GREMLIN Database
CLPP - ATP-dependent Clp protease proteolytic subunit
UniProt: P0A6G7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10158
Length: 207 (183)
Sequences: 4676 (2137)
Seq/√Len: 157.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_Q177_Q4.3551.00
150_E154_R3.9331.00
181_D196_Y3.4061.00
127_C199_V2.9641.00
100_D124_K2.5841.00
174_S177_Q2.5731.00
87_G112_M2.5531.00
100_D121_A2.5231.00
130_N162_R2.5191.00
114_A167_M2.5181.00
118_T167_M2.5161.00
65_E99_P2.4611.00
72_D100_D2.4381.00
191_P195_E2.4121.00
194_V199_V2.4031.00
132_R155_E2.2351.00
194_V201_S2.2071.00
138_P160_K2.1861.00
161_G165_E2.1421.00
45_L75_L2.1031.00
165_E169_L1.9731.00
164_N179_E1.9511.00
39_K67_E1.9461.00
127_C133_V1.9141.00
126_F201_S1.9021.00
72_D124_K1.8801.00
142_Y152_H1.8771.00
105_C109_A1.8501.00
164_N182_T1.8371.00
50_E53_M1.8181.00
51_D86_A1.7591.00
74_Y104_I1.7401.00
118_T170_H1.7361.00
103_T120_G1.7351.00
167_M182_T1.7131.00
102_S126_F1.6231.00
165_E175_L1.6091.00
189_S192_E1.6011.00
91_Y170_H1.5791.00
161_G179_E1.5731.00
47_G53_M1.5641.00
127_C131_S1.5401.00
101_V121_A1.5361.00
45_L49_V1.4981.00
117_L133_V1.4891.00
105_C131_S1.4751.00
74_Y102_S1.4741.00
91_Y95_Q1.4611.00
158_K192_E1.4531.00
79_S113_G1.4401.00
83_V86_A1.4311.00
68_N71_K1.4131.00
192_E195_E1.4071.00
150_E157_L1.3951.00
72_D102_S1.3511.00
137_Q183_E1.3471.00
111_S136_H1.3441.00
51_D83_V1.3271.00
175_L179_E1.3211.00
161_G175_L1.3031.00
167_M178_I1.2991.00
177_Q180_R1.2931.00
115_F167_M1.2881.00
24_T27_G1.2881.00
194_V202_I1.2611.00
95_Q170_H1.2271.00
147_T183_E1.2121.00
166_L170_H1.1991.00
23_Q26_R1.1821.00
102_S124_K1.1761.00
65_E98_K1.1561.00
28_E31_F1.1531.00
124_K201_S1.1451.00
168_A175_L1.1371.00
164_N175_L1.1311.00
95_Q169_L1.1261.00
32_D35_S1.1011.00
191_P194_V1.0800.99
85_T108_Q1.0780.99
134_M187_F1.0590.99
49_V53_M1.0590.99
122_K172_G1.0520.99
114_A182_T1.0480.99
94_M101_V1.0340.99
127_C194_V1.0190.99
118_T198_L1.0160.99
45_L53_M1.0000.99
54_A90_I0.9930.99
140_G156_I0.9900.99
171_T178_I0.9820.99
127_C190_A0.9750.99
114_A135_I0.9710.99
139_L182_T0.9610.99
58_V89_S0.9550.99
105_C117_L0.9510.99
190_A202_I0.9350.98
61_M97_I0.9240.98
91_Y166_L0.9120.98
152_H187_F0.9100.98
84_I112_M0.9010.98
84_I163_M0.8740.97
142_Y149_I0.8710.97
152_H155_E0.8550.97
84_I159_V0.8550.97
31_F39_K0.8490.97
146_A153_A0.8480.97
97_I101_V0.8410.97
91_Y119_A0.8340.97
104_I126_F0.8270.96
108_Q132_R0.8260.96
75_L94_M0.8200.96
146_A156_I0.8170.96
36_R40_E0.8150.96
158_K189_S0.8150.96
177_Q196_Y0.8130.96
164_N178_I0.8130.96
65_E69_P0.8070.96
154_R158_K0.8020.96
176_E179_E0.8020.96
176_E180_R0.8010.96
180_R183_E0.8010.96
190_A199_V0.7980.96
46_T55_N0.7880.95
88_M166_L0.7850.95
111_S134_M0.7840.95
188_L196_Y0.7810.95
171_T198_L0.7810.95
179_E183_E0.7760.95
94_M119_A0.7730.95
63_F67_E0.7700.95
119_A170_H0.7690.95
46_T53_M0.7680.95
45_L57_I0.7630.94
82_G136_H0.7630.94
155_E158_K0.7620.94
149_I153_A0.7590.94
88_M112_M0.7570.94
70_E99_P0.7550.94
35_S38_L0.7520.94
57_I60_Q0.7490.94
70_E98_K0.7480.94
23_Q30_S0.7460.94
132_R158_K0.7390.94
151_I155_E0.7380.93
50_E86_A0.7370.93
57_I90_I0.7350.93
135_I182_T0.7310.93
108_Q187_F0.7260.93
147_T150_E0.7210.93
80_P110_A0.7200.93
177_Q181_D0.7190.93
95_Q119_A0.7160.92
146_A157_L0.7160.92
122_K170_H0.7150.92
139_L145_Q0.7150.92
191_P204_T0.7110.92
151_I184_R0.7110.92
109_A114_A0.7100.92
155_E159_V0.7060.92
43_I73_I0.7050.92
132_R189_S0.7020.92
137_Q160_K0.7000.92
173_Q181_D0.6930.91
181_D186_R0.6930.91
82_G111_S0.6900.91
48_Q80_P0.6880.91
115_F166_L0.6860.91
24_T30_S0.6860.91
126_F203_L0.6830.91
158_K162_R0.6810.90
103_T117_L0.6810.90
121_A124_K0.6810.90
53_M56_L0.6760.90
128_L131_S0.6730.90
115_F170_H0.6670.89
56_L60_Q0.6660.89
173_Q178_I0.6630.89
173_Q196_Y0.6610.89
180_R184_R0.6600.89
186_R198_L0.6590.89
156_I159_V0.6580.89
84_I111_S0.6560.89
57_I75_L0.6550.89
30_S34_Y0.6540.89
149_I156_I0.6530.88
177_Q186_R0.6530.88
108_Q155_E0.6520.88
117_L125_R0.6500.88
191_P202_I0.6500.88
84_I138_P0.6480.88
53_M75_L0.6470.88
39_K63_F0.6470.88
55_N59_A0.6460.88
49_V113_G0.6440.88
112_M139_L0.6370.87
115_F118_T0.6320.87
132_R159_V0.6310.87
49_V116_L0.6250.86
58_V93_T0.6220.86
117_L120_G0.6160.85
133_V199_V0.6150.85
42_V76_Y0.6130.85
145_Q148_D0.6120.85
103_T125_R0.6110.85
155_E187_F0.6100.85
30_S35_S0.6080.85
52_H56_L0.6040.84
38_L60_Q0.6030.84
115_F163_M0.6030.84
99_P121_A0.5990.84
43_I61_M0.5990.84
49_V90_I0.5980.84
123_G200_D0.5950.83
160_K164_N0.5930.83
88_M159_V0.5930.83
75_L101_V0.5860.83
150_E153_A0.5810.82
148_D184_R0.5790.82
201_S204_T0.5770.82
54_A61_M0.5770.82
85_T159_V0.5760.81
42_V74_Y0.5760.81
40_E66_A0.5750.81
135_I181_D0.5710.81
178_I196_Y0.5710.81
24_T39_K0.5660.80
117_L200_D0.5600.80
76_Y93_T0.5600.80
57_I61_M0.5580.79
152_H185_D0.5580.79
33_I36_R0.5570.79
176_E195_E0.5560.79
77_I103_T0.5550.79
174_S180_R0.5540.79
112_M136_H0.5520.79
26_R29_R0.5470.78
168_A178_I0.5460.78
110_A187_F0.5430.78
47_G51_D0.5420.77
87_G136_H0.5390.77
102_S201_S0.5350.76
162_R165_E0.5330.76
53_M57_I0.5310.76
88_M92_D0.5300.76
165_E168_A0.5290.76
30_S38_L0.5280.76
77_I117_L0.5270.75
154_R157_L0.5230.75
29_R32_D0.5230.75
34_Y56_L0.5230.75
159_V162_R0.5230.75
47_G50_E0.5220.75
42_V46_T0.5220.75
97_I121_A0.5210.75
78_N109_A0.5200.74
41_R72_D0.5180.74
153_A157_L0.5170.74
61_M65_E0.5160.74
110_A113_G0.5130.73
95_Q121_A0.5110.73
94_M103_T0.5110.73
30_S33_I0.5100.73
135_I167_M0.5090.73
58_V106_M0.5080.73
87_G111_S0.5080.73
23_Q27_G0.5080.73
27_G30_S0.5050.72
49_V139_L0.5040.72
168_A171_T0.5040.72
135_I186_R0.5040.72
169_L204_T0.5020.72
154_R161_G0.5010.72
118_T171_T0.5000.72
28_E38_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tg6A 4 0.8889 100 0.332 Contact Map
4gm2A 3 0.8309 100 0.376 Contact Map
1y7oA 5 0.8599 100 0.379 Contact Map
3p2lA 4 0.913 100 0.448 Contact Map
1yg6A 4 0.9324 100 0.449 Contact Map
2cbyA 3 0.8213 100 0.453 Contact Map
2f6iA 5 0.8551 100 0.462 Contact Map
4u0gA 4 0.9324 100 0.464 Contact Map
3qwdA 5 0.9082 100 0.469 Contact Map
4jcqA 5 0.8068 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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