GREMLIN Database
COAE - Dephospho-CoA kinase
UniProt: P0A6I9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12312
Length: 206 (191)
Sequences: 5101 (3957)
Seq/√Len: 286.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_H83_W3.2911.00
149_R153_E2.7871.00
116_V168_V2.6381.00
95_E98_H2.3041.00
80_E83_W2.2781.00
25_L187_A2.2461.00
126_R171_D2.2211.00
129_V169_A2.1491.00
88_L92_I2.0731.00
141_T152_V1.9891.00
133_S176_N1.9721.00
49_A91_L1.9641.00
95_E99_Q1.9531.00
46_A91_L1.9421.00
60_A64_T1.9271.00
51_A59_I1.9271.00
53_H80_E1.8341.00
139_K143_Q1.8041.00
24_D183_A1.7371.00
21_A183_A1.7141.00
71_R155_I1.7141.00
18_V182_I1.7091.00
138_L153_E1.7011.00
35_I95_E1.6751.00
7_L19_A1.6591.00
74_I81_K1.6531.00
69_A72_E1.6361.00
131_D162_R1.5851.00
136_T139_K1.5711.00
133_S136_T1.5681.00
21_A187_A1.5641.00
142_M149_R1.5441.00
12_G141_T1.5411.00
153_E157_A1.5241.00
121_Y168_V1.5201.00
27_I109_L1.5171.00
38_Q99_Q1.4951.00
178_A181_A1.4791.00
116_V127_V1.4721.00
20_N23_A1.4321.00
58_M69_A1.4211.00
128_L189_L1.4201.00
23_A29_V1.4101.00
73_R80_E1.3861.00
110_W124_A1.3791.00
18_V186_V1.3611.00
100_I108_V1.3501.00
32_A96_T1.3441.00
131_D166_L1.3431.00
22_F109_L1.3431.00
83_W86_A1.3421.00
40_V50_I1.3401.00
50_I84_L1.3391.00
58_M73_R1.3351.00
134_P153_E1.3331.00
60_A66_Q1.3311.00
4_I100_I1.3211.00
47_L65_L1.3161.00
38_Q95_E1.3061.00
138_L149_R1.2971.00
142_M152_V1.2971.00
27_I190_H1.2941.00
30_I35_I1.2921.00
171_D189_L1.2771.00
164_A168_V1.2721.00
35_I38_Q1.2661.00
164_A167_A1.2641.00
47_L51_A1.2591.00
7_L109_L1.2561.00
107_Y190_H1.2521.00
5_V128_L1.2321.00
161_T164_A1.2201.00
77_N80_E1.2141.00
171_D193_Y1.1911.00
74_I84_L1.1771.00
137_Q162_R1.1741.00
91_L94_Q1.1721.00
28_N105_S1.1701.00
65_L70_L1.1511.00
6_A115_L1.1501.00
41_E64_T1.1441.00
51_A56_A1.1421.00
132_V136_T1.1261.00
185_D188_R1.1241.00
151_H154_Q1.1121.00
96_T110_W1.1061.00
39_V88_L1.1051.00
160_A164_A1.1041.00
19_A111_V1.1011.00
147_V155_I1.1011.00
36_A40_V1.0971.00
128_L171_D1.0851.00
130_V175_N1.0841.00
151_H155_I1.0711.00
66_Q69_A1.0691.00
42_P64_T1.0681.00
78_P81_K1.0641.00
18_V130_V1.0571.00
82_N85_N1.0541.00
31_D34_I1.0541.00
6_A124_A1.0531.00
78_P82_N1.0511.00
12_G152_V1.0481.00
3_Y126_R1.0421.00
69_A73_R1.0411.00
16_S20_N1.0381.00
98_H102_Q1.0301.00
148_T151_H1.0291.00
34_I38_Q1.0281.00
76_A154_Q1.0281.00
53_H87_L1.0251.00
132_V137_Q1.0211.00
50_I58_M1.0201.00
81_K158_A1.0161.00
21_A25_L1.0101.00
72_E151_H1.0091.00
25_L183_A1.0081.00
83_W87_L1.0051.00
99_Q102_Q1.0041.00
13_S162_R1.0041.00
21_A24_D1.0011.00
166_L172_V0.9941.00
8_T129_V0.9931.00
40_V65_L0.9851.00
17_T179_P0.9791.00
94_Q98_H0.9781.00
116_V160_A0.9731.00
25_L190_H0.9671.00
97_Q123_K0.9621.00
40_V88_L0.9571.00
177_G181_A0.9501.00
147_V152_V0.9481.00
81_K85_N0.9481.00
152_V156_L0.9371.00
20_N24_D0.9301.00
38_Q41_E0.9151.00
13_S132_V0.9071.00
126_R170_D0.9001.00
100_I110_W0.8971.00
126_R193_Y0.8961.00
10_G162_R0.8861.00
160_A165_R0.8841.00
82_N86_A0.8811.00
57_N69_A0.8801.00
48_H52_D0.8721.00
21_A186_V0.8671.00
129_V165_R0.8621.00
183_A187_A0.8611.00
134_P157_A0.8601.00
137_Q156_L0.8581.00
117_E165_R0.8571.00
44_A95_E0.8541.00
54_F80_E0.8541.00
27_I107_Y0.8511.00
39_V91_L0.8501.00
19_A29_V0.8341.00
173_I189_L0.8301.00
150_E154_Q0.8251.00
141_T145_D0.8231.00
162_R165_R0.8221.00
28_N99_Q0.8221.00
13_S137_Q0.8181.00
181_A184_S0.8141.00
74_I80_E0.8100.99
47_L59_I0.8070.99
138_L152_V0.8030.99
180_D183_A0.7970.99
5_V107_Y0.7950.99
46_A87_L0.7900.99
135_E149_R0.7880.99
128_L193_Y0.7840.99
44_A47_L0.7830.99
49_A52_D0.7830.99
32_A110_W0.7820.99
75_F155_I0.7790.99
35_I99_Q0.7730.99
30_I95_E0.7720.99
30_I96_T0.7670.99
68_R72_E0.7610.99
188_R192_H0.7590.99
97_Q101_Q0.7580.99
31_D111_V0.7570.99
57_N73_R0.7530.99
112_V120_L0.7520.99
161_T165_R0.7470.99
136_T176_N0.7340.99
39_V46_A0.7340.99
36_A39_V0.7340.99
116_V121_Y0.7330.99
37_R67_R0.7270.99
179_P183_A0.7250.99
10_G156_L0.7170.99
162_R166_L0.7150.99
30_I99_Q0.7150.99
68_R145_D0.7090.99
58_M70_L0.7050.99
22_F186_V0.6980.98
5_V126_R0.6910.98
85_N89_H0.6900.98
189_L193_Y0.6850.98
4_I124_A0.6840.98
85_N118_N0.6800.98
175_N182_I0.6790.98
135_E139_K0.6780.98
45_P91_L0.6760.98
36_A92_I0.6750.98
184_S188_R0.6740.98
45_P94_Q0.6740.98
48_H51_A0.6740.98
37_R40_V0.6730.98
28_N106_P0.6630.98
127_V169_A0.6620.98
5_V109_L0.6620.98
181_A185_D0.6600.98
37_R65_L0.6580.98
163_E167_A0.6540.98
54_F70_L0.6520.98
10_G165_R0.6510.98
147_V151_H0.6500.98
43_G47_L0.6490.98
160_A168_V0.6420.97
188_R191_A0.6420.97
17_T20_N0.6390.97
134_P137_Q0.6370.97
145_D151_H0.6370.97
47_L63_G0.6300.97
25_L186_V0.6250.97
79_E82_N0.6200.97
187_A191_A0.6180.97
131_D172_V0.6170.97
131_D165_R0.6170.97
54_F84_L0.6170.97
96_T123_K0.6130.97
36_A113_P0.6120.97
18_V173_I0.6110.97
112_V124_A0.6110.97
141_T147_V0.6100.96
35_I39_V0.6090.96
129_V166_L0.6070.96
41_E44_A0.6060.96
49_A53_H0.6050.96
32_A112_V0.6040.96
138_L156_L0.6030.96
89_H92_I0.6030.96
121_Y124_A0.6010.96
178_A182_I0.5990.96
120_L123_K0.5990.96
22_F128_L0.5970.96
28_N104_T0.5950.96
134_P156_L0.5910.96
171_D192_H0.5900.96
28_N103_A0.5840.96
73_R76_A0.5840.96
42_P47_L0.5810.95
51_A58_M0.5800.95
16_S111_V0.5780.95
163_E166_L0.5770.95
4_I110_W0.5720.95
23_A34_I0.5650.95
129_V172_V0.5640.95
61_A66_Q0.5630.95
174_D185_D0.5630.95
117_E160_A0.5620.94
11_I141_T0.5600.94
85_N88_L0.5550.94
29_V111_V0.5510.94
51_A55_G0.5500.94
49_A87_L0.5470.94
73_R77_N0.5470.94
58_M65_L0.5450.94
119_S122_K0.5330.93
173_I182_I0.5300.93
72_E76_A0.5290.93
55_G59_I0.5270.92
3_Y125_N0.5230.92
80_E84_L0.5230.92
46_A88_L0.5220.92
22_F27_I0.5200.92
3_Y107_Y0.5180.92
21_A182_I0.5100.91
35_I96_T0.5060.91
96_T100_I0.5060.91
93_Q96_T0.5050.91
17_T21_A0.5030.91
134_P163_E0.5030.91
115_L124_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dekA 2 0.8738 100 0.399 Contact Map
1uf9A 1 0.9126 100 0.424 Contact Map
1vhtA 1 1 100 0.441 Contact Map
2grjA 2 0.8592 100 0.443 Contact Map
2if2A 1 0.9369 100 0.444 Contact Map
4i1uA 2 0.9757 100 0.444 Contact Map
4ttrA 1 0.9709 100 0.449 Contact Map
2f6rA 1 0.9612 100 0.452 Contact Map
4zo4A 4 0.9417 100 0.463 Contact Map
1jjvA 1 0.9223 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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