GREMLIN Database
COAA - Pantothenate kinase
UniProt: P0A6I3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10922
Length: 316 (303)
Sequences: 915 (525)
Seq/√Len: 30.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_V138_E8.1371.00
169_N191_V5.6001.00
237_Q279_K4.4481.00
162_D167_V4.2471.00
171_T187_D3.7771.00
237_Q275_M3.6781.00
134_Q181_D3.6411.00
276_T280_E3.5481.00
163_L196_L3.2851.00
233_E287_K3.2331.00
302_T310_E3.1311.00
16_D19_Q3.0201.00
135_V139_R2.9781.00
174_V185_D2.7211.00
279_K283_W2.7141.00
304_S310_E2.6791.00
245_L271_I2.5500.99
158_K162_D2.5070.99
168_P191_V2.4920.99
59_S115_W2.4780.99
99_V236_L2.3950.99
41_G44_E2.3080.99
178_L257_S2.2480.99
248_R267_K2.2060.98
14_Q311_E2.1540.98
301_L312_V2.1380.98
133_N182_V2.1040.98
302_T311_E2.0810.98
241_I271_I2.0520.98
174_V183_I2.0420.97
49_E52_A2.0280.97
237_Q283_W1.9910.97
46_L107_V1.9430.97
134_Q138_E1.9390.97
72_R76_L1.9370.96
238_T242_N1.9080.96
24_R28_P1.9030.96
179_I183_I1.8930.96
70_L86_R1.8820.96
266_T269_E1.8750.96
169_N189_T1.8670.96
24_R30_T1.8430.95
112_L195_I1.8270.95
62_L299_L1.8170.95
72_R223_V1.7910.95
235_L238_T1.7900.94
198_L223_V1.7870.94
272_K276_T1.7500.94
233_E283_W1.7180.93
171_T189_T1.6930.93
232_P235_L1.6850.92
273_T277_L1.6750.92
151_Y257_S1.6660.92
140_G170_V1.6560.92
144_K149_E1.6500.92
174_V182_V1.6500.92
63_N118_H1.6300.91
15_F19_Q1.6190.91
225_F299_L1.5970.90
67_S117_E1.5600.89
43_N47_S1.5400.89
203_V223_V1.5370.88
238_T305_A1.5340.88
14_Q313_R1.5340.88
17_R53_E1.5290.88
24_R60_R1.5020.87
133_N142_M1.4990.87
59_S62_L1.4930.87
93_I105_A1.4840.87
263_A266_T1.4710.86
208_M216_H1.4510.85
168_P192_Q1.4430.85
156_L198_L1.4420.85
116_P119_R1.3890.83
271_I275_M1.3880.83
284_L288_Q1.3840.82
27_V223_V1.3630.81
93_I227_I1.3600.81
49_E53_E1.3370.80
260_H264_K1.3370.80
304_S309_V1.3340.80
47_S50_E1.3320.80
35_E114_R1.3280.80
56_L60_R1.3250.80
52_A56_L1.3130.79
235_L305_A1.3070.79
267_K271_I1.3040.78
244_F270_A1.3020.78
195_I290_I1.3010.78
304_S308_A1.2850.77
122_E188_K1.2740.77
104_T254_D1.2660.76
14_Q300_I1.2630.76
29_M48_L1.2540.76
60_R115_W1.2330.74
207_G218_F1.2230.74
33_E37_A1.2230.74
249_E267_K1.2180.74
254_D294_R1.2130.73
105_A152_D1.2090.73
247_F250_G1.1850.71
179_I254_D1.1800.71
161_S222_F1.1610.70
92_S223_V1.1600.70
193_P196_L1.1590.70
12_Y280_E1.1580.70
265_L277_L1.1570.70
248_R304_S1.1540.69
93_I304_S1.1400.68
32_S35_E1.1380.68
253_T260_H1.1370.68
265_L273_T1.1300.68
156_L219_V1.1230.67
250_G253_T1.1100.66
35_E41_G1.1090.66
160_V216_H1.1050.66
71_R219_V1.0780.64
62_L91_I1.0620.63
51_V107_V1.0590.63
66_I70_L1.0590.63
63_N117_E1.0440.61
143_K280_E1.0430.61
86_R120_R1.0410.61
205_Q290_I1.0380.61
16_D90_I1.0360.61
105_A123_L1.0350.61
87_I216_H1.0330.61
124_I172_A1.0300.60
16_D311_E1.0290.60
43_N290_I1.0220.60
69_N86_R1.0210.60
43_N218_F1.0180.59
137_K140_G1.0120.59
71_R74_A1.0080.59
259_F289_N1.0060.59
291_L294_R1.0020.58
13_L217_V0.9970.58
201_L245_L0.9970.58
108_L294_R0.9920.57
68_S75_V0.9880.57
120_R196_L0.9840.57
252_F259_F0.9800.57
153_M160_V0.9770.56
104_T156_L0.9770.56
131_H135_V0.9770.56
104_T229_V0.9770.56
43_N153_M0.9760.56
118_H195_I0.9730.56
132_P135_V0.9600.55
17_R23_L0.9570.55
32_S305_A0.9540.54
67_S118_H0.9540.54
35_E45_D0.9540.54
128_G172_A0.9510.54
268_E272_K0.9510.54
90_I117_E0.9500.54
124_I198_L0.9460.54
54_I284_L0.9460.54
59_S119_R0.9460.54
93_I196_L0.9430.54
34_D38_R0.9320.53
186_G189_T0.9300.53
76_L223_V0.9240.52
287_K291_L0.9210.52
73_Q76_L0.9110.51
129_F159_F0.9030.50
271_I277_L0.8980.50
283_W287_K0.8900.49
27_V30_T0.8840.49
262_Y273_T0.8820.49
24_R29_M0.8810.49
48_L68_S0.8810.49
171_T188_K0.8650.47
43_N246_K0.8640.47
172_A188_K0.8620.47
13_L26_S0.8560.47
268_E271_I0.8560.47
68_S314_L0.8560.47
154_H160_V0.8420.46
73_Q198_L0.8410.46
108_L112_L0.8380.45
223_V236_L0.8370.45
125_T128_G0.8360.45
15_F283_W0.8330.45
47_S51_V0.8320.45
206_S218_F0.8320.45
278_W282_N0.8240.44
160_V229_V0.8240.44
198_L207_G0.8220.44
266_T273_T0.8200.44
61_L180_Y0.8180.44
25_D28_P0.8150.43
18_N168_P0.8140.43
39_L67_S0.8130.43
67_S78_Q0.8100.43
62_L222_F0.8090.43
232_P302_T0.8090.43
157_V216_H0.8050.43
40_K47_S0.7990.42
294_R306_N0.7990.42
276_T279_K0.7980.42
33_E40_K0.7930.42
86_R192_Q0.7900.42
236_L302_T0.7890.41
37_A40_K0.7890.41
11_P39_L0.7880.41
208_M214_P0.7870.41
105_A284_L0.7870.41
234_D238_T0.7840.41
232_P304_S0.7830.41
15_F28_P0.7820.41
12_Y105_A0.7820.41
180_Y251_A0.7810.41
241_I265_L0.7770.41
92_S198_L0.7750.40
269_E272_K0.7710.40
122_E191_V0.7710.40
28_P60_R0.7690.40
94_A248_R0.7650.40
137_K142_M0.7650.40
12_Y84_G0.7640.40
248_R289_N0.7640.40
153_M206_S0.7620.39
104_T312_V0.7580.39
19_Q74_A0.7560.39
15_F54_I0.7550.39
14_Q217_V0.7530.39
44_E50_E0.7510.39
48_L189_T0.7450.38
48_L105_A0.7450.38
9_M16_D0.7440.38
67_S74_A0.7430.38
12_Y15_F0.7330.37
114_R170_V0.7320.37
295_E312_V0.7320.37
91_I195_I0.7310.37
12_Y19_Q0.7300.37
257_S289_N0.7290.37
273_T280_E0.7280.37
133_N137_K0.7240.37
120_R169_N0.7230.36
90_I152_D0.7230.36
91_I112_L0.7200.36
108_L196_L0.7190.36
245_L265_L0.7160.36
24_R56_L0.7160.36
22_A266_T0.7130.36
36_I66_I0.7120.36
53_E107_V0.7110.36
54_I132_P0.7080.35
232_P305_A0.7060.35
40_K46_L0.7050.35
306_N310_E0.7050.35
32_S108_L0.7010.35
234_D306_N0.6970.35
47_S57_P0.6960.34
36_I48_L0.6940.34
241_I275_M0.6900.34
72_R121_V0.6890.34
35_E51_V0.6870.34
189_T192_Q0.6840.34
115_W118_H0.6830.34
138_E188_K0.6820.33
30_T35_E0.6820.33
73_Q300_I0.6810.33
66_I118_H0.6800.33
25_D144_K0.6800.33
266_T271_I0.6760.33
219_V229_V0.6730.33
122_E168_P0.6730.33
66_I115_W0.6720.33
195_I313_R0.6700.33
32_S288_Q0.6690.33
168_P306_N0.6680.32
91_I232_P0.6670.32
13_L137_K0.6660.32
73_Q107_V0.6650.32
22_A168_P0.6650.32
52_A90_I0.6630.32
242_N271_I0.6630.32
39_L49_E0.6590.32
24_R68_S0.6550.32
178_L256_D0.6550.32
54_I107_V0.6540.32
120_R237_Q0.6530.31
225_F314_L0.6520.31
203_V229_V0.6500.31
157_V312_V0.6480.31
87_I165_S0.6480.31
159_F231_A0.6460.31
233_E288_Q0.6440.31
25_D253_T0.6430.31
190_V273_T0.6420.31
65_Y69_N0.6410.31
45_D155_R0.6410.31
17_R229_V0.6390.30
32_S53_E0.6390.30
275_M279_K0.6340.30
178_L237_Q0.6280.30
35_E314_L0.6250.30
24_R43_N0.6250.30
61_L225_F0.6230.29
63_N67_S0.6230.29
197_I281_I0.6230.29
157_V214_P0.6220.29
260_H271_I0.6210.29
32_S313_R0.6190.29
25_D29_M0.6190.29
21_A69_N0.6190.29
122_E263_A0.6170.29
29_M110_A0.6130.29
34_D190_V0.6120.29
238_T306_N0.6120.29
163_L255_P0.6110.29
29_M179_I0.6090.29
156_L229_V0.6090.29
53_E56_L0.6070.28
263_A267_K0.6070.28
35_E113_S0.6060.28
62_L309_V0.6060.28
259_F265_L0.6050.28
89_Y223_V0.6050.28
178_L260_H0.6040.28
116_P161_S0.6020.28
59_S116_P0.6010.28
180_Y203_V0.6010.28
126_T147_F0.6000.28
113_S300_I0.6000.28
141_L186_G0.6000.28
89_Y247_F0.5980.28
273_T284_L0.5980.28
216_H283_W0.5950.28
29_M52_A0.5940.28
45_D271_I0.5940.28
164_K316_K0.5910.27
10_T50_E0.5900.27
117_E137_K0.5890.27
51_V172_A0.5880.27
196_L279_K0.5880.27
12_Y75_V0.5870.27
128_G220_S0.5860.27
113_S279_K0.5860.27
252_F289_N0.5840.27
253_T263_A0.5830.27
64_F78_Q0.5830.27
89_Y110_A0.5810.27
248_R263_A0.5810.27
32_S93_I0.5810.27
88_P202_N0.5800.27
63_N157_V0.5800.27
65_Y182_V0.5800.27
40_K144_K0.5790.27
19_Q110_A0.5790.27
83_N174_V0.5780.27
57_P177_H0.5780.27
9_M12_Y0.5750.26
33_E52_A0.5740.26
100_G200_G0.5740.26
95_G101_K0.5740.26
95_G200_G0.5740.26
95_G100_G0.5740.26
101_K200_G0.5740.26
30_T53_E0.5730.26
31_L56_L0.5730.26
37_A54_I0.5730.26
149_E236_L0.5730.26
196_L294_R0.5710.26
70_L76_L0.5700.26
38_R189_T0.5700.26
24_R33_E0.5680.26
136_L146_G0.5680.26
245_L281_I0.5640.26
10_T18_N0.5620.26
180_Y262_Y0.5620.26
37_A249_E0.5610.25
59_S299_L0.5610.25
138_E190_V0.5560.25
241_I273_T0.5560.25
76_L81_G0.5550.25
302_T308_A0.5540.25
92_S229_V0.5540.25
227_I299_L0.5530.25
135_V207_G0.5500.25
278_W285_N0.5500.25
24_R110_A0.5490.25
56_L176_S0.5490.25
141_L281_I0.5480.25
284_L315_R0.5470.25
93_I172_A0.5450.25
86_R107_V0.5450.25
37_A310_E0.5450.25
241_I245_L0.5410.24
133_N258_Y0.5400.24
221_D224_D0.5400.24
185_D188_K0.5400.24
177_H180_Y0.5400.24
32_S77_E0.5380.24
258_Y314_L0.5370.24
140_G152_D0.5360.24
38_R214_P0.5360.24
196_L220_S0.5350.24
51_V84_G0.5350.24
34_D271_I0.5350.24
89_Y92_S0.5350.24
68_S118_H0.5340.24
136_L147_F0.5330.24
22_A25_D0.5320.24
58_L93_I0.5320.24
47_S308_A0.5310.24
42_I45_D0.5310.24
27_V63_N0.5300.24
122_E195_I0.5300.24
38_R294_R0.5290.24
298_S313_R0.5280.24
137_K170_V0.5270.23
235_L264_K0.5260.23
179_I279_K0.5240.23
94_A204_L0.5240.23
124_I188_K0.5230.23
105_A240_Y0.5230.23
65_Y76_L0.5230.23
223_V250_G0.5220.23
84_G142_M0.5220.23
12_Y18_N0.5210.23
32_S46_L0.5210.23
9_M305_A0.5210.23
44_E151_Y0.5210.23
89_Y275_M0.5200.23
247_F252_F0.5200.23
275_M288_Q0.5200.23
18_N22_A0.5180.23
132_P282_N0.5170.23
46_L309_V0.5150.23
157_V217_V0.5150.23
178_L254_D0.5150.23
9_M162_D0.5140.23
218_F298_S0.5140.23
24_R64_F0.5130.23
183_I186_G0.5130.23
111_L304_S0.5110.23
279_K284_L0.5110.23
89_Y280_E0.5110.23
36_I280_E0.5110.23
162_D171_T0.5090.22
54_I290_I0.5090.22
170_V262_Y0.5070.22
184_P191_V0.5070.22
49_E305_A0.5050.22
18_N21_A0.5040.22
167_V170_V0.5040.22
208_M288_Q0.5030.22
19_Q141_L0.5030.22
17_R298_S0.5000.22
25_D313_R0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqcA 2 0.962 100 0.516 Contact Map
4ne2A 2 0.962 100 0.627 Contact Map
4bfzA 2 0.9525 100 0.641 Contact Map
1odfA 1 0.769 100 0.694 Contact Map
2ga8A 1 0.6835 100 0.725 Contact Map
1a7jA 5 0.6804 99.9 0.789 Contact Map
2jeoA 3 0.6456 99.9 0.791 Contact Map
1rz3A 1 0.557 99.9 0.808 Contact Map
3c8uA 1 0.6519 99.8 0.816 Contact Map
1uj2A 3 0.6487 99.8 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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