GREMLIN Database
CARA - Carbamoyl-phosphate synthase small chain
UniProt: P0A6F1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10134
Length: 382 (355)
Sequences: 4103 (2018)
Seq/√Len: 107.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_H215_R4.0791.00
96_E104_R3.9631.00
255_I274_L3.9611.00
212_R368_D3.9501.00
30_V130_G3.4551.00
195_V219_V3.4481.00
52_I81_V3.0911.00
326_R341_H2.9571.00
55_L80_L2.9391.00
194_V374_I2.8721.00
246_A282_K2.8681.00
163_T221_A2.6831.00
283_T316_V2.6261.00
276_A316_V2.5581.00
193_H217_T2.4341.00
22_A106_N2.4161.00
10_E129_N2.3251.00
326_R343_T2.3141.00
89_A94_N2.2951.00
11_D121_L2.2581.00
33_N48_Y2.2541.00
168_Y218_I2.2451.00
284_V315_A2.2331.00
318_E330_K2.1731.00
99_S103_K2.1281.00
284_V317_D2.0881.00
24_G108_V2.0711.00
196_A237_F2.0581.00
204_N207_R2.0571.00
291_H313_G2.0421.00
266_F366_L2.0411.00
35_S293_G2.0311.00
169_S215_R2.0291.00
224_S227_D2.0181.00
164_T168_Y1.9721.00
275_L349_S1.9691.00
214_C371_I1.9581.00
20_I109_A1.9201.00
276_A340_I1.9191.00
219_V223_T1.8691.00
86_P89_A1.8661.00
67_D95_T1.8641.00
197_Y219_V1.8611.00
4_S16_H1.8531.00
42_I53_V1.8451.00
327_V337_L1.8351.00
25_S146_K1.8181.00
145_E149_A1.8141.00
324_N344_D1.8111.00
124_E288_F1.8081.00
275_L347_A1.8031.00
199_F251_A1.7791.00
340_I349_S1.7661.00
192_F375_E1.7641.00
229_L263_I1.7611.00
226_E257_K1.7201.00
282_K317_D1.7011.00
196_A201_A1.7011.00
236_I263_I1.6871.00
298_K303_N1.6831.00
81_V110_I1.6731.00
324_N343_T1.6681.00
341_H369_H1.6631.00
197_Y254_A1.6631.00
18_R112_D1.6601.00
15_F121_L1.6591.00
13_T121_L1.6441.00
8_V144_L1.6381.00
157_D160_K1.6351.00
70_E101_Y1.6311.00
259_L347_A1.6291.00
195_V231_M1.6171.00
342_R346_P1.6091.00
192_F374_I1.6041.00
75_V105_H1.5821.00
113_I118_L1.5711.00
144_L148_R1.5651.00
56_T119_T1.5641.00
208_M364_A1.5541.00
253_T256_Q1.5511.00
52_I79_G1.5501.00
342_R345_K1.5481.00
301_E326_R1.5351.00
325_L342_R1.5241.00
53_V77_A1.5221.00
225_A229_L1.5211.00
219_V231_M1.5111.00
52_I130_G1.5081.00
262_D345_K1.4971.00
279_S342_R1.4741.00
5_A110_I1.4651.00
33_N42_I1.4351.00
222_Q250_Y1.4351.00
223_T227_D1.4321.00
79_G132_I1.4301.00
254_A257_K1.4291.00
89_A97_D1.4231.00
97_D100_S1.4201.00
49_S76_H1.4131.00
197_Y228_V1.4041.00
300_V330_K1.4021.00
272_H349_S1.4011.00
18_R111_A1.3981.00
299_D369_H1.3911.00
306_M365_P1.3901.00
199_F238_L1.3891.00
225_A257_K1.3781.00
82_I85_L1.3771.00
195_V233_P1.3741.00
279_S325_L1.3631.00
96_E100_S1.3621.00
236_I258_F1.3551.00
145_E148_R1.3471.00
214_C374_I1.3220.99
252_I277_L1.3200.99
191_P375_E1.2940.99
43_L77_A1.2840.99
301_E341_H1.2760.99
196_A216_L1.2750.99
13_T117_K1.2650.99
284_V336_T1.2510.99
159_A270_L1.2430.99
69_D93_R1.2420.99
196_A206_L1.2360.99
306_M363_A1.2340.99
49_S161_E1.2180.99
237_F266_F1.2170.99
194_V214_C1.2160.99
142_L145_E1.2140.99
227_D230_K1.2130.99
8_V14_Q1.2130.99
259_L279_S1.2060.99
281_A320_T1.2010.99
301_E369_H1.1920.99
5_A19_A1.1910.99
298_K330_K1.1890.99
43_L80_L1.1860.99
197_Y223_T1.1820.99
372_E375_E1.1750.99
325_L340_I1.1750.99
238_L255_I1.1670.99
246_A283_T1.1560.99
23_T103_K1.1480.98
235_G374_I1.1420.98
10_E128_Q1.1390.98
210_V216_L1.1340.98
318_E327_V1.1330.98
258_F265_V1.1270.98
246_A277_L1.1240.98
193_H231_M1.1240.98
201_A206_L1.1200.98
66_N69_D1.1110.98
73_S76_H1.1100.98
317_D320_T1.1070.98
171_T190_L1.1050.98
266_F348_F1.1030.98
253_T257_K1.1010.98
299_D306_M1.1010.98
229_L262_D1.0890.98
30_V122_L1.0890.98
24_G106_N1.0880.98
329_H352_G1.0850.98
159_A248_C1.0830.98
163_T222_Q1.0700.98
8_V147_A1.0690.98
67_D96_E1.0520.97
85_L99_S1.0450.97
194_V371_I1.0430.97
7_L110_I1.0400.97
281_A321_L1.0380.97
372_E376_Q1.0300.97
254_A258_F1.0280.97
35_S42_I1.0240.97
26_A79_G1.0190.97
348_F366_L1.0150.97
65_T96_E1.0140.97
275_L340_I1.0070.96
225_A254_A1.0060.96
298_K332_L1.0050.96
75_V107_I1.0020.96
190_L215_R1.0010.96
164_T167_A1.0010.96
117_K121_L0.9940.96
71_E207_R0.9880.96
257_K260_E0.9850.96
138_P142_L0.9830.96
197_Y224_S0.9810.96
265_V275_L0.9790.96
171_T215_R0.9760.96
26_A132_I0.9650.95
42_I55_L0.9610.95
255_I265_V0.9540.95
5_A134_A0.9530.95
204_N208_M0.9380.95
208_M211_D0.9360.95
369_H372_E0.9300.94
122_L130_G0.9300.94
169_S217_T0.9280.94
217_T231_M0.9260.94
299_D304_V0.9200.94
81_V113_I0.9180.94
269_C353_H0.9130.94
209_L214_C0.9100.94
232_N263_I0.9100.94
25_S135_G0.9100.94
100_S103_K0.9080.94
50_R78_Q0.9080.94
151_P156_M0.9070.94
192_F214_C0.9070.94
201_A237_F0.9060.94
293_G309_A0.9020.93
352_G363_A0.8990.93
40_Q66_N0.8980.93
6_L16_H0.8930.93
192_F371_I0.8920.93
157_D251_A0.8920.93
15_F117_K0.8890.93
142_L146_K0.8840.93
226_E230_K0.8820.93
68_A93_R0.8810.93
170_W210_V0.8790.93
160_K222_Q0.8780.93
248_C251_A0.8770.92
59_H84_D0.8760.92
87_L111_A0.8720.92
153_L156_M0.8680.92
20_I82_I0.8680.92
224_S254_A0.8680.92
156_M161_E0.8650.92
328_T341_H0.8650.92
223_T231_M0.8640.92
74_Q105_H0.8600.92
330_K335_G0.8570.92
249_D253_T0.8530.91
297_V338_Q0.8490.91
129_N152_G0.8440.91
212_R371_I0.8370.91
164_T218_I0.8350.91
82_I111_A0.8340.90
11_D125_K0.8310.90
73_S203_R0.8300.90
6_L136_D0.8290.90
6_L14_Q0.8290.90
26_A78_Q0.8290.90
21_G109_A0.8260.90
259_L275_L0.8220.90
371_I374_I0.8160.90
216_L237_F0.8150.89
28_G52_I0.8100.89
144_L147_A0.8100.89
208_M212_R0.8090.89
324_N342_R0.8050.89
136_D142_L0.7990.89
102_L107_I0.7980.88
50_R161_E0.7960.88
47_S269_C0.7940.88
172_Q191_P0.7920.88
30_V54_T0.7920.88
8_V133_I0.7880.88
65_T70_E0.7880.88
150_F153_L0.7880.88
43_L98_L0.7860.88
279_S347_A0.7760.87
291_H295_H0.7760.87
196_A239_S0.7760.87
260_E345_K0.7740.87
157_D250_Y0.7740.87
131_C143_A0.7730.87
281_A325_L0.7690.87
299_D302_K0.7690.87
19_A134_A0.7680.86
168_Y206_L0.7680.86
199_F274_L0.7650.86
238_L265_V0.7640.86
155_G247_P0.7620.86
342_R347_A0.7590.86
228_V254_A0.7560.86
153_L158_L0.7560.86
133_I143_A0.7550.86
100_S104_R0.7540.85
211_D364_A0.7540.85
44_T70_E0.7520.85
295_H333_F0.7510.85
81_V130_G0.7500.85
228_V233_P0.7480.85
228_V236_I0.7480.85
221_A250_Y0.7460.85
21_G99_S0.7450.85
94_N97_D0.7450.85
352_G365_P0.7430.85
270_L277_L0.7420.85
236_I261_T0.7410.84
253_T260_E0.7410.84
203_R207_R0.7400.84
329_H365_P0.7370.84
194_V235_G0.7370.84
129_N153_L0.7350.84
27_V131_C0.7350.84
368_D371_I0.7350.84
240_N269_C0.7340.84
133_I137_N0.7300.84
256_Q260_E0.7280.83
293_G331_S0.7280.83
282_K320_T0.7280.83
99_S109_A0.7280.83
214_C235_G0.7270.83
121_L125_K0.7270.83
170_W206_L0.7270.83
320_T323_A0.7260.83
172_Q215_R0.7260.83
318_E337_L0.7220.83
225_A261_T0.7200.83
133_I138_P0.7180.83
43_L102_L0.7170.83
72_S76_H0.7150.82
195_V228_V0.7140.82
146_K149_A0.7050.81
250_Y253_T0.7040.81
9_L118_L0.7030.81
154_N246_A0.7000.81
49_S74_Q0.7000.81
167_A219_V0.6980.81
102_L109_A0.6980.81
101_Y105_H0.6940.80
151_P155_G0.6930.80
223_T228_V0.6920.80
77_A80_L0.6870.80
155_G314_F0.6870.80
189_E215_R0.6850.80
24_G134_A0.6840.79
49_S78_Q0.6830.79
265_V347_A0.6770.79
205_I356_A0.6770.79
44_T101_Y0.6760.79
225_A258_F0.6740.78
191_P215_R0.6740.78
205_I268_I0.6730.78
229_L257_K0.6720.78
77_A107_I0.6690.78
25_S133_I0.6680.78
251_A254_A0.6670.78
60_I82_I0.6670.78
279_S345_K0.6660.78
172_Q203_R0.6650.78
33_N55_L0.6650.78
257_K261_T0.6650.78
291_H352_G0.6630.77
228_V258_F0.6590.77
236_I265_V0.6590.77
306_M352_G0.6580.77
49_S162_V0.6570.77
250_Y254_A0.6570.77
172_Q190_L0.6540.76
63_V66_N0.6520.76
323_A343_T0.6520.76
343_T346_P0.6510.76
46_P355_E0.6510.76
168_Y210_V0.6480.76
197_Y251_A0.6460.75
122_L127_A0.6460.75
193_H234_D0.6450.75
55_L60_I0.6450.75
346_P373_L0.6440.75
48_Y51_Q0.6420.75
25_S142_L0.6420.75
197_Y238_L0.6420.75
276_A281_A0.6410.75
119_T331_S0.6390.75
108_V132_I0.6390.75
229_L261_T0.6370.74
195_V217_T0.6360.74
118_L130_G0.6360.74
277_L282_K0.6340.74
42_I48_Y0.6340.74
235_G370_F0.6340.74
286_M315_A0.6340.74
10_E125_K0.6330.74
141_A145_E0.6330.74
20_I85_L0.6330.74
310_Q338_Q0.6320.74
33_N295_H0.6310.74
54_T119_T0.6290.74
80_L102_L0.6260.73
7_L113_I0.6260.73
23_T108_V0.6260.73
212_R364_A0.6260.73
36_M63_V0.6250.73
153_L314_F0.6230.73
35_S309_A0.6230.73
222_Q227_D0.6190.72
63_V333_F0.6180.72
167_A231_M0.6180.72
247_P314_F0.6170.72
127_A314_F0.6170.72
158_L314_F0.6150.72
40_Q329_H0.6150.72
110_I113_I0.6140.72
249_D252_I0.6110.71
353_H360_P0.6110.71
235_G266_F0.6100.71
31_V291_H0.6080.71
194_V209_L0.6070.71
124_E287_K0.6060.71
317_D337_L0.6060.71
205_I269_C0.6050.71
204_N364_A0.6010.70
226_E229_L0.6000.70
30_V81_V0.6000.70
291_H338_Q0.5990.70
269_C288_F0.5980.70
252_I256_Q0.5950.69
206_L218_I0.5950.69
49_S158_L0.5940.69
4_S135_G0.5940.69
160_K250_Y0.5930.69
310_Q331_S0.5930.69
129_N151_P0.5930.69
192_F213_G0.5910.69
196_A266_F0.5910.69
192_F234_D0.5910.69
279_S322_P0.5910.69
47_S353_H0.5910.69
85_L111_A0.5910.69
269_C289_G0.5900.69
54_T81_V0.5880.69
281_A340_I0.5840.68
206_L237_F0.5840.68
159_A199_F0.5830.68
141_A144_L0.5830.68
68_A95_T0.5820.68
171_T210_V0.5810.68
298_K335_G0.5790.67
35_S291_H0.5770.67
42_I295_H0.5770.67
269_C360_P0.5760.67
155_G158_L0.5760.67
82_I109_A0.5730.67
244_D283_T0.5730.67
78_Q161_E0.5720.66
137_N146_K0.5690.66
224_S258_F0.5670.66
75_V101_Y0.5670.66
353_H359_G0.5660.66
316_V340_I0.5660.66
209_L216_L0.5650.65
19_A109_A0.5630.65
204_N357_S0.5630.65
167_A227_D0.5620.65
22_A103_K0.5620.65
270_L274_L0.5590.65
19_A23_T0.5590.65
202_K359_G0.5570.64
50_R156_M0.5570.64
350_F366_L0.5570.64
306_M329_H0.5550.64
299_D365_P0.5540.64
65_T94_N0.5540.64
368_D372_E0.5520.64
331_S338_Q0.5490.63
229_L258_F0.5490.63
70_E105_H0.5480.63
7_L30_V0.5480.63
248_C270_L0.5470.63
240_N353_H0.5470.63
357_S361_H0.5440.63
43_L55_L0.5440.63
59_H63_V0.5440.63
31_V288_F0.5430.62
237_F349_S0.5420.62
291_H333_F0.5390.62
6_L137_N0.5370.62
122_L128_Q0.5370.62
20_I111_A0.5370.62
203_R206_L0.5360.61
48_Y269_C0.5360.61
299_D329_H0.5360.61
293_G357_S0.5350.61
54_T122_L0.5340.61
252_I278_A0.5340.61
295_H314_F0.5330.61
251_A274_L0.5320.61
6_L133_I0.5300.61
237_F348_F0.5300.61
170_W218_I0.5300.61
221_A251_A0.5280.60
154_N247_P0.5280.60
33_N205_I0.5270.60
165_A256_Q0.5260.60
222_Q251_A0.5250.60
9_L121_L0.5240.60
329_H366_L0.5240.60
71_E204_N0.5220.59
338_Q352_G0.5220.59
197_Y258_F0.5210.59
272_H316_V0.5200.59
31_V287_K0.5190.59
59_H338_Q0.5180.59
21_G108_V0.5180.59
27_V147_A0.5180.59
369_H373_L0.5170.59
269_C273_Q0.5170.59
307_I355_E0.5170.59
208_M291_H0.5150.58
131_C147_A0.5150.58
315_A337_L0.5150.58
27_V146_K0.5140.58
15_F113_I0.5140.58
121_L128_Q0.5130.58
240_N273_Q0.5130.58
258_F261_T0.5130.58
209_L371_I0.5120.58
273_Q353_H0.5100.58
33_N54_T0.5100.58
45_D289_G0.5100.58
276_A325_L0.5090.58
6_L135_G0.5090.58
286_M313_G0.5080.57
28_G53_V0.5080.57
157_D247_P0.5080.57
67_D70_E0.5070.57
127_A313_G0.5050.57
283_T366_L0.5050.57
100_S106_N0.5050.57
71_E209_L0.5040.57
84_D87_L0.5040.57
281_A316_V0.5040.57
299_D328_T0.5030.57
309_A358_P0.5010.56
47_S240_N0.5010.56
42_I272_H0.5010.56
57_Y63_V0.5010.56
15_F128_Q0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a9xB 1 0.9921 100 0.206 Contact Map
1vcoA 4 0.8848 100 0.65 Contact Map
1s1mA 4 0.8874 100 0.667 Contact Map
3nvaA 2 0.8743 100 0.694 Contact Map
4zdjA 4 0.8717 100 0.713 Contact Map
2vxoA 2 0.4817 100 0.782 Contact Map
3tqiA 3 0.4581 100 0.791 Contact Map
1gpmA 3 0.5 100 0.793 Contact Map
2vpiA 1 0.4634 100 0.794 Contact Map
2ywbA 4 0.4738 100 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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