GREMLIN Database
ASSY - Argininosuccinate synthase
UniProt: P0A6E4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10068
Length: 447 (392)
Sequences: 2315 (863)
Seq/√Len: 43.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_R248_A5.2241.00
268_G299_L5.0361.00
350_R354_S4.8471.00
119_K148_N4.5591.00
235_E271_H3.9761.00
67_N121_D3.7951.00
357_T379_N3.4561.00
252_K263_E3.3671.00
235_E270_R3.3531.00
86_Q349_Q3.3221.00
235_E250_N3.2931.00
238_T359_E3.1451.00
84_A105_L3.0711.00
113_M116_A2.8031.00
240_R359_E2.7661.00
75_K79_A2.7631.00
236_E373_L2.6991.00
15_G123_V2.6981.00
44_N74_R2.6771.00
263_E266_R2.6121.00
211_N376_V2.5911.00
213_S236_E2.5771.00
243_Q354_S2.5661.00
58_R62_E2.5291.00
12_Q124_N2.5131.00
359_E376_V2.5001.00
114_L144_G2.4981.00
228_E363_E2.4791.00
255_S258_V2.4541.00
249_L263_E2.4111.00
119_K150_E2.3711.00
71_I113_M2.3691.00
304_Y353_A2.3331.00
43_A73_C2.2881.00
126_W144_G2.2731.00
33_Q179_C2.2281.00
341_A345_R2.2091.00
174_E178_A2.1741.00
221_M291_I2.1531.00
327_L345_R2.1050.99
78_V261_M2.0800.99
255_S259_E2.0610.99
283_I335_R2.0480.99
318_E329_R2.0310.99
39_Y67_N2.0120.99
29_L32_R2.0050.99
74_R262_L1.9830.99
69_R120_E1.9520.99
227_D230_V1.9120.99
218_N229_S1.9040.99
319_Q323_H1.8830.99
52_D55_A1.8720.99
218_N226_W1.8710.99
92_N281_N1.8700.99
98_T306_R1.8080.98
114_L126_W1.7770.98
240_R357_T1.7550.98
239_V246_P1.7350.98
209_Y384_P1.7250.98
86_Q245_H1.7190.98
79_A257_D1.6850.97
75_K255_S1.6580.97
12_Q152_Q1.6450.97
225_F230_V1.6380.97
103_T106_G1.6270.97
225_F270_R1.6160.97
236_E363_E1.6110.97
40_A68_A1.5870.96
254_F263_E1.5830.96
115_V151_L1.5800.96
142_R409_N1.5360.95
54_D57_P1.5340.95
14_I36_A1.5320.95
197_M261_M1.5310.95
264_A299_L1.5270.95
81_G337_F1.5230.95
242_E253_T1.5160.95
343_M352_V1.5140.95
230_V365_R1.5120.95
226_W229_S1.5070.95
242_E247_V1.4800.94
304_Y352_V1.4760.94
213_S363_E1.4760.94
246_P260_M1.4700.94
204_A389_M1.4640.94
75_K258_V1.4500.94
323_H344_L1.4480.94
224_K275_M1.4430.94
37_V66_E1.4300.93
52_D195_S1.4270.93
33_Q175_F1.4250.93
392_G395_V1.4240.93
374_N377_S1.4220.93
307_L360_V1.4210.93
386_R414_D1.4210.93
69_R121_D1.4150.93
102_T199_G1.3980.93
11_G124_N1.3900.92
225_F229_S1.3890.92
126_W151_L1.3870.92
343_M347_S1.3840.92
319_Q340_Q1.3830.92
73_C113_M1.3760.92
232_I366_R1.3710.92
266_R270_R1.3620.92
76_Q112_T1.3600.92
228_E234_A1.3560.91
57_P61_M1.3440.91
211_N361_T1.3260.90
238_T361_T1.3130.90
326_Q329_R1.3110.90
69_R117_A1.3000.90
213_S373_L1.2890.89
111_G143_Y1.2820.89
361_T374_N1.2780.89
54_D58_R1.2780.89
388_T395_V1.2730.89
386_R395_V1.2710.88
343_M350_R1.2620.88
13_R37_V1.2600.88
396_F401_R1.2580.88
11_G35_G1.2580.88
362_L369_D1.2410.87
190_A205_K1.2410.87
14_I154_Y1.2390.87
39_Y121_D1.2370.87
248_A253_T1.2340.87
81_G109_V1.2290.87
145_L406_T1.2270.87
145_L413_T1.2260.87
239_V300_L1.2090.86
206_D217_V1.2000.85
227_D365_R1.1940.85
170_H390_E1.1940.85
162_F172_M1.1910.85
36_A124_N1.1900.85
242_E357_T1.1860.85
193_T200_A1.1830.85
11_G36_A1.1760.84
311_I356_I1.1730.84
399_D402_I1.1680.84
395_V398_P1.1670.84
259_E262_L1.1600.83
148_N151_L1.1600.83
261_M296_G1.1560.83
76_Q80_E1.1560.83
39_Y66_E1.1520.83
115_V147_T1.1460.83
263_E267_I1.1420.82
145_L409_N1.1380.82
342_L350_R1.1300.82
52_D56_I1.1270.82
193_T202_H1.1240.81
113_M117_A1.1160.81
255_S260_M1.1030.80
195_S223_V1.0910.79
312_H352_V1.0890.79
237_V264_A1.0850.79
76_Q113_M1.0810.79
81_G112_T1.0810.79
267_I270_R1.0800.79
294_A297_M1.0780.79
98_T302_I1.0740.78
88_G324_G1.0730.78
36_A125_I1.0720.78
87_C348_L1.0680.78
319_Q322_A1.0660.78
254_F260_M1.0640.78
88_G301_H1.0580.77
273_L298_A1.0570.77
252_K259_E1.0570.77
209_Y212_S1.0520.77
202_H220_I1.0520.77
230_V366_R1.0480.77
250_N263_E1.0440.76
400_D406_T1.0440.76
239_V260_M1.0430.76
323_H348_L1.0430.76
78_V82_I1.0400.76
198_L297_M1.0390.76
234_A271_H1.0370.76
226_W230_V1.0320.75
397_S402_I1.0300.75
408_R411_D1.0270.75
14_I38_P1.0220.75
231_K366_R1.0210.75
347_S352_V1.0210.75
189_K205_K1.0200.75
42_T68_A1.0050.74
79_A245_H1.0030.73
321_H325_R1.0020.73
223_V269_G1.0000.73
115_V144_G0.9980.73
225_F272_G0.9970.73
218_N275_M0.9910.72
173_S185_M0.9880.72
88_G304_Y0.9830.72
28_L40_A0.9790.72
361_T376_V0.9780.71
247_V253_T0.9770.71
44_N48_P0.9770.71
322_A326_Q0.9760.71
78_V257_D0.9720.71
246_P300_L0.9700.71
388_T392_G0.9650.70
221_M275_M0.9630.70
363_E373_L0.9620.70
240_R247_V0.9580.70
236_E361_T0.9530.69
117_A121_D0.9530.69
281_N318_E0.9500.69
85_I300_L0.9480.69
401_R405_L0.9470.69
100_F290_G0.9450.69
312_H320_Y0.9450.69
186_S205_K0.9410.68
348_L352_V0.9390.68
264_A296_G0.9370.68
71_I120_E0.9370.68
346_D350_R0.9370.68
48_P195_S0.9340.68
197_M258_V0.9310.68
103_T201_T0.9310.68
195_S222_G0.9250.67
240_R253_T0.9200.67
373_L377_S0.9190.67
206_D219_P0.9120.66
392_G398_P0.9090.66
58_R61_M0.9070.66
77_L82_I0.9040.65
327_L341_A0.8980.65
26_A176_M0.8960.65
316_T352_V0.8870.64
185_M205_K0.8850.64
248_A359_E0.8840.64
238_T251_G0.8830.64
207_L210_L0.8810.63
357_T378_E0.8780.63
249_L254_F0.8770.63
240_R249_L0.8770.63
348_L353_A0.8760.63
43_A110_T0.8720.63
355_Q379_N0.8650.62
353_A356_I0.8630.62
193_T222_G0.8630.62
191_Y219_P0.8620.62
329_R333_Q0.8620.62
145_L153_I0.8550.61
11_G37_V0.8510.61
217_V220_I0.8500.61
306_R309_T0.8470.60
18_F28_L0.8470.60
227_D271_H0.8450.60
307_L357_T0.8450.60
59_R181_F0.8420.60
138_E284_I0.8420.60
174_E177_I0.8380.59
306_R372_I0.8310.59
275_M375_T0.8300.59
115_V148_N0.8260.58
237_V249_L0.8260.58
214_V374_N0.8260.58
304_Y356_I0.8230.58
67_N117_A0.8220.58
271_H366_R0.8210.58
314_E333_Q0.8200.58
80_E112_T0.8190.58
37_V124_N0.8180.58
249_L264_A0.8180.58
340_Q347_S0.8140.57
320_Y324_G0.8110.57
174_E187_V0.8090.57
176_M183_Y0.8080.57
294_A298_A0.8040.56
33_Q178_A0.7960.55
41_Y73_C0.7910.55
228_E365_R0.7910.55
162_F168_G0.7900.55
200_A290_G0.7900.55
93_T321_H0.7890.55
62_E182_D0.7850.54
42_T56_I0.7850.54
302_I369_D0.7810.54
374_N378_E0.7800.54
210_L360_V0.7790.54
308_L320_Y0.7770.54
271_H365_R0.7760.54
233_P271_H0.7760.54
338_D412_I0.7740.53
415_T419_L0.7730.53
100_F199_G0.7700.53
237_V267_I0.7650.53
102_T106_G0.7600.52
372_I375_T0.7560.52
365_R368_N0.7540.52
145_L151_L0.7540.52
299_L362_L0.7520.51
286_A396_F0.7490.51
239_V249_L0.7480.51
56_I68_A0.7470.51
241_F300_L0.7460.51
268_G273_L0.7450.51
273_L364_L0.7440.51
362_L374_N0.7420.50
239_V302_I0.7400.50
93_T305_E0.7380.50
345_R349_Q0.7380.50
11_G125_I0.7350.50
170_H174_E0.7340.50
281_N317_I0.7330.49
29_L63_Y0.7330.49
157_W290_G0.7320.49
29_L33_Q0.7270.49
162_F171_E0.7230.49
41_Y71_I0.7210.48
303_A362_L0.7200.48
85_I257_D0.7190.48
284_I396_F0.7190.48
373_L376_V0.7180.48
48_P52_D0.7170.48
308_L356_I0.7170.48
190_A193_T0.7140.48
55_A58_R0.7140.48
43_A71_I0.7110.47
316_T343_M0.7100.47
199_G389_M0.7080.47
286_A386_R0.7070.47
186_S189_K0.7070.47
90_F301_H0.7040.47
111_G126_W0.7000.46
84_A331_L0.7000.46
141_Y153_I0.6990.46
29_L34_K0.6980.46
155_K158_L0.6970.46
296_G299_L0.6970.46
27_A30_W0.6960.46
377_S380_L0.6950.46
202_H290_G0.6940.46
396_F400_D0.6890.45
86_Q345_R0.6880.45
253_T263_E0.6870.45
330_L344_L0.6870.45
90_F100_F0.6860.45
406_T413_T0.6860.45
41_Y114_L0.6850.45
194_D203_E0.6830.45
61_M68_A0.6830.45
190_A206_D0.6830.45
100_F157_W0.6820.45
249_L260_M0.6810.45
301_H305_E0.6800.44
250_N270_R0.6800.44
273_L362_L0.6800.44
28_L32_R0.6790.44
270_R299_L0.6790.44
57_P67_N0.6770.44
318_E326_Q0.6760.44
238_T376_V0.6750.44
40_A65_A0.6740.44
198_L261_M0.6730.44
340_Q408_R0.6720.44
29_L181_F0.6720.44
283_I333_Q0.6710.44
83_A345_R0.6690.43
177_I180_G0.6670.43
17_A114_L0.6660.43
340_Q411_D0.6650.43
81_G336_W0.6630.43
265_N296_G0.6610.43
220_I278_Q0.6610.43
98_T309_T0.6590.42
112_T116_A0.6580.42
379_N419_L0.6540.42
19_S22_L0.6540.42
28_L180_G0.6540.42
180_G185_M0.6530.42
279_I310_G0.6520.42
283_I408_R0.6510.42
235_E267_I0.6480.41
411_D414_D0.6460.41
53_Y70_L0.6430.41
168_G392_G0.6410.41
142_R283_I0.6410.41
122_G180_G0.6400.41
176_M186_S0.6390.41
177_I187_V0.6360.40
115_V126_W0.6350.40
250_N407_M0.6350.40
73_C126_W0.6330.40
84_A327_L0.6330.40
391_K395_V0.6320.40
306_R375_T0.6320.40
196_N203_E0.6260.39
32_R66_E0.6250.39
31_M157_W0.6250.39
239_V264_A0.6250.39
100_F298_A0.6240.39
232_I365_R0.6230.39
116_A120_E0.6230.39
115_V170_H0.6220.39
90_F305_E0.6220.39
173_S190_A0.6210.39
335_R408_R0.6200.39
157_W199_G0.6200.39
225_F269_G0.6200.39
106_G294_A0.6200.39
82_I261_M0.6200.39
79_A258_V0.6190.39
19_S23_D0.6190.39
85_I198_L0.6170.39
265_N295_P0.6160.38
168_G290_G0.6150.38
226_W275_M0.6140.38
198_L296_G0.6130.38
259_E263_E0.6130.38
89_A327_L0.6130.38
302_I305_E0.6130.38
259_E266_R0.6120.38
232_I271_H0.6120.38
235_E266_R0.6110.38
25_S59_R0.6110.38
310_G380_L0.6110.38
12_Q36_A0.6110.38
176_M179_C0.6100.38
173_S183_Y0.6100.38
106_G199_G0.6090.38
52_D57_P0.6080.38
37_V52_D0.6070.38
57_P68_A0.6060.38
15_G39_Y0.6060.38
88_G348_L0.6060.38
141_Y158_L0.6050.38
238_T373_L0.6040.37
290_G389_M0.6040.37
389_M398_P0.6040.37
203_E207_L0.6020.37
302_I372_I0.6010.37
271_H368_N0.6000.37
68_A71_I0.5990.37
280_E292_Y0.5970.37
138_E404_Q0.5970.37
143_Y337_F0.5970.37
320_Y352_V0.5960.37
241_F303_A0.5940.37
20_G23_D0.5940.37
26_A172_M0.5930.36
199_G290_G0.5930.36
311_I355_Q0.5920.36
148_N416_R0.5920.36
273_L299_L0.5890.36
268_G364_L0.5880.36
284_I387_L0.5870.36
237_V273_L0.5850.36
171_E391_K0.5820.35
225_F271_H0.5820.35
59_R183_Y0.5820.35
228_E236_E0.5810.35
276_S296_G0.5790.35
109_V113_M0.5790.35
305_E321_H0.5790.35
292_Y332_Y0.5770.35
88_G353_A0.5760.35
41_Y113_M0.5760.35
330_L341_A0.5750.35
106_G257_D0.5750.35
27_A313_N0.5730.35
39_Y69_R0.5720.35
16_I24_T0.5710.35
313_N316_T0.5710.35
395_V418_K0.5710.35
298_A369_D0.5680.34
388_T398_P0.5680.34
194_D280_E0.5670.34
101_N104_P0.5660.34
176_M182_D0.5640.34
13_R66_E0.5630.34
119_K153_I0.5630.34
331_L336_W0.5620.34
173_S184_K0.5600.34
237_V364_L0.5590.33
383_K386_R0.5580.33
13_R122_G0.5570.33
229_S270_R0.5560.33
313_N383_K0.5550.33
120_E124_N0.5550.33
69_R113_M0.5550.33
317_I329_R0.5530.33
119_K368_N0.5530.33
315_D411_D0.5520.33
283_I411_D0.5520.33
61_M65_A0.5510.33
220_I418_K0.5510.33
207_L382_Y0.5500.33
168_G390_E0.5500.33
63_Y66_E0.5500.33
328_G364_L0.5490.33
53_Y195_S0.5480.33
203_E208_E0.5480.33
248_A254_F0.5480.33
204_A400_D0.5460.32
12_Q125_I0.5460.32
189_K320_Y0.5440.32
202_H278_Q0.5440.32
386_R392_G0.5420.32
273_L368_N0.5410.32
40_A61_M0.5410.32
196_N208_E0.5410.32
236_E266_R0.5400.32
13_R39_Y0.5390.32
77_L105_L0.5380.32
102_T141_Y0.5380.32
102_T201_T0.5360.32
184_K222_G0.5360.32
193_T220_I0.5360.32
106_G201_T0.5360.32
402_I406_T0.5340.31
73_C109_V0.5330.31
188_E222_G0.5330.31
229_S235_E0.5320.31
41_Y126_W0.5320.31
34_K161_D0.5320.31
243_Q379_N0.5310.31
335_R412_I0.5310.31
168_G389_M0.5310.31
100_F389_M0.5310.31
369_D373_L0.5300.31
199_G294_A0.5300.31
173_S291_I0.5300.31
103_T290_G0.5300.31
304_Y308_L0.5290.31
211_N407_M0.5280.31
301_H324_G0.5280.31
260_M300_L0.5280.31
126_W148_N0.5280.31
102_T389_M0.5270.31
319_Q344_L0.5250.31
321_H324_G0.5250.31
47_Q51_E0.5240.31
130_S412_I0.5240.31
239_V303_A0.5230.30
80_E257_D0.5230.30
315_D326_Q0.5230.30
195_S221_M0.5220.30
35_G346_D0.5210.30
45_L106_G0.5210.30
147_T401_R0.5200.30
253_T266_R0.5200.30
41_Y117_A0.5200.30
312_H317_I0.5200.30
28_L33_Q0.5200.30
15_G25_S0.5190.30
335_R411_D0.5190.30
301_H320_Y0.5180.30
86_Q327_L0.5180.30
86_Q348_L0.5170.30
136_D332_Y0.5170.30
276_S288_S0.5170.30
157_W160_T0.5160.30
355_Q418_K0.5150.30
317_I321_H0.5150.30
330_L340_Q0.5140.30
57_P70_L0.5140.30
168_G398_P0.5130.30
316_T411_D0.5130.30
160_T389_M0.5130.30
54_D259_E0.5120.30
224_K268_G0.5120.30
74_R113_M0.5110.30
241_F246_P0.5110.30
138_E405_L0.5100.29
12_Q37_V0.5100.29
47_Q278_Q0.5090.29
347_S409_N0.5080.29
234_A363_E0.5080.29
102_T298_A0.5080.29
85_I211_N0.5070.29
384_P390_E0.5050.29
14_I27_A0.5050.29
17_A20_G0.5050.29
56_I223_V0.5040.29
373_L378_E0.5020.29
413_T417_E0.5020.29
386_R398_P0.5010.29
172_M198_L0.5010.29
197_M337_F0.5010.29
56_I70_L0.5000.29
334_G388_T0.5000.29
102_T157_W0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl2A 4 0.8814 100 0.267 Contact Map
1k92A 4 0.9843 100 0.274 Contact Map
2nz2A 4 0.8859 100 0.281 Contact Map
4xfjA 4 0.8837 100 0.311 Contact Map
1korA 4 0.8591 100 0.324 Contact Map
4nzpA 4 0.8501 100 0.336 Contact Map
2hmaA 2 0.7271 100 0.84 Contact Map
3rjzA 2 0.4564 99.8 0.877 Contact Map
2derA 1 0.7002 99.8 0.883 Contact Map
4f4hA 2 0.5078 99.8 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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