V178_T1.2511.00
119_F157_I1.2461.00
129_C136_L1.2391.00
25_T28_K1.2181.00
26_D55_I1.2001.00
50_P81_D1.1951.00
27_E30_I1.1911.00
159_I197_T1.1891.00
155_S189_I1.1801.00
26_D52_F1.1781.00
55_I59_T1.1741.00
63_Q68_I1.1701.00
43_T228_A1.1561.00
50_P72_T1.1551.00
37_K63_Q1.1511.00
19_T28_K1.1481.00
140_I166_I1.1450.99
210_E214_K1.1220.99
151_I188_V1.1200.99
53_I72_T1.1140.99
186_M199_G1.1130.99
45_A69_R1.1040.99
207_R227_W1.0990.99
28_K31_A1.0900.99
83_I121_L1.0890.99
120_D124_A1.0880.99
81_D89_E1.0880.99
56_A70_I1.0820.99
147_D150_L1.0780.99
17_L228_A1.0700.99
13_K42_N1.0530.99
142_T181_S1.0430.99
42_N67_E1.0390.99
38_T41_G1.0260.99
189_I200_F1.0240.99
33_C46_I1.0230.99
74_T101_V1.0220.99
179_P215_Y0.9950.99
13_K67_E0.9920.99
126_K164_D0.9880.98
26_D30_I0.9870.98
130_A164_D0.9820.98
126_K129_C0.9800.98
60_L68_I0.9780.98
210_E213_Q0.9680.98
57_R61_K0.9610.98
23_D144_E0.9600.98
155_S166_I0.9570.98
12_L42_N0.9510.98
229_D232_H0.9460.98
180_E183_R0.9390.98
47_C73_V0.9380.98
135_L164_D0.9380.98
106_P121_L0.9360.98
186_M221_E0.9360.98
124_A127_E0.9350.98
120_D123_K0.9320.98
86_A121_L0.9310.98
140_I154_A0.9230.98
47_C71_A0.9220.98
118_G121_L0.9180.98
22_D78_H0.9180.98
57_R70_I0.9150.98
33_C59_T0.9120.97
158_S163_A0.9090.97
26_D114_N0.9080.97
158_S161_A0.9040.97
41_G229_D0.9010.97
87_L128_A0.9000.97
50_P82_D0.9000.97
94_I134_V0.8880.97
115_E157_I0.8870.97
119_F161_A0.8850.97
54_P58_K0.8830.97
75_N81_D0.8800.97
116_Q119_F0.8700.97
116_Q120_D0.8690.97
11_A14_L0.8660.97
53_I96_Y0.8560.96
34_H37_K0.8520.96
16_D45_A0.8490.96
166_I185_M0.8330.96
11_A212_A0.8330.96
29_V52_F0.8320.96
179_P183_R0.8310.96
158_S185_M0.8240.95
18_T32_L0.8190.95
88_A91_R0.8180.95
122_V158_S0.8090.95
136_L164_D0.8060.95
166_I189_I0.8050.95
185_M200_F0.8040.95
214_K218_I0.8020.95
78_H172_K0.7980.95
43_T229_D0.7980.95
175_V181_S0.7970.95
189_I195_E0.7950.94
17_L35_Q0.7910.94
214_K217_A0.7840.94
165_F199_G0.7820.94
48_I56_A0.7770.94
87_L125_C0.7760.94
82_D85_I0.7750.94
19_T32_L0.7710.93
169_S176_N0.7700.93
156_E188_V0.7690.93
140_I150_L0.7690.93
140_I158_S0.7680.93
31_A35_Q0.7620.93
122_V163_A0.7590.93
143_G169_S0.7590.93
52_F112_A0.7560.93
188_V195_E0.7530.93
131_A134_V0.7520.93
144_E174_A0.7430.92
58_K61_K0.7400.92
103_V125_C0.7370.92
48_I53_I0.7280.91
109_A112_A0.7250.91
150_L184_I0.7190.91
225_A228_A0.7170.91
159_I166_I0.7120.90
101_V129_C0.7110.90
87_L91_R0.7080.90
106_P109_A0.7050.90
87_L124_A0.7050.90
230_A233_Y0.6990.90
13_K44_A0.6980.90
228_A232_H0.6980.90
51_R109_A0.6930.89
72_T93_A0.6920.89
130_A134_V0.6900.89
51_R117_V0.6890.89
10_R13_K0.6850.89
75_N89_E0.6830.89
93_A98_A0.6830.89
183_R217_A0.6830.89
225_A231_R0.6830.89
159_I189_I0.6760.88
93_A96_Y0.6750.88
30_I33_C0.6750.88
29_V32_L0.6750.88
169_S177_A0.6730.88
84_D88_A0.6690.88
37_K62_E0.6680.87
157_I161_A0.6660.87
206_V227_W0.6630.87
31_A34_H0.6590.87
126_K131_A0.6570.87
37_K59_T0.6550.86
142_T175_V0.6540.86
111_M146_K0.6540.86
16_D71_A0.6500.86
212_A232_H0.6500.86
159_I188_V0.6490.86
156_E160_K0.6470.86
43_T232_H0.6430.85
14_L221_E0.6420.85
103_V163_A0.6420.85
38_T233_Y0.6370.85
140_I151_I0.6360.85
140_I185_M0.6350.85
212_A216_L0.6340.85
11_A209_A0.6320.84
90_T125_C0.6290.84
48_I72_T0.6270.84
88_A92_A0.6250.84
153_K157_I0.6240.84
74_T93_A0.6230.84
41_G232_H0.6220.84
103_V121_L0.6220.84
53_I56_A0.6210.83
41_G233_Y0.6140.83
117_V120_D0.6130.83
78_H81_D0.6110.82
27_E31_A0.6060.82
33_C60_L0.6040.82
125_C136_L0.6000.81
186_M200_F0.5990.81
84_D96_Y0.5970.81
94_I101_V0.5960.81
227_W230_A0.5950.81
90_T94_I0.5930.81
83_I117_V0.5910.80
83_I120_D0.5870.80
105_F118_G0.5860.80
30_I58_K0.5860.80
22_D174_A0.5860.80
91_R127_E0.5840.80
25_T112_A0.5840.80
102_D167_K0.5780.79
103_V138_V0.5760.79
202_P206_V0.5720.78
75_N86_A0.5710.78
50_P85_I0.5710.78
122_V138_V0.5670.78
113_G118_G0.5670.78
130_A136_L0.5660.77
108_R112_A0.5640.77
113_G149_A0.5620.77
182_A220_D0.5580.76
11_A232_H0.5540.76
181_S184_I0.5540.76
24_D28_K0.5520.76
14_L165_F0.5460.75
50_P74_T0.5430.74
23_D28_K0.5430.74
159_I196_K0.5400.74
107_Y110_L0.5380.74
33_C56_A0.5370.74
87_L121_L0.5350.73
84_D124_A0.5330.73
103_V136_L0.5330.73
101_V136_L0.5320.73
20_L172_K0.5310.73
157_I160_K0.5280.72
36_A68_I0.5260.72
12_L15_M0.5240.72
10_R42_N0.5230.72
80_N106_P0.5230.72
143_G175_V0.5230.72
69_R135_L0.5220.72
154_A161_A0.5210.71
156_E159_I0.5200.71
94_I129_C0.5190.71
9_L42_N0.5190.71
20_L73_V0.5160.71
52_F55_I0.5160.71
140_I155_S0.5130.70
125_C128_A0.5130.70
107_Y144_E0.5120.70
151_I181_S0.5100.70
37_K58_K0.5090.70
206_V215_Y0.5080.70
150_L175_V0.5070.69
176_N203_A0.5060.69
186_M195_E0.5050.69
10_R14_L0.5030.69
15_M43_T0.5030.69
110_L153_K0.5020.69
182_A215_Y0.5020.69
105_F138_V0.5020.69
155_S158_S0.5010.69
70_I99_D0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p1xA 1 0.9653 100 0.237 Contact Map
4eivA 2 0.9421 100 0.237 Contact Map
2a4aA 2 0.9112 100 0.238 Contact Map
3r12A 2 0.8764 100 0.308 Contact Map
1vcvA 2 0.8069 100 0.313 Contact Map
3oa3A 2 0.8687 100 0.314 Contact Map
3ngjA 4 0.8571 100 0.325 Contact Map
3ndoA 2 0.8494 100 0.353 Contact Map
1ub3A 3 0.8185 100 0.404 Contact Map
1n7kA 3 0.8571 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.