GREMLIN Database
DEF - Peptide deformylase
UniProt: P0A6K3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11440
Length: 169 (153)
Sequences: 5991 (3717)
Seq/√Len: 300.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_R139_V3.7181.00
111_A119_F2.9441.00
110_R118_P2.5831.00
59_I135_M2.5541.00
36_F70_R2.4781.00
113_D117_K2.4631.00
77_E110_R2.3261.00
108_K120_E2.2521.00
15_R145_D2.2451.00
110_R120_E2.2141.00
87_I129_I1.9801.00
123_A131_I1.9651.00
50_T55_H1.9241.00
32_V72_V1.8831.00
112_L118_P1.8651.00
33_D114_R1.8251.00
40_Y62_D1.8181.00
24_V28_I1.7911.00
7_L13_R1.7601.00
104_A132_Q1.7331.00
79_L110_R1.7111.00
106_K122_E1.7101.00
86_G102_P1.6761.00
18_A50_T1.6711.00
18_A55_H1.6371.00
7_L11_D1.6261.00
108_K122_E1.6131.00
72_V114_R1.6111.00
32_V114_R1.6091.00
45_I126_L1.5571.00
81_K104_A1.5561.00
113_D119_F1.5361.00
88_E100_L1.5271.00
106_K124_D1.5201.00
6_V42_E1.5101.00
7_L53_D1.4911.00
40_Y70_R1.4531.00
31_I54_I1.4431.00
80_E108_K1.4421.00
86_G100_L1.4391.00
63_V130_C1.4311.00
82_S106_K1.4251.00
29_Q115_D1.3961.00
59_I73_L1.3951.00
8_H95_P1.3941.00
123_A127_L1.3801.00
17_V20_P1.3791.00
135_M139_V1.3701.00
4_L34_D1.3631.00
4_L52_V1.3521.00
30_R34_D1.3321.00
24_V112_L1.3311.00
32_V58_I1.3301.00
105_E125_G1.3291.00
20_P57_R1.3251.00
29_Q114_R1.3001.00
73_L111_A1.2501.00
16_K55_H1.2451.00
71_L121_L1.2421.00
31_I52_V1.2401.00
31_I58_I1.2151.00
36_F72_V1.1911.00
20_P77_E1.1851.00
99_A143_F1.1851.00
73_L131_I1.1851.00
32_V36_F1.1711.00
26_A29_Q1.1681.00
121_L131_I1.1641.00
32_V74_I1.1521.00
62_D70_R1.1401.00
141_K146_Y1.1311.00
25_N28_I1.1291.00
19_K55_H1.1161.00
17_V139_V1.1131.00
94_I142_L1.1081.00
85_T104_A1.0971.00
36_F40_Y1.0891.00
13_R55_H1.0841.00
27_E56_Q1.0801.00
34_D38_T1.0601.00
149_P153_Q1.0251.00
58_I74_I1.0101.00
79_L108_K0.9751.00
36_F60_V0.9601.00
3_V38_T0.9551.00
73_L119_F0.9541.00
85_T102_P0.9531.00
9_I94_I0.9511.00
85_T105_E0.9491.00
111_A121_L0.9471.00
102_P148_S0.9471.00
45_I130_C0.9341.00
126_L130_C0.9261.00
61_I71_L0.9201.00
13_R53_D0.9121.00
80_E83_G0.8941.00
21_V58_I0.8941.00
136_D146_Y0.8911.00
38_T52_V0.8901.00
79_L120_E0.8831.00
64_S67_R0.8801.00
127_L131_I0.8741.00
76_P138_L0.8631.00
9_I144_M0.8601.00
98_R143_F0.8541.00
78_L81_K0.8511.00
148_S151_K0.8501.00
97_Q155_I0.8431.00
141_K145_D0.8411.00
22_E75_N0.8401.00
61_I130_C0.8391.00
109_I121_L0.8391.00
151_K154_R0.8381.00
71_L127_L0.8341.00
24_V29_Q0.8151.00
18_A57_R0.8121.00
112_L116_G0.8091.00
11_D53_D0.8081.00
9_I142_L0.8061.00
78_L135_M0.8011.00
136_D141_K0.7971.00
19_K22_E0.7850.99
131_I135_M0.7770.99
64_S68_D0.7730.99
4_L54_I0.7700.99
28_I58_I0.7670.99
33_D37_E0.7620.99
73_L109_I0.7620.99
109_I131_I0.7620.99
107_V123_A0.7610.99
66_N69_E0.7550.99
3_V34_D0.7510.99
90_G98_R0.7500.99
63_V126_L0.7500.99
101_V143_F0.7390.99
4_L30_R0.7390.99
45_I63_V0.7390.99
17_V57_R0.7390.99
105_E124_D0.7380.99
109_I123_A0.7350.99
97_Q143_F0.7280.99
73_L121_L0.7220.99
84_E102_P0.7220.99
88_E98_R0.7220.99
28_I56_Q0.7200.99
16_K19_K0.7170.99
39_M46_G0.7170.99
3_V41_A0.7130.99
91_C137_H0.7090.99
63_V127_L0.7090.99
121_L127_L0.7050.99
3_V37_E0.7010.99
99_A154_R0.7010.99
47_L60_V0.6880.99
44_G92_L0.6850.99
99_A147_L0.6790.98
61_I131_I0.6770.98
39_M44_G0.6740.98
94_I144_M0.6740.98
57_R77_E0.6730.98
59_I131_I0.6700.98
5_Q8_H0.6690.98
24_V116_G0.6640.98
9_I15_R0.6620.98
32_V60_V0.6590.98
19_K56_Q0.6570.98
84_E105_E0.6560.98
78_L107_V0.6560.98
26_A30_R0.6530.98
34_D37_E0.6530.98
51_Q137_H0.6480.98
31_I35_M0.6330.98
59_I111_A0.6300.98
28_I31_I0.6280.97
29_Q32_V0.6270.97
39_M42_E0.6220.97
39_M60_V0.6200.97
30_R33_D0.6120.97
117_K120_E0.6090.97
85_T129_I0.6070.97
49_A58_I0.6050.97
147_L150_L0.6000.97
23_E26_A0.5980.97
24_V74_I0.5970.97
78_L104_A0.5950.96
64_S69_E0.5910.96
4_L38_T0.5900.96
74_I112_L0.5890.96
107_V131_I0.5860.96
48_A91_C0.5850.96
51_Q91_C0.5830.96
39_M62_D0.5830.96
148_S152_Q0.5820.96
78_L132_Q0.5800.96
65_E68_D0.5800.96
9_I97_Q0.5730.96
36_F39_M0.5590.95
61_I127_L0.5520.95
80_E106_K0.5460.94
80_E104_A0.5460.94
82_S85_T0.5460.94
35_M58_I0.5440.94
35_M47_L0.5420.94
38_T41_A0.5400.94
111_A123_A0.5390.94
150_L154_R0.5390.94
12_E16_K0.5380.94
17_V141_K0.5380.94
143_F147_L0.5320.94
87_I126_L0.5270.93
48_A137_H0.5240.93
144_M155_I0.5240.93
27_E30_R0.5240.93
147_L155_I0.5230.93
79_L82_S0.5230.93
137_H142_L0.5220.93
49_A54_I0.5190.93
43_E98_R0.5080.92
31_I34_D0.5080.92
33_D72_V0.5070.92
91_C134_E0.5060.92
39_M45_I0.5050.92
61_I111_A0.5050.92
87_I100_L0.5050.92
60_V72_V0.5040.92
109_I135_M0.5030.92
82_S108_K0.5030.92
89_E129_I0.5020.92
48_A92_L0.5010.91
79_L118_P0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u04A 2 0.9763 100 0.023 Contact Map
1n5nA 1 0.9763 100 0.039 Contact Map
3qu1A 2 0.9882 100 0.042 Contact Map
1xeoA 1 0.9763 100 0.042 Contact Map
2w3tA 1 0.9882 100 0.043 Contact Map
1rl4A 1 0.9172 100 0.044 Contact Map
4e9aA 1 0.9349 100 0.048 Contact Map
3e3uA 1 0.9941 100 0.053 Contact Map
3pn3A 2 0.9822 100 0.053 Contact Map
1v3yA 1 0.9704 100 0.058 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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