GREMLIN Database
CLSA - Cardiolipin synthase A
UniProt: P0A6H8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11608
Length: 486 (468)
Sequences: 3664 (2738)
Seq/√Len: 126.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_Q167_A6.3201.00
168_A171_R6.0231.00
394_K459_L5.8901.00
137_D236_Y5.5131.00
138_I164_S5.4001.00
363_D394_K4.0781.00
134_L228_I3.9361.00
137_D263_R3.7521.00
235_A272_M3.7301.00
167_A171_R3.3671.00
135_I164_S3.2971.00
152_W177_L3.2741.00
412_G447_A3.2131.00
135_I161_V2.9741.00
122_Q133_A2.8271.00
118_G267_P2.7731.00
120_Q265_E2.7051.00
174_H202_E2.6871.00
130_V149_F2.6371.00
130_V134_L2.6351.00
367_I457_S2.6171.00
400_G456_R2.5751.00
358_A393_V2.5501.00
365_S394_K2.5301.00
310_T435_L2.5291.00
166_M199_A2.4941.00
137_D140_L2.4841.00
452_D455_S2.4761.00
415_S446_L2.4591.00
338_I365_S2.4071.00
458_R464_L2.3441.00
415_S443_G2.3401.00
235_A269_A2.3381.00
416_L434_T2.2991.00
437_I442_F2.2901.00
336_Y447_A2.2751.00
137_D234_I2.2691.00
136_R140_L2.2561.00
162_A195_L2.2251.00
138_I145_I2.1801.00
164_S168_A2.1531.00
236_Y263_R2.1441.00
133_A236_Y2.1151.00
468_R476_E2.0961.00
399_E458_R2.0931.00
336_Y412_G2.0921.00
196_M201_I2.0801.00
146_E176_R2.0671.00
133_A137_D2.0461.00
142_R233_Y2.0411.00
365_S454_I2.0391.00
162_A166_M2.0311.00
329_A410_V2.0251.00
396_Y459_L2.0221.00
367_I454_I1.9781.00
340_T367_I1.9761.00
166_M170_R1.9641.00
370_R399_E1.9601.00
409_L443_G1.9431.00
147_M228_I1.9381.00
462_A466_L1.9291.00
372_N378_G1.9191.00
124_M133_A1.9191.00
142_R171_R1.9071.00
154_P159_D1.8961.00
133_A263_R1.8941.00
330_A337_L1.8751.00
338_I363_D1.8711.00
194_E198_N1.8611.00
227_M272_M1.8581.00
385_F395_I1.8521.00
368_L385_F1.8481.00
139_Q164_S1.8361.00
179_L205_E1.8101.00
447_A451_D1.7991.00
338_I451_D1.7831.00
139_Q160_Q1.7791.00
202_E286_K1.7781.00
382_R397_Q1.7751.00
144_N273_G1.7631.00
337_L410_V1.7571.00
264_M268_I1.7561.00
156_G250_Q1.7271.00
268_I308_I1.7241.00
355_C387_E1.7081.00
126_E129_D1.7011.00
135_I160_Q1.6921.00
258_I453_Y1.6821.00
454_I457_S1.6741.00
204_V284_T1.6611.00
116_V271_A1.6191.00
163_E166_M1.6171.00
144_N232_N1.5961.00
322_I420_V1.5941.00
119_N264_M1.5781.00
162_A192_W1.5701.00
227_M433_I1.5611.00
122_Q263_R1.5611.00
306_H439_D1.5481.00
335_E412_G1.5451.00
132_Q160_Q1.5351.00
233_Y265_E1.5261.00
155_G158_A1.5261.00
126_E256_Q1.5141.00
146_E273_G1.5111.00
336_Y363_D1.5021.00
128_D132_Q1.5021.00
234_I263_R1.5001.00
123_L449_V1.4921.00
147_M161_V1.4851.00
370_R458_R1.4801.00
390_A462_A1.4731.00
329_A414_L1.4711.00
365_S451_D1.4671.00
389_L462_A1.4651.00
388_L393_V1.4521.00
164_S167_A1.4511.00
133_A136_R1.4441.00
308_I435_L1.4311.00
166_M195_L1.4271.00
234_I265_E1.4271.00
125_T449_V1.4121.00
155_G159_D1.3971.00
135_I139_Q1.3961.00
178_M283_E1.3961.00
465_W468_R1.3911.00
47_L50_V1.3891.00
385_F397_Q1.3871.00
121_L437_I1.3811.00
365_S396_Y1.3801.00
340_T403_L1.3741.00
134_L161_V1.3681.00
181_S205_E1.3531.00
122_Q445_D1.3341.00
397_Q460_L1.3331.00
156_G244_D1.3331.00
237_T272_M1.3261.00
338_I447_A1.3231.00
264_M435_L1.3171.00
137_D230_I1.3111.00
157_M244_D1.3061.00
232_N273_G1.3051.00
275_I312_A1.3051.00
175_C201_I1.2971.00
150_Y430_N1.2971.00
246_R249_K1.2931.00
121_L308_I1.2911.00
130_V261_M1.2841.00
132_Q136_R1.2691.00
268_I310_T1.2661.00
384_F480_Y1.2551.00
161_V242_M1.2461.00
139_Q171_R1.2451.00
340_T407_S1.2270.99
243_V246_R1.2250.99
325_A436_A1.2210.99
164_S171_R1.2020.99
115_G307_T1.1990.99
461_D464_L1.1980.99
323_H347_S1.1960.99
136_R139_Q1.1930.99
295_V298_M1.1910.99
107_C325_A1.1770.99
149_F228_I1.1760.99
448_A452_D1.1720.99
159_D163_E1.1700.99
139_Q168_A1.1690.99
382_R472_Q1.1640.99
376_L479_F1.1640.99
275_I433_I1.1620.99
229_M272_M1.1570.99
148_V223_Q1.1480.99
143_H233_Y1.1370.99
344_F366_I1.1260.99
417_V446_L1.1240.99
330_A357_A1.1190.99
262_A437_I1.1150.99
153_Q246_R1.1120.99
162_A201_I1.1090.99
367_I450_Q1.1070.99
383_A480_Y1.1070.99
336_Y409_L1.1050.99
124_M236_Y1.1050.99
340_T450_Q1.0910.99
335_E413_E1.0870.99
337_L354_I1.0860.99
195_L199_A1.0810.99
272_M433_I1.0660.99
379_W476_E1.0640.99
327_L350_L1.0620.99
130_V240_M1.0590.98
223_Q279_D1.0580.98
139_Q142_R1.0550.98
420_V434_T1.0550.98
237_T433_I1.0500.98
152_W242_M1.0500.98
379_W475_A1.0480.98
104_F107_C1.0470.98
123_L442_F1.0430.98
478_L482_F1.0390.98
24_T45_Y1.0300.98
452_D456_R1.0290.98
386_T466_L1.0250.98
389_L465_W1.0220.98
337_L357_A1.0190.98
336_Y410_V1.0180.98
305_G441_G1.0160.98
445_D448_A1.0150.98
161_V164_S1.0100.98
384_F483_S1.0090.98
137_D265_E1.0060.98
415_S442_F1.0030.98
367_I403_L1.0030.98
412_G444_A1.0010.98
160_Q163_E0.9990.98
179_L192_W0.9980.98
294_D298_M0.9890.98
153_Q243_V0.9870.98
163_E167_A0.9860.98
319_E359_Q0.9850.98
310_T433_I0.9830.98
294_D297_I0.9820.98
129_D132_Q0.9770.97
237_T435_L0.9760.97
450_Q454_I0.9750.97
334_R413_E0.9740.97
119_N267_P0.9740.97
350_L427_L0.9730.97
192_W196_M0.9710.97
365_S459_L0.9690.97
169_A199_A0.9670.97
422_L427_L0.9630.97
355_C359_Q0.9630.97
339_M408_V0.9610.97
147_M242_M0.9510.97
331_Y353_A0.9450.97
368_L381_S0.9420.97
169_A201_I0.9410.97
320_D428_W0.9360.97
262_A435_L0.9320.97
451_D454_I0.9320.97
407_S450_Q0.9300.97
220_D425_R0.9270.96
138_I161_V0.9240.96
247_Y257_W0.9210.96
124_M263_R0.9200.96
121_L306_H0.9190.96
39_A43_I0.9150.96
306_H437_I0.9140.96
471_W475_A0.9120.96
256_Q398_F0.9090.96
396_Y454_I0.9080.96
145_I230_I0.9050.96
370_R397_Q0.8890.96
335_E363_D0.8890.96
363_D459_L0.8890.96
140_L230_I0.8870.95
166_M169_A0.8840.95
305_G439_D0.8820.95
370_R378_G0.8810.95
386_T390_A0.8790.95
85_L88_C0.8790.95
388_L395_I0.8740.95
140_L234_I0.8740.95
389_L460_L0.8700.95
125_T452_D0.8670.95
77_S82_L0.8650.95
176_R202_E0.8620.95
371_K375_M0.8570.95
327_L353_A0.8570.95
18_L22_G0.8560.95
149_F261_M0.8540.94
451_D455_S0.8530.94
257_W401_G0.8500.94
122_Q265_E0.8480.94
382_R385_F0.8470.94
382_R476_E0.8470.94
326_L416_L0.8460.94
416_L436_A0.8430.94
182_A185_V0.8430.94
413_E440_K0.8410.94
150_Y251_D0.8390.94
132_Q135_I0.8390.94
389_L459_L0.8370.94
409_L447_A0.8360.94
423_D430_N0.8360.94
146_E174_H0.8340.94
327_L331_Y0.8330.94
229_M269_A0.8310.94
333_A410_V0.8310.94
151_I246_R0.8300.94
193_P201_I0.8260.93
408_V416_L0.8240.93
134_L230_I0.8220.93
344_F388_L0.8220.93
368_L397_Q0.8200.93
386_T462_A0.8160.93
320_D323_H0.8150.93
308_I437_I0.8150.93
315_P431_F0.8140.93
121_L442_F0.8120.93
470_L473_R0.8110.93
155_G244_D0.8080.93
192_W195_L0.8080.93
188_F192_W0.8080.93
358_A391_A0.8070.93
166_M201_I0.8060.93
311_I325_A0.8030.92
228_I242_M0.8030.92
140_L143_H0.8020.92
366_I395_I0.8010.92
104_F115_G0.8010.92
71_A75_W0.8010.92
389_L395_I0.8000.92
260_L405_T0.7980.92
386_T468_R0.7980.92
146_E232_N0.7970.92
323_H349_D0.7960.92
24_T41_L0.7910.92
103_L106_L0.7900.92
131_M157_M0.7860.92
409_L415_S0.7860.92
419_T433_I0.7850.92
309_H313_S0.7810.91
398_F456_R0.7800.91
344_F351_L0.7790.91
459_L462_A0.7790.91
158_A162_A0.7760.91
251_D255_G0.7680.91
116_V119_N0.7680.91
330_A354_I0.7660.91
20_I24_T0.7650.90
474_V478_L0.7650.90
251_D254_V0.7630.90
386_T465_W0.7630.90
398_F401_G0.7620.90
152_W162_A0.7610.90
181_S207_L0.7610.90
42_L45_Y0.7600.90
146_E277_S0.7600.90
63_L67_R0.7600.90
385_F389_L0.7590.90
378_G397_Q0.7540.90
448_A451_D0.7530.90
21_A25_L0.7530.90
472_Q475_A0.7530.90
293_P296_N0.7500.90
442_F446_L0.7500.90
157_M160_Q0.7470.89
344_F395_I0.7450.89
179_L203_V0.7440.89
127_S131_M0.7420.89
131_M242_M0.7410.89
89_K92_F0.7410.89
102_P334_R0.7380.89
264_M308_I0.7370.89
407_S446_L0.7370.89
152_W161_V0.7350.89
260_L407_S0.7340.89
127_S239_S0.7340.89
139_Q175_C0.7330.89
313_S322_I0.7320.88
134_L137_D0.7320.88
237_T262_A0.7310.88
337_L362_V0.7290.88
463_R467_K0.7270.88
146_E229_M0.7250.88
322_I434_T0.7230.88
348_D352_H0.7210.88
99_V413_E0.7200.88
147_M177_L0.7200.88
19_L26_R0.7180.87
450_Q453_Y0.7170.87
409_L454_I0.7160.87
285_G288_I0.7140.87
353_A357_A0.7140.87
167_A170_R0.7130.87
328_T332_S0.7130.87
268_I271_A0.7130.87
77_S81_W0.7130.87
131_M161_V0.7130.87
23_V56_L0.7120.87
408_V422_L0.7120.87
160_Q164_S0.7110.87
324_Q359_Q0.7090.87
90_H93_A0.7090.87
259_D369_P0.7090.87
385_F460_L0.7080.87
16_Y24_T0.7060.87
140_L233_Y0.7060.87
125_T129_D0.7050.87
87_A90_H0.7050.87
243_V248_F0.7030.86
281_E284_T0.7020.86
148_V242_M0.7010.86
193_P197_R0.7000.86
156_G160_Q0.6990.86
306_H442_F0.6990.86
241_N247_Y0.6980.86
157_M248_F0.6960.86
78_T81_W0.6950.86
193_P203_V0.6940.86
249_K255_G0.6940.86
43_I47_L0.6890.85
86_K90_H0.6880.85
357_A360_R0.6870.85
336_Y365_S0.6870.85
101_A105_K0.6840.85
79_A82_L0.6810.85
354_I393_V0.6810.85
188_F191_P0.6800.85
230_I236_Y0.6790.84
351_L355_C0.6790.84
301_E448_A0.6780.84
380_A479_F0.6760.84
265_E303_A0.6740.84
169_A175_C0.6680.83
419_T430_N0.6660.83
166_M196_M0.6660.83
220_D239_S0.6660.83
152_W192_W0.6650.83
159_D195_L0.6640.83
169_A174_H0.6620.83
27_I37_A0.6610.83
42_L46_I0.6600.83
343_Y373_D0.6600.83
277_S288_I0.6600.83
190_S194_E0.6590.83
240_M261_M0.6560.82
188_F193_P0.6560.82
367_I453_Y0.6550.82
344_F422_L0.6550.82
257_W373_D0.6540.82
144_N277_S0.6540.82
458_R461_D0.6540.82
397_Q458_R0.6530.82
324_Q356_T0.6530.82
134_L419_T0.6520.82
442_F445_D0.6500.82
98_S101_A0.6500.82
195_L198_N0.6480.82
355_C391_A0.6470.81
381_S384_F0.6460.81
468_R473_R0.6460.81
187_F193_P0.6450.81
444_A448_A0.6440.81
47_L54_A0.6440.81
66_R70_R0.6440.81
470_L474_V0.6430.81
413_E439_D0.6420.81
440_K444_A0.6420.81
38_M42_L0.6390.81
158_A242_M0.6370.80
88_C91_I0.6350.80
179_L184_S0.6350.80
157_M242_M0.6330.80
135_I157_M0.6320.80
115_G438_D0.6320.80
124_M130_V0.6320.80
246_R254_V0.6320.80
44_I52_I0.6310.80
204_V283_E0.6300.80
449_V453_Y0.6300.80
102_P360_R0.6280.80
154_P191_P0.6250.79
244_D250_Q0.6240.79
73_A77_S0.6230.79
176_R280_W0.6230.79
260_L453_Y0.6220.79
319_E391_A0.6210.79
416_L420_V0.6180.78
16_Y20_I0.6170.78
290_P293_P0.6160.78
68_A71_A0.6160.78
152_W179_L0.6160.78
124_M129_D0.6140.78
20_I52_I0.6140.78
377_V381_S0.6110.78
166_M173_I0.6110.78
244_D248_F0.6110.78
323_H350_L0.6110.78
306_H440_K0.6110.78
221_L429_L0.6100.78
33_A36_S0.6090.77
329_A336_Y0.6090.77
461_D465_W0.6080.77
363_D451_D0.6070.77
239_S450_Q0.6070.77
317_F321_L0.6060.77
221_L315_P0.6060.77
206_A220_D0.6060.77
468_R472_Q0.6040.77
369_P374_S0.6040.77
409_L412_G0.6030.77
15_G90_H0.6020.77
170_R200_G0.6020.77
327_L330_A0.6020.77
326_L341_T0.6010.77
379_W468_R0.5980.76
120_Q305_G0.5980.76
61_L64_G0.5970.76
38_M41_L0.5970.76
243_V251_D0.5960.76
342_P402_L0.5960.76
155_G241_N0.5960.76
124_M137_D0.5950.76
178_M204_V0.5950.76
326_L420_V0.5950.76
128_D250_Q0.5950.76
131_M135_I0.5950.76
177_L203_V0.5950.76
116_V268_I0.5940.76
407_S417_V0.5930.76
119_N308_I0.5930.76
311_I436_A0.5930.76
170_R198_N0.5910.75
246_R250_Q0.5910.75
466_L469_P0.5900.75
469_P474_V0.5900.75
135_I168_A0.5870.75
176_R276_Y0.5870.75
374_S378_G0.5860.75
414_L436_A0.5860.75
380_A430_N0.5860.75
401_G431_F0.5830.74
47_L80_K0.5830.74
53_I101_A0.5820.74
126_E395_I0.5820.74
236_Y261_M0.5810.74
184_S187_F0.5810.74
127_S157_M0.5810.74
462_A469_P0.5800.74
28_L54_A0.5790.74
225_R279_D0.5760.73
281_E287_R0.5760.73
126_E132_Q0.5760.73
369_P402_L0.5750.73
329_A337_L0.5750.73
377_V380_A0.5730.73
89_K93_A0.5720.73
135_I145_I0.5720.73
326_L434_T0.5710.73
130_V228_I0.5710.73
135_I152_W0.5710.73
127_S259_D0.5700.73
156_G159_D0.5700.73
99_V334_R0.5680.72
324_Q355_C0.5670.72
384_F387_E0.5670.72
84_D98_S0.5670.72
197_R203_V0.5660.72
103_L107_C0.5640.72
88_C92_F0.5640.72
60_E63_L0.5640.72
46_I85_L0.5640.72
52_I56_L0.5630.72
279_D314_G0.5630.72
148_V225_R0.5620.72
170_R199_A0.5620.72
20_I26_R0.5620.72
265_E441_G0.5620.72
381_S385_F0.5610.72
154_P162_A0.5610.72
239_S453_Y0.5600.71
443_G446_L0.5600.71
387_E390_A0.5600.71
64_G68_A0.5590.71
91_I117_K0.5590.71
143_H455_S0.5590.71
23_V52_I0.5580.71
78_T82_L0.5580.71
369_P431_F0.5570.71
424_M428_W0.5560.71
48_P51_G0.5560.71
17_W21_A0.5560.71
350_L422_L0.5550.71
409_L450_Q0.5550.71
246_R374_S0.5540.71
349_D352_H0.5530.70
153_Q242_M0.5520.70
96_N99_V0.5510.70
313_S317_F0.5510.70
79_A83_N0.5500.70
117_K267_P0.5490.70
129_D256_Q0.5480.70
338_I454_I0.5480.70
364_V393_V0.5480.70
351_L387_E0.5460.70
347_S427_L0.5450.69
264_M272_M0.5440.69
87_A95_E0.5440.69
338_I409_L0.5440.69
127_S130_V0.5430.69
106_L110_R0.5430.69
78_T85_L0.5430.69
31_R34_V0.5430.69
127_S261_M0.5420.69
369_P381_S0.5410.69
79_A88_C0.5410.69
31_R477_R0.5400.69
454_I459_L0.5390.69
439_D442_F0.5390.69
33_A38_M0.5390.69
375_M475_A0.5380.68
383_A476_E0.5380.68
317_F322_I0.5370.68
92_F96_N0.5360.68
154_P188_F0.5350.68
136_R142_R0.5350.68
16_Y30_K0.5350.68
161_V470_L0.5340.68
126_E240_M0.5340.68
330_A350_L0.5340.68
248_F402_L0.5340.68
158_A192_W0.5340.68
399_E456_R0.5340.68
143_H174_H0.5320.68
368_L382_R0.5320.68
85_L90_H0.5320.68
375_M379_W0.5320.68
298_M301_E0.5320.68
144_N176_R0.5300.67
145_I165_L0.5300.67
138_I147_M0.5300.67
19_L22_G0.5300.67
437_I443_G0.5300.67
26_R60_E0.5290.67
191_P195_L0.5270.67
412_G443_G0.5270.67
130_V236_Y0.5270.67
23_V26_R0.5270.67
268_I435_L0.5260.67
315_P425_R0.5250.67
180_D225_R0.5250.67
29_M474_V0.5240.66
180_D222_R0.5240.66
145_I175_C0.5240.66
23_V45_Y0.5230.66
247_Y251_D0.5230.66
444_A447_A0.5230.66
256_Q400_G0.5220.66
119_N268_I0.5210.66
359_Q391_A0.5210.66
187_F419_T0.5210.66
115_G309_H0.5200.66
276_Y419_T0.5200.66
331_Y422_L0.5190.66
281_E285_G0.5190.66
236_Y269_A0.5180.65
159_D162_A0.5180.65
331_Y356_T0.5180.65
479_F482_F0.5180.65
227_M310_T0.5160.65
356_T360_R0.5160.65
323_H329_A0.5150.65
127_S220_D0.5150.65
131_M239_S0.5150.65
239_S259_D0.5140.65
137_D233_Y0.5140.65
426_S432_E0.5130.65
161_V228_I0.5130.65
379_W479_F0.5130.65
76_P285_G0.5120.65
306_H441_G0.5120.65
19_L23_V0.5110.64
20_I31_R0.5110.64
191_P194_E0.5110.64
60_E64_G0.5110.64
89_K94_E0.5110.64
458_R469_P0.5110.64
370_R375_M0.5100.64
118_G304_S0.5100.64
139_Q143_H0.5090.64
25_L29_M0.5090.64
176_R273_G0.5090.64
99_V102_P0.5080.64
88_C95_E0.5080.64
50_V54_A0.5080.64
41_L45_Y0.5080.64
180_D342_P0.5070.64
164_S230_I0.5070.64
159_D244_D0.5070.64
152_W158_A0.5070.64
191_P362_V0.5070.64
366_I459_L0.5060.64
229_M277_S0.5060.64
37_A42_L0.5050.64
82_L85_L0.5050.64
206_A431_F0.5050.64
234_I302_Q0.5050.64
390_A466_L0.5050.64
128_D256_Q0.5050.64
18_L21_A0.5030.63
145_I161_V0.5020.63
345_V424_M0.5020.63
75_W90_H0.5020.63
84_D88_C0.5020.63
65_K69_E0.5010.63
206_A239_S0.5010.63
62_H67_R0.5000.63
221_L269_A0.5000.63
33_A41_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.7798 100 0.494 Contact Map
3hsiA 2 0.784 100 0.502 Contact Map
2o8rA 2 0.7963 100 0.617 Contact Map
1xdpA 4 0.7449 100 0.619 Contact Map
4urjA 1 0.3374 100 0.794 Contact Map
2c1lA 2 0.3683 100 0.806 Contact Map
1byrA 2 0.3086 100 0.809 Contact Map
4gelA 2 0.358 100 0.811 Contact Map
4ggjA 2 0.3374 99.9 0.82 Contact Map
4rctA 2 0.3601 99.4 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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