GREMLIN Database
DDLA - D-alanine--D-alanine ligase A
UniProt: P0A6J8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10213
Length: 364 (283)
Sequences: 14683 (7271)
Seq/√Len: 432.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_S201_E3.7401.00
200_S203_Q3.3931.00
118_G136_A3.2481.00
284_A288_Q3.2141.00
157_P222_Q3.1101.00
172_A205_A3.0901.00
148_L289_A3.0201.00
118_G122_V2.9021.00
275_A278_I2.8801.00
180_L201_E2.6881.00
150_D292_T2.6731.00
92_N96_L2.4741.00
199_T225_K2.4511.00
237_D296_A2.4261.00
276_P280_D2.3511.00
61_A77_A2.3381.00
285_I311_V2.3181.00
278_I281_K2.2271.00
306_T310_E2.1331.00
174_V177_K2.0981.00
280_D284_A2.0961.00
197_K223_G2.0611.00
287_V291_Q2.0521.00
212_F216_H1.9871.00
154_N310_E1.9831.00
231_C282_I1.9631.00
275_A309_N1.9631.00
172_A201_E1.9521.00
119_M123_A1.9271.00
131_D134_A1.9111.00
163_R166_R1.8961.00
120_L125_L1.8481.00
146_R150_D1.8481.00
137_A147_L1.8361.00
199_T203_Q1.8321.00
143_V146_R1.8261.00
278_I305_L1.7761.00
131_D296_A1.7711.00
201_E205_A1.7561.00
159_I177_K1.7481.00
235_G241_A1.7421.00
154_N285_I1.7351.00
136_A143_V1.6971.00
173_E177_K1.6651.00
225_K307_P1.6641.00
89_D92_N1.6381.00
137_A143_V1.6081.00
148_L313_I1.6031.00
233_V290_Y1.6011.00
159_I174_V1.5911.00
95_P123_A1.5881.00
76_L93_G1.5691.00
281_K284_A1.5681.00
341_D345_R1.5671.00
338_G341_D1.5591.00
142_D146_R1.5441.00
121_R132_V1.5331.00
133_L137_A1.5321.00
205_A209_D1.5321.00
138_C316_I1.5031.00
270_V332_W1.4731.00
149_R155_I1.4621.00
172_A176_S1.4521.00
281_K310_E1.4501.00
278_I309_N1.4481.00
187_A217_K1.4451.00
118_G132_V1.4441.00
320_P339_Y1.4411.00
206_I210_L1.4371.00
234_L346_L1.4361.00
288_Q291_Q1.4331.00
175_E180_L1.4321.00
234_L298_M1.4321.00
234_L342_L1.4201.00
54_A74_T1.4161.00
233_V286_A1.4121.00
94_Q125_L1.4081.00
58_L78_Q1.4021.00
344_T348_E1.4001.00
280_D283_R1.3991.00
188_N215_D1.3931.00
241_A287_V1.3901.00
243_T283_R1.3891.00
174_V178_L1.3881.00
210_L213_E1.3851.00
76_L97_P1.3781.00
120_L127_F1.3771.00
231_C283_R1.3561.00
89_D93_G1.3551.00
57_Y68_A1.3481.00
239_P291_Q1.3341.00
91_Q95_P1.3301.00
82_K85_H1.3281.00
171_F204_Y1.2951.00
276_P279_N1.2901.00
147_L292_T1.2861.00
198_V207_A1.2841.00
157_P177_K1.2791.00
102_I120_L1.2771.00
226_G307_P1.2601.00
138_C293_L1.2411.00
182_L220_V1.2391.00
149_R157_P1.2381.00
229_I305_L1.2351.00
144_T148_L1.2341.00
337_L342_L1.2341.00
281_K285_I1.2321.00
298_M319_L1.2241.00
121_R127_F1.2161.00
208_V218_V1.2001.00
128_V344_T1.1971.00
126_P237_D1.1961.00
145_K155_I1.1891.00
196_S210_L1.1851.00
77_A81_G1.1741.00
342_L345_R1.1691.00
94_Q102_I1.1691.00
121_R131_D1.1651.00
277_E281_K1.1491.00
183_F197_K1.1321.00
208_V212_F1.1271.00
279_N283_R1.1251.00
246_E272_A1.1131.00
231_C286_A1.1101.00
146_R149_R1.1051.00
147_L150_D1.1041.00
142_D187_A1.1021.00
274_I278_I1.0881.00
305_L311_V1.0781.00
305_L309_N1.0681.00
79_V86_Q1.0661.00
285_I288_Q1.0601.00
175_E182_L1.0561.00
142_D160_T1.0521.00
173_E176_S1.0511.00
135_S318_T1.0461.00
240_Q291_Q1.0411.00
118_G121_R1.0401.00
212_F218_V1.0371.00
119_M122_V1.0341.00
50_H341_D1.0331.00
153_L313_I1.0291.00
286_A303_V1.0271.00
118_G133_L1.0231.00
184_V204_Y1.0231.00
227_R246_E1.0171.00
180_L204_Y0.9921.00
133_L143_V0.9891.00
134_A294_G0.9861.00
80_P85_H0.9841.00
164_A209_D0.9831.00
59_L64_P0.9781.00
229_I282_I0.9761.00
164_A208_V0.9761.00
93_G97_P0.9681.00
92_N95_P0.9651.00
81_G86_Q0.9641.00
143_V147_L0.9591.00
184_V218_V0.9561.00
145_K221_E0.9551.00
254_Y258_T0.9521.00
282_I311_V0.9511.00
269_V273_A0.9481.00
209_D213_E0.9441.00
114_G136_A0.9421.00
175_E201_E0.9401.00
277_E309_N0.9381.00
101_V128_V0.9381.00
246_E279_N0.9371.00
289_A313_I0.9321.00
225_K308_E0.9311.00
140_D217_K0.9281.00
244_C279_N0.9221.00
171_F208_V0.9211.00
222_Q310_E0.9091.00
235_G291_Q0.9081.00
134_A296_A0.9031.00
162_T217_K0.9021.00
153_L285_I0.9011.00
222_Q312_V0.9001.00
126_P296_A0.8991.00
161_L171_F0.8991.00
184_V198_V0.8991.00
82_K86_Q0.8951.00
162_T166_R0.8931.00
281_K311_V0.8931.00
102_I125_L0.8891.00
161_L164_A0.8821.00
284_A287_V0.8821.00
151_A292_T0.8811.00
285_I303_V0.8781.00
138_C318_T0.8671.00
145_K219_I0.8611.00
94_Q120_L0.8601.00
140_D187_A0.8581.00
91_Q123_A0.8551.00
59_L75_S0.8551.00
184_V207_A0.8491.00
154_N281_K0.8461.00
283_R287_V0.8461.00
206_I209_D0.8401.00
160_T217_K0.8381.00
183_F223_G0.8321.00
211_A218_V0.8321.00
67_I71_P0.8281.00
164_A205_A0.8251.00
290_Y293_L0.8201.00
121_R133_L0.8201.00
222_Q306_T0.8191.00
288_Q292_T0.8171.00
301_V316_I0.8171.00
115_S136_A0.8121.00
243_T287_V0.8101.00
248_V272_A0.8061.00
242_S245_G0.8061.00
184_V220_V0.7921.00
243_T335_S0.7901.00
142_D219_I0.7891.00
293_L316_I0.7881.00
204_Y208_V0.7851.00
304_F314_N0.7791.00
133_L136_A0.7731.00
121_R296_A0.7711.00
182_L198_V0.7681.00
72_S75_S0.7661.00
100_D126_P0.7631.00
106_V116_L0.7601.00
156_A224_I0.7571.00
142_D217_K0.7571.00
131_D294_G0.7561.00
231_C246_E0.7521.00
180_L200_S0.7511.00
80_P86_Q0.7511.00
178_L182_L0.7421.00
345_R348_E0.7411.00
152_G288_Q0.7381.00
240_Q345_R0.7371.00
176_S180_L0.7331.00
172_A175_E0.7321.00
179_G222_Q0.7311.00
165_N173_E0.7291.00
203_Q206_I0.7291.00
69_L75_S0.7291.00
195_V257_D0.7241.00
161_L208_V0.7211.00
61_A81_G0.7201.00
164_A172_A0.7191.00
183_F195_V0.7171.00
253_F260_Y0.7121.00
134_A137_A0.7111.00
140_D143_V0.7081.00
295_C299_A0.7061.00
160_T163_R0.7041.00
229_I274_I0.6991.00
145_K149_R0.6961.00
154_N312_V0.6951.00
94_Q99_V0.6931.00
54_A73_A0.6921.00
239_P287_V0.6911.00
286_A290_Y0.6911.00
156_A312_V0.6911.00
275_A305_L0.6891.00
307_P310_E0.6881.00
224_I304_F0.6841.00
117_Q132_V0.6831.00
196_S207_A0.6821.00
290_Y301_V0.6801.00
227_R273_A0.6771.00
104_P128_V0.6731.00
148_L151_A0.6721.00
234_L339_Y0.6701.00
289_A292_T0.6691.00
203_Q207_A0.6691.00
202_E206_I0.6661.00
235_G349_L0.6661.00
281_K288_Q0.6641.00
245_G332_W0.6631.00
171_F220_V0.6621.00
120_L123_A0.6611.00
99_V102_I0.6570.99
340_T344_T0.6530.99
277_E280_D0.6520.99
284_A291_Q0.6510.99
236_N349_L0.6510.99
339_Y343_I0.6500.99
157_P312_V0.6500.99
290_Y299_A0.6490.99
174_V220_V0.6460.99
145_K158_F0.6460.99
345_R349_L0.6450.99
233_V301_V0.6450.99
243_T279_N0.6440.99
280_D287_V0.6440.99
100_D348_E0.6420.99
175_E204_Y0.6420.99
60_N63_D0.6410.99
270_V328_Y0.6400.99
147_L293_L0.6390.99
58_L90_A0.6390.99
148_L153_L0.6380.99
59_L69_L0.6380.99
115_S119_M0.6380.99
62_D345_R0.6350.99
132_V136_A0.6310.99
62_D81_G0.6300.99
61_A80_P0.6300.99
165_N205_A0.6280.99
225_K306_T0.6270.99
131_D237_D0.6250.99
114_G117_Q0.6250.99
91_Q125_L0.6240.99
51_V55_S0.6230.99
52_S56_N0.6210.99
141_K185_K0.6200.99
137_A150_D0.6200.99
285_I289_A0.6170.99
117_Q121_R0.6170.99
171_F175_E0.6160.99
113_D139_M0.6150.99
207_A211_A0.6150.99
59_L62_D0.6140.99
230_E254_Y0.6130.99
106_V111_G0.6130.99
73_A77_A0.6130.99
289_A293_L0.6120.99
94_Q97_P0.6110.99
127_F132_V0.6090.99
325_I330_K0.6080.99
116_L120_L0.6070.99
51_V56_N0.6060.99
161_L166_R0.6060.99
197_K225_K0.6050.99
91_Q119_M0.6050.99
63_D66_H0.6040.99
138_C289_A0.6020.99
83_H86_Q0.6020.99
61_A64_P0.6020.99
194_G211_A0.6000.99
235_G290_Y0.5970.99
166_R212_F0.5960.99
248_V269_V0.5950.99
240_Q332_W0.5940.99
162_T212_F0.5940.99
59_L63_D0.5940.99
57_Y72_S0.5930.99
153_L288_Q0.5930.99
147_L151_A0.5920.99
187_A219_I0.5910.99
204_Y220_V0.5900.99
166_R173_E0.5880.99
161_L165_N0.5870.99
224_I312_V0.5870.99
184_V208_V0.5840.99
233_V299_A0.5830.99
235_G296_A0.5780.99
93_G96_L0.5770.99
53_D348_E0.5750.99
297_G343_I0.5740.99
193_V256_Y0.5730.99
207_A210_L0.5730.99
164_A212_F0.5680.99
247_I254_Y0.5680.99
52_S58_L0.5680.99
130_S295_C0.5670.99
299_A316_I0.5650.98
229_I244_C0.5640.98
289_A301_V0.5640.98
146_R151_A0.5640.98
80_P83_H0.5620.98
117_Q135_S0.5610.98
164_A171_F0.5580.98
112_E190_G0.5580.98
156_A222_Q0.5580.98
196_S206_I0.5550.98
58_L68_A0.5550.98
67_I70_R0.5540.98
175_E179_G0.5520.98
161_L174_V0.5510.98
90_A93_G0.5480.98
182_L222_Q0.5470.98
229_I272_A0.5470.98
188_N216_H0.5460.98
59_L66_H0.5440.98
255_A258_T0.5440.98
103_F343_I0.5390.98
198_V204_Y0.5380.98
204_Y207_A0.5370.98
103_F128_V0.5370.98
60_N86_Q0.5370.98
142_D314_N0.5360.98
100_D128_V0.5350.98
241_A290_Y0.5350.98
234_L328_Y0.5340.98
269_V272_A0.5330.98
164_A204_Y0.5330.98
226_G308_E0.5310.98
248_V273_A0.5300.98
98_T123_A0.5290.98
78_Q81_G0.5270.98
202_E205_A0.5260.98
244_C335_S0.5250.98
159_I164_A0.5240.98
83_H87_L0.5230.98
65_A84_E0.5230.98
135_S139_M0.5230.98
272_A279_N0.5230.98
344_T347_I0.5230.98
241_A291_Q0.5220.97
196_S211_A0.5190.97
109_T189_Q0.5170.97
161_L220_V0.5170.97
197_K257_D0.5130.97
209_D212_F0.5120.97
171_F174_V0.5110.97
95_P119_M0.5110.97
142_D145_K0.5090.97
286_A301_V0.5090.97
134_A138_C0.5050.97
275_A279_N0.5040.97
335_S338_G0.5040.97
114_G135_S0.5040.97
320_P340_T0.5040.97
272_A275_A0.5000.97
76_L84_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i12A 2 0.9945 100 0.242 Contact Map
3lwbA 2 0.8709 100 0.249 Contact Map
3e5nA 2 0.9341 100 0.25 Contact Map
2fb9A 2 0.8819 100 0.252 Contact Map
3tqtA 2 0.9505 100 0.253 Contact Map
1ehiA 2 0.9753 100 0.268 Contact Map
4fu0A 2 0.9341 100 0.272 Contact Map
1e4eA 4 0.9258 100 0.272 Contact Map
2i87A 2 0.9313 100 0.273 Contact Map
3k3pA 2 0.8681 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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