GREMLIN Database
ARGR - Arginine repressor
UniProt: P0A6D0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10070
Length: 156 (143)
Sequences: 1734 (1152)
Seq/√Len: 96.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E32_A4.8971.00
90_D136_A4.4611.00
93_D138_G3.4891.00
13_A36_Q3.3401.00
23_F32_A2.8261.00
32_A35_E2.2491.00
13_A16_A2.1731.00
13_A38_F2.1361.00
95_V134_T2.0141.00
15_K69_L1.9871.00
22_K66_V1.9821.00
110_R129_D1.9801.00
109_A126_A1.9291.00
137_N140_T1.8961.00
93_D137_N1.8721.00
58_T68_C1.8541.00
112_L148_I1.8331.00
120_G147_A1.7791.00
135_P144_L1.7691.00
50_L55_A1.7221.00
95_V132_F1.6921.00
135_P141_V1.6871.00
96_V145_Y1.5961.00
14_F23_F1.5921.00
16_A20_E1.5801.00
92_N122_L1.5781.00
140_T143_D1.5721.00
113_D127_G1.4961.00
113_D123_G1.4771.00
113_D124_T1.4751.00
10_L49_M1.4711.00
30_V46_V1.4651.00
31_A35_E1.4191.00
121_I133_T1.3850.99
17_L32_A1.3810.99
7_Q11_V1.3740.99
54_G59_R1.3400.99
60_N66_V1.3060.99
142_K146_E1.3030.99
7_Q52_K1.2930.99
117_K120_G1.2790.99
102_P128_D1.2600.99
100_T127_G1.2060.98
23_F29_I1.2000.98
17_L23_F1.1850.98
24_S64_E1.1840.98
25_S50_L1.1790.98
102_P110_R1.1760.98
22_K60_N1.1730.98
91_Y145_Y1.1660.98
141_V145_Y1.1500.98
124_T127_G1.1490.98
96_V135_P1.1450.98
92_N95_V1.1390.98
51_T65_M1.1350.98
146_E150_E1.1120.97
44_S48_R1.0970.97
25_S55_A1.0960.97
24_S28_E1.0960.97
91_Y141_V1.0890.97
14_F29_I1.0860.97
113_D130_T1.0790.97
96_V141_V1.0790.97
98_I133_T1.0740.97
82_L86_V1.0650.96
126_A131_I1.0630.96
91_Y96_V1.0450.96
145_Y149_L1.0420.96
103_G128_D1.0260.96
127_G130_T1.0250.96
11_V52_K1.0200.95
137_N141_V1.0190.95
41_I46_V1.0170.95
22_K62_K1.0050.95
102_P129_D1.0030.95
32_A36_Q0.9990.95
120_G143_D0.9990.95
104_A107_L0.9820.94
100_T109_A0.9810.94
85_L104_A0.9760.94
120_G136_A0.9750.94
97_V130_T0.9610.94
85_L107_L0.9550.94
7_Q10_L0.9540.94
80_S84_N0.9440.93
18_L111_L0.9410.93
59_R65_M0.9400.93
106_Q128_D0.9360.93
44_S57_R0.9330.93
139_F142_K0.9300.93
89_I96_V0.9260.92
89_I145_Y0.9180.92
97_V127_G0.9010.91
86_V98_I0.9000.91
25_S28_E0.8990.91
100_T105_A0.8870.91
117_K121_I0.8810.91
92_N141_V0.8730.90
97_V123_G0.8650.90
60_N64_E0.8640.90
122_L127_G0.8610.89
26_Q43_Q0.8590.89
46_V104_A0.8580.89
88_D99_H0.8510.89
100_T104_A0.8490.89
46_V50_L0.8490.89
123_G130_T0.8490.89
125_I134_T0.8190.87
91_Y138_G0.8180.87
92_N135_P0.8180.87
18_L51_T0.8170.87
105_A129_D0.8160.87
106_Q131_I0.8110.86
81_P111_L0.8070.86
45_K49_M0.8030.86
55_A82_L0.8000.86
113_D129_D0.7990.86
42_N48_R0.7990.86
96_V144_L0.7930.85
18_L55_A0.7870.85
34_Q40_N0.7870.85
109_A113_D0.7770.84
17_L21_E0.7710.84
11_V53_F0.7670.83
138_G141_V0.7660.83
27_G57_R0.7490.82
109_A131_I0.7430.81
96_V122_L0.7380.81
89_I98_I0.7380.81
27_G51_T0.7350.81
23_F73_L0.7330.80
106_Q125_I0.7230.79
81_P108_I0.7220.79
109_A124_T0.7190.79
42_N49_M0.7160.79
17_L107_L0.7120.78
30_V41_I0.7070.78
26_Q47_S0.7070.78
105_A113_D0.7050.78
139_F143_D0.7020.77
123_G127_G0.6960.77
9_E38_F0.6900.76
97_V113_D0.6860.76
31_A119_E0.6750.75
35_E89_I0.6650.74
92_N137_N0.6620.73
10_L14_F0.6620.73
19_K71_A0.6610.73
146_E149_L0.6540.72
91_Y134_T0.6530.72
97_V124_T0.6460.71
65_M82_L0.6450.71
60_N63_M0.6410.71
94_A134_T0.6410.71
43_Q47_S0.6340.70
44_S49_M0.6300.70
82_L148_I0.6290.69
147_A150_E0.6270.69
20_E74_G0.6220.69
78_T110_R0.6210.68
21_E36_Q0.6180.68
19_K70_P0.6160.68
92_N134_T0.6160.68
76_P98_I0.6120.67
10_L45_K0.6110.67
28_E32_A0.6090.67
113_D122_L0.6060.67
90_D122_L0.6050.66
51_T59_R0.6040.66
124_T133_T0.6000.66
138_G143_D0.5920.65
113_D126_A0.5900.65
122_L136_A0.5870.64
104_A111_L0.5850.64
51_T106_Q0.5840.64
93_D141_V0.5840.64
56_V81_P0.5800.63
14_F49_M0.5790.63
25_S57_R0.5740.62
23_F44_S0.5730.62
97_V126_A0.5730.62
22_K64_E0.5640.61
117_K147_A0.5640.61
125_I132_F0.5600.61
20_E36_Q0.5580.60
82_L144_L0.5560.60
24_S27_G0.5530.60
24_S50_L0.5470.59
78_T101_S0.5470.59
77_T102_P0.5460.59
106_Q129_D0.5390.58
144_L147_A0.5380.57
18_L32_A0.5330.57
136_A140_T0.5310.57
109_A127_G0.5310.57
112_L121_I0.5300.56
92_N127_G0.5290.56
11_V55_A0.5270.56
12_K150_E0.5230.55
35_E74_G0.5220.55
11_V15_K0.5200.55
34_Q46_V0.5190.55
14_F46_V0.5150.54
67_Y103_G0.5130.54
41_I55_A0.5100.54
94_A128_D0.5100.54
42_N45_K0.5100.54
105_A127_G0.5100.54
54_G116_G0.5080.53
19_K133_T0.5070.53
54_G85_L0.5040.53
49_M52_K0.5020.52
38_F68_C0.5000.52
124_T130_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v4gA 5 0.9167 100 0.068 Contact Map
3lapA 6 0.9359 100 0.108 Contact Map
1b4aA 5 0.9167 100 0.209 Contact Map
2p5mA 4 0.5256 99.9 0.546 Contact Map
2zfzA 4 0.5064 99.9 0.551 Contact Map
1xxaA 4 0.4615 99.9 0.563 Contact Map
1b4bA 4 0.4551 99.9 0.566 Contact Map
2p5kA 1 0.4038 98.9 0.762 Contact Map
4l5jA 4 0.8013 96.3 0.864 Contact Map
2fu4A 2 0.4423 96.3 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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