GREMLIN Database
BIOD2 - ATP-dependent dethiobiotin synthetase BioD 2
UniProt: P0A6E9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13849
Length: 231 (210)
Sequences: 4751 (2968)
Seq/√Len: 204.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_A101_N3.3451.00
27_L108_H3.2531.00
140_M155_T2.9931.00
142_V148_C2.6361.00
135_Q165_P2.6321.00
157_Q162_D2.4571.00
156_A166_L2.3091.00
130_W134_E2.3081.00
132_V162_D2.2971.00
33_T107_D2.2391.00
11_D14_V2.2101.00
24_L34_V2.1901.00
19_V200_L2.1581.00
142_V152_A2.1261.00
33_T106_V2.0951.00
20_S110_V2.0711.00
19_V170_V2.0621.00
11_D151_H2.0331.00
138_V159_I2.0061.00
4_R136_L1.9651.00
187_V191_K1.9451.00
79_E89_P1.9131.00
122_N125_R1.8791.00
100_A103_T1.8781.00
182_A186_D1.8661.00
86_H89_P1.8641.00
47_T50_G1.8401.00
71_A105_K1.7961.00
44_S76_A1.7801.00
186_D190_K1.7201.00
183_E186_D1.7121.00
88_C123_D1.6641.00
111_V136_L1.6171.00
150_N154_L1.6001.00
148_C152_A1.5931.00
94_L97_N1.5911.00
152_A169_W1.5711.00
8_T138_V1.5651.00
208_Q211_L1.5441.00
5_F167_I1.5311.00
48_P67_L1.5281.00
46_E78_S1.5151.00
119_S187_V1.4991.00
73_N76_A1.4921.00
144_I171_A1.4851.00
208_Q212_G1.4771.00
5_F139_L1.4691.00
53_N58_V1.4641.00
7_I23_L1.4531.00
156_A194_A1.4401.00
96_S100_A1.4291.00
96_S133_Q1.4181.00
179_A182_A1.4171.00
28_A65_I1.3991.00
138_V164_L1.3951.00
137_P167_I1.3911.00
35_A106_V1.3781.00
153_L191_K1.3711.00
169_W196_L1.3661.00
32_K108_H1.3561.00
7_I141_V1.3541.00
92_Y133_Q1.3391.00
80_E83_S1.3311.00
29_S65_I1.3301.00
24_L110_V1.3261.00
157_Q161_N1.3161.00
37_Y99_L1.3091.00
149_I188_L1.2911.00
139_L197_I1.2891.00
22_A26_A1.2831.00
37_Y98_G1.2761.00
132_V165_P1.2741.00
128_S162_D1.2701.00
99_L103_T1.2331.00
91_N94_L1.2321.00
96_S134_E1.2301.00
11_D143_G1.2271.00
117_W159_I1.2231.00
11_D145_Q1.2191.00
4_R99_L1.2181.00
189_G196_L1.2111.00
8_T128_S1.2051.00
156_A169_W1.1991.00
187_V190_K1.1941.00
26_A30_Q1.1861.00
122_N162_D1.1781.00
93_T97_N1.1751.00
140_M166_L1.1721.00
90_I94_L1.1721.00
23_L27_L1.1701.00
142_V169_W1.1691.00
28_A34_V1.1681.00
7_I20_S1.1621.00
90_I95_I1.1541.00
153_L157_Q1.1511.00
8_T113_G1.1301.00
118_R158_A1.1251.00
57_L60_Q1.1241.00
35_A109_V1.1231.00
94_L98_G1.1221.00
156_A192_L1.1121.00
74_P98_G1.1071.00
36_G63_S1.1071.00
81_E84_V1.0801.00
143_G148_C1.0641.00
19_V141_V1.0611.00
6_F131_V1.0531.00
9_G14_V1.0451.00
97_N101_N1.0421.00
100_A133_Q1.0341.00
111_V130_W1.0291.00
4_R103_T1.0261.00
114_T127_L1.0261.00
101_N105_K1.0201.00
58_V62_V1.0191.00
188_L192_L1.0101.00
81_E85_A1.0101.00
82_S85_A1.0091.00
102_L109_V1.0011.00
210_E213_Q0.9911.00
80_E84_V0.9881.00
208_Q213_Q0.9771.00
186_D189_G0.9691.00
39_P111_V0.9691.00
150_N155_T0.9500.99
118_R128_S0.9460.99
85_A183_E0.9430.99
125_R133_Q0.9350.99
196_L199_E0.9260.99
141_V172_N0.9260.99
180_H183_E0.9250.99
14_V143_G0.9250.99
37_Y102_L0.9240.99
207_E212_G0.9220.99
206_A211_L0.9080.99
37_Y74_P0.9010.99
98_G101_N0.9000.99
103_T109_V0.8890.99
81_E184_I0.8870.99
42_K77_L0.8800.99
10_T148_C0.8800.99
21_R24_L0.8760.99
140_M156_A0.8690.99
21_R58_V0.8670.99
205_R211_L0.8670.99
40_V95_I0.8640.99
5_F110_V0.8510.99
148_C171_A0.8500.99
28_A64_T0.8490.99
169_W194_A0.8480.99
18_V203_L0.8350.99
207_E211_L0.8330.99
6_F113_G0.8300.99
26_A29_S0.8240.98
122_N160_A0.8240.98
159_I164_L0.8230.98
131_V164_L0.8220.98
34_V108_H0.8210.98
42_K81_E0.8190.98
205_R212_G0.8180.98
203_L206_A0.8150.98
137_P165_P0.8130.98
144_I148_C0.8110.98
19_V172_N0.8040.98
206_A210_E0.8030.98
24_L36_G0.7950.98
166_L194_A0.7930.98
149_I184_I0.7920.98
156_A160_A0.7900.98
153_L192_L0.7890.98
92_Y125_R0.7880.98
75_I94_L0.7860.98
143_G151_H0.7840.98
28_A33_T0.7720.98
185_I196_L0.7710.98
91_N95_I0.7710.98
117_W128_S0.7630.97
40_V121_M0.7610.97
71_A98_G0.7610.97
169_W192_L0.7610.97
95_I125_R0.7610.97
32_K107_D0.7590.97
35_A102_L0.7590.97
118_R157_Q0.7570.97
36_G59_L0.7530.97
8_T117_W0.7530.97
12_T146_E0.7510.97
96_S125_R0.7490.97
209_R213_Q0.7480.97
117_W155_T0.7440.97
27_L34_V0.7440.97
43_G80_E0.7380.97
181_Y185_I0.7360.97
58_V61_S0.7250.97
207_E210_E0.7240.96
209_R212_G0.7230.96
173_R181_Y0.7230.96
171_A196_L0.7190.96
181_Y199_E0.7150.96
128_S158_A0.7150.96
92_Y96_S0.7140.96
185_I199_E0.7060.96
99_L134_E0.6960.96
27_L32_K0.6930.95
75_I91_N0.6920.95
127_L131_V0.6920.95
129_E162_D0.6880.95
83_S86_H0.6840.95
206_A212_G0.6830.95
124_L190_K0.6830.95
41_A53_N0.6820.95
99_L130_W0.6810.95
189_G195_P0.6810.95
149_I187_V0.6800.95
126_P191_K0.6790.95
102_L106_V0.6790.95
68_P71_A0.6730.95
182_A185_I0.6730.95
13_S54_K0.6710.95
171_A185_I0.6710.95
140_M169_W0.6680.95
173_R202_Y0.6650.94
92_Y95_I0.6650.94
119_S184_I0.6650.94
128_S131_V0.6650.94
171_A199_E0.6600.94
161_N164_L0.6600.94
119_S149_I0.6550.94
205_R208_Q0.6520.94
39_P130_W0.6500.94
159_I166_L0.6500.94
4_R111_V0.6480.94
7_I170_V0.6460.93
93_T133_Q0.6450.93
92_Y130_W0.6420.93
168_G197_I0.6390.93
101_N104_E0.6350.93
205_R213_Q0.6330.93
118_R162_D0.6330.93
96_S130_W0.6320.93
20_S59_L0.6310.93
118_R153_L0.6270.92
115_G147_G0.6230.92
180_H184_I0.6200.92
43_G83_S0.6170.92
22_A25_Q0.6140.92
7_I139_L0.6140.92
164_L194_A0.6110.91
24_L64_T0.6110.91
119_S181_Y0.6070.91
92_Y129_E0.6070.91
4_R134_E0.6060.91
39_P114_T0.6060.91
23_L139_L0.6030.91
154_L158_A0.6020.91
17_T58_V0.5990.91
89_P180_H0.5960.90
81_E180_H0.5950.90
83_S87_S0.5940.90
173_R199_E0.5930.90
132_V164_L0.5920.90
160_A193_P0.5920.90
56_A70_E0.5910.90
206_A213_Q0.5870.90
69_Y105_K0.5840.90
97_N100_A0.5830.89
153_L156_A0.5790.89
34_V107_D0.5790.89
113_G127_L0.5770.89
99_L111_V0.5750.89
33_T105_K0.5730.89
82_S146_E0.5720.89
157_Q160_A0.5710.88
175_N181_Y0.5690.88
20_S36_G0.5680.88
168_G195_P0.5670.88
126_P153_L0.5670.88
18_V206_A0.5590.87
158_A162_D0.5550.87
56_A60_Q0.5510.87
115_G146_E0.5510.87
140_M159_I0.5500.87
6_F127_L0.5500.87
95_I98_G0.5420.86
99_L136_L0.5420.86
157_Q191_K0.5420.86
49_E69_Y0.5400.86
55_D59_L0.5390.86
41_A76_A0.5370.85
117_W131_V0.5340.85
85_A180_H0.5340.85
6_F111_V0.5340.85
21_R59_L0.5330.85
207_E213_Q0.5330.85
27_L110_V0.5280.84
84_V187_V0.5270.84
41_A73_N0.5200.83
80_E146_E0.5180.83
157_Q163_G0.5170.83
14_V151_H0.5160.83
203_L207_E0.5160.83
13_S80_E0.5160.83
152_A171_A0.5160.83
13_S18_V0.5160.83
112_E115_G0.5160.83
132_V160_A0.5150.83
158_A161_N0.5120.82
67_L71_A0.5110.82
41_A114_T0.5100.82
156_A163_G0.5100.82
44_S73_N0.5080.82
45_K78_S0.5060.82
46_E49_E0.5050.82
94_L101_N0.5020.81
26_A200_L0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a0gA 2 0.987 100 0.331 Contact Map
2obnA 2 0.7879 100 0.532 Contact Map
3fgnA 2 0.9524 100 0.54 Contact Map
1s1mA 4 0.974 100 0.557 Contact Map
1byiA 2 0.9481 100 0.583 Contact Map
3of5A 2 0.9307 100 0.59 Contact Map
3zq6A 2 0.9004 99.9 0.605 Contact Map
3qxcA 2 0.9048 99.9 0.608 Contact Map
3ug7A 4 0.9437 99.9 0.629 Contact Map
1vcoA 4 0.9957 99.9 0.638 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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