GREMLIN Database
KCY - Cytidylate kinase
UniProt: P0A6I0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11265
Length: 227 (216)
Sequences: 3765 (2618)
Seq/√Len: 178.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_D187_N4.5501.00
195_P201_V3.5621.00
49_H85_E3.1371.00
79_E86_D2.7681.00
152_E175_L2.5801.00
135_T196_A2.5431.00
156_H160_L2.4581.00
56_S59_A2.4551.00
153_E156_H2.4261.00
171_F175_L2.2851.00
159_M163_Q2.1721.00
45_L49_H2.1411.00
208_S211_Q2.1281.00
7_V138_F2.1131.00
153_E205_T2.0131.00
176_A180_E1.9741.00
57_E108_R1.9111.00
44_A99_A1.9011.00
46_A83_E1.8971.00
44_A100_A1.8891.00
146_F186_R1.8861.00
204_S212_V1.8541.00
143_V219_Y1.8461.00
121_R138_F1.8291.00
45_L82_L1.8271.00
115_R119_A1.8251.00
57_E106_F1.8081.00
207_L215_K1.7931.00
175_L179_K1.7731.00
215_K218_Q1.7691.00
180_E184_R1.7621.00
61_V108_R1.7491.00
24_A213_I1.7451.00
28_A217_L1.7261.00
47_A60_L1.7251.00
25_M216_A1.7071.00
20_T209_I1.6921.00
9_T133_M1.6581.00
145_I219_Y1.6541.00
170_N173_R1.6381.00
112_A116_R1.6001.00
31_W125_G1.5661.00
46_A50_H1.5591.00
151_S179_K1.5541.00
24_A28_A1.5481.00
48_L99_A1.5321.00
48_L96_V1.5131.00
176_A179_K1.4971.00
136_V191_A1.4821.00
46_A67_L1.4791.00
214_E218_Q1.4771.00
100_A184_R1.4541.00
200_L219_Y1.4461.00
29_L217_L1.4331.00
107_P111_E1.4331.00
107_P190_V1.4311.00
128_A133_M1.4261.00
34_L128_A1.4131.00
145_I216_A1.4071.00
180_E183_D1.3941.00
116_R119_A1.3891.00
39_I114_L1.3751.00
21_L213_I1.3741.00
160_L163_Q1.3491.00
160_L164_E1.3341.00
97_A100_A1.3261.00
135_T194_V1.3161.00
24_A27_E1.3161.00
188_R192_P1.3151.00
49_H90_E1.2871.00
6_P125_G1.2701.00
42_V80_V1.2631.00
28_A214_E1.2571.00
143_V220_A1.2571.00
47_A63_L1.2491.00
94_Q97_A1.2461.00
215_K219_Y1.2461.00
68_D83_E1.2341.00
115_R118_R1.2131.00
159_M169_V1.2011.00
8_I220_A1.2001.00
21_L216_A1.1881.00
112_A115_R1.1861.00
202_L215_K1.1781.00
25_M217_L1.1781.00
151_S175_L1.1731.00
62_P66_H1.1691.00
114_L191_A1.1631.00
25_M213_I1.1601.00
10_I22_C1.1541.00
111_E190_V1.1531.00
55_A102_Q1.1481.00
113_L117_Q1.1331.00
29_L221_R1.1321.00
70_R84_G1.1321.00
153_E206_T1.1291.00
45_L87_V1.1281.00
97_A162_L1.1181.00
6_P142_P1.1131.00
148_D186_R1.1071.00
85_E90_E1.0951.00
82_L87_V1.0891.00
173_R177_E1.0891.00
102_Q184_R1.0841.00
202_L219_Y1.0781.00
179_K183_D1.0681.00
62_P65_S1.0631.00
38_A91_I1.0591.00
65_S112_A1.0441.00
46_A63_L1.0270.99
119_A122_E1.0200.99
211_Q214_E1.0140.99
114_L137_V1.0050.99
147_L204_S0.9930.99
43_L67_L0.9890.99
43_L64_A0.9880.99
40_Y114_L0.9730.99
202_L216_A0.9720.99
69_V80_V0.9650.99
24_A210_E0.9650.99
6_P31_W0.9560.99
90_E93_T0.9560.99
59_A62_P0.9480.99
24_A209_I0.9470.99
161_Q165_K0.9450.99
196_A199_A0.9410.99
27_E76_G0.9390.99
35_D92_R0.9380.99
64_A112_A0.9300.99
173_R176_A0.9280.99
61_V106_F0.9270.99
54_V99_A0.9150.99
155_A175_L0.9100.99
39_I113_L0.9080.99
72_V81_I0.9050.99
57_E61_V0.9010.99
81_I86_D0.8960.99
172_E175_L0.8930.99
169_V174_L0.8920.99
218_Q222_Q0.8840.98
28_A213_I0.8840.98
23_K161_Q0.8830.98
114_L117_Q0.8830.98
194_V197_A0.8820.98
34_L120_F0.8810.98
121_R140_D0.8790.98
28_A221_R0.8780.98
39_I117_Q0.8760.98
7_V140_D0.8760.98
44_A96_V0.8730.98
102_Q105_A0.8640.98
22_C127_I0.8630.98
94_Q98_N0.8620.98
134_G196_A0.8580.98
148_D201_V0.8530.98
44_A184_R0.8510.98
98_N177_E0.8490.98
152_E179_K0.8480.98
108_R111_E0.8410.98
105_A184_R0.8230.97
38_A92_R0.8210.97
50_H66_H0.8190.97
45_L90_E0.8130.97
53_D56_S0.8130.97
7_V142_P0.8110.97
58_D62_P0.8100.97
209_I213_I0.8100.97
151_S178_I0.8040.97
150_S206_T0.8030.97
34_L126_L0.8010.97
152_E156_H0.8000.97
50_H83_E0.7990.97
35_D38_A0.7980.97
207_L211_Q0.7870.97
48_L95_E0.7850.97
49_H95_E0.7820.97
63_L66_H0.7780.96
68_D84_G0.7730.96
171_F174_L0.7690.96
163_Q166_G0.7680.96
210_E214_E0.7670.96
204_S216_A0.7650.96
35_D91_I0.7610.96
150_S205_T0.7580.96
219_Y222_Q0.7550.96
46_A82_L0.7530.96
207_L212_V0.7520.96
21_L209_I0.7500.96
29_L220_A0.7410.95
159_M174_L0.7350.95
71_F80_V0.7320.95
32_H124_P0.7310.95
7_V121_R0.7300.95
155_A171_F0.7260.95
15_G204_S0.7230.95
54_V103_V0.7230.95
163_Q168_S0.7190.95
43_L113_L0.7150.94
67_L83_E0.7080.94
170_N174_L0.7080.94
28_A210_E0.7080.94
72_V79_E0.7080.94
44_A97_A0.7050.94
133_M137_V0.7030.94
36_S113_L0.7020.94
79_E89_G0.7010.94
79_E88_S0.7000.94
68_D119_A0.6970.94
217_L221_R0.6950.94
44_A48_L0.6940.93
188_R191_A0.6920.93
162_L169_V0.6870.93
143_V200_L0.6850.93
114_L118_R0.6830.93
133_M138_F0.6820.93
58_D108_R0.6820.93
97_A184_R0.6800.93
98_N184_R0.6770.93
174_L178_I0.6760.93
25_M220_A0.6690.92
94_Q177_E0.6690.92
42_V91_I0.6690.92
15_G148_D0.6680.92
128_A138_F0.6650.92
144_K199_A0.6640.92
52_V63_L0.6630.92
145_I200_L0.6570.91
9_T196_A0.6550.91
45_L96_V0.6550.91
159_M170_N0.6500.91
9_T128_A0.6480.91
16_A178_I0.6480.91
150_S153_E0.6470.91
162_L167_F0.6420.91
145_I202_L0.6420.91
52_V59_A0.6410.90
186_R193_L0.6390.90
94_Q162_L0.6380.90
159_M171_F0.6380.90
91_I96_V0.6340.90
134_G199_A0.6340.90
156_H171_F0.6330.90
174_L177_E0.6320.90
212_V215_K0.6310.90
95_E98_N0.6300.90
150_S178_I0.6280.90
42_V69_V0.6250.89
36_S117_Q0.6200.89
122_E140_D0.6200.89
152_E171_F0.6200.89
136_V190_V0.6190.89
54_V60_L0.6180.89
8_I29_L0.6160.89
47_A54_V0.6150.89
21_L212_V0.6130.88
36_S128_A0.6070.88
14_S178_I0.6070.88
25_M127_I0.6020.88
71_F120_F0.6010.87
118_R138_F0.6010.87
93_T96_V0.5990.87
13_P16_A0.5930.87
16_A204_S0.5930.87
60_L106_F0.5930.87
73_S78_L0.5920.87
45_L85_E0.5890.86
118_R122_E0.5860.86
15_G147_L0.5850.86
166_G169_V0.5840.86
195_P198_D0.5810.86
86_D91_I0.5790.85
202_L212_V0.5780.85
36_S39_I0.5750.85
42_V87_V0.5730.85
177_E180_E0.5720.85
135_T198_D0.5720.85
52_V60_L0.5720.85
9_T134_G0.5710.85
183_D186_R0.5700.85
214_E217_L0.5660.84
146_F192_P0.5660.84
90_E95_E0.5650.84
111_E115_R0.5650.84
64_A108_R0.5630.84
96_V100_A0.5620.84
10_I127_I0.5580.83
135_T195_P0.5570.83
119_A123_L0.5570.83
146_F193_L0.5550.83
12_G18_K0.5540.83
142_P220_A0.5530.83
126_L138_F0.5520.83
9_T138_F0.5460.82
61_V65_S0.5440.82
43_L63_L0.5440.82
52_V56_S0.5430.82
111_E114_L0.5390.81
31_W220_A0.5380.81
70_R123_L0.5380.81
47_A103_V0.5380.81
121_R126_L0.5370.81
144_K198_D0.5370.81
152_E172_E0.5360.81
50_H63_L0.5350.81
19_G39_I0.5320.80
167_F170_N0.5310.80
93_T167_F0.5290.80
19_G42_V0.5280.80
42_V82_L0.5200.79
65_S115_R0.5200.79
100_A105_A0.5150.78
22_C33_L0.5130.78
16_A148_D0.5130.78
114_L190_V0.5120.78
8_I25_M0.5080.77
126_L133_M0.5070.77
54_V102_Q0.5060.77
7_V126_L0.5040.77
39_I42_V0.5040.77
187_N190_V0.5030.77
172_E176_A0.5030.77
70_R81_I0.5020.76
7_V124_P0.5020.76
61_V109_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r20A 3 0.9515 100 0.491 Contact Map
1ckeA 1 0.9339 100 0.502 Contact Map
2h92A 1 0.9471 100 0.554 Contact Map
4e22A 1 0.9383 100 0.557 Contact Map
1q3tA 1 0.9692 100 0.559 Contact Map
3akeA 1 0.9075 100 0.565 Contact Map
1a7jA 5 0.859 100 0.657 Contact Map
3hdtA 2 0.696 99.9 0.719 Contact Map
3fdiA 3 0.7489 99.9 0.722 Contact Map
2grjA 2 0.7797 99.8 0.739 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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