GREMLIN Database
CYSZ - Protein CysZ
UniProt: P0A6J3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10003
Length: 253 (230)
Sequences: 1250 (826)
Seq/√Len: 54.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_P197_E3.9301.00
19_G236_G3.8121.00
151_I155_I3.2991.00
148_P152_V3.1421.00
12_G211_Q3.1331.00
34_L38_V3.0711.00
115_L239_A3.0411.00
212_F236_G2.9921.00
27_G30_R2.9761.00
139_E142_K2.9261.00
222_I225_L2.7761.00
15_Y243_D2.5201.00
48_W52_T2.4571.00
150_A171_W2.3911.00
216_T233_A2.2841.00
18_Q243_D2.1931.00
14_Y18_Q2.1931.00
149_R174_F2.1621.00
188_F201_A2.0981.00
19_G232_V2.0861.00
41_L45_G2.0711.00
29_R33_I1.9971.00
26_P29_R1.9641.00
43_M91_F1.9361.00
152_V155_I1.9151.00
112_E191_H1.8900.99
140_W144_A1.8820.99
157_Y163_G1.7900.99
57_W60_T1.7750.99
23_V235_C1.7460.99
25_Q114_R1.7310.99
110_Q114_R1.7010.99
16_F233_A1.6950.99
100_A104_N1.6800.99
31_F107_L1.6640.99
163_G188_F1.6550.99
200_T204_T1.6470.99
66_P69_L1.6390.99
108_A190_N1.6260.98
138_R189_D1.6260.98
131_D135_I1.6060.98
169_V173_L1.6040.98
68_W86_L1.6010.98
16_F20_W1.6000.98
32_V35_P1.5800.98
176_A214_A1.5730.98
132_V135_I1.5690.98
39_N99_I1.5530.98
136_M196_K1.5280.98
197_E200_T1.5280.98
134_R189_D1.5270.98
29_R37_L1.5260.98
102_P231_P1.5160.98
211_Q215_L1.4630.97
47_F51_F1.4490.97
55_D59_P1.4480.97
44_G48_W1.4260.96
43_M95_I1.4190.96
154_L157_Y1.4180.96
74_Y78_P1.3790.96
41_L44_G1.3760.96
210_M214_A1.3650.95
19_G212_F1.3520.95
140_W148_P1.3480.95
214_A218_L1.3450.95
193_V201_A1.3380.95
17_A140_W1.3290.95
80_A84_V1.3020.94
182_Q185_D1.3000.94
22_L239_A1.2690.93
57_W161_G1.2540.93
77_W81_V1.2510.93
98_W140_W1.2440.93
219_F229_I1.2390.92
22_L115_L1.2350.92
27_G34_L1.2270.92
182_Q198_M1.2250.92
61_L169_V1.2200.92
205_R244_C1.2070.91
153_L174_F1.2060.91
35_P102_P1.1830.90
239_A243_D1.1810.90
101_A186_Y1.1750.90
138_R198_M1.1740.90
181_I198_M1.1710.90
201_A222_I1.1690.90
226_N241_W1.1660.90
101_A225_L1.1560.89
88_F94_T1.1300.88
208_T240_M1.1280.88
18_Q21_K1.1260.88
15_Y19_G1.1190.88
111_L235_C1.1140.88
45_G49_W1.1070.87
212_F216_T1.1040.87
158_F162_I1.1020.87
116_T242_V1.0880.86
16_F232_V1.0790.86
147_L170_L1.0780.86
177_W206_K1.0770.86
137_K141_Q1.0750.86
61_L228_F1.0650.85
32_V39_N1.0620.85
76_L141_Q1.0410.84
86_L89_G1.0380.84
70_Q73_S1.0370.84
15_Y239_A1.0250.83
207_I228_F1.0150.82
182_Q230_M1.0140.82
147_L200_T1.0110.82
36_L171_W1.0070.82
92_F97_N1.0050.82
110_Q113_A1.0030.82
49_W52_T0.9910.81
40_I44_G0.9820.80
113_A119_T0.9810.80
29_R39_N0.9800.80
18_Q25_Q0.9790.80
56_V60_T0.9710.79
18_Q188_F0.9660.79
148_P151_I0.9640.79
149_R169_V0.9510.78
157_Y168_P0.9360.77
84_V221_M0.9320.76
86_L96_A0.9310.76
103_F213_G0.9280.76
35_P92_F0.9270.76
146_Y150_A0.9270.76
32_V42_L0.9220.76
85_L170_L0.9180.75
21_K33_I0.9070.75
25_Q30_R0.8960.74
128_I162_I0.8940.73
19_G190_N0.8870.73
60_T64_Y0.8860.73
50_L84_V0.8850.73
116_T119_T0.8830.73
112_E190_N0.8820.72
120_P123_T0.8800.72
130_K221_M0.8780.72
74_Y163_G0.8770.72
99_I102_P0.8730.72
182_Q226_N0.8720.72
20_W215_L0.8690.71
35_P231_P0.8670.71
97_N183_Y0.8660.71
33_I37_L0.8660.71
138_R182_Q0.8630.71
43_M47_F0.8610.71
55_D80_A0.8600.71
142_K150_A0.8550.70
96_A187_P0.8510.70
108_A112_E0.8490.70
39_N142_K0.8460.69
38_V218_L0.8450.69
183_Y230_M0.8400.69
67_D219_F0.8390.69
36_L151_I0.8350.68
220_T229_I0.8350.68
179_L199_R0.8320.68
57_W79_L0.8310.68
41_L82_I0.8280.68
145_W177_W0.8280.68
47_F88_F0.8280.68
92_F226_N0.8270.67
62_M81_V0.8230.67
111_L114_R0.8220.67
50_L163_G0.8200.67
48_W83_S0.8190.67
40_I196_K0.8170.67
217_S220_T0.8140.66
94_T97_N0.8110.66
83_S86_L0.8050.65
136_M204_T0.8010.65
144_A196_K0.7990.65
213_G223_P0.7980.65
148_P198_M0.7980.65
108_A216_T0.7930.64
132_V152_V0.7920.64
163_G169_V0.7880.64
20_W232_V0.7880.64
35_P38_V0.7880.64
195_F199_R0.7840.63
13_F215_L0.7840.63
203_R206_K0.7840.63
104_N230_M0.7840.63
27_G235_C0.7780.63
56_V170_L0.7770.63
69_L72_L0.7750.62
199_R203_R0.7720.62
82_I85_L0.7670.62
70_Q90_Y0.7670.62
237_A240_M0.7660.62
28_I109_E0.7650.61
40_I90_Y0.7650.61
135_I224_L0.7650.61
57_W62_M0.7550.60
86_L114_R0.7550.60
169_V172_F0.7490.60
144_A148_P0.7470.60
153_L168_P0.7430.59
51_F55_D0.7400.59
11_S208_T0.7270.58
51_F54_L0.7260.57
41_L56_V0.7260.57
97_N104_N0.7240.57
139_E143_F0.7230.57
155_I171_W0.7230.57
206_K218_L0.7220.57
179_L182_Q0.7220.57
196_K211_Q0.7210.57
131_D134_R0.7210.57
131_D192_K0.7210.57
112_E117_G0.7160.56
116_T122_D0.7150.56
175_S217_S0.7130.56
13_F38_V0.7120.56
90_Y153_L0.7120.56
45_G48_W0.7110.56
100_A106_L0.7090.56
16_F54_L0.7090.56
183_Y226_N0.7090.56
99_I202_L0.7050.55
12_G230_M0.7030.55
56_V59_P0.6990.55
87_V99_I0.6990.55
160_P233_A0.6980.54
211_Q236_G0.6970.54
58_I64_Y0.6920.54
109_E134_R0.6830.53
36_L97_N0.6830.53
177_W190_N0.6830.53
22_L28_I0.6800.53
40_I220_T0.6760.52
18_Q45_G0.6750.52
91_F98_W0.6710.52
131_D224_L0.6710.52
109_E158_F0.6700.51
98_W234_V0.6670.51
188_F198_M0.6660.51
172_F217_S0.6650.51
30_R34_L0.6620.51
58_I76_L0.6610.50
31_F105_G0.6610.50
61_L215_L0.6600.50
39_N108_A0.6570.50
89_G219_F0.6560.50
137_K158_F0.6510.49
144_A224_L0.6500.49
113_A204_T0.6450.49
20_W25_Q0.6430.49
238_T242_V0.6370.48
26_P39_N0.6350.48
158_F161_G0.6340.48
70_Q85_L0.6260.47
34_L158_F0.6250.47
99_I103_F0.6230.46
50_L89_G0.6190.46
69_L139_E0.6170.46
193_V197_E0.6170.46
154_L161_G0.6170.46
156_L159_I0.6160.46
91_F222_I0.6160.46
169_V214_A0.6100.45
22_L25_Q0.6090.45
146_Y241_W0.6080.45
135_I139_E0.6030.44
189_D198_M0.5990.44
112_E246_R0.5960.44
93_S222_I0.5950.43
23_V225_L0.5950.43
96_A100_A0.5940.43
44_G49_W0.5930.43
207_I211_Q0.5900.43
52_T57_W0.5890.43
60_T63_S0.5880.43
23_V43_M0.5860.43
97_N198_M0.5840.42
113_A225_L0.5840.42
86_L228_F0.5810.42
151_I204_T0.5810.42
14_Y46_A0.5800.42
18_Q27_G0.5780.42
68_W233_A0.5770.42
231_P234_V0.5750.41
139_E146_Y0.5750.41
188_F241_W0.5700.41
61_L80_A0.5700.41
93_S230_M0.5680.41
13_F18_Q0.5680.41
26_P30_R0.5670.41
42_L48_W0.5670.41
186_Y190_N0.5650.40
175_S180_A0.5650.40
185_D189_D0.5650.40
206_K210_M0.5650.40
31_F35_P0.5640.40
119_T122_D0.5630.40
71_W239_A0.5630.40
239_A242_V0.5620.40
215_L240_M0.5620.40
145_W149_R0.5600.40
139_E231_P0.5560.39
17_A86_L0.5530.39
49_W65_V0.5530.39
76_L81_V0.5520.39
189_D197_E0.5510.39
47_F86_L0.5490.39
50_L54_L0.5480.39
42_L200_T0.5450.38
69_L75_L0.5430.38
12_G236_G0.5390.38
194_P204_T0.5360.37
53_Q80_A0.5320.37
95_I180_A0.5310.37
51_F196_K0.5310.37
123_T211_Q0.5310.37
95_I208_T0.5300.37
21_K204_T0.5290.37
73_S222_I0.5290.37
27_G105_G0.5280.37
58_I61_L0.5280.37
12_G67_D0.5280.37
224_L228_F0.5260.36
38_V43_M0.5260.36
232_V236_G0.5250.36
218_L221_M0.5240.36
36_L93_S0.5230.36
20_W38_V0.5230.36
31_F102_P0.5210.36
74_Y77_W0.5180.36
49_W224_L0.5140.35
31_F109_E0.5110.35
55_D68_W0.5110.35
147_L150_A0.5100.35
74_Y214_A0.5100.35
100_A231_P0.5090.35
29_R190_N0.5090.35
130_K192_K0.5090.35
191_H239_A0.5080.35
216_T219_F0.5080.35
127_G230_M0.5080.35
26_P110_Q0.5070.35
15_Y240_M0.5060.34
47_F221_M0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.8972 100 0.217 Contact Map
4he8H 1 0.5534 6.4 0.961 Contact Map
4xp4A 1 0.3874 6.2 0.961 Contact Map
1xc0A 1 0.1304 5.8 0.962 Contact Map
4xk8I 1 0.1146 5.1 0.963 Contact Map
1jb0I 1 0.1502 5 0.963 Contact Map
4l6vi 1 0.1502 4.7 0.963 Contact Map
2m8rA 1 0.2095 3.7 0.965 Contact Map
2qjyC 2 0.2174 3.4 0.966 Contact Map
2wscI 1 0.1186 3.1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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