GREMLIN Database
DEOB - Phosphopentomutase
UniProt: P0A6K6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10220
Length: 407 (382)
Sequences: 1415 (849)
Seq/√Len: 43.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_K335_L4.7221.00
283_D328_R3.5981.00
135_R199_E3.4651.00
143_G152_I3.2571.00
151_V154_D3.2321.00
126_Q130_D3.2181.00
244_Q267_C3.0861.00
132_L176_F2.9331.00
285_T300_T2.8791.00
271_K291_E2.8131.00
33_H36_E2.8121.00
161_M224_F2.7751.00
145_C155_Q2.7551.00
132_L197_A2.7281.00
158_E162_K2.7211.00
143_G156_L2.6631.00
247_V270_T2.6381.00
133_V140_G2.6081.00
356_G360_T2.5531.00
159_E165_K2.5351.00
328_R331_E2.5091.00
236_E267_C2.3961.00
29_D32_G2.3571.00
29_D65_H2.3341.00
105_I387_I2.3181.00
240_P249_E2.2991.00
279_D283_D2.2971.00
246_L395_F2.2501.00
140_G165_K2.2361.00
142_L159_E2.2311.00
158_E224_F2.1871.00
131_K135_R2.1821.00
152_I156_L2.1601.00
98_T263_I2.1581.00
21_E26_V2.1551.00
88_W380_H2.1391.00
161_M184_T2.0920.99
131_K134_E2.0890.99
381_R386_D2.0170.99
99_P234_A2.0030.99
151_V155_Q2.0000.99
160_H216_F1.9980.99
189_K192_E1.9930.99
35_A75_G1.9410.99
135_R196_I1.8870.99
257_V288_E1.8700.99
282_F332_L1.8670.99
368_V406_M1.8650.99
55_N58_R1.8420.99
129_L141_Y1.8150.98
219_D223_N1.8040.98
85_A373_V1.8010.98
5_F298_V1.7880.98
370_G373_V1.7850.98
313_R360_T1.7660.98
284_A287_K1.7520.98
53_L322_L1.7510.98
166_P193_L1.7440.98
33_H353_T1.7420.98
58_R83_I1.7390.98
154_D222_G1.7390.98
309_W321_G1.7240.98
159_E162_K1.7230.98
279_D328_R1.7200.98
280_A284_A1.7180.98
87_A379_G1.7100.98
382_E404_K1.7070.98
89_A366_V1.7060.98
231_H274_K1.6980.97
192_E195_E1.6960.97
182_E229_N1.6950.97
240_P245_K1.6930.97
18_E363_H1.6730.97
242_V392_A1.6730.97
261_A266_N1.6660.97
147_S152_I1.6600.97
315_V353_T1.6500.97
158_E221_A1.6470.97
187_L229_N1.6430.97
152_I155_Q1.6390.97
195_E233_L1.6310.97
354_W360_T1.6270.97
55_N330_P1.6250.97
28_A354_W1.6210.97
393_K405_A1.6170.97
339_D372_K1.6080.97
313_R354_W1.6010.96
289_M332_L1.5990.96
279_D324_L1.5890.96
128_L206_Y1.5840.96
142_L165_K1.5770.96
147_S155_Q1.5590.96
143_G147_S1.5500.96
90_H382_E1.5480.96
139_P189_K1.5390.96
147_S156_L1.5310.95
256_S269_I1.5190.95
88_W363_H1.5100.95
16_A27_G1.5100.95
236_E265_A1.5060.95
313_R356_G1.5060.95
90_H363_H1.4970.95
53_L61_L1.4650.94
38_C319_A1.4430.94
192_E196_I1.4280.93
130_D134_E1.4270.93
129_L133_V1.4230.93
314_D320_A1.4190.93
176_F201_L1.4160.93
244_Q249_E1.4050.93
244_Q247_V1.4000.93
38_C316_A1.3940.92
252_G295_N1.3870.92
343_I368_V1.3650.92
381_R406_M1.3640.92
28_A356_G1.3610.91
161_M221_A1.3550.91
166_P185_F1.3550.91
141_Y168_F1.3500.91
282_F330_P1.3480.91
89_A387_I1.3350.91
108_V238_P1.3260.90
22_R94_S1.3260.90
341_I394_Y1.3170.90
294_D298_V1.3080.90
201_L211_V1.3050.90
286_I289_M1.2990.89
17_T90_H1.2890.89
338_D371_P1.2850.89
118_S206_Y1.2740.89
189_K193_L1.2740.89
57_T77_D1.2720.88
5_F289_M1.2720.88
389_Q400_M1.2710.88
57_T76_M1.2640.88
89_A381_R1.2560.88
89_A364_I1.2520.88
28_A360_T1.2510.88
282_F302_F1.2490.88
243_L269_I1.2410.87
133_V141_Y1.2260.87
20_A28_A1.2160.86
282_F328_R1.2130.86
63_K82_V1.2060.86
181_H218_G1.2050.86
183_E219_D1.2040.86
12_F322_L1.2030.85
386_D406_M1.1970.85
316_A320_A1.1960.85
59_L84_G1.1930.85
283_D331_E1.1880.85
108_V239_A1.1880.85
246_L252_G1.1800.84
313_R355_T1.1780.84
225_Q308_S1.1600.83
38_C49_G1.1530.83
342_L369_Y1.1530.83
279_D282_F1.1470.83
257_V300_T1.1430.82
142_L156_L1.1320.82
62_A76_M1.1310.82
364_I387_I1.1230.81
57_T63_K1.0990.80
221_A224_F1.0960.80
6_I105_I1.0930.79
53_L323_E1.0860.79
217_I225_Q1.0830.79
279_D331_E1.0830.79
11_S318_Y1.0780.78
253_Q271_K1.0730.78
277_G308_S1.0690.78
87_A406_M1.0690.78
250_K397_T1.0550.77
185_F193_L1.0530.77
59_L333_M1.0530.77
2_K295_N1.0430.76
242_V400_M1.0420.76
85_A370_G1.0410.76
343_I366_V1.0380.76
278_L324_L1.0320.75
139_P166_P1.0060.73
23_F94_S1.0010.73
106_A388_G1.0000.73
16_A363_H0.9940.73
4_A394_Y0.9930.72
17_T363_H0.9920.72
256_S261_A0.9910.72
128_L200_E0.9910.72
245_K400_M0.9910.72
136_A166_P0.9900.72
261_A272_K0.9900.72
320_A324_L0.9900.72
132_L168_F0.9890.72
343_I387_I0.9880.72
57_T62_A0.9870.72
143_G155_Q0.9820.72
254_V270_T0.9780.71
91_E384_F0.9740.71
128_L201_L0.9660.70
273_V288_E0.9650.70
105_I264_Y0.9650.70
160_H166_P0.9640.70
9_L344_L0.9620.70
6_I387_I0.9620.70
136_A193_L0.9600.70
49_G75_G0.9590.70
133_V139_P0.9530.69
6_I106_A0.9490.69
85_A378_L0.9460.69
12_F31_L0.9430.68
115_G208_I0.9410.68
31_L61_L0.9400.68
368_V378_L0.9370.68
255_V288_E0.9360.68
51_L323_E0.9330.68
85_A375_P0.9310.67
6_I297_I0.9280.67
275_A281_L0.9220.67
235_V238_P0.9220.67
264_Y299_F0.9200.67
241_T244_Q0.9170.66
51_L319_A0.9160.66
16_A354_W0.9050.65
3_R337_R0.9040.65
118_S122_N0.9020.65
257_V285_T0.9010.65
231_H261_A0.8930.64
59_L83_I0.8880.64
87_A378_L0.8840.63
147_S151_V0.8790.63
246_L397_T0.8770.63
185_F216_F0.8750.63
139_P165_K0.8750.63
286_I331_E0.8730.62
161_M181_H0.8720.62
245_K389_Q0.8690.62
62_A75_G0.8660.62
324_L327_R0.8640.62
5_F336_L0.8630.62
38_C315_V0.8600.61
341_I368_V0.8590.61
205_G208_I0.8560.61
35_A51_L0.8530.61
33_H360_T0.8510.60
98_T318_Y0.8470.60
36_E68_S0.8470.60
92_M109_P0.8460.60
304_D307_S0.8350.59
256_S272_K0.8330.59
157_G224_F0.8300.59
2_K339_D0.8280.58
2_K394_Y0.8280.58
16_A26_V0.8280.58
132_L193_L0.8270.58
200_E205_G0.8200.58
14_I65_H0.8200.58
37_A316_A0.8180.57
391_L395_F0.8160.57
385_A402_Y0.8130.57
383_T404_K0.8130.57
229_N276_T0.8100.57
31_L53_L0.8070.56
84_G367_L0.8060.56
136_A196_I0.8050.56
22_R396_G0.8030.56
253_Q270_T0.8000.56
370_G375_P0.7990.56
330_P334_S0.7930.55
14_I64_A0.7920.55
292_A296_T0.7890.55
183_E217_I0.7890.55
309_W324_L0.7890.55
52_N323_E0.7870.54
278_L321_G0.7870.54
245_K397_T0.7860.54
255_V294_D0.7850.54
196_I199_E0.7840.54
261_A269_I0.7840.54
100_S110_V0.7780.54
185_F189_K0.7740.53
176_F211_V0.7720.53
34_I315_V0.7670.53
160_H185_F0.7660.53
180_C190_L0.7660.53
24_G355_T0.7630.52
18_E90_H0.7580.52
53_L57_T0.7580.52
239_A401_E0.7570.52
195_E274_K0.7570.52
247_V254_V0.7560.52
289_M335_L0.7550.51
264_Y388_G0.7530.51
53_L56_L0.7520.51
323_E327_R0.7510.51
158_E161_M0.7470.51
28_A313_R0.7450.50
99_P265_A0.7450.50
135_R197_A0.7410.50
63_K78_G0.7400.50
252_G395_F0.7400.50
286_I328_R0.7390.50
254_V269_I0.7380.50
142_L166_P0.7370.50
228_G277_G0.7350.50
49_G316_A0.7330.49
8_V345_T0.7310.49
57_T75_G0.7300.49
57_T79_N0.7300.49
161_M219_D0.7290.49
307_S350_C0.7270.49
316_A319_A0.7250.49
12_F53_L0.7250.49
87_A366_V0.7240.48
153_L221_A0.7200.48
6_I299_F0.7190.48
34_I318_Y0.7170.48
277_G304_D0.7160.48
281_L302_F0.7080.47
289_M336_L0.7050.47
139_P193_L0.7050.47
282_F289_M0.7050.47
257_V264_Y0.7040.47
66_E78_G0.7040.47
392_A397_T0.7030.46
261_A274_K0.7030.46
202_T208_I0.7010.46
126_Q134_E0.7010.46
280_A283_D0.7010.46
6_I391_L0.7010.46
366_V378_L0.6980.46
67_G88_W0.6960.46
118_S123_S0.6940.46
12_F344_L0.6940.46
333_M342_L0.6920.45
388_G399_D0.6890.45
117_F128_L0.6860.45
18_E68_S0.6860.45
105_I364_I0.6830.45
285_T298_V0.6820.44
154_D223_N0.6810.44
168_F176_F0.6790.44
292_A337_R0.6770.44
118_S121_E0.6760.44
92_M402_Y0.6730.44
276_T280_A0.6730.44
57_T367_L0.6720.44
242_V245_K0.6720.44
90_H380_H0.6720.44
111_L402_Y0.6710.43
6_I343_I0.6710.43
9_L325_F0.6710.43
184_T219_D0.6680.43
83_I369_Y0.6680.43
313_R350_C0.6660.43
390_T403_G0.6660.43
79_N82_V0.6660.43
63_K79_N0.6660.43
108_V241_T0.6650.43
38_C323_E0.6630.43
286_I335_L0.6610.43
121_E146_H0.6600.42
127_E206_Y0.6600.42
288_E291_E0.6590.42
4_A391_L0.6580.42
130_D133_V0.6550.42
139_P185_F0.6540.42
115_G206_Y0.6540.42
132_L201_L0.6530.42
195_E199_E0.6520.42
100_S117_F0.6520.42
12_F61_L0.6520.42
57_T78_G0.6510.42
65_H377_S0.6510.42
204_G207_N0.6510.42
388_G401_E0.6490.41
112_F205_G0.6490.41
2_K337_R0.6490.41
23_F356_G0.6480.41
23_F313_R0.6480.41
255_V271_K0.6470.41
282_F325_F0.6440.41
243_L256_S0.6420.41
304_D308_S0.6420.41
288_E298_V0.6420.41
89_A386_D0.6390.40
7_M302_F0.6380.40
228_G276_T0.6360.40
37_A49_G0.6350.40
181_H219_D0.6340.40
86_Y367_L0.6340.40
105_I391_L0.6320.40
346_A365_P0.6320.40
19_D361_R0.6310.40
240_P267_C0.6310.40
271_K288_E0.6310.40
131_K196_I0.6280.39
243_L254_V0.6270.39
332_L336_L0.6260.39
277_G280_A0.6250.39
50_P315_V0.6250.39
33_H356_G0.6240.39
363_H380_H0.6240.39
253_Q296_T0.6240.39
28_A355_T0.6240.39
123_S144_N0.6220.39
127_E205_G0.6210.39
16_A64_A0.6200.39
275_A284_A0.6170.38
8_V364_I0.6170.38
287_K291_E0.6170.38
342_L367_L0.6160.38
117_F206_Y0.6160.38
255_V296_T0.6140.38
5_F332_L0.6130.38
129_L168_F0.6120.38
160_H179_A0.6110.38
257_V286_I0.6110.38
129_L140_G0.6060.37
53_L75_G0.6060.37
319_A323_E0.6040.37
17_T364_I0.5990.37
147_S153_L0.5970.37
161_M229_N0.5960.37
295_N395_F0.5960.37
5_F340_D0.5960.37
296_T389_Q0.5960.37
333_M369_Y0.5940.36
327_R330_P0.5930.36
7_M325_F0.5930.36
346_A364_I0.5920.36
31_L322_L0.5910.36
245_K401_E0.5910.36
252_G297_I0.5900.36
390_T406_M0.5900.36
34_I209_G0.5890.36
81_E396_G0.5890.36
182_E227_T0.5880.36
66_E84_G0.5870.36
377_S380_H0.5860.36
207_N238_P0.5860.36
160_H163_T0.5860.36
386_D389_Q0.5860.36
289_M342_L0.5850.36
187_L190_L0.5830.35
14_I61_L0.5820.35
35_A62_A0.5820.35
207_N235_V0.5820.35
392_A399_D0.5820.35
135_R200_E0.5800.35
204_G350_C0.5800.35
370_G394_Y0.5800.35
87_A381_R0.5790.35
133_V168_F0.5790.35
389_Q401_E0.5790.35
115_G205_G0.5770.35
134_E382_E0.5770.35
86_Y377_S0.5770.35
209_G308_S0.5760.35
105_I108_V0.5760.35
52_N249_E0.5740.35
331_E334_S0.5740.35
339_D391_L0.5720.34
17_T53_L0.5710.34
174_S177_Q0.5710.34
197_A208_I0.5700.34
255_V273_V0.5690.34
282_F286_I0.5680.34
242_V395_F0.5680.34
373_V376_G0.5680.34
176_F379_G0.5680.34
282_F329_L0.5670.34
392_A400_M0.5670.34
99_P209_G0.5660.34
133_V189_K0.5650.34
395_F400_M0.5640.34
89_A383_T0.5620.34
339_D394_Y0.5620.34
3_R340_D0.5610.34
84_G404_K0.5610.34
81_E84_G0.5610.34
64_A88_W0.5600.33
180_C185_F0.5600.33
236_E244_Q0.5590.33
38_C50_P0.5590.33
242_V297_I0.5580.33
55_N333_M0.5580.33
114_W118_S0.5580.33
282_F331_E0.5580.33
87_A377_S0.5560.33
100_S114_W0.5560.33
253_Q294_D0.5550.33
17_T20_A0.5550.33
370_G374_K0.5540.33
68_S75_G0.5540.33
128_L152_I0.5530.33
329_L342_L0.5530.33
188_D195_E0.5520.33
23_F354_W0.5520.33
245_K392_A0.5490.33
106_A242_V0.5490.33
12_F318_Y0.5490.33
252_G270_T0.5480.32
66_E380_H0.5470.32
86_Y375_P0.5470.32
149_G226_R0.5460.32
84_G370_G0.5450.32
207_N234_A0.5420.32
126_Q291_E0.5400.32
266_N272_K0.5400.32
61_L367_L0.5390.32
132_L136_A0.5390.32
150_T312_R0.5370.32
133_V165_K0.5370.32
156_L159_E0.5370.32
92_M383_T0.5370.32
105_I315_V0.5360.31
26_V355_T0.5360.31
305_F325_F0.5360.31
166_P189_K0.5340.31
297_I388_G0.5320.31
57_T86_Y0.5320.31
341_I370_G0.5310.31
110_V238_P0.5310.31
339_D371_P0.5290.31
289_M334_S0.5290.31
314_D376_G0.5280.31
169_Y173_D0.5280.31
269_I272_K0.5280.31
32_G36_E0.5280.31
286_I290_K0.5280.31
332_L342_L0.5270.31
35_A38_C0.5260.31
134_E398_S0.5260.31
114_W206_Y0.5250.31
250_K396_G0.5250.31
145_C151_V0.5220.30
218_G224_F0.5210.30
27_G354_W0.5190.30
158_E222_G0.5190.30
31_L344_L0.5180.30
20_A26_V0.5180.30
279_D327_R0.5170.30
62_A78_G0.5160.30
37_A51_L0.5150.30
142_L160_H0.5150.30
9_L346_A0.5150.30
116_Y206_Y0.5140.30
9_L56_L0.5130.30
231_H272_K0.5120.30
63_K81_E0.5110.29
194_C213_A0.5100.29
87_A176_F0.5100.29
273_V284_A0.5090.29
321_G336_L0.5090.29
5_F300_T0.5080.29
226_R312_R0.5080.29
166_P216_F0.5080.29
257_V273_V0.5080.29
136_A189_K0.5070.29
307_S313_R0.5070.29
78_G371_P0.5060.29
339_D342_L0.5050.29
85_A88_W0.5040.29
108_V388_G0.5040.29
5_F174_S0.5040.29
33_H38_C0.5030.29
23_F360_T0.5030.29
244_Q264_Y0.5020.29
324_L328_R0.5020.29
3_R289_M0.5010.29
282_F324_L0.5010.29
90_H404_K0.5000.29
7_M342_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m7vA 1 0.9386 100 0.366 Contact Map
3ot9A 1 0.9435 100 0.368 Contact Map
3kd8A 1 0.7961 100 0.79 Contact Map
2zktA 3 0.8084 100 0.841 Contact Map
1zedA 2 0.8329 99.9 0.849 Contact Map
2x98A 4 0.7936 99.9 0.863 Contact Map
1k7hA 2 0.8206 99.9 0.864 Contact Map
1o98A 1 0.9484 99.9 0.865 Contact Map
3igzB 1 0.9607 99.9 0.871 Contact Map
3a52A 2 0.7469 99.9 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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