COAE - ECOLI - GREMLIN Contacts

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COAE - Dephospho-CoA kinase

UniProt:	P0A6I9	Sequences: MRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHAIADHFGANMIAADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQIQQATSPYVLWVVPLLVENSLYKKANRVLVVDVSPETQLKRTMQRDDVTREHVEQILAAQATREARLAVADDVIDNNGAPDAIASDVARLHAHYLQLASQFVSQEKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12312
Length:	206 (191)
Sequences:	5101 (3957)
Seq/√Len:	286.3

ECOLI - COAE
BACSU - COAE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_H	83_W	3.291	1.00
149_R	153_E	2.787	1.00
116_V	168_V	2.638	1.00
95_E	98_H	2.304	1.00
80_E	83_W	2.278	1.00
25_L	187_A	2.246	1.00
126_R	171_D	2.221	1.00
129_V	169_A	2.149	1.00
88_L	92_I	2.073	1.00
141_T	152_V	1.989	1.00
133_S	176_N	1.972	1.00
49_A	91_L	1.964	1.00
95_E	99_Q	1.953	1.00
46_A	91_L	1.942	1.00
60_A	64_T	1.927	1.00
51_A	59_I	1.927	1.00
53_H	80_E	1.834	1.00
139_K	143_Q	1.804	1.00
24_D	183_A	1.737	1.00
21_A	183_A	1.714	1.00
71_R	155_I	1.714	1.00
18_V	182_I	1.709	1.00
138_L	153_E	1.701	1.00
35_I	95_E	1.675	1.00
7_L	19_A	1.659	1.00
74_I	81_K	1.653	1.00
69_A	72_E	1.636	1.00
131_D	162_R	1.585	1.00
136_T	139_K	1.571	1.00
133_S	136_T	1.568	1.00
21_A	187_A	1.564	1.00
142_M	149_R	1.544	1.00
12_G	141_T	1.541	1.00
153_E	157_A	1.524	1.00
121_Y	168_V	1.520	1.00
27_I	109_L	1.517	1.00
38_Q	99_Q	1.495	1.00
178_A	181_A	1.479	1.00
116_V	127_V	1.472	1.00
20_N	23_A	1.432	1.00
58_M	69_A	1.421	1.00
128_L	189_L	1.420	1.00
23_A	29_V	1.410	1.00
73_R	80_E	1.386	1.00
110_W	124_A	1.379	1.00
18_V	186_V	1.361	1.00
100_I	108_V	1.350	1.00
32_A	96_T	1.344	1.00
131_D	166_L	1.343	1.00
22_F	109_L	1.343	1.00
83_W	86_A	1.342	1.00
40_V	50_I	1.340	1.00
50_I	84_L	1.339	1.00
58_M	73_R	1.335	1.00
134_P	153_E	1.333	1.00
60_A	66_Q	1.331	1.00
4_I	100_I	1.321	1.00
47_L	65_L	1.316	1.00
38_Q	95_E	1.306	1.00
138_L	149_R	1.297	1.00
142_M	152_V	1.297	1.00
27_I	190_H	1.294	1.00
30_I	35_I	1.292	1.00
171_D	189_L	1.277	1.00
164_A	168_V	1.272	1.00
35_I	38_Q	1.266	1.00
164_A	167_A	1.264	1.00
47_L	51_A	1.259	1.00
7_L	109_L	1.256	1.00
107_Y	190_H	1.252	1.00
5_V	128_L	1.232	1.00
161_T	164_A	1.220	1.00
77_N	80_E	1.214	1.00
171_D	193_Y	1.191	1.00
74_I	84_L	1.177	1.00
137_Q	162_R	1.174	1.00
91_L	94_Q	1.172	1.00
28_N	105_S	1.170	1.00
65_L	70_L	1.151	1.00
6_A	115_L	1.150	1.00
41_E	64_T	1.144	1.00
51_A	56_A	1.142	1.00
132_V	136_T	1.126	1.00
185_D	188_R	1.124	1.00
151_H	154_Q	1.112	1.00
96_T	110_W	1.106	1.00
39_V	88_L	1.105	1.00
160_A	164_A	1.104	1.00
19_A	111_V	1.101	1.00
147_V	155_I	1.101	1.00
36_A	40_V	1.097	1.00
128_L	171_D	1.085	1.00
130_V	175_N	1.084	1.00
151_H	155_I	1.071	1.00
66_Q	69_A	1.069	1.00
42_P	64_T	1.068	1.00
78_P	81_K	1.064	1.00
18_V	130_V	1.057	1.00
82_N	85_N	1.054	1.00
31_D	34_I	1.054	1.00
6_A	124_A	1.053	1.00
78_P	82_N	1.051	1.00
12_G	152_V	1.048	1.00
3_Y	126_R	1.042	1.00
69_A	73_R	1.041	1.00
16_S	20_N	1.038	1.00
98_H	102_Q	1.030	1.00
148_T	151_H	1.029	1.00
34_I	38_Q	1.028	1.00
76_A	154_Q	1.028	1.00
53_H	87_L	1.025	1.00
132_V	137_Q	1.021	1.00
50_I	58_M	1.020	1.00
81_K	158_A	1.016	1.00
21_A	25_L	1.010	1.00
72_E	151_H	1.009	1.00
25_L	183_A	1.008	1.00
83_W	87_L	1.005	1.00
99_Q	102_Q	1.004	1.00
13_S	162_R	1.004	1.00
21_A	24_D	1.001	1.00
166_L	172_V	0.994	1.00
8_T	129_V	0.993	1.00
40_V	65_L	0.985	1.00
17_T	179_P	0.979	1.00
94_Q	98_H	0.978	1.00
116_V	160_A	0.973	1.00
25_L	190_H	0.967	1.00
97_Q	123_K	0.962	1.00
40_V	88_L	0.957	1.00
177_G	181_A	0.950	1.00
147_V	152_V	0.948	1.00
81_K	85_N	0.948	1.00
152_V	156_L	0.937	1.00
20_N	24_D	0.930	1.00
38_Q	41_E	0.915	1.00
13_S	132_V	0.907	1.00
126_R	170_D	0.900	1.00
100_I	110_W	0.897	1.00
126_R	193_Y	0.896	1.00
10_G	162_R	0.886	1.00
160_A	165_R	0.884	1.00
82_N	86_A	0.881	1.00
57_N	69_A	0.880	1.00
48_H	52_D	0.872	1.00
21_A	186_V	0.867	1.00
129_V	165_R	0.862	1.00
183_A	187_A	0.861	1.00
134_P	157_A	0.860	1.00
137_Q	156_L	0.858	1.00
117_E	165_R	0.857	1.00
44_A	95_E	0.854	1.00
54_F	80_E	0.854	1.00
27_I	107_Y	0.851	1.00
39_V	91_L	0.850	1.00
19_A	29_V	0.834	1.00
173_I	189_L	0.830	1.00
150_E	154_Q	0.825	1.00
141_T	145_D	0.823	1.00
162_R	165_R	0.822	1.00
28_N	99_Q	0.822	1.00
13_S	137_Q	0.818	1.00
181_A	184_S	0.814	1.00
74_I	80_E	0.810	0.99
47_L	59_I	0.807	0.99
138_L	152_V	0.803	0.99
180_D	183_A	0.797	0.99
5_V	107_Y	0.795	0.99
46_A	87_L	0.790	0.99
135_E	149_R	0.788	0.99
128_L	193_Y	0.784	0.99
44_A	47_L	0.783	0.99
49_A	52_D	0.783	0.99
32_A	110_W	0.782	0.99
75_F	155_I	0.779	0.99
35_I	99_Q	0.773	0.99
30_I	95_E	0.772	0.99
30_I	96_T	0.767	0.99
68_R	72_E	0.761	0.99
188_R	192_H	0.759	0.99
97_Q	101_Q	0.758	0.99
31_D	111_V	0.757	0.99
57_N	73_R	0.753	0.99
112_V	120_L	0.752	0.99
161_T	165_R	0.747	0.99
136_T	176_N	0.734	0.99
39_V	46_A	0.734	0.99
36_A	39_V	0.734	0.99
116_V	121_Y	0.733	0.99
37_R	67_R	0.727	0.99
179_P	183_A	0.725	0.99
10_G	156_L	0.717	0.99
162_R	166_L	0.715	0.99
30_I	99_Q	0.715	0.99
68_R	145_D	0.709	0.99
58_M	70_L	0.705	0.99
22_F	186_V	0.698	0.98
5_V	126_R	0.691	0.98
85_N	89_H	0.690	0.98
189_L	193_Y	0.685	0.98
4_I	124_A	0.684	0.98
85_N	118_N	0.680	0.98
175_N	182_I	0.679	0.98
135_E	139_K	0.678	0.98
45_P	91_L	0.676	0.98
36_A	92_I	0.675	0.98
184_S	188_R	0.674	0.98
45_P	94_Q	0.674	0.98
48_H	51_A	0.674	0.98
37_R	40_V	0.673	0.98
28_N	106_P	0.663	0.98
127_V	169_A	0.662	0.98
5_V	109_L	0.662	0.98
181_A	185_D	0.660	0.98
37_R	65_L	0.658	0.98
163_E	167_A	0.654	0.98
54_F	70_L	0.652	0.98
10_G	165_R	0.651	0.98
147_V	151_H	0.650	0.98
43_G	47_L	0.649	0.98
160_A	168_V	0.642	0.97
188_R	191_A	0.642	0.97
17_T	20_N	0.639	0.97
134_P	137_Q	0.637	0.97
145_D	151_H	0.637	0.97
47_L	63_G	0.630	0.97
25_L	186_V	0.625	0.97
79_E	82_N	0.620	0.97
187_A	191_A	0.618	0.97
131_D	172_V	0.617	0.97
131_D	165_R	0.617	0.97
54_F	84_L	0.617	0.97
96_T	123_K	0.613	0.97
36_A	113_P	0.612	0.97
18_V	173_I	0.611	0.97
112_V	124_A	0.611	0.97
141_T	147_V	0.610	0.96
35_I	39_V	0.609	0.96
129_V	166_L	0.607	0.96
41_E	44_A	0.606	0.96
49_A	53_H	0.605	0.96
32_A	112_V	0.604	0.96
138_L	156_L	0.603	0.96
89_H	92_I	0.603	0.96
121_Y	124_A	0.601	0.96
178_A	182_I	0.599	0.96
120_L	123_K	0.599	0.96
22_F	128_L	0.597	0.96
28_N	104_T	0.595	0.96
134_P	156_L	0.591	0.96
171_D	192_H	0.590	0.96
28_N	103_A	0.584	0.96
73_R	76_A	0.584	0.96
42_P	47_L	0.581	0.95
51_A	58_M	0.580	0.95
16_S	111_V	0.578	0.95
163_E	166_L	0.577	0.95
4_I	110_W	0.572	0.95
23_A	34_I	0.565	0.95
129_V	172_V	0.564	0.95
61_A	66_Q	0.563	0.95
174_D	185_D	0.563	0.95
117_E	160_A	0.562	0.94
11_I	141_T	0.560	0.94
85_N	88_L	0.555	0.94
29_V	111_V	0.551	0.94
51_A	55_G	0.550	0.94
49_A	87_L	0.547	0.94
73_R	77_N	0.547	0.94
58_M	65_L	0.545	0.94
119_S	122_K	0.533	0.93
173_I	182_I	0.530	0.93
72_E	76_A	0.529	0.93
55_G	59_I	0.527	0.92
3_Y	125_N	0.523	0.92
80_E	84_L	0.523	0.92
46_A	88_L	0.522	0.92
22_F	27_I	0.520	0.92
3_Y	107_Y	0.518	0.92
21_A	182_I	0.510	0.91
35_I	96_T	0.506	0.91
96_T	100_I	0.506	0.91
93_Q	96_T	0.505	0.91
17_T	21_A	0.503	0.91
134_P	163_E	0.503	0.91
115_L	124_A	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1dekA	2	0.8738	100	0.399	Contact Map
1uf9A	1	0.9126	100	0.424	Contact Map
1vhtA	1	1	100	0.441	Contact Map
2grjA	2	0.8592	100	0.443	Contact Map
2if2A	1	0.9369	100	0.444	Contact Map
4i1uA	2	0.9757	100	0.444	Contact Map
4ttrA	1	0.9709	100	0.449	Contact Map
2f6rA	1	0.9612	100	0.452	Contact Map
4zo4A	4	0.9417	100	0.463	Contact Map
1jjvA	1	0.9223	100	0.479	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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