KCY - ECOLI - GREMLIN Contacts

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KCY - Cytidylate kinase

UniProt:	P0A6I0	Sequences: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11265
Length:	227 (216)
Sequences:	3765 (2618)
Seq/√Len:	178.1

ECOLI - KCY
BACSU - KCY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_D	187_N	4.550	1.00
195_P	201_V	3.562	1.00
49_H	85_E	3.137	1.00
79_E	86_D	2.768	1.00
152_E	175_L	2.580	1.00
135_T	196_A	2.543	1.00
156_H	160_L	2.458	1.00
56_S	59_A	2.455	1.00
153_E	156_H	2.426	1.00
171_F	175_L	2.285	1.00
159_M	163_Q	2.172	1.00
45_L	49_H	2.141	1.00
208_S	211_Q	2.128	1.00
7_V	138_F	2.113	1.00
153_E	205_T	2.013	1.00
176_A	180_E	1.974	1.00
57_E	108_R	1.911	1.00
44_A	99_A	1.901	1.00
46_A	83_E	1.897	1.00
44_A	100_A	1.889	1.00
146_F	186_R	1.886	1.00
204_S	212_V	1.854	1.00
143_V	219_Y	1.846	1.00
121_R	138_F	1.829	1.00
45_L	82_L	1.827	1.00
115_R	119_A	1.825	1.00
57_E	106_F	1.808	1.00
207_L	215_K	1.793	1.00
175_L	179_K	1.773	1.00
215_K	218_Q	1.769	1.00
180_E	184_R	1.762	1.00
61_V	108_R	1.749	1.00
24_A	213_I	1.745	1.00
28_A	217_L	1.726	1.00
47_A	60_L	1.725	1.00
25_M	216_A	1.707	1.00
20_T	209_I	1.692	1.00
9_T	133_M	1.658	1.00
145_I	219_Y	1.654	1.00
170_N	173_R	1.638	1.00
112_A	116_R	1.600	1.00
31_W	125_G	1.566	1.00
46_A	50_H	1.559	1.00
151_S	179_K	1.554	1.00
24_A	28_A	1.548	1.00
48_L	99_A	1.532	1.00
48_L	96_V	1.513	1.00
176_A	179_K	1.497	1.00
136_V	191_A	1.482	1.00
46_A	67_L	1.479	1.00
214_E	218_Q	1.477	1.00
100_A	184_R	1.454	1.00
200_L	219_Y	1.446	1.00
29_L	217_L	1.433	1.00
107_P	111_E	1.433	1.00
107_P	190_V	1.431	1.00
128_A	133_M	1.426	1.00
34_L	128_A	1.413	1.00
145_I	216_A	1.407	1.00
180_E	183_D	1.394	1.00
116_R	119_A	1.389	1.00
39_I	114_L	1.375	1.00
21_L	213_I	1.374	1.00
160_L	163_Q	1.349	1.00
160_L	164_E	1.334	1.00
97_A	100_A	1.326	1.00
135_T	194_V	1.316	1.00
24_A	27_E	1.316	1.00
188_R	192_P	1.315	1.00
49_H	90_E	1.287	1.00
6_P	125_G	1.270	1.00
42_V	80_V	1.263	1.00
28_A	214_E	1.257	1.00
143_V	220_A	1.257	1.00
47_A	63_L	1.249	1.00
94_Q	97_A	1.246	1.00
215_K	219_Y	1.246	1.00
68_D	83_E	1.234	1.00
115_R	118_R	1.213	1.00
159_M	169_V	1.201	1.00
8_I	220_A	1.200	1.00
21_L	216_A	1.188	1.00
112_A	115_R	1.186	1.00
202_L	215_K	1.178	1.00
25_M	217_L	1.178	1.00
151_S	175_L	1.173	1.00
62_P	66_H	1.169	1.00
114_L	191_A	1.163	1.00
25_M	213_I	1.160	1.00
10_I	22_C	1.154	1.00
111_E	190_V	1.153	1.00
55_A	102_Q	1.148	1.00
113_L	117_Q	1.133	1.00
29_L	221_R	1.132	1.00
70_R	84_G	1.132	1.00
153_E	206_T	1.129	1.00
45_L	87_V	1.128	1.00
97_A	162_L	1.118	1.00
6_P	142_P	1.113	1.00
148_D	186_R	1.107	1.00
85_E	90_E	1.095	1.00
82_L	87_V	1.089	1.00
173_R	177_E	1.089	1.00
102_Q	184_R	1.084	1.00
202_L	219_Y	1.078	1.00
179_K	183_D	1.068	1.00
62_P	65_S	1.063	1.00
38_A	91_I	1.059	1.00
65_S	112_A	1.044	1.00
46_A	63_L	1.027	0.99
119_A	122_E	1.020	0.99
211_Q	214_E	1.014	0.99
114_L	137_V	1.005	0.99
147_L	204_S	0.993	0.99
43_L	67_L	0.989	0.99
43_L	64_A	0.988	0.99
40_Y	114_L	0.973	0.99
202_L	216_A	0.972	0.99
69_V	80_V	0.965	0.99
24_A	210_E	0.965	0.99
6_P	31_W	0.956	0.99
90_E	93_T	0.956	0.99
59_A	62_P	0.948	0.99
24_A	209_I	0.947	0.99
161_Q	165_K	0.945	0.99
196_A	199_A	0.941	0.99
27_E	76_G	0.939	0.99
35_D	92_R	0.938	0.99
64_A	112_A	0.930	0.99
173_R	176_A	0.928	0.99
61_V	106_F	0.927	0.99
54_V	99_A	0.915	0.99
155_A	175_L	0.910	0.99
39_I	113_L	0.908	0.99
72_V	81_I	0.905	0.99
57_E	61_V	0.901	0.99
81_I	86_D	0.896	0.99
172_E	175_L	0.893	0.99
169_V	174_L	0.892	0.99
218_Q	222_Q	0.884	0.98
28_A	213_I	0.884	0.98
23_K	161_Q	0.883	0.98
114_L	117_Q	0.883	0.98
194_V	197_A	0.882	0.98
34_L	120_F	0.881	0.98
121_R	140_D	0.879	0.98
28_A	221_R	0.878	0.98
39_I	117_Q	0.876	0.98
7_V	140_D	0.876	0.98
44_A	96_V	0.873	0.98
102_Q	105_A	0.864	0.98
22_C	127_I	0.863	0.98
94_Q	98_N	0.862	0.98
134_G	196_A	0.858	0.98
148_D	201_V	0.853	0.98
44_A	184_R	0.851	0.98
98_N	177_E	0.849	0.98
152_E	179_K	0.848	0.98
108_R	111_E	0.841	0.98
105_A	184_R	0.823	0.97
38_A	92_R	0.821	0.97
50_H	66_H	0.819	0.97
45_L	90_E	0.813	0.97
53_D	56_S	0.813	0.97
7_V	142_P	0.811	0.97
58_D	62_P	0.810	0.97
209_I	213_I	0.810	0.97
151_S	178_I	0.804	0.97
150_S	206_T	0.803	0.97
34_L	126_L	0.801	0.97
152_E	156_H	0.800	0.97
50_H	83_E	0.799	0.97
35_D	38_A	0.798	0.97
207_L	211_Q	0.787	0.97
48_L	95_E	0.785	0.97
49_H	95_E	0.782	0.97
63_L	66_H	0.778	0.96
68_D	84_G	0.773	0.96
171_F	174_L	0.769	0.96
163_Q	166_G	0.768	0.96
210_E	214_E	0.767	0.96
204_S	216_A	0.765	0.96
35_D	91_I	0.761	0.96
150_S	205_T	0.758	0.96
219_Y	222_Q	0.755	0.96
46_A	82_L	0.753	0.96
207_L	212_V	0.752	0.96
21_L	209_I	0.750	0.96
29_L	220_A	0.741	0.95
159_M	174_L	0.735	0.95
71_F	80_V	0.732	0.95
32_H	124_P	0.731	0.95
7_V	121_R	0.730	0.95
155_A	171_F	0.726	0.95
15_G	204_S	0.723	0.95
54_V	103_V	0.723	0.95
163_Q	168_S	0.719	0.95
43_L	113_L	0.715	0.94
67_L	83_E	0.708	0.94
170_N	174_L	0.708	0.94
28_A	210_E	0.708	0.94
72_V	79_E	0.708	0.94
44_A	97_A	0.705	0.94
133_M	137_V	0.703	0.94
36_S	113_L	0.702	0.94
79_E	89_G	0.701	0.94
79_E	88_S	0.700	0.94
68_D	119_A	0.697	0.94
217_L	221_R	0.695	0.94
44_A	48_L	0.694	0.93
188_R	191_A	0.692	0.93
162_L	169_V	0.687	0.93
143_V	200_L	0.685	0.93
114_L	118_R	0.683	0.93
133_M	138_F	0.682	0.93
58_D	108_R	0.682	0.93
97_A	184_R	0.680	0.93
98_N	184_R	0.677	0.93
174_L	178_I	0.676	0.93
25_M	220_A	0.669	0.92
94_Q	177_E	0.669	0.92
42_V	91_I	0.669	0.92
15_G	148_D	0.668	0.92
128_A	138_F	0.665	0.92
144_K	199_A	0.664	0.92
52_V	63_L	0.663	0.92
145_I	200_L	0.657	0.91
9_T	196_A	0.655	0.91
45_L	96_V	0.655	0.91
159_M	170_N	0.650	0.91
9_T	128_A	0.648	0.91
16_A	178_I	0.648	0.91
150_S	153_E	0.647	0.91
162_L	167_F	0.642	0.91
145_I	202_L	0.642	0.91
52_V	59_A	0.641	0.90
186_R	193_L	0.639	0.90
94_Q	162_L	0.638	0.90
159_M	171_F	0.638	0.90
91_I	96_V	0.634	0.90
134_G	199_A	0.634	0.90
156_H	171_F	0.633	0.90
174_L	177_E	0.632	0.90
212_V	215_K	0.631	0.90
95_E	98_N	0.630	0.90
150_S	178_I	0.628	0.90
42_V	69_V	0.625	0.89
36_S	117_Q	0.620	0.89
122_E	140_D	0.620	0.89
152_E	171_F	0.620	0.89
136_V	190_V	0.619	0.89
54_V	60_L	0.618	0.89
8_I	29_L	0.616	0.89
47_A	54_V	0.615	0.89
21_L	212_V	0.613	0.88
36_S	128_A	0.607	0.88
14_S	178_I	0.607	0.88
25_M	127_I	0.602	0.88
71_F	120_F	0.601	0.87
118_R	138_F	0.601	0.87
93_T	96_V	0.599	0.87
13_P	16_A	0.593	0.87
16_A	204_S	0.593	0.87
60_L	106_F	0.593	0.87
73_S	78_L	0.592	0.87
45_L	85_E	0.589	0.86
118_R	122_E	0.586	0.86
15_G	147_L	0.585	0.86
166_G	169_V	0.584	0.86
195_P	198_D	0.581	0.86
86_D	91_I	0.579	0.85
202_L	212_V	0.578	0.85
36_S	39_I	0.575	0.85
42_V	87_V	0.573	0.85
177_E	180_E	0.572	0.85
135_T	198_D	0.572	0.85
52_V	60_L	0.572	0.85
9_T	134_G	0.571	0.85
183_D	186_R	0.570	0.85
214_E	217_L	0.566	0.84
146_F	192_P	0.566	0.84
90_E	95_E	0.565	0.84
111_E	115_R	0.565	0.84
64_A	108_R	0.563	0.84
96_V	100_A	0.562	0.84
10_I	127_I	0.558	0.83
135_T	195_P	0.557	0.83
119_A	123_L	0.557	0.83
146_F	193_L	0.555	0.83
12_G	18_K	0.554	0.83
142_P	220_A	0.553	0.83
126_L	138_F	0.552	0.83
9_T	138_F	0.546	0.82
61_V	65_S	0.544	0.82
43_L	63_L	0.544	0.82
52_V	56_S	0.543	0.82
111_E	114_L	0.539	0.81
31_W	220_A	0.538	0.81
70_R	123_L	0.538	0.81
47_A	103_V	0.538	0.81
121_R	126_L	0.537	0.81
144_K	198_D	0.537	0.81
152_E	172_E	0.536	0.81
50_H	63_L	0.535	0.81
19_G	39_I	0.532	0.80
167_F	170_N	0.531	0.80
93_T	167_F	0.529	0.80
19_G	42_V	0.528	0.80
42_V	82_L	0.520	0.79
65_S	115_R	0.520	0.79
100_A	105_A	0.515	0.78
22_C	33_L	0.513	0.78
16_A	148_D	0.513	0.78
114_L	190_V	0.512	0.78
8_I	25_M	0.508	0.77
126_L	133_M	0.507	0.77
54_V	102_Q	0.506	0.77
7_V	126_L	0.504	0.77
39_I	42_V	0.504	0.77
187_N	190_V	0.503	0.77
172_E	176_A	0.503	0.77
70_R	81_I	0.502	0.76
7_V	124_P	0.502	0.76
61_V	109_V	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3r20A	3	0.9515	100	0.491	Contact Map
1ckeA	1	0.9339	100	0.502	Contact Map
2h92A	1	0.9471	100	0.554	Contact Map
4e22A	1	0.9383	100	0.557	Contact Map
1q3tA	1	0.9692	100	0.559	Contact Map
3akeA	1	0.9075	100	0.565	Contact Map
1a7jA	5	0.859	100	0.657	Contact Map
3hdtA	2	0.696	99.9	0.719	Contact Map
3fdiA	3	0.7489	99.9	0.722	Contact Map
2grjA	2	0.7797	99.8	0.739	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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