GREMLIN Database
COAD - Phosphopantetheine adenylyltransferase
UniProt: P0A6I6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11190
Length: 159 (155)
Sequences: 3514 (2171)
Seq/√Len: 174.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_H66_E4.7991.00
68_V77_F3.6621.00
14_I55_A3.3741.00
4_R31_H3.2261.00
68_V81_Q3.0211.00
25_A87_I2.9751.00
23_T61_H2.7271.00
26_T64_N2.5661.00
58_A149_N2.2151.00
14_I22_V2.2041.00
6_I78_A2.1921.00
47_T50_E2.1131.00
10_T44_P1.9731.00
50_E157_K1.9011.00
108_H144_H1.8701.00
54_L153_A1.8511.00
88_R102_L1.8131.00
52_V56_Q1.7991.00
135_V140_G1.7931.00
79_R110_M1.7931.00
53_A56_Q1.7881.00
151_H155_M1.7631.00
29_F32_V1.6611.00
59_T62_L1.5931.00
72_D80_N1.5851.00
33_I81_Q1.5751.00
79_R112_E1.5681.00
19_I59_T1.5621.00
19_I147_P1.5621.00
24_R114_E1.5281.00
78_A113_L1.4951.00
57_Q149_N1.4841.00
53_A57_Q1.4801.00
152_Q156_A1.4771.00
57_Q153_A1.4751.00
52_V69_G1.4681.00
75_A110_M1.4641.00
86_L113_L1.4621.00
77_F81_Q1.4451.00
105_M135_V1.4081.00
74_M86_L1.4041.00
5_A32_V1.3961.00
57_Q60_A1.3831.00
20_D121_S1.3641.00
105_M131_L1.3571.00
37_A70_F1.3511.00
22_V34_L1.3491.00
46_F54_L1.3481.00
4_R33_I1.3391.00
48_L69_G1.3041.00
35_A70_F1.3031.00
134_E138_H1.2861.00
153_A156_A1.2771.00
72_D76_N1.2481.00
41_S134_E1.2391.00
28_M116_V1.2201.00
76_N79_R1.2051.00
26_T62_L1.1781.00
90_L96_F1.1641.00
143_T151_H1.1441.00
75_A113_L1.1271.00
6_I77_F1.1221.00
36_I52_V1.1041.00
90_L117_F1.0961.00
146_L150_V1.0841.00
28_M118_L1.0821.00
35_A77_F1.0781.00
148_E152_Q1.0771.00
142_V154_L1.0721.00
62_L65_V1.0651.00
3_K84_T1.0471.00
23_T62_L1.0350.99
4_R82_H1.0130.99
29_F85_V1.0130.99
58_A147_P1.0090.99
92_A101_Q1.0030.99
8_P74_M1.0010.99
4_R83_A0.9980.99
92_A100_M0.9940.99
8_P86_L0.9910.99
3_K30_D0.9870.99
16_N147_P0.9810.99
124_W127_I0.9720.99
29_F87_I0.9670.99
21_I118_L0.9630.99
78_A83_A0.9590.99
40_P138_H0.9580.99
52_V67_V0.9560.99
150_V154_L0.9550.99
5_A29_F0.9540.99
104_H125_S0.9410.99
5_A87_I0.9330.99
103_A117_F0.9330.99
93_V97_E0.9280.99
38_A71_S0.9070.99
10_T37_A0.8890.98
22_V32_V0.8870.98
38_A48_L0.8850.98
33_I83_A0.8820.98
36_I69_G0.8820.98
3_K85_V0.8780.98
94_A101_Q0.8760.98
142_V146_L0.8680.98
100_M119_M0.8670.98
5_A85_V0.8640.98
66_E81_Q0.8620.98
37_A138_H0.8550.98
54_L150_V0.8480.98
45_M157_K0.8410.98
141_D144_H0.8400.98
100_M104_H0.8320.97
110_M113_L0.8290.97
7_Y88_R0.8140.97
33_I66_E0.8070.97
57_Q152_Q0.8000.97
120_P125_S0.7970.97
53_A153_A0.7940.97
6_I83_A0.7830.96
6_I35_A0.7790.96
55_A67_V0.7750.96
36_I55_A0.7720.96
15_T132_V0.7700.96
148_E151_H0.7650.96
19_I58_A0.7600.96
108_H145_F0.7580.96
22_V59_T0.7550.96
59_T64_N0.7550.96
14_I150_V0.7520.95
27_Q84_T0.7420.95
32_V87_I0.7270.95
106_N115_S0.7240.94
152_Q155_M0.7240.94
109_L135_V0.7200.94
149_N152_Q0.7180.94
55_A59_T0.7170.94
46_F50_E0.7140.94
49_E53_A0.7140.94
92_A97_E0.7130.94
22_V65_V0.7110.94
25_A32_V0.7070.94
76_N80_N0.7040.94
104_H122_K0.7030.94
100_M125_S0.7020.93
150_V153_A0.7010.93
14_I19_I0.7000.93
122_K125_S0.6990.93
7_Y22_V0.6980.93
59_T65_V0.6950.93
7_Y120_P0.6950.93
8_P88_R0.6940.93
44_P48_L0.6870.93
16_N19_I0.6870.93
56_Q66_E0.6850.93
20_D24_R0.6850.93
48_L52_V0.6820.92
34_L55_A0.6750.92
96_F100_M0.6700.92
19_I23_T0.6590.91
28_M85_V0.6550.91
35_A74_M0.6450.90
46_F157_K0.6440.90
23_T27_Q0.6410.90
102_L106_N0.6380.90
46_F153_A0.6360.90
39_S133_K0.6350.90
15_T20_D0.6350.90
144_H148_E0.6340.89
72_D77_F0.6320.89
143_T148_E0.6290.89
106_N109_L0.6280.89
49_E69_G0.6250.89
7_Y32_V0.6190.88
54_L149_N0.6110.88
39_S44_P0.6110.88
53_A149_N0.6090.88
149_N153_A0.6080.87
33_I68_V0.6040.87
10_T39_S0.6000.87
40_P102_L0.5980.87
92_A119_M0.5950.86
5_A116_V0.5940.86
39_S129_S0.5930.86
130_S133_K0.5930.86
132_V135_V0.5910.86
22_V26_T0.5840.85
108_H127_I0.5800.85
50_E153_A0.5790.85
143_T155_M0.5770.85
92_A126_F0.5770.85
6_I81_Q0.5760.85
34_L59_T0.5760.85
74_M102_L0.5740.84
133_K136_A0.5730.84
21_I87_I0.5670.84
84_T112_E0.5660.84
14_I58_A0.5620.83
131_L135_V0.5600.83
107_R121_S0.5580.83
108_H123_E0.5570.83
146_L151_H0.5550.82
73_L140_G0.5510.82
68_V80_N0.5500.82
47_T157_K0.5500.82
37_A100_M0.5470.81
7_Y21_I0.5470.81
70_F74_M0.5450.81
39_S138_H0.5390.80
41_S137_R0.5370.80
4_R66_E0.5370.80
6_I74_M0.5360.80
14_I54_L0.5350.80
136_A142_V0.5330.80
146_L154_L0.5330.80
16_N124_W0.5290.79
58_A62_L0.5260.79
136_A151_H0.5240.79
75_A106_N0.5190.78
75_A109_L0.5190.78
93_V101_Q0.5130.77
108_H122_K0.5130.77
27_Q31_H0.5100.77
3_K28_M0.5080.76
108_H126_F0.5080.76
78_A82_H0.5050.76
7_Y98_Y0.5040.76
104_H145_F0.5040.76
94_A97_E0.5030.76
132_V146_L0.5030.76
94_A119_M0.5030.76
88_R120_P0.5020.76
75_A78_A0.5000.75
142_V151_H0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k9wA 5 1 100 0.471 Contact Map
1vlhA 5 0.9811 100 0.473 Contact Map
3nbkA 5 0.9937 100 0.478 Contact Map
3nd5A 5 0.9497 100 0.481 Contact Map
4natA 5 0.9748 100 0.49 Contact Map
1o6bA 5 0.9937 100 0.492 Contact Map
3nv7A 4 0.9748 100 0.494 Contact Map
1od6A 5 0.956 100 0.495 Contact Map
1qjcA 4 0.9874 100 0.495 Contact Map
4f3rA 5 0.9371 100 0.502 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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