GREMLIN Database
CH10 - 10 kDa chaperonin
UniProt: P0A6F9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10600
Length: 97 (93)
Sequences: 2743 (1221)
Seq/√Len: 126.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K81_E4.2811.00
13_K39_E3.8591.00
10_V91_I2.9351.00
48_I54_V2.6411.00
49_L53_E2.5101.00
77_K82_E2.3871.00
14_R67_F2.2221.00
37_R64_I2.1111.00
49_L55_K2.0671.00
42_A61_V2.0461.00
60_K63_D1.9791.00
38_G67_F1.9631.00
59_V91_I1.8991.00
3_I93_A1.7931.00
41_L83_V1.7581.00
68_N71_Y1.6801.00
57_L88_E1.6361.00
19_T32_A1.6191.00
43_V57_L1.6051.00
39_E64_I1.5991.00
3_I11_I1.5311.00
20_K26_V1.5301.00
11_I85_I1.5191.00
58_D88_E1.4991.00
15_K64_I1.4721.00
4_R94_I1.4251.00
12_V86_M1.4211.00
15_K39_E1.4171.00
45_N58_D1.4101.00
70_G87_S1.4091.00
12_V38_G1.3551.00
69_D74_K1.2841.00
67_F84_L1.2741.00
74_K82_E1.2691.00
36_T69_D1.2631.00
39_E61_V1.2260.99
38_G86_M1.2180.99
36_T73_V1.2120.99
47_R89_S1.2050.99
39_E62_G1.1690.99
65_V91_I1.1320.99
13_K83_V1.1060.99
9_R87_S1.0510.98
29_G32_A1.0450.98
8_D87_S1.0420.98
21_S24_G1.0030.98
35_S69_D0.9950.98
45_N57_L0.9810.98
59_V94_I0.9790.97
54_V58_D0.9600.97
15_K37_R0.9440.97
11_I83_V0.9150.96
85_I92_L0.8960.96
63_D94_I0.8390.94
47_R88_E0.8380.94
78_I83_V0.8370.94
7_H58_D0.8260.93
70_G83_V0.7940.92
73_V90_D0.7800.91
68_N74_K0.7770.91
38_G84_L0.7590.90
15_K38_G0.7590.90
46_G57_L0.7580.90
13_K16_E0.7520.90
15_K28_T0.7430.89
47_R70_G0.7380.89
48_I55_K0.7370.89
43_V61_V0.7310.88
3_I85_I0.7260.88
32_A36_T0.7190.88
48_I56_P0.7100.87
18_E21_S0.7100.87
28_T68_N0.7080.87
35_S73_V0.7070.87
8_D46_G0.6950.86
68_N90_D0.6940.86
49_L52_G0.6930.86
12_V65_V0.6890.85
2_N79_D0.6880.85
68_N92_L0.6860.85
46_G52_G0.6780.84
69_D72_G0.6750.84
70_G73_V0.6720.84
8_D88_E0.6710.84
14_R89_S0.6710.84
17_V23_G0.6680.83
66_I76_E0.6660.83
7_H27_L0.6640.83
47_R87_S0.6610.83
60_K94_I0.6560.82
7_H54_V0.6530.82
87_S90_D0.6510.82
37_R95_V0.6500.82
14_R34_K0.6460.81
45_N54_V0.6450.81
25_I77_K0.6440.81
72_G76_E0.6340.80
67_F86_M0.6320.80
73_V76_E0.6300.80
33_A69_D0.6260.79
5_P8_D0.6250.79
32_A74_K0.6250.79
47_R54_V0.6240.79
24_G65_V0.6130.78
59_V88_E0.6040.77
78_I93_A0.6010.77
26_V38_G0.5970.76
22_A30_S0.5960.76
10_V92_L0.5960.76
28_T31_A0.5890.75
69_D90_D0.5850.75
12_V42_A0.5740.73
48_I52_G0.5690.73
19_T29_G0.5600.71
22_A79_D0.5530.70
49_L54_V0.5490.70
69_D73_V0.5480.70
20_K24_G0.5450.69
39_E81_E0.5420.69
66_I92_L0.5410.69
14_R37_R0.5380.68
71_Y86_M0.5370.68
48_I58_D0.5360.68
45_N48_I0.5350.68
5_P9_R0.5320.68
19_T27_L0.5320.68
16_E19_T0.5270.67
48_I51_N0.5270.67
9_R68_N0.5260.67
9_R85_I0.5240.66
50_E58_D0.5240.66
44_G52_G0.5160.65
3_I66_I0.5160.65
12_V72_G0.5110.64
73_V92_L0.5100.64
17_V45_N0.5100.64
46_G88_E0.5100.64
21_S25_I0.5100.64
7_H45_N0.5080.64
6_L59_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pj1O 3 0.9897 100 0.026 Contact Map
3nx6A 1 0.7732 100 0.029 Contact Map
1pcqO 3 0.9897 100 0.032 Contact Map
1we3O 3 0.9794 100 0.033 Contact Map
1p3hA 5 0.9897 100 0.046 Contact Map
1g31A 4 0.866 100 0.236 Contact Map
3gqvA 1 0.8454 56.9 0.891 Contact Map
1yb5A 3 0.8351 54.2 0.893 Contact Map
4gi2A 2 0.9072 53.6 0.893 Contact Map
1kolA 4 0.8969 51.9 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0059 seconds.