GREMLIN Database
CYSC - Adenylyl-sulfate kinase
UniProt: P0A6J1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10185
Length: 201 (178)
Sequences: 2692 (1655)
Seq/√Len: 124.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_E152_R4.2721.00
138_I141_A3.9891.00
90_G118_V2.7681.00
133_D175_H2.6691.00
30_V122_V2.6411.00
181_L188_Q2.6271.00
111_H164_S2.5731.00
24_H58_S2.5431.00
135_P179_E2.2781.00
181_L185_L2.2781.00
157_R163_D2.2731.00
158_N163_D2.2711.00
60_Y98_E2.2701.00
30_V97_V2.2291.00
133_D177_N2.2291.00
116_Q120_E2.2141.00
51_A187_Q2.1411.00
112_R170_E2.1251.00
78_S81_D2.0671.00
89_V107_F2.0261.00
176_L185_L2.0071.00
33_F104_L1.9991.00
128_I192_L1.9761.00
67_V89_V1.9661.00
177_N180_Q1.9631.00
57_V102_V1.9521.00
150_K155_E1.9431.00
48_L189_L1.9211.00
71_L92_V1.9141.00
47_A182_V1.9001.00
31_L130_V1.8261.00
55_L194_R1.8201.00
133_D168_A1.8001.00
119_R173_E1.7821.00
134_T139_C1.7431.00
182_V186_V1.7331.00
192_L196_N1.7021.00
21_E28_G1.6931.00
135_P138_I1.6851.00
51_A55_L1.6191.00
131_F175_H1.6181.00
79_D164_S1.6151.00
79_D111_H1.5961.00
149_K153_A1.5821.00
112_R116_Q1.5431.00
187_Q191_D1.4691.00
76_G81_D1.4481.00
47_A186_V1.4461.00
97_V122_V1.4321.00
51_A186_V1.4191.00
96_M101_L1.4171.00
48_L186_V1.3851.00
51_A54_K1.3591.00
26_H57_V1.3451.00
83_K114_E1.3251.00
23_H53_H1.3021.00
178_G185_L1.2871.00
44_V132_V1.2861.00
84_E87_R1.2771.00
174_I192_L1.2521.00
44_V186_V1.2280.99
176_L189_L1.2210.99
117_M120_E1.1720.99
136_L140_E1.1410.99
32_W109_S1.1200.99
44_V176_L1.1190.99
134_T178_G1.1110.99
46_G61_L1.1110.99
28_G97_V1.1000.99
47_A50_E1.0960.99
152_R162_I1.0790.99
118_V127_F1.0780.99
23_H58_S1.0730.99
48_L190_L1.0680.98
131_F168_A1.0630.98
78_S158_N1.0570.98
70_G91_E1.0490.98
37_S108_I1.0480.98
83_K113_A1.0370.98
19_Q22_L1.0360.98
191_D195_Q1.0330.98
50_E54_K1.0300.98
30_V93_A1.0270.98
49_E104_L1.0230.98
94_N121_R1.0220.98
134_T138_I1.0210.98
47_A51_A0.9980.98
67_V107_F0.9950.98
112_R168_A0.9880.97
29_V102_V0.9870.97
138_I179_E0.9860.97
123_G126_R0.9770.97
86_I118_V0.9680.97
116_Q170_E0.9590.97
90_G121_R0.9570.97
159_F163_D0.9560.97
86_I107_F0.9440.97
49_E61_L0.9210.96
36_L139_C0.9150.96
129_E172_A0.9130.96
137_A141_A0.8940.95
134_T179_E0.8910.95
60_Y99_A0.8900.95
34_T166_Y0.8860.95
19_Q50_E0.8830.95
158_N164_S0.8830.95
29_V193_L0.8830.95
182_V185_L0.8820.95
128_I174_I0.8810.95
21_E27_R0.8770.95
66_N69_H0.8610.94
172_A175_H0.8600.94
109_S127_F0.8600.94
38_G144_P0.8580.94
188_Q191_D0.8580.94
48_L104_L0.8510.94
122_V126_R0.8490.94
38_G147_L0.8470.94
51_A190_L0.8470.94
47_A183_T0.8460.94
136_L162_I0.8420.94
55_L190_L0.8400.94
96_M99_A0.8340.93
51_A183_T0.8310.93
140_E162_I0.8210.93
21_E24_H0.8160.93
20_R49_E0.8140.93
26_H58_S0.8130.92
122_V125_G0.8130.92
191_D194_R0.8030.92
19_Q53_H0.7960.92
181_L184_N0.7890.91
136_L152_R0.7870.91
27_R126_R0.7860.91
49_E53_H0.7790.91
134_T175_H0.7770.91
21_E126_R0.7760.91
128_I173_E0.7740.91
188_Q192_L0.7690.90
31_L48_L0.7650.90
91_E94_N0.7620.90
97_V126_R0.7600.90
70_G84_E0.7440.89
111_H114_E0.7440.89
119_R127_F0.7430.89
159_F162_I0.7430.89
111_H165_V0.7360.88
118_V121_R0.7350.88
75_L81_D0.7330.88
46_G49_E0.7290.88
120_E124_E0.7210.87
44_V185_L0.7180.87
29_V128_I0.7060.86
37_S147_L0.7050.86
84_E91_E0.7040.86
93_A105_T0.7040.86
83_K117_M0.6960.85
112_R167_E0.6930.85
131_F177_N0.6810.84
75_L88_R0.6780.84
186_V189_L0.6760.84
37_S136_L0.6750.83
22_L25_G0.6740.83
64_G145_K0.6740.83
113_A117_M0.6650.83
184_N187_Q0.6590.82
178_G181_L0.6570.82
46_G103_V0.6570.82
79_D113_A0.6550.82
151_A163_D0.6520.81
160_T164_S0.6520.81
49_E59_T0.6520.81
73_S121_R0.6460.81
130_V174_I0.6440.81
34_T109_S0.6440.81
23_H59_T0.6440.81
192_L195_Q0.6360.80
79_D83_K0.6320.79
33_F45_A0.6320.79
24_H28_G0.6270.79
70_G74_D0.6260.79
105_T118_V0.6240.78
20_R60_Y0.6220.78
168_A177_N0.6190.78
19_Q54_K0.6190.78
119_R129_E0.6180.78
66_N91_E0.6100.77
140_E151_A0.6090.77
93_A97_V0.6050.76
105_T108_I0.6020.76
86_I111_H0.6000.76
129_E171_S0.6000.76
174_I188_Q0.6000.76
61_L106_A0.5970.75
48_L193_L0.5970.75
60_Y96_M0.5960.75
79_D158_N0.5960.75
35_G40_G0.5940.75
75_L85_N0.5930.75
73_S117_M0.5910.75
19_Q23_H0.5910.75
90_G122_V0.5900.74
65_D145_K0.5880.74
128_I196_N0.5860.74
112_R129_E0.5860.74
174_I189_L0.5850.74
128_I193_L0.5840.74
24_H53_H0.5840.74
144_P149_K0.5820.73
185_L188_Q0.5820.73
109_S129_E0.5800.73
108_I160_T0.5770.73
43_T182_V0.5730.72
127_F173_E0.5720.72
29_V103_V0.5700.72
53_H59_T0.5690.72
108_I164_S0.5690.72
34_T127_F0.5680.72
32_W129_E0.5680.72
74_D88_R0.5660.71
143_D146_G0.5630.71
29_V97_V0.5620.71
122_V127_F0.5600.71
85_N89_V0.5590.70
110_P160_T0.5590.70
85_N88_R0.5580.70
112_R166_Y0.5550.70
36_L161_G0.5540.70
147_L159_F0.5530.70
67_V71_L0.5510.69
109_S166_Y0.5510.69
156_L159_F0.5500.69
80_A83_K0.5480.69
118_V122_V0.5410.68
148_Y161_G0.5410.68
31_L193_L0.5400.68
21_E26_H0.5400.68
25_G57_V0.5390.68
45_A106_A0.5390.68
97_V123_G0.5390.68
46_G59_T0.5390.68
25_G194_R0.5390.68
30_V105_T0.5390.68
87_R114_E0.5380.68
117_M121_R0.5270.66
116_Q119_R0.5270.66
33_F132_V0.5260.66
66_N95_L0.5250.66
187_Q194_R0.5230.65
139_C152_R0.5230.65
30_V106_A0.5220.65
46_G50_E0.5190.65
22_L55_L0.5170.65
28_G126_R0.5170.65
90_G111_H0.5150.64
62_L103_V0.5140.64
77_F108_I0.5120.64
30_V118_V0.5070.63
75_L110_P0.5050.63
87_R91_E0.5050.63
27_R184_N0.5040.63
155_E163_D0.5030.62
187_Q190_L0.5020.62
112_R173_E0.5020.62
61_L104_L0.5020.62
60_Y97_V0.5000.62
44_V139_C0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x6vB 2 0.9154 100 0.448 Contact Map
1m8pA 5 1 100 0.502 Contact Map
2gksA 2 1 100 0.505 Contact Map
1m7gA 4 0.9801 100 0.546 Contact Map
3cr8A 4 0.8706 100 0.55 Contact Map
4rfvA 2 0.7015 100 0.586 Contact Map
2pezA 2 0.8657 100 0.602 Contact Map
4bzpA 2 0.8507 100 0.614 Contact Map
2yvuA 2 0.8756 100 0.617 Contact Map
3uieA 2 0.9701 99.9 0.653 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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