GREMLIN Database
ARGA - Amino-acid acetyltransferase
UniProt: P0A6C5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10063
Length: 443 (426)
Sequences: 782 (422)
Seq/√Len: 20.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
361_G394_L8.7251.00
379_E411_R5.4361.00
386_A440_A4.9931.00
30_I49_I4.6091.00
173_M196_L4.3191.00
231_Q259_R4.2651.00
105_Q109_T4.1281.00
87_R186_N3.9131.00
314_R318_Q3.8531.00
42_F108_I3.8181.00
348_A368_V3.2571.00
28_F57_I3.1291.00
363_M385_I3.0680.99
416_V439_M2.9380.99
416_V420_L2.9190.99
60_V200_L2.9080.99
98_K107_D2.8940.99
164_Q169_A2.8610.99
34_G68_Q2.8260.99
137_Q152_R2.6560.98
89_T186_N2.5630.98
428_L432_Q2.5610.98
230_A255_V2.5550.98
350_A385_I2.5440.98
142_D403_R2.5340.98
185_F406_H2.4630.97
405_I438_L2.4370.97
152_R403_R2.4300.97
419_D426_K2.4280.97
141_V436_K2.4240.97
415_P436_K2.4140.97
142_D152_R2.4000.97
216_N220_D2.2990.96
417_D420_L2.2350.95
336_K353_Y2.1880.95
32_L208_F2.1810.94
289_Q295_A2.1600.94
94_L97_V2.1280.94
326_S330_L2.1070.93
213_G269_S2.1050.93
90_D93_T2.0590.92
129_V164_Q2.0070.91
69_I100_A1.9870.91
81_L90_D1.9840.91
361_G385_I1.9670.91
428_L431_Y1.9610.90
281_F288_T1.9140.89
359_K395_S1.9100.89
128_V172_L1.9100.89
423_E426_K1.9020.89
426_K438_L1.8870.89
105_Q404_S1.8820.89
63_Y174_G1.8590.88
72_N100_A1.8510.88
24_R27_T1.8430.87
120_P123_G1.7930.86
161_I171_V1.7640.85
38_E71_A1.7460.84
295_A366_V1.7070.83
418_I437_V1.6930.82
284_D342_R1.6890.82
192_I425_K1.6390.80
72_N99_Q1.6390.80
23_H342_R1.6190.79
347_I372_Y1.6110.79
70_D87_R1.6010.79
337_F353_Y1.5950.78
174_G177_A1.5920.78
65_A101_A1.5830.78
295_A342_R1.5800.78
417_D426_K1.5790.78
225_L230_A1.5700.77
37_I108_I1.5620.77
46_V112_L1.5590.77
216_N219_G1.5560.77
353_Y428_L1.5350.76
63_Y108_I1.5210.75
134_I153_I1.5080.74
206_I229_E1.5080.74
83_H143_D1.5030.74
372_Y377_R1.5010.74
330_L337_F1.4870.73
265_C269_S1.4790.73
303_I306_I1.4700.72
213_G221_I1.4640.72
35_E67_P1.4610.72
109_T404_S1.4440.71
30_I162_H1.4380.71
91_A149_H1.4320.70
106_L178_V1.4110.69
57_I281_F1.3990.68
31_M207_G1.3960.68
76_H95_E1.3950.68
134_I192_I1.3920.68
76_H96_L1.3900.68
41_N44_S1.3890.68
245_S418_I1.3890.68
231_Q255_V1.3840.68
33_G67_P1.3800.67
282_S292_M1.3690.67
401_T425_K1.3680.67
423_E427_Q1.3490.66
342_R372_Y1.3480.66
333_E353_Y1.3470.65
150_S186_N1.3410.65
213_G219_G1.3390.65
283_R342_R1.3230.64
49_I59_L1.3200.64
313_I365_C1.3160.64
229_E232_A1.3160.64
23_H283_R1.3160.64
88_V417_D1.3060.63
10_V277_L1.3050.63
296_E377_R1.3050.63
96_L100_A1.2950.62
16_S31_M1.2920.62
181_T401_T1.2920.62
327_R331_E1.2840.62
290_I438_L1.2760.61
134_I196_L1.2680.61
280_L328_E1.2620.60
366_V379_E1.2550.60
396_K441_D1.2490.59
141_V441_D1.2370.59
96_L99_Q1.2360.59
168_G268_I1.2350.59
32_L37_I1.2320.58
368_V378_G1.2300.58
352_L361_G1.2290.58
23_H46_V1.2150.57
54_S124_A1.2110.57
227_P258_C1.2100.57
230_A289_Q1.2030.57
37_I425_K1.2020.56
125_H157_D1.1960.56
322_L325_R1.1950.56
323_V330_L1.1870.55
300_R388_Q1.1870.55
178_V437_V1.1770.55
401_T405_I1.1760.55
39_H271_Q1.1760.55
71_A232_A1.1720.54
121_L124_A1.1650.54
49_I69_I1.1580.54
68_Q193_A1.1410.52
72_N97_V1.1390.52
137_Q353_Y1.1350.52
189_S342_R1.1350.52
342_R377_R1.1340.52
23_H372_Y1.1340.52
75_A214_V1.1330.52
88_V371_D1.1320.52
150_S176_V1.1310.52
214_V222_V1.1270.52
252_R339_I1.1250.51
293_E415_P1.1200.51
353_Y432_Q1.1190.51
89_T150_S1.1180.51
91_A214_V1.1150.51
157_D160_A1.1150.51
207_G250_F1.1070.50
69_I321_I1.1050.50
303_I307_G1.1000.50
57_I282_S1.0990.50
20_I176_V1.0900.49
85_N409_Q1.0900.49
177_A192_I1.0870.49
37_I104_L1.0830.49
30_I399_V1.0820.49
369_H372_Y1.0790.48
66_R87_R1.0790.48
219_G263_R1.0660.48
338_T388_Q1.0660.48
122_Q295_A1.0650.47
355_F425_K1.0630.47
195_Q199_K1.0610.47
363_M399_V1.0600.47
40_E176_V1.0590.47
246_G250_F1.0540.47
61_V157_D1.0520.47
61_V265_C1.0520.47
30_I74_A1.0510.47
90_D95_E1.0490.46
176_V386_A1.0470.46
331_E334_I1.0470.46
34_G67_P1.0410.46
120_P406_H1.0400.46
309_I337_F1.0400.46
121_L406_H1.0350.46
176_V371_D1.0310.45
42_F367_A1.0300.45
268_I399_V1.0290.45
112_L276_L1.0260.45
214_V225_L1.0240.45
278_Q286_I1.0230.45
134_I156_I1.0200.45
267_L289_Q1.0190.44
129_V167_S1.0160.44
99_Q180_V1.0100.44
127_N157_D1.0080.44
321_I367_A1.0070.44
385_I411_R1.0000.43
12_G440_A0.9970.43
109_T130_S0.9950.43
86_I147_Y0.9950.43
303_I428_L0.9940.43
11_E39_H0.9890.43
77_H424_S0.9890.43
348_A352_L0.9870.42
425_K431_Y0.9830.42
324_R337_F0.9760.42
106_L111_R0.9750.42
178_V184_S0.9740.42
70_D141_V0.9710.41
296_E308_G0.9710.41
119_T281_F0.9680.41
208_F268_I0.9670.41
327_R330_L0.9660.41
9_L41_N0.9660.41
339_I346_T0.9640.41
224_E403_R0.9640.41
138_P365_C0.9620.41
376_S411_R0.9580.41
324_R333_E0.9510.40
409_Q414_T0.9490.40
333_E432_Q0.9480.40
156_I251_L0.9480.40
307_G426_K0.9480.40
71_A75_A0.9470.40
100_A273_D0.9450.40
420_L436_K0.9440.40
30_I304_N0.9410.40
37_I385_I0.9380.39
9_L45_I0.9330.39
100_A104_L0.9320.39
195_Q198_I0.9260.39
358_E398_F0.9220.38
350_A366_V0.9210.38
26_K348_A0.9200.38
214_V255_V0.9190.38
360_I363_M0.9180.38
150_S434_K0.9160.38
46_V111_R0.9160.38
138_P185_F0.9150.38
77_H231_Q0.9120.38
48_D144_G0.9090.38
19_Y29_V0.9030.37
297_Q436_K0.9030.37
355_F358_E0.9030.37
142_D250_F0.9010.37
70_D76_H0.8980.37
418_I431_Y0.8940.37
82_Y414_T0.8940.37
52_L281_F0.8910.36
324_R353_Y0.8900.36
345_T369_H0.8820.36
9_L44_S0.8790.36
9_L109_T0.8790.36
78_H96_L0.8770.36
33_G61_V0.8770.36
203_E304_N0.8770.36
67_P96_L0.8750.35
171_V291_V0.8740.35
21_N120_P0.8730.35
196_L200_L0.8730.35
49_I112_L0.8710.35
239_E391_Q0.8680.35
21_N54_S0.8670.35
315_P320_G0.8670.35
219_G222_V0.8650.35
156_I388_Q0.8640.35
13_F24_R0.8620.35
142_D366_V0.8600.35
138_P154_R0.8580.34
333_E430_N0.8520.34
371_D381_L0.8500.34
415_P438_L0.8500.34
396_K420_L0.8480.34
291_V295_A0.8460.34
269_S278_Q0.8460.34
246_G253_G0.8430.34
14_R382_L0.8350.33
226_F265_C0.8350.33
109_T184_S0.8300.33
105_Q178_V0.8290.33
14_R29_V0.8280.33
80_P90_D0.8260.33
377_R410_E0.8220.32
154_R331_E0.8210.32
241_G419_D0.8190.32
203_E401_T0.8170.32
304_N307_G0.8160.32
70_D80_P0.8160.32
230_A259_R0.8140.32
277_L368_V0.8130.32
37_I42_F0.8110.32
226_F295_A0.8100.32
112_L410_E0.8080.32
73_L113_S0.8070.32
64_G68_Q0.8050.31
230_A267_L0.8040.31
35_E214_V0.8030.31
30_I321_I0.8030.31
305_D325_R0.8020.31
137_Q196_L0.7990.31
154_R179_S0.7980.31
32_L270_Y0.7970.31
187_L429_Y0.7970.31
50_G295_A0.7940.31
63_Y100_A0.7930.31
131_G179_S0.7920.31
423_E437_V0.7920.31
401_T406_H0.7900.31
120_P124_A0.7900.31
416_V437_V0.7900.31
222_V288_T0.7880.30
15_H350_A0.7860.30
335_D419_D0.7860.30
273_D339_I0.7860.30
138_P331_E0.7860.30
133_F171_V0.7850.30
308_G316_L0.7850.30
417_D423_E0.7790.30
16_S45_I0.7790.30
198_I260_S0.7780.30
283_R295_A0.7740.30
89_T94_L0.7720.30
325_R362_E0.7710.30
13_F438_L0.7700.29
161_I300_R0.7690.29
234_V346_T0.7670.29
39_H270_Y0.7650.29
252_R416_V0.7640.29
53_H73_L0.7630.29
94_L149_H0.7620.29
319_Q403_R0.7620.29
14_R19_Y0.7610.29
166_D318_Q0.7590.29
366_V401_T0.7560.29
338_T384_R0.7560.29
363_M397_L0.7560.29
23_H147_Y0.7540.29
30_I208_F0.7510.28
325_R352_L0.7510.28
299_R362_E0.7470.28
134_I149_H0.7450.28
171_V190_E0.7440.28
14_R325_R0.7440.28
25_G168_G0.7410.28
127_N160_A0.7390.28
131_G315_P0.7360.28
41_N270_Y0.7350.28
39_H309_I0.7300.27
181_T317_E0.7280.27
289_Q409_Q0.7270.27
88_V228_N0.7200.27
63_Y233_R0.7170.27
164_Q376_S0.7150.27
176_V184_S0.7140.26
225_L231_Q0.7120.26
33_G157_D0.7110.26
88_V418_I0.7110.26
339_I369_H0.7110.26
10_V28_F0.7110.26
161_I246_G0.7100.26
30_I139_L0.7100.26
289_Q401_T0.7090.26
139_L425_K0.7090.26
207_G376_S0.7080.26
43_S314_R0.7070.26
279_E285_G0.7050.26
167_S196_L0.7040.26
280_L410_E0.7040.26
180_V289_Q0.7020.26
59_L282_S0.6990.26
181_T406_H0.6980.26
60_V366_V0.6970.26
147_Y378_G0.6950.26
360_I439_M0.6940.25
162_H201_K0.6900.25
45_I208_F0.6900.25
394_L397_L0.6890.25
61_V348_A0.6880.25
101_A130_S0.6880.25
213_G281_F0.6870.25
112_L184_S0.6870.25
63_Y177_A0.6860.25
319_Q390_K0.6860.25
119_T286_I0.6860.25
213_G270_Y0.6830.25
119_T403_R0.6820.25
157_D192_I0.6810.25
229_E441_D0.6810.25
8_E11_E0.6790.25
81_L356_P0.6790.25
102_G316_L0.6760.25
246_G268_I0.6730.24
16_S345_T0.6720.24
8_E156_I0.6700.24
428_L434_K0.6690.24
154_R171_V0.6690.24
23_H308_G0.6600.24
230_A233_R0.6590.24
16_S377_R0.6590.24
73_L78_H0.6580.24
72_N180_V0.6580.24
147_Y339_I0.6560.24
365_C410_E0.6550.24
109_T178_V0.6530.23
49_I170_I0.6520.23
223_S226_F0.6510.23
134_I141_V0.6510.23
180_V190_E0.6500.23
303_I333_E0.6490.23
171_V340_I0.6490.23
58_R139_L0.6480.23
33_G268_I0.6480.23
48_D362_E0.6460.23
16_S297_Q0.6460.23
217_D222_V0.6450.23
337_F376_S0.6450.23
306_I331_E0.6430.23
213_G222_V0.6420.23
155_R377_R0.6400.23
53_H168_G0.6380.23
21_N297_Q0.6370.23
35_E183_E0.6370.23
306_I354_P0.6370.23
366_V374_S0.6370.23
320_G325_R0.6360.23
43_S50_G0.6330.23
173_M354_P0.6320.23
156_I195_Q0.6320.23
23_H377_R0.6290.22
391_Q419_D0.6290.22
333_E336_K0.6280.22
350_A378_G0.6280.22
47_N121_L0.6270.22
95_E98_K0.6260.22
222_V229_E0.6260.22
178_V440_A0.6260.22
337_F428_L0.6250.22
185_F331_E0.6240.22
188_T434_K0.6240.22
12_G288_T0.6240.22
170_I298_I0.6230.22
61_V344_N0.6230.22
102_G313_I0.6230.22
184_S401_T0.6190.22
256_K395_S0.6190.22
399_V405_I0.6190.22
50_G53_H0.6180.22
17_V110_A0.6170.22
86_I93_T0.6150.22
326_S333_E0.6150.22
416_V419_D0.6150.22
10_V200_L0.6140.22
186_N407_W0.6140.22
78_H232_A0.6130.22
113_S224_E0.6130.22
13_F373_R0.6130.22
160_A229_E0.6120.22
97_V112_L0.6100.22
417_D437_V0.6100.22
152_R405_I0.6090.21
48_D299_R0.6090.21
105_Q130_S0.6080.21
396_K414_T0.6080.21
32_L207_G0.6070.21
33_G121_L0.6070.21
43_S309_I0.6070.21
296_E347_I0.6060.21
33_G85_N0.6060.21
409_Q415_P0.6060.21
21_N41_N0.6050.21
299_R349_C0.6050.21
203_E253_G0.6030.21
23_H369_H0.6030.21
108_I391_Q0.6030.21
94_L130_S0.6020.21
127_N438_L0.6020.21
18_P373_R0.5990.21
51_L54_S0.5990.21
246_G249_R0.5980.21
415_P420_L0.5970.21
330_L385_I0.5970.21
26_K63_Y0.5960.21
315_P331_E0.5960.21
281_F329_Q0.5940.21
299_R343_D0.5940.21
88_V143_D0.5920.21
8_E427_Q0.5920.21
227_P259_R0.5920.21
33_G63_Y0.5910.21
327_R333_E0.5900.21
58_R162_H0.5890.21
26_K214_V0.5880.21
131_G316_L0.5870.21
30_I223_S0.5870.21
203_E284_D0.5850.20
44_S311_E0.5850.20
337_F343_D0.5850.20
209_C246_G0.5840.20
18_P171_V0.5840.20
73_L93_T0.5830.20
48_D325_R0.5820.20
57_I167_S0.5820.20
168_G249_R0.5810.20
100_A119_T0.5810.20
299_R341_Q0.5810.20
391_Q441_D0.5810.20
255_V259_R0.5790.20
101_A380_V0.5780.20
207_G361_G0.5770.20
127_N180_V0.5760.20
426_K431_Y0.5760.20
322_L352_L0.5760.20
99_Q103_T0.5750.20
23_H284_D0.5730.20
50_G342_R0.5730.20
57_I69_I0.5720.20
69_I97_V0.5710.20
175_P356_P0.5700.20
74_A92_K0.5690.20
392_S428_L0.5690.20
131_G320_G0.5680.20
258_C265_C0.5680.20
119_T223_S0.5680.20
177_A434_K0.5670.20
19_Y23_H0.5670.20
45_I265_C0.5670.20
16_S55_L0.5670.20
23_H31_M0.5660.20
209_C268_I0.5630.20
131_G181_T0.5620.19
8_E12_G0.5610.19
55_L183_E0.5600.19
301_A325_R0.5600.19
60_V218_D0.5600.19
15_H23_H0.5590.19
129_V209_C0.5590.19
43_S111_R0.5580.19
163_R166_D0.5570.19
107_D129_V0.5570.19
168_G363_M0.5560.19
380_V403_R0.5560.19
347_I377_R0.5560.19
83_H142_D0.5550.19
396_K439_M0.5550.19
368_V411_R0.5540.19
46_V50_G0.5530.19
81_L395_S0.5530.19
338_T374_S0.5520.19
382_L438_L0.5510.19
153_I199_K0.5500.19
36_A155_R0.5500.19
190_E194_T0.5500.19
92_K427_Q0.5500.19
16_S283_R0.5490.19
380_V397_L0.5480.19
315_P325_R0.5480.19
21_N330_L0.5480.19
303_I406_H0.5470.19
312_L421_L0.5460.19
129_V178_V0.5460.19
342_R384_R0.5450.19
325_R330_L0.5450.19
59_L309_I0.5440.19
255_V265_C0.5440.19
77_H282_S0.5430.19
226_F294_S0.5420.19
281_F332_M0.5410.19
106_L129_V0.5410.19
79_E196_L0.5410.19
22_T344_N0.5410.19
217_D341_Q0.5400.19
208_F282_S0.5370.18
362_E378_G0.5360.18
296_E393_G0.5350.18
216_N222_V0.5340.18
242_D392_S0.5340.18
367_A410_E0.5330.18
66_R190_E0.5320.18
215_T290_I0.5320.18
232_A403_R0.5310.18
103_T167_S0.5300.18
268_I352_L0.5300.18
313_I378_G0.5280.18
137_Q390_K0.5280.18
31_M195_Q0.5270.18
91_A437_V0.5270.18
65_A337_F0.5270.18
31_M189_S0.5270.18
99_Q184_S0.5260.18
194_T198_I0.5240.18
20_I425_K0.5240.18
327_R430_N0.5240.18
359_K394_L0.5220.18
220_D414_T0.5210.18
54_S275_A0.5200.18
112_L425_K0.5200.18
308_G350_A0.5190.18
75_A125_H0.5180.18
43_S97_V0.5180.18
86_I289_Q0.5170.18
23_H295_A0.5170.18
328_E410_E0.5170.18
283_R345_T0.5170.18
337_F352_L0.5160.18
22_T187_L0.5160.18
65_A69_I0.5150.18
84_K368_V0.5150.18
350_A353_Y0.5150.18
101_A106_L0.5140.18
273_D348_A0.5140.18
240_K383_E0.5140.18
250_F289_Q0.5140.18
234_V265_C0.5140.18
32_L126_I0.5120.18
46_V167_S0.5120.18
141_V398_F0.5110.17
144_G301_A0.5110.17
102_G309_I0.5090.17
20_I223_S0.5080.17
30_I368_V0.5080.17
143_D419_D0.5080.17
76_H129_V0.5080.17
324_R428_L0.5070.17
307_G430_N0.5060.17
274_G320_G0.5040.17
74_A387_A0.5040.17
188_T286_I0.5030.17
133_F214_V0.5020.17
173_M290_I0.5020.17
363_M386_A0.5020.17
424_S427_Q0.5010.17
206_I313_I0.5010.17
188_T290_I0.5010.17
122_Q384_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d2mA 5 0.9526 100 0.52 Contact Map
3s6kA 3 0.9187 100 0.59 Contact Map
3s6gA 4 0.912 100 0.593 Contact Map
4ab7A 3 0.9097 100 0.634 Contact Map
2ap9A 3 0.6569 100 0.673 Contact Map
2v5hA 3 0.6411 100 0.673 Contact Map
2bufA 3 0.6501 100 0.674 Contact Map
2rd5A 3 0.623 100 0.683 Contact Map
2btyA 3 0.6321 100 0.685 Contact Map
3zzhA 3 0.6275 100 0.703 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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