GREMLIN Database
HSLU - ATP-dependent protease ATPase subunit HslU
UniProt: P0A6H5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11881
Length: 443 (436)
Sequences: 1509 (733)
Seq/√Len: 35.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
375_R426_S6.1441.00
40_L48_V5.5861.00
216_L224_L5.4031.00
337_T378_E4.9621.00
114_Q246_A4.8271.00
342_R346_E4.5361.00
100_I253_V4.5311.00
131_I173_I4.5101.00
99_I253_V4.4001.00
169_D222_M4.2931.00
128_E164_R4.1651.00
375_R378_E4.1051.00
22_N333_Q4.0581.00
336_T339_D4.0511.00
341_E374_K3.9741.00
161_K165_E3.8481.00
365_N417_N3.8391.00
162_K167_Q3.5471.00
285_V326_L3.5381.00
107_A247_V3.4071.00
115_A118_K3.3031.00
337_T374_K3.1961.00
367_E417_N3.1761.00
115_A242_D3.0521.00
8_E11_S3.0211.00
413_L416_Q3.0041.00
360_A365_N2.9821.00
217_K220_D2.9271.00
117_E120_R2.9241.00
134_V173_I2.7571.00
289_T296_M2.7531.00
357_A360_A2.7531.00
12_E15_K2.7441.00
75_N114_Q2.6891.00
104_T247_V2.6671.00
81_V255_I2.6651.00
14_D21_D2.5981.00
341_E373_I2.4291.00
247_V302_I2.4001.00
423_D426_S2.3290.99
131_I222_M2.2940.99
379_A398_V2.2940.99
245_D249_Q2.2650.99
104_T244_I2.2000.99
247_V297_V2.1210.99
124_E226_I2.0020.98
35_W39_Q1.9720.98
51_K400_E1.9410.98
371_S422_A1.9050.98
104_T294_H1.8910.97
176_D213_A1.8890.97
222_M226_I1.8880.97
113_V117_E1.8730.97
157_Q165_E1.8710.97
386_S436_E1.8660.97
40_L43_E1.8480.97
104_T297_V1.8470.97
366_I420_I1.8420.97
131_I134_V1.8160.97
129_E160_R1.8130.97
246_A250_H1.8120.97
352_T372_G1.8100.97
341_E370_D1.8070.97
367_E419_T1.7940.97
421_D427_K1.7810.96
43_E348_N1.7790.96
185_E188_A1.7780.96
364_V415_G1.7690.96
130_R228_E1.7490.96
25_R401_R1.7150.95
177_L224_L1.7150.95
159_F162_K1.7020.95
7_R412_D1.7020.95
155_A159_F1.6970.95
242_D245_D1.6870.95
11_S121_Y1.6790.95
235_N238_E1.6760.95
155_A158_A1.6340.94
158_A162_K1.6320.94
371_S421_D1.6040.93
115_A238_E1.5980.93
100_I247_V1.5800.93
405_E409_D1.5740.93
46_H72_K1.5700.93
111_V246_A1.5620.93
236_P239_L1.5620.93
108_V294_H1.5510.92
25_R404_E1.5220.92
120_R124_E1.5110.91
79_I247_V1.4720.90
284_L288_C1.4620.90
160_R164_R1.4580.90
116_I231_A1.4560.90
132_L160_R1.4520.89
382_Q386_S1.4330.89
94_K311_Q1.4300.89
383_V387_T1.4290.89
120_R226_I1.4190.88
128_E160_R1.4150.88
353_V356_K1.4130.88
383_V398_V1.4100.88
366_I403_M1.4070.88
352_T373_I1.4060.88
111_V114_Q1.3910.87
133_D156_R1.3500.86
219_K222_M1.3500.86
128_E163_L1.3430.85
16_H349_A1.3420.85
42_E45_R1.3330.85
163_L168_L1.3300.85
79_I106_A1.3240.85
345_T370_D1.3240.85
369_T419_T1.3220.84
131_I218_I1.3140.84
258_I261_I1.3040.84
347_P442_I1.3020.84
35_W281_L1.2980.83
43_E48_V1.2880.83
123_A127_A1.2870.83
263_K270_P1.2560.81
372_G421_D1.2460.81
409_D416_Q1.2420.81
376_I402_L1.2410.80
131_I221_A1.2340.80
184_V187_M1.2300.80
127_A226_I1.2220.79
423_D427_K1.2190.79
163_L169_D1.2190.79
347_P396_H1.2180.79
421_D424_Y1.2180.79
198_Q201_S1.2150.79
163_L222_M1.1990.78
400_E410_A1.1910.78
197_S200_Q1.1740.77
399_L402_L1.1730.77
178_A228_E1.1690.76
226_I230_A1.1610.76
360_A363_G1.1560.76
362_E415_G1.1550.75
105_D294_H1.1460.75
405_E428_H1.1420.75
130_R229_E1.1380.74
422_A426_S1.1380.74
136_I159_F1.1320.74
183_G187_M1.1290.74
369_T421_D1.1240.73
162_K171_K1.1060.72
338_S374_K1.0980.72
336_T340_F1.0930.71
26_S404_E1.0890.71
157_Q160_R1.0850.71
48_V361_T1.0850.71
4_M11_S1.0830.71
109_K281_L1.0790.70
119_N123_A1.0760.70
362_E412_D1.0740.70
356_K367_E1.0730.70
179_A210_K1.0700.70
112_R236_P1.0690.70
187_M191_G1.0690.70
229_E232_K1.0680.69
86_F99_I1.0670.69
159_F171_K1.0540.68
134_V175_I1.0530.68
407_S410_A1.0520.68
192_M195_M1.0490.68
178_A211_Q1.0450.68
110_M258_I1.0370.67
401_R432_L1.0280.67
40_L366_I1.0260.66
44_L349_A1.0260.66
91_Y272_V1.0200.66
379_A433_V1.0160.66
70_L301_H1.0140.65
420_I424_Y1.0130.65
21_D25_R1.0040.65
174_E213_A1.0020.64
264_R267_S1.0000.64
44_L357_A0.9960.64
288_C396_H0.9950.64
25_R169_D0.9950.64
38_M250_H0.9920.64
54_L84_T0.9920.64
170_D217_K0.9790.63
122_R126_L0.9750.62
107_A244_I0.9740.62
91_Y274_R0.9620.61
76_A79_I0.9580.61
40_L360_A0.9520.60
337_T381_W0.9510.60
127_A222_M0.9510.60
43_E46_H0.9510.60
128_E222_M0.9480.60
243_A301_H0.9410.60
176_D211_Q0.9370.59
406_I418_I0.9370.59
104_T108_V0.9330.59
29_I404_E0.9310.59
26_S328_I0.9270.58
262_C312_I0.9240.58
400_E407_S0.9210.58
375_R422_A0.9180.58
379_A383_V0.9130.57
15_K348_N0.9100.57
372_G406_I0.9100.57
291_S352_T0.9100.57
436_E440_R0.9070.57
51_K410_A0.9040.56
18_I334_A0.9030.56
21_D333_Q0.8970.56
111_V115_A0.8960.56
56_I439_S0.8930.56
352_T366_I0.8910.55
110_M288_C0.8880.55
121_Y124_E0.8850.55
111_V242_D0.8840.55
155_A171_K0.8840.55
184_V188_A0.8830.55
108_V203_F0.8800.54
185_E191_G0.8760.54
350_S353_V0.8760.54
350_S411_S0.8750.54
187_M190_P0.8700.54
136_I155_A0.8690.53
85_K94_K0.8690.53
29_I33_N0.8670.53
382_Q434_A0.8660.53
387_T440_R0.8650.53
119_N230_A0.8630.53
174_E215_K0.8620.53
252_I305_I0.8620.53
27_V66_I0.8610.53
239_L350_S0.8590.53
54_L326_L0.8550.52
284_L326_L0.8550.52
297_V348_N0.8520.52
372_G424_Y0.8520.52
136_I352_T0.8470.52
112_R231_A0.8470.52
114_Q118_K0.8460.52
8_E412_D0.8410.51
169_D219_K0.8410.51
125_E129_E0.8410.51
236_P284_L0.8390.51
357_A405_E0.8360.51
409_D412_D0.8360.51
108_V239_L0.8350.51
404_E424_Y0.8350.51
157_Q161_K0.8330.50
406_I420_I0.8330.50
15_K48_V0.8320.50
58_P84_T0.8300.50
162_K165_E0.8240.50
97_D403_M0.8210.49
51_K407_S0.8170.49
374_K422_A0.8160.49
249_Q340_F0.8160.49
56_I383_V0.8120.49
288_C319_I0.8090.48
275_E350_S0.8060.48
86_F231_A0.8020.48
362_E410_A0.8020.48
11_S16_H0.7970.47
262_C281_L0.7950.47
75_N111_V0.7940.47
119_N127_A0.7930.47
382_Q385_E0.7930.47
84_T138_P0.7920.47
218_I223_K0.7900.47
362_E413_L0.7890.47
91_Y320_P0.7890.47
379_A430_D0.7840.46
334_A389_N0.7800.46
127_A230_A0.7790.46
172_E215_K0.7780.46
26_S203_F0.7770.46
92_V272_V0.7740.45
86_F136_I0.7740.45
253_V284_L0.7730.45
201_S207_G0.7680.45
359_M403_M0.7680.45
439_S442_I0.7660.45
185_E194_E0.7640.44
347_P439_S0.7630.44
193_E196_T0.7530.44
118_K122_R0.7530.44
307_S373_I0.7520.43
185_E189_P0.7500.43
188_A196_T0.7470.43
274_R320_P0.7450.43
356_K359_M0.7440.43
378_E382_Q0.7440.43
315_P329_R0.7440.43
130_R135_L0.7420.43
7_R43_E0.7420.43
126_L232_K0.7400.42
108_V240_K0.7390.42
166_G169_D0.7380.42
409_D413_L0.7380.42
18_I21_D0.7370.42
132_L159_F0.7370.42
100_I121_Y0.7340.42
379_A402_L0.7330.42
97_D215_K0.7330.42
204_Q337_T0.7290.42
190_P281_L0.7280.41
17_I27_V0.7280.41
193_E200_Q0.7270.41
150_Q154_A0.7250.41
334_A342_R0.7230.41
190_P198_Q0.7230.41
126_L215_K0.7220.41
173_I225_L0.7220.41
123_A233_L0.7220.41
328_I439_S0.7210.41
29_I372_G0.7210.41
132_L163_L0.7200.41
8_E117_E0.7190.41
92_V274_R0.7190.41
284_L307_S0.7180.41
31_L74_A0.7160.40
212_K237_E0.7160.40
112_R234_V0.7130.40
401_R404_E0.7110.40
158_A171_K0.7110.40
356_K360_A0.7110.40
75_N246_A0.7100.40
190_P297_V0.7100.40
179_A211_Q0.7100.40
9_I61_V0.7090.40
359_M415_G0.7080.40
29_I318_L0.7070.40
38_M255_I0.7060.40
7_R409_D0.7060.40
79_I253_V0.7050.40
194_E261_I0.7050.40
132_L136_I0.7040.39
356_K374_K0.7030.39
240_K294_H0.7030.39
136_I441_F0.7020.39
312_I385_E0.7000.39
175_I216_L0.6990.39
356_K365_N0.6980.39
347_P398_V0.6980.39
167_Q372_G0.6970.39
18_I182_M0.6960.39
187_M192_M0.6940.39
290_V420_I0.6940.39
188_A194_E0.6920.38
104_T118_K0.6920.38
95_E311_Q0.6900.38
127_A218_I0.6820.38
26_S131_I0.6800.38
173_I217_K0.6800.38
54_L175_I0.6790.37
157_Q337_T0.6780.37
202_M369_T0.6780.37
154_A158_A0.6760.37
265_G270_P0.6750.37
161_K167_Q0.6750.37
9_I433_V0.6750.37
237_E360_A0.6740.37
177_L363_G0.6720.37
341_E356_K0.6710.37
51_K424_Y0.6710.37
227_E250_H0.6700.37
47_E361_T0.6700.37
39_Q281_L0.6690.37
54_L230_A0.6680.37
198_Q207_G0.6670.36
91_Y156_R0.6670.36
18_I382_Q0.6660.36
426_S430_D0.6610.36
11_S14_D0.6600.36
94_K101_R0.6590.36
99_I284_L0.6560.36
217_K222_M0.6560.36
188_A275_E0.6550.36
84_T307_S0.6550.36
429_L433_V0.6540.35
129_E265_G0.6530.35
202_M360_A0.6530.35
111_V429_L0.6520.35
236_P240_K0.6520.35
173_I218_I0.6490.35
380_A398_V0.6480.35
97_D428_H0.6480.35
347_P399_L0.6470.35
356_K441_F0.6470.35
424_Y428_H0.6450.35
47_E73_L0.6450.35
366_I406_I0.6440.35
186_I193_E0.6440.35
15_K313_A0.6440.35
211_Q297_V0.6430.35
125_E405_E0.6430.35
127_A229_E0.6420.35
265_G297_V0.6420.35
188_A193_E0.6420.35
110_M347_P0.6410.34
200_Q429_L0.6410.34
338_S341_E0.6400.34
151_E430_D0.6400.34
221_A224_L0.6350.34
350_S355_Y0.6340.34
97_D355_Y0.6340.34
76_A200_Q0.6340.34
352_T399_L0.6330.34
231_A234_V0.6330.34
359_M371_S0.6330.34
351_I399_L0.6320.34
275_E412_D0.6320.34
56_I432_L0.6300.34
255_I431_A0.6280.33
176_D378_E0.6270.33
362_E372_G0.6260.33
371_S406_I0.6250.33
265_G441_F0.6240.33
328_I331_E0.6240.33
125_E161_K0.6230.33
131_I169_D0.6230.33
376_I399_L0.6220.33
16_H350_S0.6220.33
223_K238_E0.6220.33
432_L439_S0.6210.33
3_E39_Q0.6210.33
248_E340_F0.6200.33
100_I104_T0.6200.33
133_D138_P0.6200.33
8_E164_R0.6190.33
371_S423_D0.6180.33
56_I315_P0.6170.33
412_D416_Q0.6150.32
40_L271_D0.6150.32
342_R347_P0.6140.32
383_V432_L0.6130.32
15_K18_I0.6110.32
7_R426_S0.6110.32
4_M8_E0.6110.32
347_P412_D0.6100.32
124_E128_E0.6100.32
326_L334_A0.6090.32
406_I416_Q0.6090.32
364_V414_S0.6080.32
29_I212_K0.6080.32
352_T428_H0.6080.32
174_E289_T0.6070.32
47_E99_I0.6070.32
35_W74_A0.6060.32
129_E408_Y0.6060.32
379_A429_L0.6050.32
390_I397_T0.6050.32
162_K262_C0.6050.32
95_E101_R0.6050.32
244_I328_I0.6040.32
374_K421_D0.6040.32
15_K297_V0.6040.32
171_K341_E0.6030.32
94_K108_V0.6020.31
100_I396_H0.6010.31
76_A84_T0.5990.31
267_S270_P0.5990.31
15_K174_E0.5990.31
72_K441_F0.5980.31
100_I302_I0.5970.31
130_R232_K0.5970.31
38_M48_V0.5960.31
337_T375_R0.5960.31
5_T137_P0.5960.31
271_D307_S0.5960.31
122_R125_E0.5950.31
429_L432_L0.5950.31
111_V250_H0.5940.31
151_E154_A0.5930.31
128_E157_Q0.5920.31
182_M217_K0.5910.31
46_H298_K0.5910.31
48_V212_K0.5910.31
49_T244_I0.5900.31
134_V307_S0.5890.31
25_R127_A0.5890.31
109_K296_M0.5880.30
107_A110_M0.5880.30
107_A161_K0.5870.30
341_E345_T0.5860.30
17_I255_I0.5850.30
26_S220_D0.5850.30
362_E416_Q0.5830.30
386_S433_V0.5830.30
137_P319_I0.5820.30
12_E229_E0.5810.30
75_N184_V0.5790.30
234_V288_C0.5790.30
411_S424_Y0.5780.30
211_Q396_H0.5760.30
386_S440_R0.5750.30
359_M416_Q0.5730.29
44_L135_L0.5730.29
177_L423_D0.5730.29
54_L315_P0.5730.29
55_M66_I0.5720.29
383_V439_S0.5720.29
186_I199_L0.5680.29
195_M261_I0.5670.29
255_I306_A0.5670.29
132_L155_A0.5660.29
179_A202_M0.5650.29
58_P389_N0.5650.29
396_H399_L0.5640.29
213_A293_K0.5630.29
238_E398_V0.5630.29
415_G421_D0.5630.29
40_L399_L0.5630.29
187_M195_M0.5620.29
364_V413_L0.5600.28
21_D369_T0.5600.28
138_P398_V0.5590.28
185_E192_M0.5590.28
181_P220_D0.5590.28
274_R293_K0.5590.28
369_T418_I0.5580.28
21_D427_K0.5580.28
84_T400_E0.5570.28
132_L156_R0.5570.28
155_A162_K0.5560.28
240_K244_I0.5560.28
107_A246_A0.5550.28
252_I376_I0.5550.28
15_K229_E0.5550.28
301_H415_G0.5540.28
133_D155_A0.5540.28
92_V320_P0.5540.28
137_P140_K0.5530.28
3_E38_M0.5520.28
189_P195_M0.5510.28
149_Q152_P0.5510.28
27_V123_A0.5500.28
110_M368_F0.5490.28
419_T432_L0.5480.28
106_A302_I0.5480.28
124_E222_M0.5470.28
38_M348_N0.5460.27
28_A423_D0.5460.27
334_A436_E0.5460.27
334_A337_T0.5450.27
16_H438_L0.5450.27
154_A367_E0.5450.27
179_A352_T0.5440.27
48_V366_I0.5440.27
110_M247_V0.5430.27
16_H233_L0.5420.27
174_E232_K0.5420.27
244_I298_K0.5420.27
280_D283_P0.5420.27
25_R409_D0.5420.27
21_D225_L0.5410.27
150_Q227_E0.5400.27
111_V285_V0.5400.27
61_V355_Y0.5400.27
92_V388_E0.5390.27
340_F381_W0.5380.27
38_M288_C0.5380.27
194_E198_Q0.5370.27
35_W159_F0.5370.27
106_A158_A0.5370.27
313_A417_N0.5370.27
402_L427_K0.5370.27
234_V434_A0.5370.27
328_I377_A0.5370.27
348_N353_V0.5350.27
155_A281_L0.5350.27
11_S107_A0.5350.27
202_M205_N0.5350.27
58_P152_P0.5340.27
29_I442_I0.5330.27
197_S204_Q0.5330.27
35_W38_M0.5300.26
191_G195_M0.5300.26
111_V261_I0.5300.26
84_T326_L0.5300.26
337_T418_I0.5290.26
230_A244_I0.5290.26
235_N326_L0.5290.26
297_V302_I0.5290.26
135_L218_I0.5280.26
197_S201_S0.5280.26
92_V355_Y0.5280.26
184_V373_I0.5280.26
374_K378_E0.5270.26
132_L157_Q0.5270.26
134_V218_I0.5270.26
232_K314_K0.5270.26
289_T300_D0.5270.26
167_Q173_I0.5270.26
79_I288_C0.5270.26
128_E132_L0.5260.26
54_L284_L0.5260.26
27_V70_L0.5260.26
119_N234_V0.5250.26
281_L284_L0.5250.26
242_D386_S0.5240.26
51_K84_T0.5240.26
196_T349_A0.5240.26
86_F97_D0.5240.26
316_S346_E0.5240.26
91_Y201_S0.5240.26
75_N250_H0.5240.26
11_S124_E0.5230.26
269_G272_V0.5230.26
193_E319_I0.5230.26
289_T298_K0.5210.26
22_N418_I0.5210.26
118_K223_K0.5200.26
98_S158_A0.5200.26
161_K170_D0.5200.26
212_K272_V0.5180.26
385_E388_E0.5160.25
237_E420_I0.5140.25
376_I398_V0.5140.25
206_L214_R0.5140.25
9_I225_L0.5130.25
126_L129_E0.5130.25
174_E269_G0.5130.25
364_V416_Q0.5120.25
137_P285_V0.5120.25
17_I47_E0.5100.25
136_I158_A0.5100.25
49_T240_K0.5090.25
91_Y123_A0.5090.25
336_T430_D0.5090.25
5_T381_W0.5090.25
67_A222_M0.5090.25
49_T199_L0.5080.25
337_T341_E0.5080.25
288_C398_V0.5070.25
41_N360_A0.5070.25
409_D428_H0.5060.25
181_P232_K0.5060.25
178_A208_G0.5060.25
108_V363_G0.5060.25
45_R249_Q0.5060.25
138_P255_I0.5040.25
121_Y178_A0.5040.25
106_A401_R0.5040.25
40_L400_E0.5040.25
285_V334_A0.5030.25
123_A272_V0.5020.25
336_T364_V0.5020.25
245_D421_D0.5010.25
56_I307_S0.5010.25
375_R433_V0.5010.25
261_I326_L0.5010.25
174_E359_M0.5000.24
263_K271_D0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g41A 3 0.754 100 0.616 Contact Map
1ofhA 3 0.6975 100 0.742 Contact Map
1um8A 1 0.614 100 0.811 Contact Map
1r6bX 1 0.6321 100 0.827 Contact Map
3hwsA 3 0.6637 100 0.829 Contact Map
3pxiA 3 0.5688 100 0.84 Contact Map
1qvrA 3 0.5801 100 0.85 Contact Map
4d2uA 3 0.8962 100 0.852 Contact Map
4ciuA 1 0.5959 100 0.858 Contact Map
4lj9A 1 0.6163 99.9 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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