GREMLIN Database
AROA - 3-phosphoshikimate 1-carboxyvinyltransferase
UniProt: P0A6D3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10073
Length: 427 (395)
Sequences: 7930 (4906)
Seq/√Len: 246.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_T295_S4.3441.00
15_T263_T4.0681.00
358_E369_T3.7361.00
42_T236_T3.4191.00
261_K295_S3.3931.00
259_T297_T3.3751.00
161_N190_R3.2171.00
186_D226_K3.1631.00
415_D418_E3.0531.00
214_E226_K2.8061.00
36_H230_S2.7621.00
42_T238_L2.7461.00
17_N263_T2.7351.00
380_A404_L2.6961.00
38_K76_I2.6941.00
413_F419_Q2.6561.00
254_A285_A2.6491.00
208_M213_V2.6111.00
116_T122_K2.6081.00
328_T369_T2.5811.00
286_T297_T2.5691.00
40_V236_T2.5421.00
163_D190_R2.5001.00
351_E354_K2.4451.00
255_I393_L2.4251.00
300_E326_K2.4011.00
378_E404_L2.3751.00
46_D51_R2.3741.00
161_N188_V2.3491.00
260_V423_I2.3371.00
42_T72_R2.3351.00
55_N58_T2.3031.00
251_A321_A2.2801.00
290_G293_Y2.2121.00
65_T74_E2.1841.00
378_E402_T2.1631.00
40_V72_R2.1571.00
40_V74_E2.1321.00
38_K74_E2.1211.00
169_S172_F2.1121.00
132_A176_L2.1111.00
395_A401_V2.0991.00
156_G184_P2.0881.00
362_G365_Y2.0811.00
46_D66_L2.0221.00
373_K398_D1.9781.00
177_L205_L1.9751.00
186_D224_V1.9701.00
139_K154_Q1.9451.00
305_D332_R1.9361.00
351_E391_F1.9301.00
13_D259_T1.9281.00
330_T367_R1.9111.00
32_A39_T1.8471.00
63_S76_I1.8111.00
127_G131_D1.7631.00
352_L357_A1.7461.00
30_L53_M1.7331.00
261_K290_G1.7111.00
288_C295_S1.7071.00
320_T390_C1.6681.00
188_V224_V1.6521.00
302_N326_K1.6431.00
360_E369_T1.6341.00
357_A374_L1.6311.00
360_E367_R1.6281.00
159_G183_A1.6281.00
25_S44_L1.6261.00
56_A90_L1.6241.00
355_V401_V1.6241.00
213_V231_Y1.6211.00
54_L73_C1.6211.00
131_D135_L1.6181.00
104_A175_A1.6161.00
328_T367_R1.6071.00
67_S74_E1.5881.00
247_S314_A1.5771.00
141_T152_R1.5641.00
190_R222_Q1.5541.00
28_A207_L1.5421.00
54_L64_Y1.5401.00
110_S152_R1.5171.00
290_G295_S1.5121.00
158_T184_P1.5031.00
355_V377_A1.4931.00
305_D330_T1.4881.00
216_E226_K1.4871.00
29_L57_L1.4761.00
66_L73_C1.4751.00
188_V222_Q1.4741.00
261_K293_Y1.4671.00
250_L277_A1.4631.00
319_A348_M1.4591.00
209_K218_Q1.4491.00
392_S416_Y1.4491.00
379_I391_F1.4301.00
349_A359_V1.4091.00
112_D150_P1.4091.00
218_Q223_F1.3721.00
349_A361_E1.3611.00
58_T64_Y1.3541.00
120_R123_E1.3531.00
323_L357_A1.3531.00
15_T261_K1.3421.00
303_A328_T1.3381.00
278_D281_E1.3301.00
99_M149_P1.3291.00
419_Q422_R1.3271.00
355_V394_V1.3261.00
327_G370_P1.3181.00
322_A329_T1.3161.00
211_F235_G1.3041.00
240_E269_S1.3031.00
349_A366_I1.3011.00
319_A331_L1.2951.00
252_A396_L1.2941.00
303_A329_T1.2851.00
250_L262_V1.2831.00
100_R174_T1.2801.00
246_A265_I1.2741.00
51_R66_L1.2731.00
251_A276_F1.2731.00
203_I237_Y1.2691.00
130_V142_Y1.2661.00
16_I423_I1.2651.00
209_K214_E1.2641.00
44_L50_V1.2611.00
89_E114_V1.2611.00
18_L262_V1.2571.00
280_L285_A1.2541.00
112_D152_R1.2491.00
283_M304_I1.2481.00
138_A157_F1.2431.00
210_T235_G1.2411.00
205_L215_I1.2411.00
29_L54_L1.2401.00
362_G367_R1.2391.00
35_A39_T1.2351.00
37_G233_S1.2341.00
380_A405_D1.2281.00
62_V75_I1.2261.00
55_N59_A1.2241.00
41_L239_V1.2211.00
140_I151_L1.2161.00
216_E224_V1.2111.00
250_L280_L1.2101.00
288_C297_T1.2061.00
17_N264_G1.2051.00
65_T76_I1.2001.00
25_S50_V1.1901.00
184_P229_Q1.1891.00
177_L225_V1.1891.00
202_D206_N1.1861.00
67_S72_R1.1761.00
198_K201_I1.1751.00
112_D154_Q1.1661.00
134_R139_K1.1641.00
324_F371_P1.1591.00
307_D333_N1.1521.00
28_A239_V1.1511.00
388_A409_T1.1481.00
141_T154_Q1.1441.00
308_M333_N1.1431.00
250_L296_C1.1421.00
39_T207_L1.1311.00
395_A403_I1.1301.00
95_A98_A1.1291.00
249_F413_F1.1291.00
189_I195_L1.1291.00
415_D419_Q1.1251.00
32_A75_I1.1131.00
252_A393_L1.1081.00
26_N53_M1.1071.00
388_A408_C1.0941.00
136_G160_G1.0931.00
320_T394_V1.0921.00
37_G232_Q1.0881.00
58_T63_S1.0881.00
280_L321_A1.0861.00
279_V318_I1.0851.00
180_A187_T1.0841.00
267_R289_W1.0771.00
359_V366_I1.0671.00
139_K152_R1.0601.00
131_D134_R1.0521.00
379_I401_V1.0501.00
52_H55_N1.0391.00
162_V165_D1.0361.00
41_L75_I1.0341.00
254_A299_G1.0251.00
418_E421_A1.0241.00
283_M325_A1.0231.00
197_S221_Q1.0231.00
266_G269_S1.0221.00
248_Y389_M1.0201.00
35_A233_S1.0121.00
130_V134_R1.0091.00
56_A92_L1.0081.00
52_H93_G1.0051.00
157_F183_A0.9951.00
185_E227_G0.9931.00
247_S317_T0.9891.00
12_V252_A0.9881.00
174_T204_T0.9861.00
58_T66_L0.9781.00
39_T235_G0.9751.00
279_V306_M0.9681.00
281_E289_W0.9651.00
57_L62_V0.9621.00
328_T370_P0.9611.00
164_V176_L0.9581.00
205_L218_Q0.9571.00
110_S150_P0.9541.00
208_M231_Y0.9531.00
279_V282_K0.9511.00
251_A314_A0.9511.00
322_A331_L0.9501.00
251_A280_L0.9481.00
62_V77_G0.9471.00
28_A41_L0.9471.00
375_N398_D0.9431.00
89_E116_T0.9411.00
281_E286_T0.9381.00
245_S419_Q0.9341.00
142_Y147_N0.9331.00
353_R358_E0.9321.00
354_K377_A0.9261.00
87_A90_L0.9251.00
257_G298_R0.9231.00
181_P231_Y0.9201.00
335_Y363_H0.9191.00
243_A276_F0.9181.00
383_N405_D0.9161.00
377_A401_V0.9081.00
331_L366_I0.9071.00
275_R278_D0.9061.00
68_A72_R0.9051.00
141_T145_Q0.9031.00
314_A317_T0.9011.00
283_M301_L0.9001.00
324_F372_E0.8981.00
44_L73_C0.8961.00
27_R30_L0.8951.00
238_L264_G0.8941.00
128_H166_G0.8931.00
48_D410_A0.8871.00
348_M387_M0.8841.00
405_D408_C0.8831.00
43_N238_L0.8730.99
237_Y240_E0.8730.99
14_G423_I0.8710.99
200_Y243_A0.8700.99
114_V152_R0.8670.99
253_A256_K0.8640.99
54_L58_T0.8630.99
303_A327_G0.8620.99
129_L175_A0.8510.99
131_D165_D0.8510.99
12_V258_G0.8500.99
303_A325_A0.8490.99
37_G77_G0.8480.99
381_T388_A0.8450.99
34_L105_A0.8400.99
119_P385_H0.8390.99
323_L352_L0.8390.99
106_L138_A0.8390.99
181_P213_V0.8350.99
319_A366_I0.8320.99
218_Q222_Q0.8280.99
30_L105_A0.8280.99
217_N220_Y0.8240.99
334_I365_Y0.8220.99
104_A178_M0.8210.99
121_M336_N0.8200.99
209_K215_I0.8180.99
153_L156_G0.8160.99
92_L121_M0.8150.99
209_K217_N0.8140.99
206_N210_T0.8140.99
207_L211_F0.8130.99
186_D227_G0.8130.99
325_A329_T0.8120.99
319_A368_I0.8120.99
301_L325_A0.8110.99
407_K410_A0.8060.99
18_L246_A0.8050.99
250_L253_A0.8050.99
130_V140_I0.8030.99
206_N209_K0.8000.99
275_R311_I0.7980.99
59_A87_A0.7960.99
165_D279_V0.7960.99
255_I324_F0.7930.99
210_T237_Y0.7910.99
38_K77_G0.7900.99
54_L66_L0.7900.99
36_H232_Q0.7890.99
16_I262_V0.7810.99
33_A57_L0.7800.99
255_I320_T0.7760.99
142_Y146_E0.7760.99
25_S239_V0.7760.99
183_A187_T0.7750.99
58_T65_T0.7750.99
103_A153_L0.7700.99
18_L249_F0.7700.99
207_L235_G0.7700.99
99_M126_I0.7670.99
159_G187_T0.7660.99
48_D52_H0.7660.99
159_G184_P0.7660.99
395_A420_L0.7640.99
119_P123_E0.7620.99
254_A296_C0.7600.99
180_A189_I0.7580.99
283_M321_A0.7500.98
24_V207_L0.7500.98
397_S401_V0.7490.98
19_P419_Q0.7490.98
289_W294_I0.7480.98
392_S409_T0.7450.98
317_T393_L0.7450.98
43_N264_G0.7420.98
128_H165_D0.7420.98
21_S25_S0.7370.98
406_P409_T0.7360.98
285_A301_L0.7350.98
19_P245_S0.7330.98
361_E365_Y0.7300.98
357_A372_E0.7290.98
250_L254_A0.7280.98
136_G162_V0.7270.98
254_A280_L0.7260.98
289_W293_Y0.7240.98
253_A260_V0.7230.98
283_M322_A0.7210.98
17_N43_N0.7200.98
32_A77_G0.7190.98
381_T403_I0.7190.98
209_K216_E0.7180.98
329_T368_I0.7170.98
287_I296_C0.7170.98
410_A417_F0.7150.98
89_E122_K0.7150.98
332_R362_G0.7140.98
249_F419_Q0.7120.98
316_M387_M0.7120.98
323_L371_P0.7110.98
304_I329_T0.7090.98
24_V203_I0.7080.98
332_R365_Y0.7060.98
84_A112_D0.7050.98
107_C138_A0.7050.98
246_A262_V0.7040.98
308_M315_A0.7010.98
179_T183_A0.7000.98
277_A281_E0.6980.98
31_L207_L0.6980.98
376_F401_V0.6970.98
177_L223_F0.6950.97
203_I206_N0.6910.97
276_F314_A0.6910.97
355_V379_I0.6900.97
211_F231_Y0.6900.97
133_L138_A0.6880.97
252_A420_L0.6870.97
88_L122_K0.6840.97
232_Q235_G0.6830.97
277_A289_W0.6820.97
86_G89_E0.6800.97
176_L189_I0.6790.97
98_A411_K0.6780.97
92_L115_L0.6770.97
20_G239_V0.6760.97
396_L420_L0.6760.97
198_K202_D0.6730.97
106_L113_I0.6730.97
254_A301_L0.6730.97
12_V260_V0.6720.97
162_V189_I0.6720.97
196_V200_Y0.6720.97
202_D217_N0.6700.97
103_A115_L0.6680.97
57_L102_L0.6680.97
248_Y317_T0.6630.97
57_L64_Y0.6620.97
121_M149_P0.6600.97
103_A129_L0.6590.97
11_R258_G0.6580.96
253_A258_G0.6570.96
29_L75_I0.6570.96
171_Q201_I0.6560.96
136_G187_T0.6550.96
159_G185_E0.6540.96
307_D332_R0.6530.96
214_E228_G0.6500.96
197_S201_I0.6500.96
25_S45_L0.6480.96
29_L73_C0.6470.96
257_G299_G0.6460.96
24_V27_R0.6440.96
355_V397_S0.6420.96
100_R171_Q0.6410.96
166_G334_I0.6400.96
320_T391_F0.6390.96
157_F185_E0.6380.96
102_L133_L0.6360.96
267_R294_I0.6360.96
115_L149_P0.6360.96
99_M115_L0.6350.96
164_V189_I0.6330.96
281_E287_I0.6310.96
249_F416_Y0.6300.96
36_H77_G0.6290.95
285_A296_C0.6280.95
69_D72_R0.6280.95
206_N237_Y0.6270.95
38_K233_S0.6260.95
28_A237_Y0.6260.95
241_G262_V0.6260.95
316_M348_M0.6250.95
417_F421_A0.6250.95
77_G80_G0.6240.95
253_A262_V0.6230.95
139_K156_G0.6220.95
16_I419_Q0.6210.95
217_N221_Q0.6200.95
124_R386_R0.6190.95
106_L115_L0.6190.95
308_M311_I0.6170.95
187_T227_G0.6150.95
62_V78_N0.6140.95
33_A62_V0.6140.95
247_S276_F0.6140.95
265_I294_I0.6120.95
92_L98_A0.6080.95
217_N223_F0.6070.95
338_R361_E0.6060.94
251_A317_T0.6060.94
126_I149_P0.6050.94
128_H131_D0.6050.94
319_A349_A0.6050.94
106_L133_L0.6030.94
209_K213_V0.6020.94
35_A77_G0.6010.94
253_A257_G0.5980.94
8_P11_R0.5970.94
409_T417_F0.5960.94
392_S417_F0.5960.94
78_N81_P0.5960.94
126_I130_V0.5960.94
35_A76_I0.5950.94
197_S200_Y0.5940.94
26_N30_L0.5930.94
354_K380_A0.5930.94
388_A417_F0.5930.94
66_L69_D0.5910.94
92_L99_M0.5910.94
78_N82_L0.5880.94
277_A287_I0.5880.94
27_R100_R0.5870.93
226_K229_Q0.5870.93
54_L75_I0.5830.93
134_R141_T0.5820.93
158_T185_E0.5820.93
323_L374_L0.5810.93
16_I249_F0.5810.93
249_F420_L0.5810.93
177_L189_I0.5810.93
353_R359_V0.5800.93
207_L237_Y0.5800.93
358_E372_E0.5790.93
56_A102_L0.5790.93
134_R140_I0.5790.93
376_F398_D0.5790.93
348_M391_F0.5760.93
348_M390_C0.5760.93
330_T362_G0.5750.93
320_T323_L0.5740.93
255_I321_A0.5730.93
104_A107_C0.5730.93
127_G147_N0.5730.93
357_A394_V0.5720.93
214_E229_Q0.5700.92
282_K310_H0.5690.92
303_A326_K0.5670.92
164_V167_S0.5670.92
22_K124_R0.5670.92
48_D51_R0.5650.92
312_P337_W0.5650.92
381_T408_C0.5650.92
145_Q150_P0.5640.92
134_R146_E0.5640.92
51_R55_N0.5620.92
331_L334_I0.5610.92
265_I269_S0.5610.92
376_F399_T0.5600.92
374_L394_V0.5600.92
142_Y151_L0.5560.92
203_I240_E0.5530.91
60_L106_L0.5530.91
132_A136_G0.5520.91
355_V374_L0.5510.91
308_M318_I0.5500.91
171_Q174_T0.5490.91
303_A370_P0.5490.91
350_T353_R0.5490.91
56_A101_P0.5480.91
40_V67_S0.5480.91
130_V151_L0.5470.91
389_M416_Y0.5470.91
383_N408_C0.5460.91
205_L223_F0.5460.91
406_P417_F0.5450.91
286_T299_G0.5440.91
286_T289_W0.5400.90
129_L132_A0.5400.90
45_L245_S0.5400.90
94_N118_E0.5400.90
287_I294_I0.5390.90
46_D68_A0.5390.90
348_M351_E0.5380.90
377_A399_T0.5370.90
323_L372_E0.5370.90
263_T293_Y0.5370.90
253_A285_A0.5360.90
219_H222_Q0.5350.90
319_A359_V0.5350.90
196_V336_N0.5340.90
350_T380_A0.5330.90
39_T233_S0.5330.90
265_I293_Y0.5310.90
18_L265_I0.5300.90
26_N98_A0.5290.89
37_G76_I0.5280.89
250_L287_I0.5270.89
145_Q148_Y0.5270.89
134_R142_Y0.5270.89
279_V304_I0.5260.89
330_T365_Y0.5260.89
337_W412_T0.5260.89
181_P228_G0.5250.89
39_T211_F0.5250.89
244_S385_H0.5240.89
279_V311_I0.5240.89
208_M211_F0.5240.89
322_A368_I0.5220.89
233_S236_T0.5220.89
309_N333_N0.5210.89
213_V228_G0.5210.89
97_T101_P0.5200.89
175_A179_T0.5200.89
376_F395_A0.5190.89
218_Q224_V0.5190.89
283_M329_T0.5180.88
86_G90_L0.5170.88
326_K371_P0.5170.88
256_K298_R0.5160.88
353_R357_A0.5160.88
418_E422_R0.5160.88
46_D69_D0.5160.88
354_K391_F0.5160.88
37_G235_G0.5150.88
80_G108_L0.5150.88
26_N412_T0.5140.88
213_V233_S0.5130.88
67_S73_C0.5120.88
53_M100_R0.5110.88
30_L57_L0.5110.88
243_A277_A0.5110.88
202_D220_Y0.5110.88
278_D282_K0.5100.88
331_L368_I0.5100.88
338_R363_H0.5100.88
323_L370_P0.5090.88
198_K217_N0.5080.87
337_W347_A0.5080.87
195_L201_I0.5080.87
315_A331_L0.5080.87
128_H169_S0.5080.87
257_G297_T0.5060.87
35_A211_F0.5060.87
213_V229_Q0.5050.87
29_L53_M0.5030.87
355_V399_T0.5020.87
21_S240_E0.5010.87
206_N218_Q0.5010.87
256_K259_T0.5010.87
202_D205_L0.5000.87
103_A175_A0.5000.87
86_G92_L0.5000.87
63_S66_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.9696 100 0.099 Contact Map
2pqcA 1 0.9719 100 0.126 Contact Map
3nvsA 1 0.993 100 0.132 Contact Map
3slhA 4 0.9672 100 0.145 Contact Map
1rf6A 1 0.9649 100 0.159 Contact Map
2o0bA 1 0.9625 100 0.17 Contact Map
3zh4A 1 0.9321 100 0.238 Contact Map
4fqdA 2 0.9391 100 0.245 Contact Map
3r38A 2 0.9415 100 0.247 Contact Map
1ejdA 4 0.9461 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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