GREMLIN Database
DADA - D-amino acid dehydrogenase
UniProt: P0A6J5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11407
Length: 432 (392)
Sequences: 5758 (4596)
Seq/√Len: 232.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_A216_V5.0101.00
31_R223_P4.0661.00
4_V246_A4.0471.00
226_Q238_K3.8211.00
239_C242_E3.3721.00
228_L238_K3.3671.00
27_T219_R3.1051.00
208_A212_E3.0551.00
223_P240_G2.9831.00
168_E171_R2.9761.00
20_N216_V2.9231.00
29_I244_I2.8331.00
24_H399_S2.7061.00
228_L236_G2.7041.00
4_V29_I2.6641.00
35_A220_F2.4801.00
144_E148_E2.4771.00
8_S35_A2.4631.00
25_E217_K2.4611.00
4_V237_V2.4551.00
238_K243_V2.4091.00
228_L243_V2.3471.00
225_D240_G2.3101.00
202_L205_Q2.2861.00
22_A399_S2.2701.00
227_L234_I2.2381.00
3_V24_H2.1871.00
208_A218_F2.0831.00
4_V244_I2.0791.00
209_R212_E1.9801.00
222_T239_C1.9631.00
225_D238_K1.9501.00
35_A208_A1.9391.00
28_V218_F1.9371.00
236_G243_V1.9181.00
20_N211_A1.9101.00
391_G395_S1.8951.00
20_N214_A1.8741.00
18_Y391_G1.8701.00
376_N390_S1.8481.00
351_W354_L1.8161.00
311_G314_A1.8111.00
296_T299_I1.8001.00
15_S250_V1.7941.00
27_T217_K1.7801.00
297_Y302_T1.7791.00
211_A218_F1.7541.00
353_G356_P1.7501.00
301_I304_F1.7311.00
298_K302_T1.7301.00
43_N48_S1.7271.00
374_W398_L1.7271.00
21_Q125_E1.6811.00
275_Y281_I1.6801.00
6_L253_F1.6791.00
151_T158_E1.6441.00
172_L189_G1.6431.00
230_D235_Y1.6291.00
29_I219_R1.6091.00
309_R312_G1.6061.00
272_L276_S1.5981.00
336_R341_R1.5661.00
21_Q214_A1.5651.00
310_V313_M1.5631.00
29_I246_A1.5631.00
219_R244_I1.5581.00
226_Q263_G1.5321.00
277_L280_P1.5241.00
219_R222_T1.5101.00
154_I158_E1.5071.00
257_S377_T1.5061.00
272_L275_Y1.5031.00
396_D401_R1.5011.00
8_S28_V1.5011.00
275_Y282_A1.4991.00
297_Y300_A1.4991.00
287_A292_I1.4881.00
309_R314_A1.4861.00
232_E371_K1.4841.00
374_W394_L1.4771.00
107_R110_R1.4611.00
246_A249_Y1.4611.00
310_V314_A1.4561.00
325_Q329_E1.4351.00
260_M263_G1.4261.00
229_C370_F1.4231.00
77_V194_N1.4211.00
312_G316_I1.4211.00
320_N324_L1.4211.00
329_E333_M1.4201.00
295_E298_K1.4161.00
95_N100_H1.4141.00
239_C244_I1.4091.00
3_V248_A1.3951.00
273_K276_S1.3921.00
97_D100_H1.3841.00
297_Y301_I1.3801.00
201_Q205_Q1.3761.00
151_T154_I1.3751.00
305_D308_I1.3691.00
289_V292_I1.3681.00
308_I311_G1.3661.00
233_Q371_K1.3621.00
336_R343_G1.3611.00
287_A290_S1.3571.00
16_A28_V1.3411.00
71_R74_P1.3391.00
300_A303_R1.3351.00
308_I314_A1.3321.00
286_G289_V1.3301.00
210_M214_A1.3281.00
118_C121_A1.3211.00
308_I312_G1.3141.00
11_V252_A1.3101.00
165_Q171_R1.3101.00
296_T300_A1.3091.00
287_A291_T1.3041.00
309_R315_E1.3031.00
376_N394_L1.3021.00
392_Q396_D1.3021.00
310_V315_E1.2931.00
275_Y278_T1.2901.00
306_N309_R1.2881.00
236_G249_Y1.2831.00
311_G316_I1.2811.00
62_L73_A1.2801.00
79_L194_N1.2731.00
309_R313_M1.2671.00
22_A401_R1.2661.00
70_Q213_Q1.2601.00
163_P194_N1.2601.00
311_G315_E1.2511.00
312_G315_E1.2451.00
313_M316_I1.2421.00
296_T302_T1.2331.00
277_L282_A1.2291.00
17_W214_A1.2281.00
299_I302_T1.2271.00
305_D309_R1.2231.00
210_M213_Q1.2211.00
276_S282_A1.2211.00
208_A220_F1.2151.00
202_L206_N1.2091.00
333_M343_G1.2041.00
298_K301_I1.2021.00
212_E217_K1.1941.00
87_K91_Q1.1941.00
274_G279_I1.1931.00
271_P275_Y1.1901.00
230_D245_K1.1901.00
297_Y304_F1.1871.00
299_I304_F1.1871.00
275_Y279_I1.1861.00
209_R213_Q1.1841.00
19_L250_V1.1811.00
308_I313_M1.1791.00
250_V398_L1.1731.00
234_I249_Y1.1711.00
274_G277_L1.1691.00
307_R311_G1.1601.00
143_T146_Q1.1571.00
155_A158_E1.1541.00
100_H103_E1.1541.00
155_A159_D1.1531.00
305_D310_V1.1501.00
259_A262_K1.1501.00
310_V316_I1.1461.00
363_P366_G1.1441.00
158_E161_G1.1431.00
295_E299_I1.1421.00
18_Y22_A1.1411.00
225_D241_D1.1391.00
328_R349_T1.1371.00
261_L264_I1.1351.00
249_Y372_N1.1331.00
277_L281_I1.1321.00
18_Y392_Q1.1301.00
234_I372_N1.1161.00
312_G317_V1.1161.00
41_A201_Q1.1131.00
75_L213_Q1.1121.00
275_Y280_P1.1121.00
295_E301_I1.1031.00
15_S376_N1.1001.00
228_L235_Y1.0941.00
62_L72_H1.0641.00
70_Q75_L1.0591.00
273_K277_L1.0581.00
309_R316_I1.0541.00
206_N209_R1.0521.00
248_A374_W1.0521.00
306_N314_A1.0511.00
288_P291_T1.0501.00
296_T301_I1.0491.00
98_T102_M1.0471.00
276_S281_I1.0461.00
251_M257_S1.0411.00
108_M112_A1.0391.00
29_I237_V1.0341.00
227_L237_V1.0341.00
14_A388_C1.0311.00
248_A398_L1.0291.00
8_S30_D1.0221.00
169_S173_A1.0221.00
357_M363_P1.0211.00
20_N25_E1.0211.00
274_G281_I1.0201.00
96_C101_Y1.0191.00
306_N311_G1.0161.00
252_A376_N1.0161.00
297_Y303_R1.0161.00
258_T262_K1.0121.00
298_K304_F1.0021.00
251_M261_L1.0011.00
135_G139_Q0.9941.00
308_I316_I0.9901.00
296_T304_F0.9891.00
27_T247_D0.9871.00
286_G292_I0.9861.00
222_T241_D0.9821.00
101_Y104_N0.9791.00
306_N312_G0.9791.00
35_A218_F0.9771.00
103_E107_R0.9651.00
274_G278_T0.9631.00
275_Y283_Q0.9591.00
92_M95_N0.9481.00
319_F322_E0.9431.00
276_S280_P0.9381.00
97_D108_M0.9351.00
314_A317_V0.9311.00
153_D158_E0.9251.00
277_L283_Q0.9241.00
295_E300_A0.9221.00
151_T161_G0.9221.00
273_K278_T0.9201.00
171_R174_E0.9151.00
112_A115_S0.9141.00
270_Y275_Y0.9141.00
265_V375_L0.9131.00
288_P292_I0.9111.00
100_H104_N0.9101.00
299_I303_R0.9081.00
308_I317_V0.9041.00
13_V28_V0.9000.99
351_W356_P0.8980.99
309_R317_V0.8950.99
395_S399_S0.8950.99
121_A125_E0.8930.99
295_E302_T0.8920.99
102_M159_D0.8900.99
30_D220_F0.8890.99
342_G345_V0.8880.99
106_G110_R0.8860.99
102_M106_G0.8820.99
165_Q193_P0.8770.99
370_F373_L0.8730.99
313_M317_V0.8680.99
279_I282_A0.8670.99
101_Y105_K0.8670.99
225_D239_C0.8660.99
47_I347_Q0.8650.99
103_E106_G0.8650.99
229_C234_I0.8600.99
306_N310_V0.8590.99
341_R344_H0.8530.99
229_C232_E0.8500.99
360_D363_P0.8490.99
307_R313_M0.8490.99
361_G367_R0.8480.99
274_G282_A0.8420.99
352_T356_P0.8410.99
288_P293_L0.8400.99
88_W91_Q0.8390.99
151_T159_D0.8380.99
274_G280_P0.8380.99
17_W210_M0.8370.99
152_R155_A0.8330.99
358_T364_V0.8320.99
307_R314_A0.8310.99
334_V338_L0.8240.99
34_G37_L0.8230.99
153_D156_V0.8220.99
358_T361_G0.8210.99
280_P283_Q0.8210.99
13_V204_T0.8180.99
225_D228_L0.8170.99
272_L278_T0.8160.99
270_Y274_G0.8100.99
310_V317_V0.8090.99
276_S279_I0.8080.99
137_T141_F0.8080.99
300_A304_F0.8070.99
151_T155_A0.8060.99
28_V35_A0.8030.99
157_L161_G0.8020.99
341_R345_V0.8020.99
156_V161_G0.8010.99
112_A122_L0.8000.99
205_Q209_R0.7980.99
80_D83_Q0.7970.99
361_G366_G0.7970.99
29_I224_V0.7930.99
273_K281_I0.7910.99
145_Q148_E0.7910.99
115_S118_C0.7890.99
229_C235_Y0.7890.99
269_V272_L0.7890.99
298_K303_R0.7860.99
295_E303_R0.7860.99
116_R120_K0.7850.99
307_R315_E0.7800.99
24_H247_D0.7770.98
167_L171_R0.7770.98
132_G139_Q0.7750.98
261_L265_V0.7730.98
308_I315_E0.7720.98
290_S293_L0.7720.98
382_L385_T0.7700.98
13_V211_A0.7680.98
133_R136_G0.7670.98
29_I222_T0.7670.98
117_D121_A0.7660.98
153_D160_A0.7660.98
311_G317_V0.7650.98
233_Q236_G0.7640.98
271_P276_S0.7640.98
327_R331_L0.7620.98
272_L277_L0.7610.98
333_M336_R0.7600.98
271_P274_G0.7580.98
307_R310_V0.7550.98
97_D101_Y0.7540.98
305_D313_M0.7540.98
154_I157_L0.7530.98
151_T156_V0.7520.98
333_M337_D0.7500.98
165_Q191_Q0.7490.98
152_R161_G0.7480.98
135_G140_L0.7470.98
251_M373_L0.7460.98
334_V337_D0.7460.98
133_R137_T0.7460.98
34_G220_F0.7440.98
133_R139_Q0.7430.98
395_S398_L0.7420.98
70_Q73_A0.7410.98
379_H390_S0.7410.98
365_V369_R0.7380.98
5_I16_A0.7360.98
104_N108_M0.7360.98
306_N313_M0.7350.98
235_Y245_K0.7340.98
274_G283_Q0.7320.98
97_D104_N0.7250.98
17_W68_M0.7240.98
6_L251_M0.7230.98
32_E37_L0.7220.98
357_M361_G0.7210.98
291_T294_D0.7190.98
222_T244_I0.7190.98
95_N104_N0.7180.97
329_E343_G0.7170.97
319_F323_L0.7150.97
327_R330_T0.7140.97
272_L279_I0.7140.97
105_K120_K0.7130.97
62_L66_K0.7130.97
101_Y108_M0.7130.97
35_A205_Q0.7070.97
227_L249_Y0.7060.97
290_S294_D0.7060.97
228_L245_K0.7050.97
153_D157_L0.7020.97
278_T281_I0.6990.97
361_G365_V0.6970.97
6_L224_V0.6950.97
233_Q372_N0.6940.97
144_E147_Y0.6940.97
307_R312_G0.6930.97
272_L282_A0.6930.97
90_W94_R0.6920.97
362_T365_V0.6890.97
230_D233_Q0.6880.97
104_N107_R0.6870.97
108_M115_S0.6870.97
259_A263_G0.6840.97
14_A18_Y0.6830.97
126_T129_Q0.6800.97
359_P365_V0.6780.96
132_G136_G0.6780.96
153_D161_G0.6780.96
24_H27_T0.6770.96
10_V387_A0.6760.96
310_V335_V0.6740.96
120_K134_Q0.6730.96
358_T366_G0.6720.96
393_L396_D0.6720.96
82_T87_K0.6720.96
306_N315_E0.6700.96
136_G139_Q0.6690.96
286_G291_T0.6690.96
63_K392_Q0.6680.96
64_A67_W0.6680.96
145_Q149_N0.6600.96
146_Q296_T0.6590.96
147_Y166_L0.6590.96
137_T140_L0.6560.96
286_G290_S0.6550.96
24_H248_A0.6530.96
289_V293_L0.6520.96
365_V368_T0.6500.95
374_W401_R0.6490.95
233_Q245_K0.6480.95
343_G346_E0.6470.95
17_W207_L0.6430.95
296_T303_R0.6430.95
307_R316_I0.6420.95
332_E336_R0.6420.95
346_E349_T0.6420.95
154_I159_D0.6420.95
237_V249_Y0.6420.95
332_E346_E0.6420.95
305_D315_E0.6410.95
302_T305_D0.6410.95
272_L280_P0.6400.95
30_D34_G0.6400.95
95_N98_T0.6370.95
157_L160_A0.6360.95
295_E304_F0.6340.95
142_R146_Q0.6340.95
361_G368_T0.6340.95
151_T160_A0.6340.95
10_V207_L0.6330.95
146_Q149_N0.6330.95
11_V376_N0.6310.95
115_S119_L0.6290.95
305_D311_G0.6290.95
247_D372_N0.6280.95
158_E163_P0.6280.95
114_Y118_C0.6270.95
305_D312_G0.6260.94
269_V275_Y0.6250.94
376_N391_G0.6250.94
132_G137_T0.6240.94
305_D316_I0.6240.94
379_H382_L0.6220.94
232_E370_F0.6220.94
357_M368_T0.6210.94
132_G140_L0.6210.94
261_L373_L0.6200.94
108_M119_L0.6190.94
205_Q212_E0.6180.94
23_G26_V0.6170.94
335_V338_L0.6160.94
17_W211_A0.6160.94
92_M108_M0.6140.94
61_P65_I0.6130.94
355_R359_P0.6120.94
203_F384_W0.6090.94
320_N323_L0.6080.94
4_V27_T0.6080.94
60_V63_K0.6070.94
229_C236_G0.6070.94
239_C243_V0.6050.93
234_I373_L0.6030.93
305_D314_A0.6030.93
115_S122_L0.6030.93
269_V274_G0.6020.93
268_P271_P0.6010.93
344_H347_Q0.5980.93
136_G141_F0.5950.93
354_L357_M0.5940.93
304_F309_R0.5930.93
330_T333_M0.5930.93
78_R81_G0.5910.93
278_T282_A0.5910.93
363_P368_T0.5910.93
112_A116_R0.5890.93
108_M122_L0.5860.92
250_V394_L0.5850.92
63_K67_W0.5840.92
212_E220_F0.5840.92
98_T105_K0.5840.92
5_I250_V0.5840.92
126_T130_Y0.5840.92
167_L172_L0.5830.92
367_R372_N0.5820.92
293_L301_I0.5820.92
364_V367_R0.5810.92
272_L281_I0.5810.92
141_F147_Y0.5810.92
358_T365_V0.5810.92
328_R332_E0.5810.92
92_M100_H0.5800.92
31_R362_T0.5800.92
22_A395_S0.5780.92
266_D269_V0.5780.92
111_L114_Y0.5770.92
236_G245_K0.5760.92
222_T242_E0.5760.92
167_L175_V0.5750.92
173_A180_A0.5730.91
368_T375_L0.5720.91
176_E179_L0.5710.91
349_T354_L0.5690.91
128_I131_E0.5690.91
358_T363_P0.5680.91
120_K196_E0.5680.91
94_R97_D0.5680.91
287_A293_L0.5680.91
17_W21_Q0.5670.91
143_T148_E0.5670.91
350_F354_L0.5630.91
8_S220_F0.5630.91
387_A391_G0.5620.91
166_L169_S0.5620.91
46_Q49_P0.5620.91
360_D365_V0.5620.91
14_A391_G0.5610.91
267_I270_Y0.5610.91
109_V113_E0.5590.90
268_P274_G0.5590.90
143_T150_A0.5560.90
88_W276_S0.5550.90
266_D345_V0.5550.90
374_W397_L0.5530.90
111_L115_S0.5510.90
86_L96_C0.5510.90
16_A216_V0.5500.90
121_A124_A0.5500.90
91_Q94_R0.5490.90
225_D229_C0.5490.90
245_K249_Y0.5470.90
325_Q328_R0.5430.89
323_L326_P0.5400.89
156_V160_A0.5400.89
154_I161_G0.5390.89
111_L122_L0.5380.89
133_R141_F0.5370.89
113_E122_L0.5350.88
43_N46_Q0.5350.88
364_V368_T0.5340.88
92_M96_C0.5340.88
101_Y112_A0.5330.88
352_T355_R0.5330.88
276_S283_Q0.5320.88
268_P279_I0.5320.88
18_Y21_Q0.5320.88
32_E38_E0.5310.88
346_E353_G0.5310.88
114_Y117_D0.5300.88
302_T307_R0.5290.88
348_A356_P0.5260.88
113_E116_R0.5250.88
272_L357_M0.5250.88
342_G346_E0.5240.87
268_P275_Y0.5240.87
136_G140_L0.5240.87
348_A351_W0.5230.87
104_N112_A0.5220.87
4_V245_K0.5220.87
363_P367_R0.5210.87
169_S172_L0.5190.87
155_A160_A0.5190.87
4_V249_Y0.5190.87
269_V377_T0.5180.87
362_T366_G0.5170.87
151_T157_L0.5170.87
107_R112_A0.5140.86
37_L205_Q0.5130.86
135_G144_E0.5130.86
271_P277_L0.5110.86
44_A350_F0.5100.86
165_Q175_V0.5100.86
352_T360_D0.5090.86
19_L398_L0.5090.86
269_V280_P0.5060.86
130_Y133_R0.5060.86
31_R38_E0.5060.86
267_I345_V0.5050.85
46_Q50_G0.5040.85
226_Q229_C0.5020.85
9_G12_G0.5020.85
4_V224_V0.5010.85
117_D120_K0.5010.85
146_Q150_A0.5000.85
64_A68_M0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.831 100 0.404 Contact Map
1y56B 1 0.8403 100 0.428 Contact Map
3axbA 2 0.8449 100 0.428 Contact Map
2gagB 1 0.8657 100 0.43 Contact Map
3pvcA 1 0.8356 100 0.441 Contact Map
3ps9A 1 0.8333 100 0.442 Contact Map
4x9mA 1 0.838 100 0.444 Contact Map
1ryiA 4 0.8171 100 0.445 Contact Map
4rslA 1 0.8472 100 0.453 Contact Map
1pj5A 3 0.8634 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.