GREMLIN Database
DAPF - Diaminopimelate epimerase
UniProt: P0A6K1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10209
Length: 274 (258)
Sequences: 3883 (2699)
Seq/√Len: 168.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_H241_E3.5971.00
46_L76_G3.1711.00
117_N257_P3.0781.00
94_D107_T3.0551.00
199_R235_A3.0271.00
71_A187_E2.9301.00
61_R69_E2.8801.00
198_K201_H2.7641.00
241_E246_R2.7351.00
237_E250_A2.5851.00
225_V238_V2.5741.00
171_A174_T2.3761.00
82_R86_L2.2801.00
3_F270_G2.2571.00
239_R246_R2.2451.00
226_A258_L2.2411.00
194_M224_A2.1661.00
228_G234_L2.1101.00
2_Q271_F2.1071.00
195_Q203_R2.1031.00
38_L215_Q2.0771.00
59_H98_S2.0411.00
249_I260_M2.0061.00
12_D36_R1.9861.00
179_L191_I1.9791.00
124_E127_A1.8411.00
266_H269_D1.8391.00
237_E248_D1.8271.00
96_R105_V1.8261.00
201_H239_R1.8061.00
18_A49_E1.7811.00
163_Q228_G1.7731.00
115_R259_Y1.7651.00
33_L272_I1.7081.00
225_V240_V1.7071.00
107_T115_R1.6991.00
7_H265_V1.6921.00
120_E256_H1.6861.00
51_P98_S1.6811.00
150_C160_C1.6651.00
34_A42_F1.6641.00
9_L216_A1.6631.00
122_N127_A1.6631.00
203_R241_E1.6571.00
151_G227_V1.6461.00
202_I224_A1.6351.00
115_R261_T1.6321.00
180_E188_R1.5721.00
194_M202_I1.5711.00
56_L103_R1.5701.00
202_I240_V1.5671.00
2_Q269_D1.5661.00
181_S188_R1.5521.00
166_D169_T1.5481.00
16_V45_L1.5291.00
192_G220_G1.5201.00
87_K269_D1.5091.00
58_F84_V1.4791.00
49_E59_H1.4631.00
142_R145_E1.4541.00
239_R248_D1.4511.00
140_I147_T1.4491.00
205_R213_E1.4411.00
94_D105_V1.4281.00
197_V203_R1.4231.00
77_A97_V1.4201.00
69_E100_A1.3981.00
155_M258_L1.3741.00
115_R250_A1.3671.00
25_F30_I1.3661.00
163_Q194_M1.3631.00
144_A178_V1.3471.00
42_F45_L1.3441.00
192_G206_V1.3421.00
48_V80_F1.3401.00
8_G79_C1.3201.00
166_D195_Q1.3061.00
123_F230_Q1.3061.00
202_I228_G1.3021.00
57_D92_K1.2951.00
17_D20_T1.2951.00
80_F97_V1.2761.00
49_E61_R1.2671.00
109_T115_R1.2451.00
118_M222_C1.2451.00
51_P55_E1.2451.00
204_L221_A1.2421.00
163_Q233_L1.2321.00
120_E257_P1.2241.00
148_I175_L1.2221.00
162_I191_I1.2181.00
96_R103_R1.2101.00
4_S269_D1.1921.00
85_R93_R1.1911.00
204_L224_A1.1891.00
7_H38_L1.1861.00
71_A101_N1.1851.00
229_I236_E1.1811.00
168_D203_R1.1771.00
197_V201_H1.1711.00
213_E243_P1.1701.00
72_Q219_S1.1541.00
35_D39_G1.1511.00
224_A240_V1.1491.00
192_G204_L1.1431.00
250_A261_T1.1381.00
140_I149_L1.1171.00
73_C217_C1.1081.00
25_F29_L1.1081.00
14_M33_L1.1071.00
40_V268_Y1.1041.00
30_I45_L1.1001.00
225_V229_I1.1001.00
55_E98_S1.0951.00
236_E253_G1.0921.00
19_V50_P1.0831.00
86_L266_H1.0811.00
181_S207_Y1.0801.00
65_A211_A1.0731.00
10_G215_Q1.0721.00
226_A251_W1.0701.00
216_A242_L1.0691.00
200_E235_A1.0681.00
109_T113_L1.0681.00
151_G231_Q1.0590.99
58_F90_T1.0560.99
252_K257_P1.0530.99
85_R108_V1.0520.99
167_V195_Q1.0500.99
56_L98_S1.0490.99
48_V84_V1.0490.99
97_V106_L1.0430.99
82_R264_A1.0380.99
63_F69_E1.0380.99
10_G38_L1.0370.99
81_A106_L1.0370.99
35_D38_L1.0340.99
158_P209_R1.0270.99
9_L242_L1.0240.99
142_R147_T1.0240.99
229_I251_W1.0230.99
14_M42_F1.0220.99
99_T102_G1.0160.99
153_V227_V1.0140.99
172_V193_F1.0130.99
26_S29_L1.0040.99
51_P56_L1.0030.99
87_K266_H1.0020.99
27_P31_R0.9980.99
222_C258_L0.9950.99
14_M268_Y0.9910.99
152_V160_C0.9900.99
113_L261_T0.9880.99
14_M40_V0.9870.99
121_P251_W0.9810.99
48_V83_F0.9810.99
90_T95_I0.9790.99
203_R243_P0.9780.99
108_V114_V0.9690.99
160_C189_A0.9680.99
4_S266_H0.9590.99
36_R41_G0.9560.99
15_V46_L0.9530.99
143_A146_Q0.9480.99
71_A100_A0.9450.99
37_H215_Q0.9310.99
173_E177_P0.9220.99
33_L42_F0.9200.99
106_L114_V0.9190.99
252_K259_Y0.9160.98
221_A242_L0.9090.98
12_D41_G0.9040.98
18_A47_V0.9020.98
47_V63_F0.8900.98
28_E31_R0.8820.98
177_P207_Y0.8810.98
123_F226_A0.8770.98
122_N154_S0.8720.98
225_V249_I0.8670.98
113_L248_D0.8610.98
77_A106_L0.8610.98
13_F42_F0.8580.98
34_A44_Q0.8580.98
200_E237_E0.8560.98
217_C220_G0.8550.98
59_H100_A0.8510.98
40_V272_I0.8470.97
83_F87_K0.8430.97
143_A178_V0.8420.97
81_A95_I0.8390.97
180_E207_Y0.8320.97
179_L189_A0.8280.97
234_L238_V0.8220.97
80_F84_V0.8220.97
163_Q227_V0.8170.97
225_V234_L0.8160.97
155_M222_C0.8130.97
62_I70_V0.8120.97
168_D243_P0.8100.97
196_V202_I0.8070.97
192_G224_A0.8070.97
117_N259_Y0.8060.97
141_M182_H0.8050.97
58_F89_L0.8000.96
150_C162_I0.7970.96
30_I63_F0.7930.96
72_Q104_M0.7910.96
20_T50_P0.7870.96
176_G180_E0.7860.96
157_N192_G0.7820.96
121_P155_M0.7720.96
202_I234_L0.7670.95
16_V33_L0.7610.95
101_N104_M0.7550.95
93_R110_D0.7540.95
6_M79_C0.7530.95
19_V89_L0.7530.95
253_G256_H0.7520.95
141_M150_C0.7500.95
81_A108_V0.7480.95
4_S83_F0.7470.95
248_D261_T0.7460.95
98_S103_R0.7420.95
139_Y143_A0.7400.95
157_N206_V0.7400.95
13_F34_A0.7350.94
38_L244_G0.7350.94
76_G81_A0.7350.94
221_A247_L0.7310.94
206_V217_C0.7210.94
17_D89_L0.7190.94
106_L116_V0.7150.93
109_T261_T0.7140.93
172_V176_G0.7130.93
125_P139_Y0.7120.93
57_D96_R0.7120.93
95_I106_L0.7120.93
152_V189_A0.7110.93
27_P30_I0.7080.93
250_A259_Y0.7050.93
32_R272_I0.7050.93
8_G216_A0.7010.93
161_V227_V0.6990.93
148_I162_I0.6990.93
6_M266_H0.6980.93
71_A157_N0.6980.93
154_S157_N0.6960.93
194_M228_G0.6950.92
252_K256_H0.6930.92
13_F211_A0.6910.92
167_V205_R0.6890.92
60_Y72_Q0.6890.92
174_T178_V0.6880.92
29_L32_R0.6880.92
7_H267_V0.6880.92
77_A116_V0.6870.92
9_L221_A0.6870.92
51_P57_D0.6840.92
6_M15_V0.6830.92
205_R243_P0.6810.92
160_C179_L0.6790.92
164_V170_A0.6770.91
236_E250_A0.6740.91
240_V249_I0.6740.91
28_E32_R0.6730.91
167_V203_R0.6720.91
25_F28_E0.6690.91
34_A65_A0.6660.91
164_V195_Q0.6630.91
207_Y211_A0.6590.90
160_C191_I0.6590.90
15_V34_A0.6530.90
14_M270_G0.6510.90
172_V213_E0.6510.90
66_D210_G0.6470.90
247_L260_M0.6450.89
46_L80_F0.6450.89
125_P128_V0.6410.89
26_S47_V0.6390.89
228_G233_L0.6340.89
229_I235_A0.6320.88
93_R107_T0.6310.88
71_A158_P0.6300.88
70_V211_A0.6270.88
173_E212_G0.6260.88
51_P54_P0.6260.88
128_V152_V0.6260.88
93_R108_V0.6230.88
201_H246_R0.6190.87
222_C249_I0.6180.87
90_T93_R0.6170.87
200_E239_R0.6120.87
194_M204_L0.6110.87
18_A23_V0.6090.87
48_V58_F0.6080.86
32_R265_V0.6070.86
121_P153_V0.6050.86
3_F268_Y0.6040.86
77_A80_F0.6030.86
162_I179_L0.6030.86
19_V87_K0.6020.86
200_E236_E0.6010.86
34_A46_L0.6000.86
155_M226_A0.5990.86
59_H69_E0.5980.86
142_R146_Q0.5950.85
51_P59_H0.5950.85
225_V251_W0.5930.85
4_S87_K0.5930.85
192_G217_C0.5920.85
105_V117_N0.5910.85
46_L62_I0.5910.85
253_G257_P0.5880.85
229_I238_V0.5860.84
64_N157_N0.5850.84
215_Q243_P0.5820.84
221_A240_V0.5820.84
44_Q70_V0.5820.84
118_M155_M0.5810.84
11_N43_D0.5780.84
8_G263_P0.5770.84
72_Q77_A0.5770.84
242_L247_L0.5760.83
167_V172_V0.5760.83
9_L263_P0.5740.83
33_L40_V0.5710.83
95_I108_V0.5680.83
60_Y97_V0.5680.83
30_I42_F0.5670.82
64_N209_R0.5640.82
172_V177_P0.5640.82
44_Q72_Q0.5640.82
161_V220_G0.5620.82
56_L96_R0.5590.82
29_L33_L0.5590.82
217_C221_A0.5560.81
85_R90_T0.5560.81
23_V47_V0.5540.81
196_V199_R0.5530.81
167_V170_A0.5530.81
150_C179_L0.5510.81
227_V231_Q0.5440.80
17_D21_Q0.5440.80
17_D87_K0.5440.80
99_T104_M0.5430.80
6_M44_Q0.5430.80
55_E96_R0.5430.80
177_P180_E0.5420.80
148_I179_L0.5420.80
192_G213_E0.5410.79
76_G80_F0.5410.79
214_T217_C0.5400.79
11_N75_N0.5400.79
62_I69_E0.5380.79
8_G78_R0.5360.79
160_C185_F0.5350.79
196_V233_L0.5340.79
36_R39_G0.5330.78
148_I191_I0.5300.78
16_V25_F0.5300.78
222_C260_M0.5270.78
35_D41_G0.5220.77
46_L60_Y0.5220.77
76_G83_F0.5220.77
97_V104_M0.5210.77
165_D195_Q0.5210.77
153_V161_V0.5210.77
191_I207_Y0.5200.77
177_P181_S0.5200.77
17_D83_F0.5190.77
14_M39_G0.5160.76
196_V232_G0.5160.76
9_L260_M0.5160.76
170_A174_T0.5130.76
170_A175_L0.5120.76
18_A21_Q0.5090.75
118_M260_M0.5090.75
146_Q174_T0.5090.75
12_D268_Y0.5070.75
72_Q217_C0.5060.75
75_N208_E0.5060.75
143_A148_I0.5060.75
84_V89_L0.5050.75
185_F189_A0.5030.74
146_Q175_L0.5020.74
64_N190_N0.5020.74
213_E224_A0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2otnA 2 0.9891 100 0.299 Contact Map
2gkeA 1 1 100 0.303 Contact Map
3fveA 2 0.927 100 0.305 Contact Map
3ejxA 5 0.9964 100 0.311 Contact Map
3ednA 2 0.9562 100 0.433 Contact Map
1ym5A 2 0.9599 100 0.459 Contact Map
3g7kA 3 0.9927 100 0.477 Contact Map
1xubA 2 0.938 100 0.478 Contact Map
1u0kA 2 0.9343 100 0.479 Contact Map
1qyaA 2 0.9489 100 0.482 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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