GREMLIN Database
CLPX - ATP-dependent Clp protease ATP-binding subunit ClpX
UniProt: P0A6H1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10159
Length: 424 (341)
Sequences: 8824 (4534)
Seq/√Len: 245.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
319_E360_K5.1411.00
327_K355_L4.7121.00
323_I356_D4.0781.00
69_E72_N3.6351.00
318_S321_A3.5931.00
319_E356_D3.4531.00
393_V396_V3.3381.00
351_R399_D3.3171.00
73_H76_D3.2621.00
219_V229_K3.1061.00
75_D82_E3.0671.00
349_E395_K2.8181.00
335_K338_Q2.5701.00
90_V382_D2.5191.00
90_V386_D2.5051.00
396_V399_D2.4681.00
70_I135_L2.4651.00
324_Q328_E2.3901.00
114_N215_I2.3641.00
287_L290_V2.3151.00
357_A361_K2.3131.00
347_D395_K2.2231.00
73_H135_L2.2171.00
15_C19_G2.1731.00
40_C43_L2.1531.00
239_D308_L2.1261.00
71_R86_K2.1181.00
162_I238_V2.1061.00
15_C29_I2.0741.00
71_R75_D2.0501.00
361_K379_A1.9741.00
284_G287_L1.9731.00
287_L291_E1.9321.00
139_P176_A1.8881.00
20_K24_E1.8551.00
323_I352_D1.8291.00
391_E394_E1.8161.00
334_T350_F1.8081.00
243_I298_F1.8071.00
323_I355_L1.7971.00
77_Y134_R1.7831.00
256_K259_S1.7521.00
129_A238_V1.7521.00
391_E396_V1.7481.00
351_R397_V1.7391.00
342_N347_D1.7291.00
375_I379_A1.7221.00
283_E287_L1.7021.00
116_L308_L1.6901.00
214_L237_Q1.6831.00
357_A360_K1.6411.00
19_G23_H1.6321.00
339_A342_N1.6291.00
22_Q29_I1.6241.00
285_E288_A1.6161.00
71_R93_Y1.6141.00
75_D85_K1.6021.00
283_E286_L1.5971.00
16_S20_K1.5921.00
321_A324_Q1.5721.00
61_R69_E1.5681.00
294_D297_K1.5651.00
141_T179_G1.5541.00
19_G22_Q1.5391.00
16_S22_Q1.5371.00
68_H386_D1.5181.00
15_C20_K1.5101.00
358_I375_I1.5091.00
83_Q315_N1.5031.00
361_K375_I1.4921.00
352_D356_D1.4901.00
174_Q177_Q1.4851.00
69_E73_H1.4831.00
337_Y376_V1.4801.00
333_L373_R1.4751.00
111_G130_E1.4641.00
79_I328_E1.4641.00
353_E400_E1.4611.00
357_A379_A1.4461.00
349_E397_V1.4431.00
17_F21_S1.4421.00
85_K128_L1.4391.00
315_N321_A1.4391.00
68_H389_S1.4371.00
77_Y127_L1.4201.00
211_L214_L1.4131.00
333_L336_Q1.4111.00
21_S24_E1.4081.00
77_Y131_T1.4051.00
288_A292_P1.3911.00
95_H100_R1.3891.00
16_S19_G1.3891.00
353_E399_D1.3731.00
327_K352_D1.3701.00
326_L355_L1.3551.00
338_Q347_D1.3511.00
350_F355_L1.3441.00
295_L305_I1.3341.00
68_H390_M1.3331.00
24_E28_L1.3231.00
15_C22_Q1.3231.00
322_L359_A1.3111.00
286_L290_V1.3081.00
286_L291_E1.3001.00
324_Q327_K1.2841.00
71_R89_A1.2661.00
326_L359_A1.2611.00
22_Q26_R1.2591.00
362_A372_L1.2551.00
23_H27_K1.2541.00
387_L390_M1.2421.00
383_T387_L1.2401.00
379_A383_T1.2361.00
386_D390_M1.2341.00
102_G340_L1.2311.00
116_L295_L1.2241.00
338_Q342_N1.2221.00
21_S29_I1.2221.00
393_V399_D1.2201.00
350_F354_A1.2151.00
150_E157_D1.2131.00
116_L186_I1.2121.00
256_K260_H1.2101.00
288_A291_E1.2071.00
17_F20_K1.2061.00
88_L128_L1.2051.00
243_I295_L1.1951.00
323_I359_A1.1911.00
118_I241_S1.1881.00
162_I181_V1.1781.00
149_T209_Q1.1741.00
338_Q348_L1.1671.00
362_A375_I1.1651.00
65_P69_E1.1631.00
166_L238_V1.1501.00
284_G288_A1.1481.00
149_T192_K1.1461.00
131_T134_R1.1451.00
351_R354_A1.1391.00
77_Y137_D1.1391.00
214_L220_A1.1361.00
72_N75_D1.1361.00
23_H26_R1.1351.00
334_T376_V1.1311.00
70_I89_A1.1251.00
261_R264_T1.1181.00
166_L173_V1.1161.00
25_V29_I1.1161.00
154_V210_A1.1131.00
74_L78_V1.1031.00
47_I51_E1.0991.00
344_E392_D1.0941.00
93_Y386_D1.0941.00
393_V397_V1.0931.00
86_K90_V1.0901.00
22_Q25_V1.0811.00
82_E321_A1.0761.00
87_V312_A1.0741.00
21_S28_L1.0651.00
16_S29_I1.0641.00
100_R112_K1.0641.00
148_L168_K1.0511.00
232_Q235_F1.0501.00
62_S65_P1.0371.00
140_F180_I1.0271.00
353_E356_D1.0261.00
25_V28_L1.0251.00
72_N76_D1.0251.00
21_S25_V1.0241.00
30_A33_S1.0221.00
136_L236_L1.0181.00
117_L238_V1.0171.00
173_V235_F1.0161.00
357_A400_E1.0071.00
335_K339_A1.0071.00
284_G290_V1.0071.00
15_C21_S1.0051.00
258_I262_V1.0011.00
323_I327_K0.9951.00
94_N382_D0.9931.00
356_D360_K0.9881.00
293_E296_I0.9851.00
216_E373_R0.9821.00
20_K23_H0.9821.00
336_Q339_A0.9731.00
334_T355_L0.9721.00
319_E359_A0.9681.00
334_T338_Q0.9671.00
177_Q239_D0.9671.00
74_L131_T0.9581.00
320_E323_I0.9531.00
15_C18_C0.9531.00
173_V232_Q0.9481.00
286_L289_Q0.9481.00
92_V136_L0.9431.00
83_Q288_A0.9361.00
93_Y382_D0.9351.00
300_L304_F0.9311.00
326_L376_V0.9181.00
381_L385_Y0.9171.00
350_F380_L0.9151.00
285_E289_Q0.9141.00
392_D396_V0.9121.00
357_A375_I0.9121.00
391_E397_V0.9101.00
110_L373_R0.9071.00
26_R29_I0.9071.00
82_E86_K0.9041.00
19_G29_I0.8991.00
46_D57_P0.8951.00
20_K29_I0.8901.00
38_D43_L0.8811.00
232_Q237_Q0.8781.00
149_T210_A0.8770.99
43_L46_D0.8740.99
99_L337_Y0.8730.99
320_E356_D0.8700.99
293_E297_K0.8660.99
243_I294_D0.8650.99
160_N163_Q0.8600.99
36_I40_C0.8590.99
117_L314_L0.8590.99
391_E399_D0.8560.99
18_C29_I0.8550.99
151_A154_V0.8530.99
295_L311_V0.8520.99
18_C22_Q0.8510.99
382_D386_D0.8470.99
16_S21_S0.8460.99
319_E363_M0.8460.99
364_A371_G0.8430.99
327_K338_Q0.8430.99
24_E27_K0.8430.99
333_L376_V0.8340.99
361_K364_A0.8330.99
127_L131_T0.8310.99
322_L363_M0.8290.99
29_I32_P0.8280.99
102_G343_L0.8270.99
143_A181_V0.8260.99
310_V377_E0.8230.99
333_L372_L0.8220.99
79_I324_Q0.8210.99
20_K25_V0.8200.99
346_V388_P0.8200.99
78_V131_T0.8200.99
394_E397_V0.8130.99
71_R385_Y0.8120.99
83_Q86_K0.8110.99
93_Y389_S0.8100.99
212_L303_E0.8090.99
289_Q293_E0.8080.99
86_K89_A0.8080.99
327_K335_K0.8070.99
337_Y381_L0.8060.99
130_E217_G0.8060.99
45_N49_R0.8050.99
143_A153_Y0.8040.99
349_E352_D0.8030.99
270_F274_V0.8010.99
340_L381_L0.8000.99
352_D355_L0.7990.99
172_D176_A0.7980.99
36_I43_L0.7950.99
284_G291_E0.7930.99
358_I376_V0.7920.99
163_Q225_Q0.7900.99
260_H263_E0.7850.99
61_R65_P0.7780.99
141_T173_V0.7700.99
350_F376_V0.7690.99
41_V58_H0.7670.99
29_I33_S0.7630.99
75_D86_K0.7620.99
392_D395_K0.7600.99
89_A93_Y0.7590.99
319_E323_I0.7590.99
171_Y175_K0.7570.99
296_I367_T0.7550.98
221_A235_F0.7500.98
75_D321_A0.7490.98
358_I379_A0.7470.98
351_R400_E0.7460.98
396_V400_E0.7450.98
304_F308_L0.7440.98
100_R381_L0.7440.98
16_S23_H0.7430.98
141_T181_V0.7430.98
15_C25_V0.7400.98
341_F346_V0.7380.98
101_N110_L0.7330.98
158_V210_A0.7290.98
156_E165_L0.7290.98
225_Q230_H0.7240.98
118_I243_I0.7210.98
259_S263_E0.7200.98
67_P96_Y0.7180.98
258_I261_R0.7180.98
145_A183_I0.7170.98
257_V261_R0.7170.98
395_K399_D0.7150.98
338_Q350_F0.7130.98
259_S262_V0.7130.98
90_V378_A0.7130.98
288_A315_N0.7120.98
170_D220_A0.7110.98
49_R56_A0.7070.98
74_L89_A0.7060.98
322_L326_L0.7050.98
358_I380_L0.7050.98
346_V387_L0.7040.98
22_Q28_L0.7030.98
287_L313_T0.7030.98
345_G392_D0.7020.98
256_K294_D0.7010.98
373_R377_E0.6970.97
103_D138_V0.6970.97
346_V396_V0.6900.97
393_V398_I0.6890.97
294_D298_F0.6880.97
156_E183_I0.6870.97
257_V260_H0.6840.97
30_A35_Y0.6830.97
142_M216_E0.6820.97
99_L129_A0.6810.97
99_L384_M0.6810.97
101_N336_Q0.6790.97
76_D335_K0.6770.97
18_C21_S0.6760.97
128_L314_L0.6710.97
137_D175_K0.6690.97
26_R38_D0.6650.97
183_I239_D0.6650.97
354_A380_L0.6630.97
231_P234_E0.6630.97
15_C23_H0.6620.97
338_Q349_E0.6620.97
19_G26_R0.6610.97
19_G28_L0.6600.96
183_I214_L0.6590.96
209_Q301_I0.6580.96
355_L372_L0.6560.96
147_T232_Q0.6540.96
15_C28_L0.6530.96
306_G374_S0.6520.96
152_G225_Q0.6480.96
67_P93_Y0.6460.96
355_L359_A0.6460.96
292_P295_L0.6460.96
383_T398_I0.6440.96
142_M217_G0.6430.96
34_V37_C0.6430.96
210_A220_A0.6420.96
191_R301_I0.6410.96
341_F380_L0.6390.96
75_D315_N0.6380.96
49_R52_I0.6360.96
216_E304_F0.6350.96
394_E399_D0.6340.96
19_G25_V0.6320.96
338_Q341_F0.6320.96
39_E47_I0.6320.96
127_L333_L0.6320.96
305_I311_V0.6300.95
353_E357_A0.6290.95
97_K344_E0.6290.95
186_I243_I0.6290.95
35_Y38_D0.6280.95
326_L372_L0.6280.95
342_N345_G0.6280.95
219_V233_Q0.6280.95
152_G168_K0.6270.95
134_R137_D0.6260.95
117_L312_A0.6260.95
22_Q30_A0.6230.95
334_T380_L0.6220.95
63_A96_Y0.6220.95
300_L308_L0.6220.95
373_R382_D0.6210.95
20_K39_E0.6210.95
166_L169_C0.6200.95
186_I300_L0.6190.95
257_V294_D0.6170.95
360_K400_E0.6170.95
159_E162_I0.6170.95
174_Q178_R0.6110.95
91_A112_K0.6110.95
174_Q228_R0.6090.95
257_V262_V0.6090.95
94_N381_L0.6090.95
359_A363_M0.6080.94
84_A312_A0.6070.94
64_L68_H0.6070.94
141_T172_D0.6040.94
78_V142_M0.6040.94
157_D160_N0.6010.94
75_D79_I0.6000.94
16_S26_R0.5980.94
20_K26_R0.5980.94
56_A59_R0.5970.94
88_L117_L0.5960.94
358_I362_A0.5950.94
238_V243_I0.5950.94
23_H29_I0.5940.94
387_L392_D0.5900.94
283_E288_A0.5890.94
271_G274_V0.5890.94
384_M396_V0.5880.93
149_T207_V0.5880.93
101_N233_Q0.5870.93
156_E161_I0.5860.93
86_K382_D0.5850.93
52_I55_V0.5850.93
339_A343_L0.5840.93
101_N340_L0.5840.93
162_I166_L0.5830.93
326_L350_F0.5820.93
310_V378_A0.5790.93
65_P68_H0.5790.93
260_H264_T0.5780.93
341_F345_G0.5780.93
286_L292_P0.5770.93
348_L380_L0.5750.93
138_V381_L0.5750.93
376_V380_L0.5720.93
149_T225_Q0.5720.93
256_K262_V0.5710.92
260_H294_D0.5700.92
20_K27_K0.5690.92
284_G315_N0.5670.92
74_L85_K0.5670.92
17_F22_Q0.5650.92
274_V277_K0.5630.92
232_Q236_L0.5610.92
90_V93_Y0.5590.92
170_D230_H0.5570.92
181_V220_A0.5560.91
95_H112_K0.5560.91
215_I237_Q0.5550.91
56_A60_E0.5540.91
62_S137_D0.5530.91
291_E295_L0.5520.91
186_I298_F0.5500.91
149_T381_L0.5500.91
354_A357_A0.5500.91
173_V179_G0.5490.91
152_G221_A0.5490.91
71_R82_E0.5480.91
217_G229_K0.5480.91
28_L31_G0.5480.91
393_V400_E0.5470.91
47_I50_E0.5440.91
164_K226_G0.5440.91
163_Q236_L0.5440.91
186_I239_D0.5440.91
42_D45_N0.5430.90
394_E400_E0.5430.90
148_L152_G0.5420.90
192_K209_Q0.5410.90
166_L171_Y0.5400.90
143_A152_G0.5400.90
391_E395_K0.5390.90
272_A276_A0.5380.90
283_E291_E0.5370.90
53_K59_R0.5370.90
138_V176_A0.5360.90
149_T154_V0.5350.90
123_S127_L0.5340.90
15_C39_E0.5340.90
34_V39_E0.5330.90
26_R30_A0.5330.90
143_A210_A0.5300.89
33_S38_D0.5290.89
27_K31_G0.5290.89
50_E64_L0.5290.89
27_K30_A0.5280.89
338_Q346_V0.5280.89
17_F23_H0.5270.89
177_Q241_S0.5260.89
215_I304_F0.5250.89
83_Q287_L0.5250.89
110_L216_E0.5250.89
220_A232_Q0.5240.89
161_I225_Q0.5220.89
37_C40_C0.5220.89
100_R231_P0.5220.89
83_Q87_V0.5210.89
208_Q300_L0.5210.89
15_C26_R0.5210.89
157_D163_Q0.5200.89
15_C32_P0.5180.88
45_N51_E0.5170.88
341_F383_T0.5170.88
120_P241_S0.5170.88
289_Q292_P0.5160.88
163_Q169_C0.5160.88
162_I214_L0.5150.88
16_S25_V0.5150.88
97_K388_P0.5140.88
110_L309_P0.5140.88
88_L115_I0.5120.88
103_D116_L0.5100.88
156_E225_Q0.5100.88
220_A225_Q0.5090.87
148_L153_Y0.5070.87
75_D131_T0.5070.87
181_V235_F0.5040.87
328_E335_K0.5030.87
41_V45_N0.5020.87
166_L222_V0.5010.87
65_P73_H0.5000.87
123_S232_Q0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6bX 1 0.809 100 0.468 Contact Map
1qvrA 3 0.8113 100 0.501 Contact Map
4d2uA 3 0.8066 100 0.52 Contact Map
3pxiA 3 0.7429 100 0.526 Contact Map
4ciuA 1 0.8137 100 0.558 Contact Map
1um8A 1 0.7358 100 0.59 Contact Map
3hwsA 3 0.7948 100 0.597 Contact Map
4lj9A 1 0.7594 100 0.617 Contact Map
1g41A 3 0.7005 100 0.648 Contact Map
1ofhA 3 0.7146 100 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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