GREMLIN Database
PNCC - Nicotinamide-nucleotide amidohydrolase PncC
UniProt: P0A6G3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12698
Length: 165 (152)
Sequences: 4623 (3562)
Seq/√Len: 288.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G48_W2.7821.00
22_A98_Y2.7661.00
83_V103_S2.6521.00
68_R85_E2.5621.00
62_A69_E2.2961.00
71_T85_E2.2851.00
35_V102_I2.2101.00
18_K47_A2.2011.00
121_W135_R2.0981.00
25_T96_A2.0781.00
71_T82_V2.0671.00
69_E73_A2.0091.00
80_E84_V1.9811.00
32_G40_T1.9301.00
37_K41_D1.9031.00
75_H81_P1.8501.00
91_L125_A1.8281.00
34_W150_T1.7871.00
121_W133_T1.7301.00
51_R94_A1.7231.00
38_V150_T1.7051.00
51_R63_Q1.6881.00
36_A49_F1.6661.00
22_A97_D1.6451.00
55_T86_M1.5811.00
84_V133_T1.5771.00
34_W37_K1.5211.00
124_F156_T1.5041.00
51_R60_A1.4701.00
72_L77_A1.4671.00
58_N77_A1.4641.00
90_A99_A1.4571.00
155_Q159_Q1.4551.00
37_K146_R1.4551.00
41_D146_R1.4401.00
84_V88_I1.4371.00
27_A65_I1.4311.00
80_E121_W1.4031.00
68_R71_T1.3931.00
88_I131_G1.3831.00
23_T50_E1.3831.00
64_M93_A1.3831.00
36_A54_V1.3821.00
26_T35_V1.3751.00
43_A109_D1.3391.00
122_F136_E1.3301.00
10_S38_V1.3171.00
98_Y126_T1.3061.00
50_E59_E1.2931.00
105_I115_K1.2881.00
141_D144_A1.2821.00
27_A90_A1.2551.00
91_L127_A1.2511.00
39_I49_F1.2491.00
35_V153_A1.2471.00
14_G42_I1.2411.00
24_V39_I1.2391.00
34_W146_R1.2341.00
87_A125_A1.2151.00
16_A158_W1.2131.00
55_T60_A1.1571.00
12_Q158_W1.1461.00
70_E74_Q1.1441.00
119_T135_R1.1431.00
16_A20_R1.1381.00
63_Q95_R1.1281.00
75_H79_S1.1251.00
50_E96_A1.1211.00
140_G145_V1.1141.00
97_D127_A1.1111.00
155_Q158_W1.1071.00
60_A94_A1.1011.00
98_Y157_L1.0931.00
136_E152_Y1.0871.00
17_L22_A1.0841.00
152_Y155_Q1.0811.00
53_F90_A1.0781.00
25_T90_A1.0771.00
11_E15_Q1.0661.00
26_T49_F1.0581.00
124_F160_Q1.0561.00
105_I110_G1.0451.00
53_F94_A1.0341.00
132_I160_Q1.0331.00
40_T49_F1.0281.00
13_V157_L1.0251.00
102_I149_A0.9951.00
37_K150_T0.9931.00
102_I153_A0.9831.00
122_F152_Y0.9821.00
101_S123_A0.9741.00
24_V157_L0.9661.00
134_R156_T0.9641.00
138_F152_Y0.9611.00
67_V89_G0.9611.00
66_G93_A0.9581.00
13_V158_W0.9571.00
23_T97_D0.9531.00
26_T52_G0.9471.00
16_A19_A0.9351.00
36_A52_G0.9321.00
26_T36_A0.9231.00
119_T137_C0.9151.00
15_Q18_K0.9121.00
76_G115_K0.9011.00
14_G39_I0.8971.00
91_L99_A0.8871.00
8_Q11_E0.8711.00
143_D146_R0.8601.00
100_V157_L0.8581.00
84_V131_G0.8541.00
140_G144_A0.8511.00
30_C102_I0.8441.00
40_T45_S0.8411.00
10_S42_I0.8391.00
53_F64_M0.8361.00
47_A109_D0.8331.00
134_R152_Y0.8321.00
125_A131_G0.8271.00
144_A148_Q0.8241.00
25_T94_A0.8181.00
14_G18_K0.8161.00
40_T146_R0.8101.00
10_S41_D0.8081.00
30_C120_V0.8010.99
120_V149_A0.7990.99
87_A123_A0.7940.99
50_E57_S0.7920.99
156_T160_Q0.7910.99
13_V154_L0.7880.99
34_W38_V0.7830.99
62_A72_L0.7830.99
115_K119_T0.7830.99
14_G45_S0.7810.99
26_T100_V0.7670.99
44_G142_R0.7590.99
59_E63_Q0.7580.99
14_G17_L0.7570.99
41_D143_D0.7520.99
15_Q19_A0.7510.99
91_L126_T0.7490.99
110_G116_P0.7490.99
80_E135_R0.7480.99
126_T160_Q0.7370.99
10_S14_G0.7370.99
17_L98_Y0.7340.99
140_G148_Q0.7330.99
51_R64_M0.7290.99
117_V145_V0.7240.99
35_V150_T0.7190.99
38_V41_D0.7180.99
100_V153_A0.7180.99
58_N112_S0.7170.99
88_I125_A0.7170.99
67_V82_V0.7140.99
145_V149_A0.7130.99
22_A126_T0.7120.99
87_A99_A0.7080.99
90_A94_A0.7070.99
71_T81_P0.7050.99
120_V145_V0.7040.99
88_I92_K0.6860.98
9_L158_W0.6810.98
65_I86_M0.6780.98
152_Y156_T0.6710.98
12_Q15_Q0.6700.98
143_D147_R0.6700.98
58_N76_G0.6660.98
17_L24_V0.6580.98
132_I159_Q0.6520.98
139_S148_Q0.6510.98
63_Q93_A0.6450.98
79_S82_V0.6420.97
9_L13_V0.6400.97
110_G114_E0.6350.97
38_V151_A0.6300.97
53_F93_A0.6280.97
133_T138_F0.6260.97
88_I91_L0.6230.97
123_A133_T0.6220.97
67_V71_T0.6200.97
45_S48_W0.6160.97
105_I112_S0.6120.97
38_V147_R0.6090.97
71_T75_H0.6070.96
23_T96_A0.6050.96
60_A64_M0.5990.96
57_S76_G0.5930.96
147_R151_A0.5930.96
18_K48_W0.5880.96
53_F60_A0.5830.96
122_F153_A0.5820.96
53_F65_I0.5800.95
83_V121_W0.5790.95
80_E133_T0.5770.95
71_T79_S0.5740.95
37_K143_D0.5720.95
85_E89_G0.5710.95
12_Q16_A0.5710.95
109_D112_S0.5620.95
86_M101_S0.5620.95
87_A91_L0.5620.95
35_V39_I0.5590.94
77_A115_K0.5590.94
109_D117_V0.5570.94
126_T130_E0.5540.94
76_G105_I0.5540.94
26_T39_I0.5530.94
39_I42_I0.5530.94
81_P85_E0.5480.94
110_G117_V0.5450.94
83_V101_S0.5450.94
148_Q155_Q0.5450.94
148_Q151_A0.5380.93
87_A133_T0.5370.93
34_W143_D0.5360.93
156_T159_Q0.5360.93
72_L82_V0.5360.93
151_A155_Q0.5350.93
34_W147_R0.5170.92
30_C149_A0.5170.92
13_V161_F0.5160.92
98_Y127_A0.5140.92
110_G113_E0.5080.91
30_C110_G0.5080.91
35_V154_L0.5050.91
59_E95_R0.5000.91
77_A112_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a9sA 2 0.9939 100 0.075 Contact Map
4uuwA 2 0.9333 100 0.156 Contact Map
3wvaA 2 0.8 97.4 0.852 Contact Map
3htnA 3 0.7091 9.8 0.951 Contact Map
2ewtA 2 0.4182 9.2 0.952 Contact Map
2a1jA 1 0.3697 9 0.952 Contact Map
3h2tA 2 0.4364 8.1 0.953 Contact Map
1u9lA 1 0.4242 7.7 0.953 Contact Map
3wryA 1 0.5091 7.3 0.954 Contact Map
1re5A 4 0.7455 7.1 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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