AROK - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

AROK - Shikimate kinase 1

UniProt:	P0A6D7	Sequences: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDLEGEEGFRDREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLHVETPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10081
Length:	173 (160)
Sequences:	10056 (7020)
Seq/√Len:	555.0

ECOLI - AROK AROL KAD
BACSU - AROK KAD YQAC
HALSA - KAD KCY KAD6 Y2452
SULSO - KCY KAD6 Y1041

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_Q	165_Q	3.180	1.00
42_R	69_E	2.940	1.00
120_R	123_L	2.918	1.00
104_E	153_R	2.848	1.00
27_Q	167_I	2.522	1.00
134_E	138_N	2.345	1.00
47_V	50_V	2.223	1.00
49_W	53_L	2.204	1.00
39_I	63_E	2.078	1.00
135_A	139_E	2.048	1.00
23_Q	163_A	2.047	1.00
109_K	112_A	1.973	1.00
21_G	32_F	1.932	1.00
38_E	41_K	1.932	1.00
107_I	137_A	1.911	1.00
157_Q	161_V	1.890	1.00
107_I	134_E	1.809	1.00
27_Q	163_A	1.799	1.00
45_A	54_E	1.757	1.00
131_E	135_A	1.725	1.00
51_F	59_F	1.686	1.00
48_G	52_D	1.665	1.00
88_R	92_N	1.637	1.00
143_L	146_E	1.628	1.00
8_F	98_G	1.582	1.00
158_S	161_V	1.557	1.00
64_E	93_R	1.536	1.00
141_N	145_E	1.504	1.00
137_A	141_N	1.480	1.00
64_E	87_S	1.474	1.00
102_Y	153_R	1.467	1.00
64_E	89_E	1.460	1.00
111_L	130_R	1.436	1.00
45_A	53_L	1.413	1.00
28_L	167_I	1.410	1.00
15_A	105_T	1.394	1.00
128_P	131_E	1.374	1.00
61_D	65_K	1.364	1.00
104_E	151_T	1.345	1.00
41_K	45_A	1.338	1.00
54_E	58_G	1.327	1.00
38_E	66_V	1.313	1.00
30_M	75_G	1.293	1.00
58_G	62_R	1.293	1.00
23_Q	26_Q	1.287	1.00
50_V	54_E	1.270	1.00
35_S	84_S	1.269	1.00
20_I	166_I	1.265	1.00
163_A	167_I	1.258	1.00
61_D	87_S	1.256	1.00
64_E	90_T	1.244	1.00
152_I	169_M	1.224	1.00
129_P	132_V	1.223	1.00
48_G	51_F	1.216	1.00
70_L	73_K	1.201	1.00
101_V	166_I	1.199	1.00
91_R	146_E	1.191	1.00
9_L	21_G	1.189	1.00
64_E	84_S	1.189	1.00
133_L	137_A	1.185	1.00
35_S	67_I	1.181	1.00
122_L	125_V	1.170	1.00
20_I	163_A	1.164	1.00
58_G	61_D	1.156	1.00
121_P	124_H	1.152	1.00
33_Y	76_I	1.149	1.00
49_W	52_D	1.140	1.00
130_R	134_E	1.139	1.00
120_R	125_V	1.114	1.00
23_Q	160_K	1.100	1.00
107_I	130_R	1.078	1.00
93_R	96_A	1.078	1.00
105_T	110_Q	1.077	1.00
120_R	124_H	1.074	1.00
131_E	134_E	1.073	1.00
38_E	42_R	1.072	1.00
118_K	124_H	1.069	1.00
43_T	58_G	1.068	1.00
25_A	32_F	1.065	1.00
126_E	132_V	1.059	1.00
62_R	65_K	1.051	1.00
95_S	148_A	1.049	1.00
68_N	72_E	1.046	1.00
114_T	129_P	1.033	1.00
136_L	140_R	1.031	1.00
92_N	96_A	1.030	1.00
51_F	56_E	1.026	1.00
43_T	62_R	1.022	1.00
46_D	49_W	1.015	1.00
43_T	52_D	1.001	1.00
22_R	26_Q	1.000	1.00
157_Q	162_V	0.998	1.00
164_N	168_H	0.992	1.00
37_Q	40_E	0.991	1.00
164_N	167_I	0.986	1.00
9_L	24_L	0.983	1.00
42_R	66_V	0.982	1.00
65_K	68_N	0.981	1.00
95_S	149_D	0.978	1.00
102_Y	141_N	0.967	1.00
86_K	143_L	0.966	1.00
86_K	139_E	0.964	1.00
99_V	152_I	0.960	1.00
106_T	109_K	0.950	1.00
132_V	136_L	0.949	1.00
89_E	92_N	0.947	1.00
165_Q	168_H	0.943	1.00
116_R	119_K	0.935	1.00
12_P	136_L	0.934	1.00
128_P	132_V	0.918	1.00
105_T	154_T	0.915	1.00
20_I	162_V	0.914	1.00
132_V	135_A	0.912	1.00
12_P	133_L	0.910	1.00
92_N	95_S	0.910	1.00
85_V	143_L	0.910	1.00
161_V	165_Q	0.905	1.00
105_T	113_R	0.904	1.00
111_L	115_Q	0.891	1.00
6_N	76_I	0.888	1.00
145_E	153_R	0.882	1.00
119_K	124_H	0.880	1.00
105_T	109_K	0.867	1.00
103_L	166_I	0.862	1.00
159_A	163_A	0.861	1.00
30_M	76_I	0.858	1.00
103_L	156_D	0.856	1.00
6_N	75_G	0.850	1.00
68_N	97_R	0.848	1.00
8_F	78_L	0.843	1.00
59_F	63_E	0.842	1.00
57_E	61_D	0.840	1.00
47_V	52_D	0.840	1.00
67_I	84_S	0.839	1.00
106_T	155_D	0.838	1.00
129_P	133_L	0.832	1.00
165_Q	169_M	0.830	1.00
148_A	151_T	0.829	1.00
35_S	70_L	0.820	1.00
6_N	30_M	0.818	1.00
32_F	79_A	0.818	1.00
94_L	100_V	0.816	1.00
12_P	110_Q	0.813	1.00
40_E	46_D	0.803	1.00
104_E	141_N	0.803	1.00
69_E	73_K	0.797	1.00
10_V	100_V	0.793	1.00
23_Q	27_Q	0.793	1.00
47_V	65_K	0.786	1.00
150_V	169_M	0.775	1.00
24_L	166_I	0.770	1.00
31_E	70_L	0.767	1.00
91_R	143_L	0.765	1.00
47_V	51_F	0.764	1.00
94_L	98_G	0.762	1.00
101_V	150_V	0.756	1.00
108_E	112_A	0.751	1.00
22_R	32_F	0.750	1.00
37_Q	41_K	0.733	1.00
35_S	66_V	0.726	1.00
135_A	138_N	0.724	1.00
43_T	50_V	0.720	1.00
87_S	90_T	0.710	1.00
19_T	159_A	0.709	1.00
64_E	67_I	0.708	1.00
57_E	87_S	0.705	1.00
18_S	22_R	0.701	1.00
27_Q	164_N	0.694	1.00
33_Y	38_E	0.687	1.00
59_F	62_R	0.678	1.00
107_I	133_L	0.675	1.00
110_Q	133_L	0.672	1.00
8_F	94_L	0.672	1.00
121_P	125_V	0.670	1.00
67_I	90_T	0.668	1.00
107_I	111_L	0.668	1.00
23_Q	159_A	0.666	1.00
145_E	151_T	0.665	1.00
104_E	145_E	0.662	1.00
34_D	79_A	0.657	1.00
108_E	130_R	0.653	1.00
46_D	50_V	0.649	1.00
64_E	68_N	0.639	1.00
119_K	123_L	0.633	1.00
133_L	140_R	0.629	1.00
161_V	164_N	0.626	1.00
20_I	159_A	0.624	1.00
22_R	25_A	0.622	1.00
102_Y	151_T	0.616	1.00
38_E	69_E	0.613	1.00
14_G	114_T	0.612	1.00
56_E	131_E	0.610	1.00
21_G	25_A	0.608	1.00
129_P	136_L	0.608	1.00
18_S	79_A	0.606	1.00
68_N	93_R	0.606	1.00
8_F	97_R	0.603	1.00
142_P	146_E	0.602	1.00
13_M	51_F	0.601	1.00
126_E	129_P	0.599	1.00
15_A	102_Y	0.596	1.00
24_L	163_A	0.593	1.00
8_F	71_T	0.589	1.00
95_S	143_L	0.587	1.00
41_K	70_L	0.585	1.00
95_S	146_E	0.577	0.99
99_V	170_L	0.572	0.99
139_E	142_P	0.572	0.99
95_S	98_G	0.571	0.99
88_R	91_R	0.571	0.99
9_L	103_L	0.567	0.99
9_L	77_V	0.565	0.99
42_R	65_K	0.562	0.99
36_D	40_E	0.562	0.99
42_R	45_A	0.559	0.99
62_R	66_V	0.557	0.99
116_R	120_R	0.557	0.99
25_A	77_V	0.555	0.99
35_S	38_E	0.554	0.99
99_V	150_V	0.550	0.99
24_L	77_V	0.545	0.99
15_A	103_L	0.540	0.99
63_E	67_I	0.540	0.99
151_T	154_T	0.539	0.99
16_G	19_T	0.536	0.99
118_K	123_L	0.535	0.99
109_K	156_D	0.534	0.99
10_V	102_Y	0.534	0.99
54_E	62_R	0.533	0.99
110_Q	114_T	0.529	0.99
31_E	76_I	0.528	0.99
59_F	71_T	0.516	0.99
50_V	53_L	0.515	0.99
93_R	97_R	0.513	0.99
33_Y	70_L	0.512	0.99
99_V	149_D	0.508	0.99
45_A	49_W	0.505	0.99
31_E	73_K	0.505	0.99
33_Y	73_K	0.502	0.99
10_V	85_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pzlA	2	0.9769	99.9	0.449	Contact Map
1zd8A	1	0.9538	99.9	0.453	Contact Map
3tlxA	1	0.9653	99.9	0.454	Contact Map
4qbgB	1	0.948	99.9	0.456	Contact Map
1akyA	1	0.9595	99.9	0.46	Contact Map
3gmtA	1	0.8439	99.9	0.464	Contact Map
3be4A	1	0.9538	99.9	0.465	Contact Map
1viaA	2	0.9422	99.9	0.467	Contact Map
4jzkA	1	0.9422	99.9	0.469	Contact Map
1ak2A	1	0.9653	99.9	0.47	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.