GREMLIN Database
AROK - Shikimate kinase 1
UniProt: P0A6D7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10081
Length: 173 (160)
Sequences: 10056 (7020)
Seq/√Len: 555.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_Q165_Q3.1801.00
42_R69_E2.9401.00
120_R123_L2.9181.00
104_E153_R2.8481.00
27_Q167_I2.5221.00
134_E138_N2.3451.00
47_V50_V2.2231.00
49_W53_L2.2041.00
39_I63_E2.0781.00
135_A139_E2.0481.00
23_Q163_A2.0471.00
109_K112_A1.9731.00
21_G32_F1.9321.00
38_E41_K1.9321.00
107_I137_A1.9111.00
157_Q161_V1.8901.00
107_I134_E1.8091.00
27_Q163_A1.7991.00
45_A54_E1.7571.00
131_E135_A1.7251.00
51_F59_F1.6861.00
48_G52_D1.6651.00
88_R92_N1.6371.00
143_L146_E1.6281.00
8_F98_G1.5821.00
158_S161_V1.5571.00
64_E93_R1.5361.00
141_N145_E1.5041.00
137_A141_N1.4801.00
64_E87_S1.4741.00
102_Y153_R1.4671.00
64_E89_E1.4601.00
111_L130_R1.4361.00
45_A53_L1.4131.00
28_L167_I1.4101.00
15_A105_T1.3941.00
128_P131_E1.3741.00
61_D65_K1.3641.00
104_E151_T1.3451.00
41_K45_A1.3381.00
54_E58_G1.3271.00
38_E66_V1.3131.00
30_M75_G1.2931.00
58_G62_R1.2931.00
23_Q26_Q1.2871.00
50_V54_E1.2701.00
35_S84_S1.2691.00
20_I166_I1.2651.00
163_A167_I1.2581.00
61_D87_S1.2561.00
64_E90_T1.2441.00
152_I169_M1.2241.00
129_P132_V1.2231.00
48_G51_F1.2161.00
70_L73_K1.2011.00
101_V166_I1.1991.00
91_R146_E1.1911.00
9_L21_G1.1891.00
64_E84_S1.1891.00
133_L137_A1.1851.00
35_S67_I1.1811.00
122_L125_V1.1701.00
20_I163_A1.1641.00
58_G61_D1.1561.00
121_P124_H1.1521.00
33_Y76_I1.1491.00
49_W52_D1.1401.00
130_R134_E1.1391.00
120_R125_V1.1141.00
23_Q160_K1.1001.00
107_I130_R1.0781.00
93_R96_A1.0781.00
105_T110_Q1.0771.00
120_R124_H1.0741.00
131_E134_E1.0731.00
38_E42_R1.0721.00
118_K124_H1.0691.00
43_T58_G1.0681.00
25_A32_F1.0651.00
126_E132_V1.0591.00
62_R65_K1.0511.00
95_S148_A1.0491.00
68_N72_E1.0461.00
114_T129_P1.0331.00
136_L140_R1.0311.00
92_N96_A1.0301.00
51_F56_E1.0261.00
43_T62_R1.0221.00
46_D49_W1.0151.00
43_T52_D1.0011.00
22_R26_Q1.0001.00
157_Q162_V0.9981.00
164_N168_H0.9921.00
37_Q40_E0.9911.00
164_N167_I0.9861.00
9_L24_L0.9831.00
42_R66_V0.9821.00
65_K68_N0.9811.00
95_S149_D0.9781.00
102_Y141_N0.9671.00
86_K143_L0.9661.00
86_K139_E0.9641.00
99_V152_I0.9601.00
106_T109_K0.9501.00
132_V136_L0.9491.00
89_E92_N0.9471.00
165_Q168_H0.9431.00
116_R119_K0.9351.00
12_P136_L0.9341.00
128_P132_V0.9181.00
105_T154_T0.9151.00
20_I162_V0.9141.00
132_V135_A0.9121.00
12_P133_L0.9101.00
92_N95_S0.9101.00
85_V143_L0.9101.00
161_V165_Q0.9051.00
105_T113_R0.9041.00
111_L115_Q0.8911.00
6_N76_I0.8881.00
145_E153_R0.8821.00
119_K124_H0.8801.00
105_T109_K0.8671.00
103_L166_I0.8621.00
159_A163_A0.8611.00
30_M76_I0.8581.00
103_L156_D0.8561.00
6_N75_G0.8501.00
68_N97_R0.8481.00
8_F78_L0.8431.00
59_F63_E0.8421.00
57_E61_D0.8401.00
47_V52_D0.8401.00
67_I84_S0.8391.00
106_T155_D0.8381.00
129_P133_L0.8321.00
165_Q169_M0.8301.00
148_A151_T0.8291.00
35_S70_L0.8201.00
6_N30_M0.8181.00
32_F79_A0.8181.00
94_L100_V0.8161.00
12_P110_Q0.8131.00
40_E46_D0.8031.00
104_E141_N0.8031.00
69_E73_K0.7971.00
10_V100_V0.7931.00
23_Q27_Q0.7931.00
47_V65_K0.7861.00
150_V169_M0.7751.00
24_L166_I0.7701.00
31_E70_L0.7671.00
91_R143_L0.7651.00
47_V51_F0.7641.00
94_L98_G0.7621.00
101_V150_V0.7561.00
108_E112_A0.7511.00
22_R32_F0.7501.00
37_Q41_K0.7331.00
35_S66_V0.7261.00
135_A138_N0.7241.00
43_T50_V0.7201.00
87_S90_T0.7101.00
19_T159_A0.7091.00
64_E67_I0.7081.00
57_E87_S0.7051.00
18_S22_R0.7011.00
27_Q164_N0.6941.00
33_Y38_E0.6871.00
59_F62_R0.6781.00
107_I133_L0.6751.00
110_Q133_L0.6721.00
8_F94_L0.6721.00
121_P125_V0.6701.00
67_I90_T0.6681.00
107_I111_L0.6681.00
23_Q159_A0.6661.00
145_E151_T0.6651.00
104_E145_E0.6621.00
34_D79_A0.6571.00
108_E130_R0.6531.00
46_D50_V0.6491.00
64_E68_N0.6391.00
119_K123_L0.6331.00
133_L140_R0.6291.00
161_V164_N0.6261.00
20_I159_A0.6241.00
22_R25_A0.6221.00
102_Y151_T0.6161.00
38_E69_E0.6131.00
14_G114_T0.6121.00
56_E131_E0.6101.00
21_G25_A0.6081.00
129_P136_L0.6081.00
18_S79_A0.6061.00
68_N93_R0.6061.00
8_F97_R0.6031.00
142_P146_E0.6021.00
13_M51_F0.6011.00
126_E129_P0.5991.00
15_A102_Y0.5961.00
24_L163_A0.5931.00
8_F71_T0.5891.00
95_S143_L0.5871.00
41_K70_L0.5851.00
95_S146_E0.5770.99
99_V170_L0.5720.99
139_E142_P0.5720.99
95_S98_G0.5710.99
88_R91_R0.5710.99
9_L103_L0.5670.99
9_L77_V0.5650.99
42_R65_K0.5620.99
36_D40_E0.5620.99
42_R45_A0.5590.99
62_R66_V0.5570.99
116_R120_R0.5570.99
25_A77_V0.5550.99
35_S38_E0.5540.99
99_V150_V0.5500.99
24_L77_V0.5450.99
15_A103_L0.5400.99
63_E67_I0.5400.99
151_T154_T0.5390.99
16_G19_T0.5360.99
118_K123_L0.5350.99
109_K156_D0.5340.99
10_V102_Y0.5340.99
54_E62_R0.5330.99
110_Q114_T0.5290.99
31_E76_I0.5280.99
59_F71_T0.5160.99
50_V53_L0.5150.99
93_R97_R0.5130.99
33_Y70_L0.5120.99
99_V149_D0.5080.99
45_A49_W0.5050.99
31_E73_K0.5050.99
33_Y73_K0.5020.99
10_V85_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pzlA 2 0.9769 99.9 0.449 Contact Map
1zd8A 1 0.9538 99.9 0.453 Contact Map
3tlxA 1 0.9653 99.9 0.454 Contact Map
4qbgB 1 0.948 99.9 0.456 Contact Map
1akyA 1 0.9595 99.9 0.46 Contact Map
3gmtA 1 0.8439 99.9 0.464 Contact Map
3be4A 1 0.9538 99.9 0.465 Contact Map
1viaA 2 0.9422 99.9 0.467 Contact Map
4jzkA 1 0.9422 99.9 0.469 Contact Map
1ak2A 1 0.9653 99.9 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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