GREMLIN Database
ATPE - ATP synthase epsilon chain
UniProt: P0A6E6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10100
Length: 139 (129)
Sequences: 3021 (1987)
Seq/√Len: 175.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_K103_E2.9981.00
28_G33_L2.8941.00
6_H20_L2.5121.00
100_R104_E2.4561.00
26_V70_L2.4301.00
7_L21_V2.3841.00
8_D18_S2.3701.00
97_E100_R2.2661.00
50_M131_V2.1641.00
104_E108_S2.0791.00
23_K34_G2.0681.00
97_E101_K2.0361.00
93_A96_M2.0141.00
54_V60_E1.9431.00
85_I128_Q1.9241.00
72_V77_V1.8871.00
96_M99_K1.8481.00
33_L42_L1.8451.00
27_T32_E1.8151.00
92_E96_M1.7661.00
5_Y37_P1.7301.00
52_R60_E1.7011.00
27_T49_G1.6951.00
99_K122_L1.6841.00
23_K54_V1.6381.00
91_D94_R1.5631.00
14_Q89_D1.5571.00
96_M100_R1.5221.00
26_V33_L1.5141.00
103_E107_S1.5031.00
94_R98_A1.4951.00
92_E132_I1.4561.00
44_T70_L1.4491.00
93_A97_E1.4491.00
4_T22_E1.4171.00
4_T20_L1.4151.00
8_D76_N1.4091.00
28_G44_T1.3911.00
32_E47_K1.3871.00
92_E129_L1.3791.00
8_D15_Q1.3661.00
22_E57_H1.3571.00
51_I79_V1.3531.00
3_M38_G1.3471.00
23_K36_Y1.3421.00
66_S83_T1.3331.00
111_G114_D1.3091.00
38_G75_G1.3021.00
53_I63_I1.2901.00
51_I65_L1.2721.00
22_E56_Q1.2651.00
61_E86_R1.2591.00
100_R103_E1.2421.00
61_E88_Q1.1961.00
24_I77_V1.1831.00
29_S45_A1.1791.00
119_S123_A1.1511.00
104_E107_S1.1391.00
127_A131_V1.1141.00
63_I86_R1.1111.00
22_E54_V1.1101.00
101_K121_E1.0971.00
42_L72_V1.0781.00
98_A101_K1.0671.00
95_A99_K1.0591.00
113_V117_Q1.0531.00
5_Y77_V1.0441.00
63_I84_A1.0240.99
24_I51_I1.0080.99
86_R89_D1.0070.99
90_L95_A1.0070.99
19_G56_Q1.0000.99
6_H18_S0.9930.99
62_F87_G0.9790.99
25_Q52_R0.9740.99
16_M63_I0.9740.99
112_D115_Y0.9690.99
25_Q54_V0.9220.99
64_Y127_A0.9140.99
85_I94_R0.9110.99
35_I72_V0.9080.99
9_V63_I0.9060.99
27_T47_K0.8990.99
105_H121_E0.8940.98
105_H108_S0.8930.98
43_L71_E0.8880.98
95_A125_A0.8820.98
98_A102_A0.8600.98
25_Q32_E0.8590.98
120_A124_K0.8450.98
26_V46_I0.8430.98
27_T70_L0.8430.98
66_S82_D0.8390.98
64_Y131_V0.8380.98
101_K105_H0.8250.97
118_A122_L0.8240.97
17_F53_I0.8240.97
99_K126_I0.8140.97
126_I130_R0.8090.97
6_H76_N0.8030.97
85_I90_L0.7920.97
15_Q18_S0.7920.97
115_Y119_S0.7910.97
13_E80_L0.7870.97
124_K128_Q0.7780.96
94_R128_Q0.7780.96
102_A118_A0.7750.96
47_K123_A0.7610.96
67_G81_A0.7560.96
7_L53_I0.7550.96
109_S115_Y0.7530.96
20_L56_Q0.7450.95
129_L132_I0.7450.95
21_V53_I0.7430.95
16_M84_A0.7230.94
95_A128_Q0.7220.94
95_A98_A0.7170.94
7_L77_V0.7060.94
94_R101_K0.7010.93
65_L79_V0.7010.93
48_P127_A0.6930.93
10_V18_S0.6840.93
11_S21_V0.6840.93
85_I98_A0.6830.93
9_V51_I0.6810.92
106_I115_Y0.6720.92
125_A128_Q0.6690.92
43_L73_Q0.6680.92
35_I70_L0.6560.91
3_M37_P0.6520.91
16_M86_R0.6520.91
28_G42_L0.6520.91
56_Q59_H0.6480.91
25_Q34_G0.6400.90
53_I67_G0.6390.90
94_R97_E0.6390.90
32_E52_R0.6370.90
62_F131_V0.6310.89
108_S111_G0.6300.89
24_I53_I0.6090.88
103_E106_I0.6080.88
71_E78_T0.6020.87
52_R62_F0.6020.87
110_H114_D0.5940.86
64_Y90_L0.5930.86
4_T56_Q0.5900.86
5_Y23_K0.5880.86
44_T72_V0.5860.86
116_A120_A0.5860.86
56_Q61_E0.5840.85
123_A126_I0.5830.85
117_Q121_E0.5720.84
12_A48_P0.5690.84
10_V78_T0.5670.84
102_A105_H0.5660.84
114_D117_Q0.5660.84
27_T65_L0.5630.83
10_V15_Q0.5620.83
66_S127_A0.5600.83
90_L132_I0.5580.83
22_E58_G0.5570.83
109_S114_D0.5540.82
33_L44_T0.5480.82
106_I109_S0.5440.81
103_E122_L0.5430.81
70_L77_V0.5410.81
24_I36_Y0.5380.80
121_E124_K0.5380.80
25_Q40_A0.5360.80
22_E59_H0.5320.80
13_E30_E0.5310.80
26_V35_I0.5310.80
81_A84_A0.5290.79
50_M62_F0.5280.79
45_A63_I0.5280.79
3_M22_E0.5270.79
67_G82_D0.5250.79
7_L50_M0.5210.78
19_G53_I0.5200.78
114_D118_A0.5190.78
73_Q78_T0.5180.78
108_S114_D0.5180.78
26_V51_I0.5150.78
65_L84_A0.5130.77
12_A70_L0.5120.77
26_V49_G0.5110.77
5_Y76_N0.5100.77
9_V53_I0.5080.77
69_I75_G0.5060.76
123_A127_A0.5060.76
119_S126_I0.5030.76
17_F61_E0.5020.76
116_A119_S0.5020.76
15_Q76_N0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1aqtA 2 0.9712 100 0.086 Contact Map
2qe7H 1 0.964 100 0.089 Contact Map
2e5yA 2 0.9568 100 0.092 Contact Map
2rq6A 1 0.9712 100 0.126 Contact Map
2w6jH 1 0.5971 100 0.14 Contact Map
2ck3H 1 0.5971 100 0.157 Contact Map
3ziaH 1 0.8849 100 0.182 Contact Map
2xokH 1 0.8489 100 0.215 Contact Map
3hqxA 2 0.6403 24.2 0.923 Contact Map
3eo6A 2 0.6259 12.5 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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