GREMLIN Database
CITX - Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
UniProt: P0A6G5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13540
Length: 183 (166)
Sequences: 411 (353)
Seq/√Len: 27.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_P104_L3.7581.00
89_S92_E3.6351.00
46_V121_W3.4771.00
48_P170_M3.4151.00
43_F64_G3.3931.00
67_A115_H3.1971.00
150_Q160_T3.0831.00
36_H96_S2.9461.00
68_L108_T2.8471.00
53_D58_R2.7001.00
64_G121_W2.6230.99
169_R173_L2.4850.99
15_I23_D2.3880.99
150_Q154_V2.3580.99
108_T123_I2.2340.98
142_P151_S2.2050.98
32_W96_S2.1790.98
18_L21_S2.1640.98
29_Q40_L2.1050.97
44_T92_E2.0960.97
50_P163_L1.9090.95
65_V93_G1.8980.95
133_L138_Y1.8950.95
43_F123_I1.6980.91
49_G52_K1.6920.91
60_I174_L1.6810.90
169_R172_A1.6570.90
146_L169_R1.5630.87
41_V108_T1.5550.86
15_I19_L1.5330.86
115_H118_G1.4980.84
33_L40_L1.4930.84
18_L159_K1.4810.84
42_S94_M1.4760.83
61_F64_G1.4660.83
19_L119_R1.4430.82
21_S44_T1.4350.82
79_I97_I1.4120.81
57_T167_L1.3890.79
41_V104_L1.3890.79
159_K163_L1.3830.79
45_V57_T1.3650.78
101_A127_T1.3600.78
153_A156_A1.3580.78
46_V64_G1.3530.78
40_L44_T1.3460.77
68_L123_I1.3170.76
28_R54_S1.3140.75
39_P99_A1.3060.75
151_S154_V1.2710.73
45_V174_L1.2650.73
40_L60_I1.2450.71
13_V54_S1.2450.71
53_D91_P1.2300.70
19_L157_R1.2050.69
47_A61_F1.1970.68
26_Q132_I1.1950.68
69_R95_L1.1900.68
102_R106_L1.1880.68
51_I167_L1.1770.67
68_L113_H1.1580.66
46_V119_R1.1540.65
122_D157_R1.1370.64
24_E87_S1.1340.64
136_R147_L1.1150.63
43_F132_I1.1140.63
72_A107_A1.1050.62
147_L169_R1.0990.62
17_E96_S1.0980.61
18_L47_A1.0870.61
105_K112_E1.0830.60
64_G93_G1.0630.59
47_A57_T1.0520.58
145_C155_C1.0450.58
119_R157_R1.0450.58
47_A89_S1.0430.57
163_L167_L1.0390.57
33_L36_H1.0360.57
40_L88_A1.0250.56
30_H144_R0.9980.54
147_L166_L0.9680.52
29_Q126_L0.9630.51
52_K119_R0.9510.51
107_A165_D0.9480.50
145_C161_H0.9470.50
155_C161_H0.9470.50
126_L132_I0.9360.49
48_P134_S0.9330.49
50_P61_F0.9220.48
14_S17_E0.9170.48
102_R138_Y0.9090.47
17_E88_A0.9030.47
77_W107_A0.9030.47
11_H88_A0.9010.47
135_R143_R0.8980.46
31_V35_R0.8920.46
44_T121_W0.8840.45
164_T168_N0.8820.45
13_V156_A0.8790.45
100_P113_H0.8760.45
11_H139_S0.8640.44
51_I89_S0.8610.44
47_A170_M0.8500.43
15_I18_L0.8490.43
139_S169_R0.8490.43
20_V23_D0.8470.43
128_P176_D0.8470.43
40_L94_M0.8400.42
23_D27_A0.8330.42
45_V60_I0.8300.41
41_V76_G0.8290.41
51_I57_T0.8290.41
52_K157_R0.8210.41
49_G90_G0.8150.40
108_T133_L0.8140.40
23_D119_R0.8120.40
152_A157_R0.8090.40
19_L122_D0.8000.39
28_R44_T0.7960.39
48_P91_P0.7950.39
72_A97_I0.7860.38
23_D122_D0.7850.38
32_W77_W0.7780.38
16_P160_T0.7760.38
62_N106_L0.7740.37
60_I108_T0.7710.37
34_K164_T0.7660.37
18_L166_L0.7620.37
23_D68_L0.7600.36
69_R82_Q0.7590.36
143_R155_C0.7540.36
147_L167_L0.7470.35
89_S126_L0.7460.35
41_V110_E0.7370.35
44_T89_S0.7330.34
88_A168_N0.7310.34
18_L40_L0.7260.34
44_T87_S0.7260.34
111_L152_A0.7240.34
75_Q100_P0.7100.33
44_T51_I0.7090.33
73_A162_Q0.7090.33
42_S92_E0.7070.33
57_T166_L0.7070.33
119_R122_D0.7020.32
25_R45_V0.6920.32
57_T153_A0.6910.32
67_A116_P0.6900.32
38_V98_A0.6890.32
47_A121_W0.6850.31
97_I117_L0.6840.31
37_P40_L0.6840.31
78_Q109_I0.6820.31
130_G140_L0.6790.31
23_D124_D0.6770.31
19_L23_D0.6770.31
16_P168_N0.6670.30
116_P164_T0.6650.30
92_E120_L0.6640.30
50_P167_L0.6620.30
55_E173_L0.6610.30
61_F89_S0.6610.30
36_H72_A0.6560.29
23_D164_T0.6560.29
105_K124_D0.6560.29
112_E124_D0.6560.29
35_R81_E0.6560.29
13_V18_L0.6540.29
110_E133_L0.6540.29
143_R161_H0.6500.29
36_H39_P0.6500.29
58_R97_I0.6460.29
12_A144_R0.6450.29
26_Q159_K0.6450.29
167_L171_E0.6440.29
156_A163_L0.6390.28
30_H34_K0.6370.28
54_S153_A0.6370.28
156_A159_K0.6360.28
53_D57_T0.6350.28
33_L126_L0.6240.27
39_P72_A0.6230.27
118_G170_M0.6220.27
87_S94_M0.6210.27
70_A111_L0.6120.27
129_E133_L0.6090.27
45_V61_F0.6060.26
49_G119_R0.6030.26
18_L50_P0.5990.26
56_V158_G0.5970.26
80_Q140_L0.5960.26
111_L141_P0.5920.26
47_A50_P0.5900.25
87_S92_E0.5890.25
144_R149_E0.5870.25
21_S54_S0.5850.25
48_P152_A0.5830.25
98_A166_L0.5810.25
40_L81_E0.5770.25
72_A104_L0.5750.25
136_R165_D0.5730.24
53_D153_A0.5690.24
123_I126_L0.5660.24
67_A147_L0.5660.24
15_I44_T0.5660.24
131_E137_D0.5660.24
130_G169_R0.5630.24
108_T151_S0.5620.24
49_G157_R0.5610.24
22_R72_A0.5590.24
45_V156_A0.5580.24
58_R91_P0.5560.24
32_W81_E0.5550.23
41_V123_I0.5540.23
79_I136_R0.5510.23
21_S87_S0.5500.23
123_I132_I0.5460.23
29_Q44_T0.5450.23
110_E114_S0.5400.23
105_K148_C0.5390.23
112_E148_C0.5390.23
26_Q146_L0.5390.23
148_C161_H0.5390.23
22_R122_D0.5380.23
65_V84_A0.5370.23
134_S170_M0.5370.23
145_C148_C0.5360.22
148_C155_C0.5360.22
61_F120_L0.5350.22
63_H80_Q0.5330.22
151_S158_G0.5330.22
112_E122_D0.5280.22
105_K122_D0.5280.22
111_L121_W0.5270.22
53_D86_V0.5270.22
51_I138_Y0.5260.22
89_S117_L0.5230.22
25_R29_Q0.5220.22
72_A133_L0.5220.22
26_Q109_I0.5200.22
15_I42_S0.5190.22
17_E159_K0.5160.21
26_Q157_R0.5140.21
36_H81_E0.5130.21
144_R173_L0.5080.21
22_R138_Y0.5060.21
16_P110_E0.5050.21
68_L111_L0.5000.21
38_V96_S0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yciX 2 0.8306 20.9 0.953 Contact Map
1f6yA 2 0.8306 17.4 0.955 Contact Map
2pt7G 2 0.4699 15.6 0.956 Contact Map
4o1eA 2 0.8306 10.8 0.959 Contact Map
4s3qA 1 0.3497 10.7 0.959 Contact Map
1hc7A 2 0.6721 10.1 0.96 Contact Map
4adnA 2 0.8142 7.1 0.962 Contact Map
1d4bA 1 0.388 6.5 0.963 Contact Map
1zavA 1 0.8361 6.2 0.963 Contact Map
2eelA 1 0.2678 6 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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