GREMLIN Database
ARGB - Acetylglutamate kinase
UniProt: P0A6C8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10064
Length: 258 (251)
Sequences: 3503 (1986)
Seq/√Len: 125.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_V172_L3.6731.00
113_T126_Q3.6381.00
69_P72_Q3.6191.00
151_T155_Q3.4541.00
113_T124_L3.1461.00
110_V164_A3.1171.00
183_S236_S2.9811.00
202_E226_R2.8911.00
70_A121_H2.8791.00
198_A222_L2.6091.00
4_P36_R2.5831.00
3_N175_D2.5701.00
145_V168_L2.5081.00
111_K127_P2.4141.00
114_Q118_E2.3681.00
57_L71_D2.2981.00
175_D230_R2.2731.00
110_V128_G2.2051.00
188_G191_Q2.1641.00
203_Q207_Q2.1111.00
231_P255_R2.1101.00
92_A144_V2.0971.00
53_K58_P2.0621.00
149_G159_V2.0491.00
202_E206_E2.0181.00
51_L55_L2.0061.00
201_A222_L2.0041.00
112_V149_G1.9471.00
5_L35_Q1.8991.00
52_M59_V1.8761.00
170_A227_T1.8741.00
205_I219_N1.8231.00
28_V97_I1.8201.00
55_L75_I1.7931.00
26_A241_E1.7861.00
197_T200_K1.7561.00
200_K203_Q1.7521.00
114_Q157_M1.7521.00
25_S95_H1.7451.00
49_D59_V1.7431.00
77_T105_G1.7331.00
130_P134_N1.7171.00
51_L79_A1.6961.00
210_I218_V1.6611.00
135_S139_N1.6501.00
225_A232_V1.6451.00
51_L78_G1.6271.00
196_M201_A1.6191.00
50_E53_K1.6091.00
185_I218_V1.5961.00
151_T157_M1.5911.00
21_E91_W1.5841.00
65_L163_Q1.5421.00
187_D191_Q1.5421.00
73_I76_I1.5241.00
245_A251_P1.5081.00
111_K129_S1.5001.00
66_R158_N1.4981.00
97_I142_L1.4841.00
110_V168_L1.4811.00
221_A232_V1.4701.00
114_Q117_E1.4581.00
248_N251_P1.4321.00
183_S186_L1.4271.00
186_L192_R1.3941.00
76_I148_I1.3921.00
115_L124_L1.3881.00
62_K67_V1.3881.00
60_K67_V1.3451.00
133_I168_L1.3391.00
55_L78_G1.3301.00
50_E54_G1.3121.00
81_A103_F1.3051.00
29_N33_S1.3001.00
4_P134_N1.2921.00
112_V157_M1.2861.00
60_K69_P1.2851.00
20_L87_T1.2701.00
73_I148_I1.2671.00
218_V222_L1.2641.00
100_V136_L1.2621.00
188_G209_I1.2501.00
121_H155_Q1.2411.00
202_E222_L1.2300.99
36_R138_E1.2290.99
17_E20_L1.2270.99
136_L141_Y1.2220.99
134_N138_E1.2200.99
202_E219_N1.2180.99
85_N89_L1.2040.99
185_I196_M1.2020.99
111_K152_D1.2000.99
74_D83_T1.1930.99
168_L172_L1.1890.99
49_D61_K1.1840.99
148_I156_L1.1820.99
167_A170_A1.1770.99
133_I145_V1.1660.99
105_G156_L1.1590.99
132_L135_S1.1580.99
36_R137_L1.1560.99
178_L220_A1.1490.99
12_V46_C1.1470.99
21_E94_K1.1460.99
21_E95_H1.1460.99
92_A97_I1.1310.99
54_G74_D1.1250.99
195_E255_R1.1210.99
9_L20_L1.1160.99
47_V83_T1.1080.99
77_T156_L1.1050.99
184_G192_R1.0980.99
31_R36_R1.0910.99
24_F40_I1.0890.99
7_I27_L1.0880.99
176_L232_V1.0850.99
109_S132_L1.0680.99
52_M57_L1.0650.98
12_V15_D1.0530.98
233_D252_M1.0510.98
85_N101_G1.0480.98
245_A248_N1.0460.98
214_M217_K1.0410.98
167_A223_D1.0270.98
89_L101_G1.0230.98
179_L235_A1.0200.98
6_I174_A1.0180.98
170_A225_A1.0120.98
57_L75_I1.0000.98
4_P39_V0.9980.98
87_T91_W0.9930.98
203_Q206_E0.9900.98
63_N118_E0.9790.97
93_K108_D0.9770.97
81_A86_K0.9740.97
82_G101_G0.9600.97
98_A129_S0.9560.97
48_V76_I0.9550.97
132_L141_Y0.9430.97
112_V159_V0.9410.97
30_Y35_Q0.9390.97
30_Y247_F0.9380.97
219_N223_D0.9380.97
110_V159_V0.9350.97
59_V72_Q0.9300.96
71_D74_D0.9260.96
73_I121_H0.9260.96
251_P255_R0.9150.96
213_G217_K0.9120.96
49_D53_K0.9080.96
130_P171_T0.9050.96
51_L54_G0.9030.96
116_D119_L0.8980.96
24_F91_W0.8900.95
183_S239_H0.8870.95
166_T170_A0.8860.95
65_L119_L0.8820.95
4_P137_L0.8720.95
107_G141_Y0.8700.95
49_D52_M0.8630.95
19_A23_L0.8580.94
120_G213_G0.8540.94
24_F92_A0.8470.94
198_A226_R0.8430.94
89_L99_A0.8410.94
86_K103_F0.8400.94
88_L147_S0.8380.94
68_T158_N0.8370.94
77_T87_T0.8330.94
132_L136_L0.8290.93
86_K106_D0.8280.93
26_A30_Y0.8280.93
252_M255_R0.8260.93
12_V47_V0.8200.93
57_L69_P0.8190.93
204_L209_I0.8170.93
109_S133_I0.8170.93
28_V142_L0.8130.93
20_L91_W0.8100.93
6_I168_L0.8090.93
39_V137_L0.8080.92
160_N213_G0.8070.92
125_A149_G0.8060.92
111_K126_Q0.8040.92
65_L115_L0.7990.92
25_S28_V0.7940.92
183_S238_R0.7920.92
187_D193_I0.7910.92
70_A155_Q0.7870.91
245_A255_R0.7870.91
9_L14_L0.7860.91
128_G168_L0.7800.91
53_K56_N0.7790.91
162_D217_K0.7750.91
112_V125_A0.7750.91
196_M204_L0.7750.91
5_L246_L0.7740.91
75_I79_A0.7650.90
27_L142_L0.7630.90
34_H37_P0.7600.90
166_T220_A0.7580.90
149_G157_M0.7510.89
161_A217_K0.7500.89
85_N146_S0.7500.89
160_N216_V0.7480.89
28_V95_H0.7460.89
149_G164_A0.7430.89
185_I222_L0.7390.89
12_V181_D0.7360.88
10_G42_H0.7350.88
167_A171_T0.7340.88
201_A218_V0.7330.88
57_L72_Q0.7290.88
108_D111_K0.7270.88
52_M72_Q0.7260.88
20_L88_L0.7240.88
115_L119_L0.7230.88
8_K162_D0.7160.87
122_V160_N0.7140.87
129_S132_L0.7130.87
188_G207_Q0.7130.87
5_L177_I0.7130.87
239_H244_P0.7120.87
109_S145_V0.7110.87
202_E205_I0.7110.87
109_S129_S0.7080.87
8_K161_A0.7070.86
78_G83_T0.7050.86
198_A221_A0.7040.86
159_V164_A0.7040.86
100_V141_Y0.7030.86
199_A203_Q0.7030.86
108_D150_V0.7020.86
220_A232_V0.7020.86
247_F251_P0.7010.86
170_A223_D0.6980.86
78_G106_D0.6970.86
127_P152_D0.6960.86
31_R37_P0.6950.85
72_Q75_I0.6940.85
78_G104_L0.6920.85
35_Q247_F0.6900.85
81_A148_I0.6870.85
73_I156_L0.6840.85
10_G217_K0.6840.85
78_G82_G0.6840.85
198_A225_A0.6830.84
15_D50_E0.6730.84
185_I193_I0.6700.83
244_P252_M0.6670.83
187_D190_G0.6610.83
126_Q152_D0.6600.82
223_D227_T0.6590.82
128_G164_A0.6580.82
103_F106_D0.6560.82
45_G64_G0.6550.82
31_R97_I0.6530.82
176_L224_A0.6470.81
211_T218_V0.6430.81
197_T201_A0.6430.81
133_I137_L0.6420.81
222_L226_R0.6410.81
88_L191_Q0.6390.80
170_A229_G0.6380.80
195_E231_P0.6380.80
23_L47_V0.6370.80
163_Q219_N0.6370.80
233_D245_A0.6360.80
82_G106_D0.6350.80
113_T152_D0.6350.80
83_T87_T0.6300.79
31_R149_G0.6300.79
223_D226_R0.6300.79
81_A146_S0.6290.79
19_A22_R0.6280.79
107_G132_L0.6270.79
213_G216_V0.6270.79
7_I40_I0.6240.79
8_K217_K0.6220.79
110_V149_G0.6190.78
135_S140_G0.6170.78
127_P171_T0.6160.78
64_G216_V0.6140.78
24_F47_V0.6120.77
180_S214_M0.6100.77
160_N217_K0.6090.77
104_L144_V0.6080.77
9_L13_L0.6040.77
119_L122_V0.6000.76
16_S238_R0.5930.75
5_L30_Y0.5870.74
98_A141_Y0.5870.74
168_L171_T0.5850.74
193_I204_L0.5850.74
65_L124_L0.5840.74
39_V133_I0.5840.74
196_M256_I0.5840.74
27_L37_P0.5830.74
27_L40_I0.5820.74
77_T81_A0.5810.74
45_G122_V0.5800.74
224_A229_G0.5800.74
93_K98_A0.5780.73
91_W94_K0.5770.73
10_G214_M0.5740.73
11_G43_G0.5740.73
177_I233_D0.5730.73
57_L76_I0.5710.72
47_V50_E0.5700.72
10_G161_A0.5690.72
31_R142_L0.5670.72
26_A245_A0.5660.72
68_T73_I0.5630.71
210_I214_M0.5600.71
45_G162_D0.5580.71
222_L225_A0.5550.70
45_G160_N0.5520.70
163_Q167_A0.5500.70
7_I203_Q0.5500.70
9_L12_V0.5470.69
10_G158_N0.5460.69
64_G213_G0.5460.69
153_E157_M0.5450.69
55_L71_D0.5450.69
68_T213_G0.5450.69
10_G162_D0.5450.69
186_L190_G0.5440.69
163_Q220_A0.5430.69
4_P172_L0.5420.69
147_S156_L0.5400.68
152_D200_K0.5400.68
33_S248_N0.5400.68
78_G86_K0.5400.68
175_D231_P0.5380.68
183_S189_K0.5380.68
180_S234_I0.5370.68
150_V153_E0.5330.67
33_S251_P0.5300.67
29_N245_A0.5300.67
198_A202_E0.5300.67
90_A94_K0.5300.67
67_V117_E0.5290.67
10_G213_G0.5260.66
55_L74_D0.5250.66
122_V216_V0.5250.66
85_N106_D0.5230.66
122_V213_G0.5200.65
84_A88_L0.5190.65
218_V256_I0.5180.65
176_L229_G0.5170.65
8_K42_H0.5170.65
186_L189_K0.5170.65
115_L163_Q0.5160.65
94_K152_D0.5140.65
81_A90_A0.5140.65
120_G160_N0.5120.64
211_T215_I0.5100.64
165_A176_L0.5100.64
9_L23_L0.5100.64
218_V227_T0.5100.64
89_L144_V0.5090.64
91_W138_E0.5090.64
47_V51_L0.5090.64
13_L23_L0.5080.64
130_P168_L0.5080.64
65_L120_G0.5080.64
67_V119_L0.5060.63
241_E245_A0.5050.63
72_Q79_A0.5040.63
121_H157_M0.5040.63
69_P74_D0.5030.63
26_A251_P0.5030.63
185_I225_A0.5030.63
197_T222_L0.5020.63
160_N214_M0.5010.63
163_Q166_T0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gs5A 2 0.9961 100 0.294 Contact Map
2bufA 3 0.9961 100 0.3 Contact Map
2ap9A 3 0.9884 100 0.302 Contact Map
2v5hA 3 0.9961 100 0.306 Contact Map
2btyA 3 0.9922 100 0.311 Contact Map
2rd5A 3 0.9961 100 0.314 Contact Map
3l86A 1 0.9341 100 0.342 Contact Map
3wwnA 2 0.938 100 0.35 Contact Map
3s6kA 3 0.969 100 0.363 Contact Map
3d2mA 5 0.9612 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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