GREMLIN Database
GLPK - Glycerol kinase
UniProt: P0A6F3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10398
Length: 502 (474)
Sequences: 12568 (8647)
Seq/√Len: 397.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_D212_R4.0401.00
112_I147_D3.7911.00
23_D27_N3.4801.00
19_A60_T3.2891.00
115_H147_D3.2621.00
194_N197_T2.8871.00
390_R484_Y2.8681.00
430_R472_R2.8461.00
390_R394_E2.8111.00
397_Q429_T2.7671.00
128_N201_D2.7641.00
34_R59_S2.7091.00
457_N460_E2.6911.00
417_N469_R2.6561.00
421_Q425_D2.6501.00
365_I377_I2.6481.00
39_I100_N2.6291.00
98_I152_S2.6041.00
406_A432_E2.5671.00
34_R63_E2.5571.00
456_Q460_E2.5491.00
193_F218_V2.5471.00
220_R223_E2.5441.00
32_S63_E2.5431.00
21_V64_V2.4901.00
99_Y149_V2.4761.00
91_E155_R2.4391.00
51_M173_K2.4071.00
179_V217_E2.4041.00
54_W173_K2.3971.00
92_K157_R2.3671.00
199_D212_R2.3461.00
390_R481_N2.3251.00
326_D329_D2.3131.00
205_L212_R2.2911.00
91_E94_T2.2681.00
194_N201_D2.2071.00
202_D206_E2.1651.00
58_S235_G2.1631.00
325_N329_D2.1251.00
341_N376_H2.1231.00
10_L57_Q2.1231.00
244_A249_A2.0911.00
171_I243_I2.0871.00
20_V441_A2.0841.00
474_G477_T2.0021.00
313_S381_T1.9921.00
16_S33_Q1.9911.00
115_H119_D1.9341.00
327_A330_S1.9291.00
124_Y127_S1.9111.00
229_N232_G1.9051.00
51_M96_K1.8971.00
63_E67_K1.8951.00
37_E52_E1.8921.00
270_C310_A1.8901.00
397_Q403_R1.8741.00
373_N376_H1.8581.00
175_T240_I1.8461.00
8_V61_L1.8421.00
7_I449_G1.8361.00
344_Y486_G1.8341.00
409_V420_M1.8131.00
158_R180_H1.8091.00
6_Y29_I1.8051.00
336_K375_N1.7951.00
484_Y488_K1.7861.00
230_I236_T1.7811.00
345_V365_I1.7791.00
12_Q17_S1.7681.00
143_K147_D1.7681.00
8_V19_A1.7671.00
428_G478_T1.7621.00
42_K45_W1.7521.00
317_L381_T1.7261.00
219_R223_E1.7161.00
432_E470_E1.7111.00
6_Y21_V1.7111.00
128_N203_K1.7001.00
241_S451_A1.7001.00
124_Y128_N1.6941.00
425_D477_T1.6631.00
124_Y203_K1.6621.00
114_E118_R1.6611.00
425_D474_G1.6611.00
430_R470_E1.6501.00
95_G172_W1.6331.00
261_M406_A1.6251.00
89_V145_I1.6201.00
224_V227_Q1.6191.00
329_D332_Y1.6101.00
315_Q319_D1.5991.00
230_I234_G1.5931.00
181_V219_R1.5911.00
91_E96_K1.5901.00
387_Y483_R1.5801.00
88_I166_V1.5531.00
89_V214_M1.5431.00
117_K122_E1.5411.00
224_V241_S1.5391.00
111_E115_H1.5371.00
259_E277_G1.5331.00
362_R369_T1.5141.00
151_G154_E1.5031.00
7_I454_F1.4891.00
394_E488_K1.4741.00
32_S60_T1.4351.00
39_I52_E1.4351.00
478_T481_N1.4301.00
435_E468_E1.4251.00
394_E397_Q1.4251.00
476_E479_E1.4231.00
123_D127_S1.4231.00
32_S64_V1.4141.00
30_S64_V1.4091.00
65_L72_S1.4061.00
54_W58_S1.4051.00
331_E334_A1.4041.00
331_E335_T1.4001.00
49_D52_E1.3981.00
171_I225_Y1.3901.00
333_F337_V1.3871.00
333_F336_K1.3861.00
227_Q237_R1.3831.00
144_W148_H1.3741.00
418_F422_F1.3681.00
449_G455_W1.3631.00
379_R383_E1.3591.00
417_N433_R1.3541.00
417_N471_F1.3481.00
30_S67_K1.3371.00
345_V349_F1.3351.00
10_L61_L1.3321.00
332_Y335_T1.3321.00
77_A448_A1.3251.00
386_A422_F1.3181.00
224_V239_P1.3171.00
51_M55_A1.3131.00
169_W173_K1.3111.00
175_T226_G1.3011.00
90_W164_G1.2971.00
337_V376_H1.2911.00
307_V388_Q1.2901.00
262_A404_L1.2891.00
477_T480_R1.2781.00
71_S74_Q1.2761.00
266_Y423_Q1.2721.00
184_Y198_L1.2711.00
406_A430_R1.2671.00
420_M471_F1.2631.00
428_G480_R1.2611.00
433_R471_F1.2581.00
211_P214_M1.2561.00
343_V372_V1.2491.00
84_R245_G1.2481.00
386_A423_Q1.2471.00
110_A114_E1.2471.00
24_H454_F1.2421.00
112_I143_K1.2421.00
368_L372_V1.2421.00
386_A426_I1.2381.00
17_S57_Q1.2361.00
219_R225_Y1.2281.00
415_A437_R1.2271.00
55_A59_S1.2261.00
205_L215_L1.2221.00
21_V70_I1.2161.00
264_N423_Q1.2121.00
345_V381_T1.1991.00
139_G208_L1.1971.00
124_Y207_V1.1921.00
119_D207_V1.1881.00
125_I133_I1.1841.00
95_G180_H1.1821.00
146_L153_R1.1821.00
171_I181_V1.1731.00
422_F426_I1.1711.00
244_A447_L1.1671.00
49_D100_N1.1621.00
479_E482_Y1.1621.00
17_S56_T1.1601.00
394_E484_Y1.1481.00
203_K206_E1.1401.00
278_E298_E1.1391.00
428_G481_N1.1391.00
332_Y336_K1.1341.00
391_D488_K1.1341.00
86_T101_A1.1331.00
149_V152_S1.1321.00
22_M28_I1.1291.00
390_R427_L1.1241.00
321_M377_I1.1231.00
59_S63_E1.1211.00
258_K261_M1.1121.00
10_L19_A1.1101.00
179_V219_R1.1101.00
184_Y218_V1.1011.00
57_Q170_L1.0981.00
6_Y74_Q1.0981.00
89_V156_A1.0961.00
50_P88_I1.0931.00
467_I470_E1.0921.00
258_K459_D1.0871.00
196_H280_A1.0841.00
309_M313_S1.0821.00
224_V451_A1.0781.00
184_Y193_F1.0771.00
70_I74_Q1.0771.00
47_E100_N1.0751.00
261_M408_R1.0741.00
474_G478_T1.0701.00
258_K462_Q1.0701.00
121_L207_V1.0651.00
481_N485_A1.0651.00
156_A214_M1.0541.00
63_E66_A1.0501.00
77_A452_V1.0481.00
113_C133_I1.0481.00
366_F490_A1.0461.00
164_G180_H1.0461.00
446_Y461_L1.0431.00
89_V142_V1.0411.00
151_G155_R1.0361.00
7_I452_V1.0351.00
330_S378_I1.0301.00
62_V235_G1.0281.00
486_G489_K1.0281.00
22_M445_A1.0261.00
372_V376_H1.0261.00
111_E114_E1.0261.00
114_E117_K1.0251.00
460_E463_E1.0211.00
408_R432_E1.0201.00
78_I238_I1.0171.00
205_L210_I1.0161.00
193_F197_T1.0161.00
181_V225_Y1.0151.00
53_I166_V1.0131.00
435_E466_V1.0121.00
38_Q48_H1.0111.00
449_G454_F1.0101.00
450_L461_L1.0091.00
182_T187_A1.0081.00
393_L427_L1.0061.00
99_Y152_S1.0041.00
108_R144_W1.0031.00
112_I148_H1.0021.00
260_G405_H1.0001.00
231_G235_G1.0001.00
6_Y70_I1.0001.00
262_A274_M0.9991.00
313_S345_V0.9971.00
57_Q61_L0.9971.00
385_I413_A0.9961.00
121_L124_Y0.9951.00
112_I115_H0.9921.00
387_Y426_I0.9891.00
80_I171_I0.9851.00
227_Q239_P0.9821.00
52_E55_A0.9811.00
7_I77_A0.9781.00
363_G368_L0.9751.00
77_A241_S0.9741.00
152_S155_R0.9741.00
62_V66_A0.9711.00
139_G191_M0.9671.00
309_M312_A0.9671.00
345_V380_A0.9651.00
36_F56_T0.9641.00
32_S67_K0.9641.00
153_R156_A0.9631.00
58_S62_V0.9611.00
379_R418_F0.9601.00
115_H118_R0.9581.00
8_V21_V0.9521.00
198_L220_R0.9491.00
258_K463_E0.9491.00
142_V163_F0.9491.00
390_R426_I0.9471.00
125_I191_M0.9441.00
46_V105_Q0.9431.00
277_G300_N0.9371.00
76_A452_V0.9351.00
331_E417_N0.9321.00
406_A470_E0.9311.00
150_E154_E0.9311.00
19_A64_V0.9291.00
81_T440_T0.9281.00
475_I480_R0.9261.00
65_L75_I0.9241.00
80_I170_L0.9241.00
96_K173_K0.9231.00
455_W461_L0.9221.00
258_K405_H0.9211.00
413_A419_L0.9191.00
241_S452_V0.9151.00
263_K410_D0.9091.00
145_I152_S0.9051.00
22_M442_L0.9051.00
127_S196_H0.9021.00
339_N342_G0.9001.00
23_D29_I0.8991.00
8_V75_I0.8981.00
475_I478_T0.8961.00
334_A418_F0.8961.00
427_L430_R0.8941.00
334_A337_V0.8931.00
89_V163_F0.8931.00
272_M393_L0.8871.00
168_T182_T0.8871.00
87_T163_F0.8781.00
199_D217_E0.8771.00
407_L427_L0.8771.00
446_Y465_A0.8761.00
228_T233_K0.8751.00
387_Y484_Y0.8741.00
198_L299_V0.8731.00
75_I238_I0.8721.00
21_V75_I0.8701.00
184_Y220_R0.8691.00
394_E398_A0.8661.00
127_S282_K0.8641.00
270_C389_T0.8641.00
275_N300_N0.8631.00
157_R213_E0.8621.00
362_R366_F0.8611.00
352_L355_P0.8601.00
99_Y145_I0.8591.00
325_N330_S0.8521.00
176_Q229_N0.8481.00
333_F375_N0.8481.00
115_H143_K0.8471.00
358_D361_A0.8431.00
143_K146_L0.8421.00
324_I330_S0.8421.00
79_G241_S0.8411.00
181_V217_E0.8381.00
156_A163_F0.8371.00
12_Q170_L0.8361.00
34_R60_T0.8361.00
368_L377_I0.8341.00
230_I237_R0.8291.00
475_I479_E0.8251.00
450_L458_L0.8171.00
250_A410_D0.8171.00
228_T238_I0.8141.00
113_C135_P0.8131.00
85_E189_R0.8131.00
361_A364_A0.8131.00
219_R242_G0.8121.00
460_E464_K0.8101.00
80_I174_M0.8061.00
200_W215_L0.8021.00
274_M396_M0.8021.00
365_I381_T0.7991.00
316_W319_D0.7991.00
35_E315_Q0.7991.00
107_R134_D0.7971.00
76_A454_F0.7971.00
421_Q474_G0.7961.00
165_T190_T0.7961.00
409_V433_R0.7951.00
227_Q236_T0.7941.00
113_C140_T0.7931.00
333_F378_I0.7901.00
92_K155_R0.7901.00
271_F306_A0.7891.00
117_K133_I0.7871.00
199_D202_D0.7871.00
22_M436_V0.7861.00
382_L422_F0.7841.00
111_E147_D0.7821.00
331_E337_V0.7821.00
247_Q271_F0.7811.00
172_W180_H0.7801.00
342_G483_R0.7791.00
52_E56_T0.7781.00
479_E483_R0.7771.00
182_T216_P0.7741.00
111_E148_H0.7741.00
61_L65_L0.7741.00
35_E318_R0.7731.00
393_L397_Q0.7731.00
432_E467_I0.7721.00
77_A239_P0.7701.00
414_V437_R0.7701.00
72_S75_I0.7701.00
90_W95_G0.7691.00
489_K492_K0.7681.00
262_A407_L0.7661.00
317_L378_I0.7651.00
28_I31_V0.7631.00
187_A200_W0.7621.00
337_V340_T0.7621.00
382_L416_N0.7611.00
326_D330_S0.7611.00
344_Y366_F0.7591.00
395_A398_A0.7581.00
84_R304_E0.7561.00
193_F198_L0.7551.00
482_Y485_A0.7551.00
482_Y486_G0.7541.00
233_K237_R0.7541.00
194_N199_D0.7521.00
139_G192_L0.7511.00
12_Q57_Q0.7451.00
128_N194_N0.7451.00
90_W180_H0.7421.00
167_D243_I0.7411.00
409_V423_Q0.7391.00
264_N270_C0.7341.00
65_L70_I0.7341.00
36_F48_H0.7321.00
264_N389_T0.7311.00
206_E212_R0.7301.00
34_R56_T0.7291.00
50_P100_N0.7281.00
91_E157_R0.7271.00
328_Y331_E0.7271.00
391_D484_Y0.7261.00
203_K207_V0.7251.00
78_I228_T0.7231.00
331_E416_N0.7231.00
154_E158_R0.7211.00
317_L377_I0.7181.00
41_P45_W0.7181.00
254_Q410_D0.7171.00
9_A79_G0.7161.00
17_S36_F0.7151.00
55_A58_S0.7151.00
98_I155_R0.7151.00
143_K209_D0.7121.00
236_T239_P0.7121.00
31_V438_E0.7121.00
142_V192_L0.7111.00
276_T303_L0.7101.00
84_R186_N0.7101.00
322_K374_A0.7091.00
310_A385_I0.7081.00
483_R486_G0.7081.00
390_R488_K0.7081.00
329_D333_F0.7081.00
327_A331_E0.7081.00
254_Q263_K0.7071.00
14_T103_V0.7061.00
386_A419_L0.7051.00
201_D204_M0.7051.00
361_A365_I0.7041.00
104_W269_G0.7041.00
305_G392_V0.7021.00
341_N372_V0.7001.00
264_N407_L0.6991.00
477_T481_N0.6981.00
25_D464_K0.6971.00
95_G157_R0.6921.00
51_M97_P0.6921.00
125_I204_M0.6901.00
250_A440_T0.6891.00
387_Y480_R0.6860.99
340_T376_H0.6860.99
51_M169_W0.6850.99
61_L64_V0.6800.99
171_I175_T0.6790.99
89_V98_I0.6790.99
426_I480_R0.6780.99
129_T204_M0.6780.99
185_T244_A0.6760.99
414_V420_M0.6750.99
58_S173_K0.6740.99
123_D126_R0.6730.99
232_G235_G0.6730.99
285_N398_A0.6700.99
90_W158_R0.6690.99
169_W172_W0.6690.99
91_E98_I0.6690.99
342_G379_R0.6680.99
488_K492_K0.6680.99
59_S62_V0.6670.99
407_L431_V0.6670.99
322_K325_N0.6670.99
455_W464_K0.6660.99
57_Q60_T0.6660.99
47_E108_R0.6650.99
231_G234_G0.6640.99
12_Q56_T0.6640.99
449_G453_G0.6630.99
88_I101_A0.6630.99
175_T179_V0.6620.99
450_L457_N0.6610.99
225_Y242_G0.6610.99
446_Y464_K0.6600.99
284_E288_L0.6590.99
340_T383_E0.6570.99
430_R473_P0.6550.99
472_R475_I0.6550.99
409_V431_V0.6540.99
363_G366_F0.6540.99
143_K153_R0.6530.99
459_D462_Q0.6530.99
433_R468_E0.6520.99
256_C261_M0.6520.99
20_V28_I0.6510.99
114_E360_Y0.6500.99
221_S243_I0.6500.99
287_L290_T0.6490.99
233_K236_T0.6480.99
133_I191_M0.6470.99
90_W169_W0.6470.99
417_N421_Q0.6450.99
206_E211_P0.6440.99
22_M441_A0.6440.99
246_D268_T0.6430.99
51_M100_N0.6430.99
467_I473_P0.6430.99
307_V392_V0.6420.99
50_P101_A0.6420.99
317_L321_M0.6420.99
405_H429_T0.6390.99
24_H76_A0.6390.99
7_I76_A0.6380.99
346_V364_A0.6370.99
383_E422_F0.6360.99
182_T218_V0.6360.99
351_G355_P0.6350.99
340_T344_Y0.6310.99
58_S232_G0.6290.99
102_I108_R0.6280.99
336_K376_H0.6270.99
90_W172_W0.6260.99
481_N484_Y0.6260.99
286_G303_L0.6250.99
407_L429_T0.6250.99
82_N186_N0.6240.99
224_V452_V0.6220.99
435_E467_I0.6210.99
116_L208_L0.6200.99
143_K208_L0.6200.99
421_Q471_F0.6170.99
345_V384_S0.6170.99
55_A235_G0.6170.99
330_S416_N0.6150.99
54_W232_G0.6150.99
51_M54_W0.6130.99
40_Y46_V0.6100.99
146_L209_D0.6100.99
270_C423_Q0.6080.99
339_N376_H0.6070.99
239_P452_V0.6060.99
457_N463_E0.6060.99
446_Y450_L0.6050.99
461_L465_A0.6050.99
416_N419_L0.6040.99
273_L302_A0.6040.99
342_G383_E0.6040.99
227_Q230_I0.6040.99
285_N289_T0.6020.99
461_L464_K0.6020.99
331_E336_K0.6010.99
356_Y391_D0.5980.99
379_R422_F0.5980.99
355_P358_D0.5980.99
196_H199_D0.5970.99
406_A429_T0.5950.99
420_M433_R0.5950.99
102_I145_I0.5920.99
168_T180_H0.5910.99
82_N166_V0.5910.99
155_R158_R0.5900.98
131_L137_F0.5890.98
398_A488_K0.5890.98
87_T138_S0.5890.98
436_V442_L0.5890.98
342_G376_H0.5880.98
450_L455_W0.5870.98
196_H279_K0.5860.98
422_F480_R0.5860.98
428_G475_I0.5850.98
58_S61_L0.5850.98
83_Q104_W0.5840.98
245_G248_Q0.5810.98
110_A135_P0.5790.98
450_L453_G0.5780.98
343_V380_A0.5770.98
28_I436_V0.5750.98
86_T103_V0.5750.98
340_T379_R0.5740.98
404_L429_T0.5730.98
328_Y332_Y0.5720.98
116_L140_T0.5720.98
270_C307_V0.5720.98
247_Q265_T0.5710.98
335_T418_F0.5700.98
346_V352_L0.5690.98
230_I233_K0.5680.98
327_A334_A0.5680.98
206_E209_D0.5670.98
337_V341_N0.5670.98
350_T370_R0.5660.98
232_G237_R0.5640.98
176_Q231_G0.5630.98
210_I215_L0.5630.98
339_N379_R0.5620.98
346_V490_A0.5620.98
284_E287_L0.5610.98
346_V491_V0.5610.98
108_R148_H0.5610.98
142_V214_M0.5610.98
264_N272_M0.5610.98
356_Y491_V0.5600.98
485_A488_K0.5600.98
40_Y43_P0.5600.98
137_F189_R0.5580.98
323_L329_D0.5580.98
458_L462_Q0.5570.98
385_I419_L0.5560.98
356_Y488_K0.5560.98
290_T302_A0.5540.98
185_T221_S0.5530.98
348_A352_L0.5530.98
266_Y409_V0.5520.98
47_E99_Y0.5520.98
341_N371_G0.5520.98
78_I240_I0.5510.98
251_L273_L0.5510.98
432_E468_E0.5510.98
255_L465_A0.5500.98
109_T140_T0.5500.98
253_G439_V0.5500.98
88_I97_P0.5470.98
325_N328_Y0.5470.98
229_N237_R0.5460.98
192_L215_L0.5460.98
383_E387_Y0.5460.98
322_K329_D0.5440.97
7_I455_W0.5430.97
421_Q424_S0.5430.97
190_T200_W0.5430.97
140_T191_M0.5430.97
31_V67_K0.5410.97
333_F338_Q0.5410.97
95_G158_R0.5410.97
27_N435_E0.5400.97
343_V368_L0.5390.97
6_Y73_D0.5380.97
442_L446_Y0.5370.97
272_M392_V0.5370.97
329_D337_V0.5360.97
221_S244_A0.5360.97
153_R211_P0.5350.97
462_Q466_V0.5350.97
49_D55_A0.5350.97
81_T444_A0.5350.97
125_I208_L0.5350.97
119_D143_K0.5320.97
164_G172_W0.5320.97
480_R483_R0.5310.97
222_S451_A0.5290.97
424_S431_V0.5290.97
84_R189_R0.5270.97
459_D463_E0.5270.97
343_V377_I0.5260.97
414_V433_R0.5260.97
97_P100_N0.5260.97
176_Q179_V0.5260.97
252_F446_Y0.5260.97
153_R209_D0.5260.97
356_Y361_A0.5250.97
274_M404_L0.5250.97
320_E373_N0.5240.97
45_W102_I0.5240.97
15_T18_R0.5230.97
196_H282_K0.5220.97
261_M405_H0.5220.97
422_F483_R0.5220.97
276_T280_A0.5210.97
261_M462_Q0.5210.97
14_T104_W0.5210.97
85_E104_W0.5200.97
330_S334_A0.5190.97
344_Y387_Y0.5180.97
324_I329_D0.5180.97
265_T410_D0.5170.97
192_L200_W0.5170.97
255_L462_Q0.5170.97
423_Q427_L0.5170.97
89_V99_Y0.5160.97
314_I330_S0.5140.96
325_N374_A0.5130.96
242_G249_A0.5120.96
462_Q465_A0.5120.96
358_D365_I0.5100.96
85_E269_G0.5100.96
457_N461_L0.5090.96
222_S450_L0.5080.96
405_H430_R0.5080.96
347_P384_S0.5070.96
153_R157_R0.5070.96
265_T271_F0.5060.96
147_D209_D0.5060.96
389_T423_Q0.5050.96
279_K301_Y0.5050.96
397_Q404_L0.5050.96
289_T292_A0.5040.96
193_F200_W0.5040.96
165_T186_N0.5020.96
204_M208_L0.5010.96
46_V103_V0.5010.96
315_Q318_R0.5000.96
84_R166_V0.5000.96
171_I240_I0.5000.96
263_K273_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h3nX 3 0.998 100 0.133 Contact Map
3ezwA 3 0.994 100 0.133 Contact Map
3g25A 3 0.992 100 0.138 Contact Map
2d4wA 2 0.99 100 0.142 Contact Map
3ll3A 2 0.9661 100 0.144 Contact Map
3wxlA 2 0.988 100 0.145 Contact Map
2zf5O 3 0.9801 100 0.146 Contact Map
2dpnA 2 0.9801 100 0.149 Contact Map
2w40A 3 0.9801 100 0.156 Contact Map
2itmA 2 0.9382 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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