CARA - ECOLI - GREMLIN Contacts

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CARA - Carbamoyl-phosphate synthase small chain

UniProt:	P0A6F1	Sequences: MIKSALLVLEDGTQFHGRAIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAEAYSWTQGSWTLTGGLPEAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGICLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIELIEQYRKTAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10134
Length:	382 (355)
Sequences:	4103 (2018)
Seq/√Len:	107.1

ECOLI - CARA
BACSU - CARA CARX
HALSA - CARA
SULSO - CARA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_H	215_R	4.079	1.00
96_E	104_R	3.963	1.00
255_I	274_L	3.961	1.00
212_R	368_D	3.950	1.00
30_V	130_G	3.455	1.00
195_V	219_V	3.448	1.00
52_I	81_V	3.091	1.00
326_R	341_H	2.957	1.00
55_L	80_L	2.939	1.00
194_V	374_I	2.872	1.00
246_A	282_K	2.868	1.00
163_T	221_A	2.683	1.00
283_T	316_V	2.626	1.00
276_A	316_V	2.558	1.00
193_H	217_T	2.434	1.00
22_A	106_N	2.416	1.00
10_E	129_N	2.325	1.00
326_R	343_T	2.314	1.00
89_A	94_N	2.295	1.00
11_D	121_L	2.258	1.00
33_N	48_Y	2.254	1.00
168_Y	218_I	2.245	1.00
284_V	315_A	2.233	1.00
318_E	330_K	2.173	1.00
99_S	103_K	2.128	1.00
284_V	317_D	2.088	1.00
24_G	108_V	2.071	1.00
196_A	237_F	2.058	1.00
204_N	207_R	2.057	1.00
291_H	313_G	2.042	1.00
266_F	366_L	2.041	1.00
35_S	293_G	2.031	1.00
169_S	215_R	2.029	1.00
224_S	227_D	2.018	1.00
164_T	168_Y	1.972	1.00
275_L	349_S	1.969	1.00
214_C	371_I	1.958	1.00
20_I	109_A	1.920	1.00
276_A	340_I	1.919	1.00
219_V	223_T	1.869	1.00
86_P	89_A	1.866	1.00
67_D	95_T	1.864	1.00
197_Y	219_V	1.861	1.00
4_S	16_H	1.853	1.00
42_I	53_V	1.845	1.00
327_V	337_L	1.835	1.00
25_S	146_K	1.818	1.00
145_E	149_A	1.814	1.00
324_N	344_D	1.811	1.00
124_E	288_F	1.808	1.00
275_L	347_A	1.803	1.00
199_F	251_A	1.779	1.00
340_I	349_S	1.766	1.00
192_F	375_E	1.764	1.00
229_L	263_I	1.761	1.00
226_E	257_K	1.720	1.00
282_K	317_D	1.701	1.00
196_A	201_A	1.701	1.00
236_I	263_I	1.687	1.00
298_K	303_N	1.683	1.00
81_V	110_I	1.673	1.00
324_N	343_T	1.668	1.00
341_H	369_H	1.663	1.00
197_Y	254_A	1.663	1.00
18_R	112_D	1.660	1.00
15_F	121_L	1.659	1.00
13_T	121_L	1.644	1.00
8_V	144_L	1.638	1.00
157_D	160_K	1.635	1.00
70_E	101_Y	1.631	1.00
259_L	347_A	1.629	1.00
195_V	231_M	1.617	1.00
342_R	346_P	1.609	1.00
192_F	374_I	1.604	1.00
75_V	105_H	1.582	1.00
113_I	118_L	1.571	1.00
144_L	148_R	1.565	1.00
56_T	119_T	1.564	1.00
208_M	364_A	1.554	1.00
253_T	256_Q	1.551	1.00
52_I	79_G	1.550	1.00
342_R	345_K	1.548	1.00
301_E	326_R	1.535	1.00
325_L	342_R	1.524	1.00
53_V	77_A	1.522	1.00
225_A	229_L	1.521	1.00
219_V	231_M	1.511	1.00
52_I	130_G	1.508	1.00
262_D	345_K	1.497	1.00
279_S	342_R	1.474	1.00
5_A	110_I	1.465	1.00
33_N	42_I	1.435	1.00
222_Q	250_Y	1.435	1.00
223_T	227_D	1.432	1.00
79_G	132_I	1.430	1.00
254_A	257_K	1.429	1.00
89_A	97_D	1.423	1.00
97_D	100_S	1.420	1.00
49_S	76_H	1.413	1.00
197_Y	228_V	1.404	1.00
300_V	330_K	1.402	1.00
272_H	349_S	1.401	1.00
18_R	111_A	1.398	1.00
299_D	369_H	1.391	1.00
306_M	365_P	1.390	1.00
199_F	238_L	1.389	1.00
225_A	257_K	1.378	1.00
82_I	85_L	1.377	1.00
195_V	233_P	1.374	1.00
279_S	325_L	1.363	1.00
96_E	100_S	1.362	1.00
236_I	258_F	1.355	1.00
145_E	148_R	1.347	1.00
214_C	374_I	1.322	0.99
252_I	277_L	1.320	0.99
191_P	375_E	1.294	0.99
43_L	77_A	1.284	0.99
301_E	341_H	1.276	0.99
196_A	216_L	1.275	0.99
13_T	117_K	1.265	0.99
284_V	336_T	1.251	0.99
159_A	270_L	1.243	0.99
69_D	93_R	1.242	0.99
196_A	206_L	1.236	0.99
306_M	363_A	1.234	0.99
49_S	161_E	1.218	0.99
237_F	266_F	1.217	0.99
194_V	214_C	1.216	0.99
142_L	145_E	1.214	0.99
227_D	230_K	1.213	0.99
8_V	14_Q	1.213	0.99
259_L	279_S	1.206	0.99
281_A	320_T	1.201	0.99
301_E	369_H	1.192	0.99
5_A	19_A	1.191	0.99
298_K	330_K	1.189	0.99
43_L	80_L	1.186	0.99
197_Y	223_T	1.182	0.99
372_E	375_E	1.175	0.99
325_L	340_I	1.175	0.99
238_L	255_I	1.167	0.99
246_A	283_T	1.156	0.99
23_T	103_K	1.148	0.98
235_G	374_I	1.142	0.98
10_E	128_Q	1.139	0.98
210_V	216_L	1.134	0.98
318_E	327_V	1.133	0.98
258_F	265_V	1.127	0.98
246_A	277_L	1.124	0.98
193_H	231_M	1.124	0.98
201_A	206_L	1.120	0.98
66_N	69_D	1.111	0.98
73_S	76_H	1.110	0.98
317_D	320_T	1.107	0.98
171_T	190_L	1.105	0.98
266_F	348_F	1.103	0.98
253_T	257_K	1.101	0.98
299_D	306_M	1.101	0.98
229_L	262_D	1.089	0.98
30_V	122_L	1.089	0.98
24_G	106_N	1.088	0.98
329_H	352_G	1.085	0.98
159_A	248_C	1.083	0.98
163_T	222_Q	1.070	0.98
8_V	147_A	1.069	0.98
67_D	96_E	1.052	0.97
85_L	99_S	1.045	0.97
194_V	371_I	1.043	0.97
7_L	110_I	1.040	0.97
281_A	321_L	1.038	0.97
372_E	376_Q	1.030	0.97
254_A	258_F	1.028	0.97
35_S	42_I	1.024	0.97
26_A	79_G	1.019	0.97
348_F	366_L	1.015	0.97
65_T	96_E	1.014	0.97
275_L	340_I	1.007	0.96
225_A	254_A	1.006	0.96
298_K	332_L	1.005	0.96
75_V	107_I	1.002	0.96
190_L	215_R	1.001	0.96
164_T	167_A	1.001	0.96
117_K	121_L	0.994	0.96
71_E	207_R	0.988	0.96
257_K	260_E	0.985	0.96
138_P	142_L	0.983	0.96
197_Y	224_S	0.981	0.96
265_V	275_L	0.979	0.96
171_T	215_R	0.976	0.96
26_A	132_I	0.965	0.95
42_I	55_L	0.961	0.95
255_I	265_V	0.954	0.95
5_A	134_A	0.953	0.95
204_N	208_M	0.938	0.95
208_M	211_D	0.936	0.95
369_H	372_E	0.930	0.94
122_L	130_G	0.930	0.94
169_S	217_T	0.928	0.94
217_T	231_M	0.926	0.94
299_D	304_V	0.920	0.94
81_V	113_I	0.918	0.94
269_C	353_H	0.913	0.94
209_L	214_C	0.910	0.94
232_N	263_I	0.910	0.94
25_S	135_G	0.910	0.94
100_S	103_K	0.908	0.94
50_R	78_Q	0.908	0.94
151_P	156_M	0.907	0.94
192_F	214_C	0.907	0.94
201_A	237_F	0.906	0.94
293_G	309_A	0.902	0.93
352_G	363_A	0.899	0.93
40_Q	66_N	0.898	0.93
6_L	16_H	0.893	0.93
192_F	371_I	0.892	0.93
157_D	251_A	0.892	0.93
15_F	117_K	0.889	0.93
142_L	146_K	0.884	0.93
226_E	230_K	0.882	0.93
68_A	93_R	0.881	0.93
170_W	210_V	0.879	0.93
160_K	222_Q	0.878	0.93
248_C	251_A	0.877	0.92
59_H	84_D	0.876	0.92
87_L	111_A	0.872	0.92
153_L	156_M	0.868	0.92
20_I	82_I	0.868	0.92
224_S	254_A	0.868	0.92
156_M	161_E	0.865	0.92
328_T	341_H	0.865	0.92
223_T	231_M	0.864	0.92
74_Q	105_H	0.860	0.92
330_K	335_G	0.857	0.92
249_D	253_T	0.853	0.91
297_V	338_Q	0.849	0.91
129_N	152_G	0.844	0.91
212_R	371_I	0.837	0.91
164_T	218_I	0.835	0.91
82_I	111_A	0.834	0.90
11_D	125_K	0.831	0.90
73_S	203_R	0.830	0.90
6_L	136_D	0.829	0.90
6_L	14_Q	0.829	0.90
26_A	78_Q	0.829	0.90
21_G	109_A	0.826	0.90
259_L	275_L	0.822	0.90
371_I	374_I	0.816	0.90
216_L	237_F	0.815	0.89
28_G	52_I	0.810	0.89
144_L	147_A	0.810	0.89
208_M	212_R	0.809	0.89
324_N	342_R	0.805	0.89
136_D	142_L	0.799	0.89
102_L	107_I	0.798	0.88
50_R	161_E	0.796	0.88
47_S	269_C	0.794	0.88
172_Q	191_P	0.792	0.88
30_V	54_T	0.792	0.88
8_V	133_I	0.788	0.88
65_T	70_E	0.788	0.88
150_F	153_L	0.788	0.88
43_L	98_L	0.786	0.88
279_S	347_A	0.776	0.87
291_H	295_H	0.776	0.87
196_A	239_S	0.776	0.87
260_E	345_K	0.774	0.87
157_D	250_Y	0.774	0.87
131_C	143_A	0.773	0.87
281_A	325_L	0.769	0.87
299_D	302_K	0.769	0.87
19_A	134_A	0.768	0.86
168_Y	206_L	0.768	0.86
199_F	274_L	0.765	0.86
238_L	265_V	0.764	0.86
155_G	247_P	0.762	0.86
342_R	347_A	0.759	0.86
228_V	254_A	0.756	0.86
153_L	158_L	0.756	0.86
133_I	143_A	0.755	0.86
100_S	104_R	0.754	0.85
211_D	364_A	0.754	0.85
44_T	70_E	0.752	0.85
295_H	333_F	0.751	0.85
81_V	130_G	0.750	0.85
228_V	233_P	0.748	0.85
228_V	236_I	0.748	0.85
221_A	250_Y	0.746	0.85
21_G	99_S	0.745	0.85
94_N	97_D	0.745	0.85
352_G	365_P	0.743	0.85
270_L	277_L	0.742	0.85
236_I	261_T	0.741	0.84
253_T	260_E	0.741	0.84
203_R	207_R	0.740	0.84
329_H	365_P	0.737	0.84
194_V	235_G	0.737	0.84
129_N	153_L	0.735	0.84
27_V	131_C	0.735	0.84
368_D	371_I	0.735	0.84
240_N	269_C	0.734	0.84
133_I	137_N	0.730	0.84
256_Q	260_E	0.728	0.83
293_G	331_S	0.728	0.83
282_K	320_T	0.728	0.83
99_S	109_A	0.728	0.83
214_C	235_G	0.727	0.83
121_L	125_K	0.727	0.83
170_W	206_L	0.727	0.83
320_T	323_A	0.726	0.83
172_Q	215_R	0.726	0.83
318_E	337_L	0.722	0.83
225_A	261_T	0.720	0.83
133_I	138_P	0.718	0.83
43_L	102_L	0.717	0.83
72_S	76_H	0.715	0.82
195_V	228_V	0.714	0.82
146_K	149_A	0.705	0.81
250_Y	253_T	0.704	0.81
9_L	118_L	0.703	0.81
154_N	246_A	0.700	0.81
49_S	74_Q	0.700	0.81
167_A	219_V	0.698	0.81
102_L	109_A	0.698	0.81
101_Y	105_H	0.694	0.80
151_P	155_G	0.693	0.80
223_T	228_V	0.692	0.80
77_A	80_L	0.687	0.80
155_G	314_F	0.687	0.80
189_E	215_R	0.685	0.80
24_G	134_A	0.684	0.79
49_S	78_Q	0.683	0.79
265_V	347_A	0.677	0.79
205_I	356_A	0.677	0.79
44_T	101_Y	0.676	0.79
225_A	258_F	0.674	0.78
191_P	215_R	0.674	0.78
205_I	268_I	0.673	0.78
229_L	257_K	0.672	0.78
77_A	107_I	0.669	0.78
25_S	133_I	0.668	0.78
251_A	254_A	0.667	0.78
60_I	82_I	0.667	0.78
279_S	345_K	0.666	0.78
172_Q	203_R	0.665	0.78
33_N	55_L	0.665	0.78
257_K	261_T	0.665	0.78
291_H	352_G	0.663	0.77
228_V	258_F	0.659	0.77
236_I	265_V	0.659	0.77
306_M	352_G	0.658	0.77
49_S	162_V	0.657	0.77
250_Y	254_A	0.657	0.77
172_Q	190_L	0.654	0.76
63_V	66_N	0.652	0.76
323_A	343_T	0.652	0.76
343_T	346_P	0.651	0.76
46_P	355_E	0.651	0.76
168_Y	210_V	0.648	0.76
197_Y	251_A	0.646	0.75
122_L	127_A	0.646	0.75
193_H	234_D	0.645	0.75
55_L	60_I	0.645	0.75
346_P	373_L	0.644	0.75
48_Y	51_Q	0.642	0.75
25_S	142_L	0.642	0.75
197_Y	238_L	0.642	0.75
276_A	281_A	0.641	0.75
119_T	331_S	0.639	0.75
108_V	132_I	0.639	0.75
229_L	261_T	0.637	0.74
195_V	217_T	0.636	0.74
118_L	130_G	0.636	0.74
277_L	282_K	0.634	0.74
42_I	48_Y	0.634	0.74
235_G	370_F	0.634	0.74
286_M	315_A	0.634	0.74
10_E	125_K	0.633	0.74
141_A	145_E	0.633	0.74
20_I	85_L	0.633	0.74
310_Q	338_Q	0.632	0.74
33_N	295_H	0.631	0.74
54_T	119_T	0.629	0.74
80_L	102_L	0.626	0.73
7_L	113_I	0.626	0.73
23_T	108_V	0.626	0.73
212_R	364_A	0.626	0.73
36_M	63_V	0.625	0.73
153_L	314_F	0.623	0.73
35_S	309_A	0.623	0.73
222_Q	227_D	0.619	0.72
63_V	333_F	0.618	0.72
167_A	231_M	0.618	0.72
247_P	314_F	0.617	0.72
127_A	314_F	0.617	0.72
158_L	314_F	0.615	0.72
40_Q	329_H	0.615	0.72
110_I	113_I	0.614	0.72
249_D	252_I	0.611	0.71
353_H	360_P	0.611	0.71
235_G	266_F	0.610	0.71
31_V	291_H	0.608	0.71
194_V	209_L	0.607	0.71
124_E	287_K	0.606	0.71
317_D	337_L	0.606	0.71
205_I	269_C	0.605	0.71
204_N	364_A	0.601	0.70
226_E	229_L	0.600	0.70
30_V	81_V	0.600	0.70
291_H	338_Q	0.599	0.70
269_C	288_F	0.598	0.70
252_I	256_Q	0.595	0.69
206_L	218_I	0.595	0.69
49_S	158_L	0.594	0.69
4_S	135_G	0.594	0.69
160_K	250_Y	0.593	0.69
310_Q	331_S	0.593	0.69
129_N	151_P	0.593	0.69
192_F	213_G	0.591	0.69
196_A	266_F	0.591	0.69
192_F	234_D	0.591	0.69
279_S	322_P	0.591	0.69
47_S	353_H	0.591	0.69
85_L	111_A	0.591	0.69
269_C	289_G	0.590	0.69
54_T	81_V	0.588	0.69
281_A	340_I	0.584	0.68
206_L	237_F	0.584	0.68
159_A	199_F	0.583	0.68
141_A	144_L	0.583	0.68
68_A	95_T	0.582	0.68
171_T	210_V	0.581	0.68
298_K	335_G	0.579	0.67
35_S	291_H	0.577	0.67
42_I	295_H	0.577	0.67
269_C	360_P	0.576	0.67
155_G	158_L	0.576	0.67
82_I	109_A	0.573	0.67
244_D	283_T	0.573	0.67
78_Q	161_E	0.572	0.66
137_N	146_K	0.569	0.66
224_S	258_F	0.567	0.66
75_V	101_Y	0.567	0.66
353_H	359_G	0.566	0.66
316_V	340_I	0.566	0.66
209_L	216_L	0.565	0.65
19_A	109_A	0.563	0.65
204_N	357_S	0.563	0.65
167_A	227_D	0.562	0.65
22_A	103_K	0.562	0.65
270_L	274_L	0.559	0.65
19_A	23_T	0.559	0.65
202_K	359_G	0.557	0.64
50_R	156_M	0.557	0.64
350_F	366_L	0.557	0.64
306_M	329_H	0.555	0.64
299_D	365_P	0.554	0.64
65_T	94_N	0.554	0.64
368_D	372_E	0.552	0.64
331_S	338_Q	0.549	0.63
229_L	258_F	0.549	0.63
70_E	105_H	0.548	0.63
7_L	30_V	0.548	0.63
248_C	270_L	0.547	0.63
240_N	353_H	0.547	0.63
357_S	361_H	0.544	0.63
43_L	55_L	0.544	0.63
59_H	63_V	0.544	0.63
31_V	288_F	0.543	0.62
237_F	349_S	0.542	0.62
291_H	333_F	0.539	0.62
6_L	137_N	0.537	0.62
122_L	128_Q	0.537	0.62
20_I	111_A	0.537	0.62
203_R	206_L	0.536	0.61
48_Y	269_C	0.536	0.61
299_D	329_H	0.536	0.61
293_G	357_S	0.535	0.61
54_T	122_L	0.534	0.61
252_I	278_A	0.534	0.61
295_H	314_F	0.533	0.61
251_A	274_L	0.532	0.61
6_L	133_I	0.530	0.61
237_F	348_F	0.530	0.61
170_W	218_I	0.530	0.61
221_A	251_A	0.528	0.60
154_N	247_P	0.528	0.60
33_N	205_I	0.527	0.60
165_A	256_Q	0.526	0.60
222_Q	251_A	0.525	0.60
9_L	121_L	0.524	0.60
329_H	366_L	0.524	0.60
71_E	204_N	0.522	0.59
338_Q	352_G	0.522	0.59
197_Y	258_F	0.521	0.59
272_H	316_V	0.520	0.59
31_V	287_K	0.519	0.59
59_H	338_Q	0.518	0.59
21_G	108_V	0.518	0.59
27_V	147_A	0.518	0.59
369_H	373_L	0.517	0.59
269_C	273_Q	0.517	0.59
307_I	355_E	0.517	0.59
208_M	291_H	0.515	0.58
131_C	147_A	0.515	0.58
315_A	337_L	0.515	0.58
27_V	146_K	0.514	0.58
15_F	113_I	0.514	0.58
121_L	128_Q	0.513	0.58
240_N	273_Q	0.513	0.58
258_F	261_T	0.513	0.58
209_L	371_I	0.512	0.58
273_Q	353_H	0.510	0.58
33_N	54_T	0.510	0.58
45_D	289_G	0.510	0.58
276_A	325_L	0.509	0.58
6_L	135_G	0.509	0.58
286_M	313_G	0.508	0.57
28_G	53_V	0.508	0.57
157_D	247_P	0.508	0.57
67_D	70_E	0.507	0.57
127_A	313_G	0.505	0.57
283_T	366_L	0.505	0.57
100_S	106_N	0.505	0.57
71_E	209_L	0.504	0.57
84_D	87_L	0.504	0.57
281_A	316_V	0.504	0.57
299_D	328_T	0.503	0.57
309_A	358_P	0.501	0.56
47_S	240_N	0.501	0.56
42_I	272_H	0.501	0.56
57_Y	63_V	0.501	0.56
15_F	128_Q	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xB	1	0.9921	100	0.206	Contact Map
1vcoA	4	0.8848	100	0.65	Contact Map
1s1mA	4	0.8874	100	0.667	Contact Map
3nvaA	2	0.8743	100	0.694	Contact Map
4zdjA	4	0.8717	100	0.713	Contact Map
2vxoA	2	0.4817	100	0.782	Contact Map
3tqiA	3	0.4581	100	0.791	Contact Map
1gpmA	3	0.5	100	0.793	Contact Map
2vpiA	1	0.4634	100	0.794	Contact Map
2ywbA	4	0.4738	100	0.796	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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