GREMLIN Database
AROL - Shikimate kinase 2
UniProt: P0A6E1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10082
Length: 174 (159)
Sequences: 9763 (6741)
Seq/√Len: 534.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_Q67_A2.9521.00
104_V136_L2.7971.00
25_S165_R2.6921.00
133_Q137_E2.5571.00
101_C152_D2.3951.00
47_E51_R2.3721.00
101_C150_I2.3361.00
37_L61_E2.2871.00
134_E138_E2.2751.00
45_V48_I2.2691.00
21_A161_I2.1671.00
106_V109_N2.0881.00
36_W39_S2.0371.00
19_G30_F1.9651.00
25_S161_I1.9151.00
46_A50_E1.8491.00
43_M52_E1.7921.00
108_V129_S1.7691.00
85_E89_H1.7531.00
150_I153_A1.7511.00
136_L140_D1.6771.00
156_E159_Q1.6631.00
62_T90_F1.6511.00
62_T86_F1.6231.00
6_F95_G1.5521.00
43_M51_R1.5401.00
62_T84_T1.5161.00
144_R150_I1.4921.00
130_E134_E1.4851.00
59_A63_A1.4521.00
36_W64_A1.4351.00
26_L165_R1.4261.00
111_L128_L1.4211.00
18_V164_I1.3841.00
13_C102_A1.3791.00
49_V57_F1.3781.00
52_E56_G1.3751.00
103_P154_T1.3741.00
62_T81_I1.3701.00
104_V133_Q1.3611.00
161_I165_R1.3591.00
56_G60_R1.3501.00
33_T81_I1.3461.00
121_P124_T1.3461.00
39_S43_M1.3251.00
45_V49_V1.3231.00
21_A24_D1.3151.00
28_R72_S1.3051.00
59_A84_T1.3021.00
33_T65_L1.2951.00
142_L145_E1.2881.00
7_L19_G1.2831.00
47_E50_E1.2801.00
132_V136_L1.2801.00
44_T47_E1.2701.00
140_D144_R1.2571.00
104_V129_S1.2311.00
102_A153_A1.2061.00
90_F93_N1.1981.00
88_R145_E1.1981.00
130_E133_Q1.1691.00
18_V161_I1.1611.00
129_S133_Q1.1491.00
62_T87_N1.1471.00
100_L153_A1.1451.00
98_V164_I1.1361.00
40_Q64_A1.1341.00
56_G59_A1.1331.00
31_V73_T1.1311.00
23_A30_F1.1271.00
66_E70_A1.1221.00
21_A158_S1.1201.00
46_A49_V1.1021.00
10_P135_V1.0971.00
18_V160_V1.0931.00
83_L142_L1.0821.00
48_I52_E1.0781.00
108_V112_Q1.0771.00
125_G129_S1.0761.00
60_R63_A1.0751.00
54_W130_E1.0671.00
35_Q38_Q1.0641.00
162_S166_S1.0591.00
63_A66_E1.0541.00
127_P130_E1.0391.00
102_A107_L1.0381.00
41_L60_R1.0331.00
92_Q148_H1.0241.00
124_T127_P1.0201.00
113_A116_E1.0201.00
163_E167_A1.0071.00
48_I57_F1.0001.00
36_W40_Q0.9971.00
86_F89_H0.9891.00
41_L56_G0.9791.00
7_L22_L0.9741.00
89_H93_N0.9581.00
83_L138_E0.9501.00
4_P72_S0.9471.00
98_V149_I0.9411.00
103_P106_V0.9351.00
134_E137_E0.9321.00
155_N163_E0.9261.00
20_M24_D0.9191.00
89_H92_Q0.9091.00
4_P73_T0.9081.00
162_S165_R0.9031.00
126_K131_E0.9001.00
66_E94_N0.8901.00
49_V54_W0.8881.00
102_A106_V0.8851.00
100_L164_I0.8811.00
82_I142_L0.8801.00
149_I167_A0.8721.00
112_Q125_G0.8691.00
102_A110_R0.8631.00
135_V139_R0.8591.00
147_A150_I0.8591.00
99_Y140_D0.8591.00
131_E134_E0.8591.00
55_A59_A0.8521.00
10_P107_L0.8511.00
38_Q44_T0.8451.00
29_R68_V0.8441.00
30_F76_A0.8431.00
113_A117_E0.8381.00
6_F75_I0.8361.00
105_S109_N0.8361.00
21_A25_S0.8321.00
45_V50_E0.8261.00
159_Q163_E0.8191.00
152_D155_N0.8161.00
157_P161_I0.8111.00
65_L81_I0.8101.00
91_M97_V0.8101.00
88_R142_L0.8071.00
35_Q39_S0.8011.00
113_A118_D0.8011.00
163_E166_S0.7861.00
55_A84_T0.7801.00
10_P132_V0.7801.00
155_N159_Q0.7801.00
40_Q43_M0.7791.00
8_I97_V0.7711.00
107_L132_V0.7701.00
20_M30_F0.7691.00
28_R73_T0.7681.00
101_C140_D0.7571.00
33_T68_V0.7491.00
57_F60_R0.7491.00
22_L164_I0.7431.00
99_Y150_I0.7421.00
45_V63_A0.7361.00
104_V108_V0.7331.00
6_F91_M0.7321.00
4_P28_R0.7301.00
106_V154_T0.7251.00
25_S162_S0.7231.00
125_G128_L0.7221.00
91_M95_G0.7171.00
62_T65_L0.7111.00
84_T87_N0.7071.00
62_T66_E0.7031.00
116_E119_L0.6981.00
44_T48_I0.6971.00
17_T157_P0.6951.00
149_I153_A0.6941.00
66_E90_F0.6921.00
104_V132_V0.6891.00
92_Q147_A0.6841.00
31_V36_W0.6821.00
16_T20_M0.6771.00
57_F61_E0.6751.00
33_T64_A0.6751.00
150_I154_T0.6691.00
21_A157_P0.6691.00
41_L50_E0.6681.00
20_M23_A0.6681.00
143_Y148_H0.6661.00
12_G111_L0.6601.00
105_S129_S0.6521.00
18_V157_P0.6461.00
32_D76_A0.6461.00
92_Q95_G0.6461.00
151_I160_V0.6411.00
19_G23_A0.6341.00
40_Q63_A0.6331.00
22_L161_I0.6291.00
41_L48_I0.6271.00
48_I54_W0.6261.00
48_I56_G0.6241.00
85_E88_R0.6211.00
99_Y152_D0.6211.00
46_A119_L0.6151.00
148_H153_A0.6151.00
6_F94_N0.6141.00
68_V75_I0.6081.00
112_Q124_T0.6041.00
96_I168_L0.6041.00
8_I99_Y0.6041.00
99_Y144_R0.5971.00
96_I149_I0.5951.00
13_C99_Y0.5921.00
159_Q162_S0.5900.99
36_W67_A0.5890.99
131_E135_V0.5840.99
23_A74_V0.5790.99
11_R122_T0.5760.99
118_D124_T0.5740.99
22_L74_V0.5720.99
4_P71_P0.5670.99
14_G17_T0.5630.99
125_G131_E0.5580.99
33_T36_W0.5560.99
108_V128_L0.5510.99
31_V68_V0.5510.99
101_C144_R0.5480.99
7_L74_V0.5470.99
92_Q142_L0.5450.99
108_V125_G0.5450.99
10_P104_V0.5430.99
110_R153_A0.5410.99
36_W68_V0.5390.99
34_D38_Q0.5330.99
7_L100_L0.5300.99
13_C100_L0.5260.99
61_E65_L0.5250.99
106_V155_N0.5200.99
65_L87_N0.5200.99
152_D163_E0.5190.99
43_M47_E0.5180.99
11_R49_V0.5180.99
143_Y147_A0.5160.99
136_L139_R0.5110.99
60_R64_A0.5060.98
16_T76_A0.5030.98
6_F69_T0.5020.98
128_L131_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e6cA 1 0.977 99.9 0.439 Contact Map
3gmtA 1 0.8391 99.9 0.443 Contact Map
4qbgB 1 0.9598 99.9 0.445 Contact Map
3cm0A 1 0.9425 99.9 0.447 Contact Map
4pzlA 2 0.9598 99.9 0.448 Contact Map
4jzkA 1 0.9368 99.9 0.45 Contact Map
1ukzA 1 0.9655 99.9 0.455 Contact Map
1zakA 2 0.977 99.9 0.456 Contact Map
2c95A 1 0.9713 99.9 0.457 Contact Map
3be4A 1 0.9425 99.9 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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