GREMLIN Database
END4 - Endonuclease 4
UniProt: P0A6C1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10651
Length: 285 (270)
Sequences: 2246 (1439)
Seq/√Len: 87.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_K232_H4.1251.00
127_A167_G4.0581.00
223_T238_N3.0571.00
195_E198_K2.9981.00
54_A58_K2.8251.00
113_H118_S2.7261.00
85_E89_D2.7251.00
162_A166_D2.6461.00
141_T213_R2.6191.00
178_I183_A2.5811.00
21_A26_A2.5801.00
146_N183_A2.5681.00
80_V83_A2.5041.00
159_E206_T2.4871.00
201_A205_R2.3991.00
219_D235_G2.3711.00
27_T276_K2.3611.00
123_L163_A2.2341.00
84_L129_S2.2091.00
196_C250_D2.1511.00
119_E160_H2.1451.00
156_F160_H2.0711.00
120_E163_A2.0471.00
99_E139_G2.0211.00
67_L259_I1.9961.00
184_F238_N1.9681.00
241_H274_W1.9491.00
189_D192_T1.9431.00
18_A55_A1.9351.00
22_A59_Y1.9271.00
215_M258_L1.9221.00
163_A167_G1.8791.00
222_S228_V1.8721.00
239_I243_A1.8581.00
98_C103_L1.8461.00
203_F212_L1.8451.00
158_F199_T1.8211.00
268_W271_E1.8201.00
124_A167_G1.7991.00
131_N169_E1.7871.00
84_L125_R1.7731.00
15_A48_T1.7661.00
21_A29_F1.7591.00
232_H236_E1.7131.00
202_D205_R1.7121.00
119_E156_F1.7001.00
176_V203_F1.6901.00
202_D206_T1.6811.00
77_G122_C1.6811.00
76_L129_S1.6671.00
88_R132_I1.6381.00
200_F253_F1.6111.00
242_D245_R1.6081.00
53_K102_G1.5951.00
244_F247_I1.5601.00
30_A259_I1.5601.00
165_I174_V1.5541.00
196_C200_F1.5441.00
48_T51_E1.5121.00
112_S152_S1.5081.00
274_W277_A1.4720.99
159_E202_D1.4600.99
78_H83_A1.4500.99
92_I136_K1.4450.99
118_S121_D1.4430.99
19_I55_A1.4410.99
67_L214_G1.4400.99
171_K211_Y1.4370.99
16_N20_R1.3860.99
168_V174_V1.3720.99
185_A222_S1.3710.99
184_F224_F1.3650.99
105_L213_R1.3620.99
157_K160_H1.3520.99
3_Y65_Q1.3450.99
50_D54_A1.3450.99
115_M118_S1.3430.99
191_R195_E1.3280.99
269_A273_A1.3160.99
112_S153_N1.3050.99
165_I211_Y1.2890.99
144_I161_L1.2870.99
123_L154_L1.2850.99
84_L88_R1.2830.99
82_E86_K1.2620.98
46_T50_D1.2570.98
273_A277_A1.2530.98
89_D93_D1.2440.98
196_C246_W1.2380.98
251_D254_D1.2310.98
161_L176_V1.2300.98
197_E201_A1.2290.98
35_N38_Q1.2180.98
98_C106_L1.2180.98
113_H122_C1.2150.98
157_K202_D1.2130.98
53_K57_E1.2060.98
46_T100_Q1.1960.98
165_I176_V1.1770.97
44_L49_I1.1760.97
91_F108_F1.1640.97
22_A55_A1.1610.97
174_V211_Y1.1560.97
10_A31_L1.1440.97
18_A29_F1.1430.97
18_A22_A1.1410.97
81_T85_E1.1400.97
163_A166_D1.1230.97
131_N168_V1.1210.96
15_A51_E1.1130.96
124_A163_A1.1100.96
84_L128_E1.1040.96
113_H119_E1.1040.96
118_S122_C1.1020.96
68_P103_L1.1010.96
226_S238_N1.1000.96
107_N177_C1.0930.96
15_A55_A1.0900.96
125_R128_E1.0870.96
130_I142_A1.0820.96
121_D124_A1.0750.96
183_A190_L1.0720.95
55_A58_K1.0670.95
131_N171_K1.0660.95
52_F56_C1.0640.95
67_L107_N1.0550.95
3_Y27_T1.0550.95
195_E199_T1.0390.95
158_F203_F1.0390.95
68_P98_C1.0380.95
184_F191_R1.0300.94
91_F133_A1.0260.94
123_L167_G1.0260.94
268_W272_I1.0190.94
34_K41_A1.0180.94
170_D173_R1.0160.94
20_R23_E1.0090.94
14_L101_L1.0090.94
220_A238_N1.0080.94
55_A59_Y1.0060.94
33_T68_P1.0060.94
123_L164_I1.0030.94
137_T173_R0.9850.93
253_F258_L0.9840.93
245_R275_L0.9840.93
270_E273_A0.9830.93
171_K174_V0.9830.93
28_A65_Q0.9820.93
124_A128_E0.9810.93
176_V207_V0.9800.93
219_D240_G0.9790.93
36_Q71_S0.9590.92
32_F72_Y0.9590.92
54_A57_E0.9510.92
42_A45_T0.9430.91
184_F239_I0.9410.91
198_K202_D0.9390.91
51_E55_A0.9380.91
70_D108_F0.9370.91
20_R24_I0.9360.91
88_R129_S0.9360.91
50_D57_E0.9280.91
39_W86_K0.9230.90
93_D96_Q0.9210.90
56_C66_I0.9180.90
236_E270_E0.9160.90
212_L253_F0.9060.90
34_K71_S0.9050.90
4_I248_M0.8870.89
175_G213_R0.8810.88
121_D125_R0.8810.88
15_A19_I0.8780.88
271_E274_W0.8770.88
126_I164_I0.8710.88
95_M106_L0.8690.88
113_H152_S0.8680.87
3_Y64_A0.8620.87
191_R224_F0.8590.87
105_L175_G0.8560.87
76_L91_F0.8550.87
138_Q173_R0.8520.86
83_A86_K0.8500.86
143_V175_G0.8460.86
39_W73_L0.8440.86
49_I100_Q0.8390.86
200_F250_D0.8380.86
92_I96_Q0.8340.85
92_I137_T0.8340.85
12_G20_R0.8330.85
34_K90_A0.8270.85
192_T195_E0.8250.85
247_I253_F0.8220.84
3_Y61_Y0.8220.84
14_L17_A0.8200.84
105_L143_V0.8160.84
79_P114_L0.8130.84
70_D91_F0.8120.84
219_D237_G0.8090.84
81_T125_R0.8090.84
26_A272_I0.8070.83
51_E54_A0.8060.83
143_V214_G0.8060.83
201_A252_R0.8050.83
74_I90_A0.8030.83
184_F226_S0.8010.83
234_L248_M0.8000.83
96_Q99_E0.8000.83
95_M140_V0.7930.82
249_Q277_A0.7910.82
28_A259_I0.7910.82
244_F275_L0.7900.82
49_I53_K0.7880.82
214_G259_I0.7880.82
4_I272_I0.7800.81
33_T97_R0.7800.81
130_I174_V0.7790.81
204_A207_V0.7780.81
156_F227_R0.7710.80
132_I135_D0.7710.80
197_E250_D0.7680.80
31_L101_L0.7670.80
122_C154_L0.7630.80
233_S263_I0.7630.80
233_S236_E0.7590.79
105_L141_T0.7590.79
191_R238_N0.7580.79
159_E162_A0.7540.79
241_H245_R0.7520.79
203_F208_G0.7510.79
70_D106_L0.7510.79
148_A185_A0.7440.78
120_E124_A0.7440.78
196_C243_A0.7430.78
8_V20_R0.7430.78
61_Y64_A0.7430.78
151_G227_R0.7400.78
64_A104_S0.7380.78
99_E140_V0.7380.78
47_Q51_E0.7370.77
45_T48_T0.7350.77
233_S267_I0.7340.77
160_H207_V0.7340.77
6_A24_I0.7320.77
147_T153_N0.7310.77
234_L275_L0.7300.77
29_F56_C0.7300.77
94_E106_L0.7300.77
134_L142_A0.7280.77
135_D170_D0.7230.76
235_G240_G0.7220.76
204_A209_F0.7220.76
233_S264_N0.7210.76
38_Q71_S0.7180.76
158_F188_Y0.7150.75
158_F206_T0.7140.75
77_G125_R0.7090.75
77_G126_I0.7090.75
233_S271_E0.7080.75
203_F207_V0.7070.74
217_L247_I0.7040.74
8_V17_A0.7000.74
223_T226_S0.6980.73
76_L87_S0.6970.73
162_A206_T0.6960.73
3_Y60_H0.6950.73
135_D169_E0.6900.73
122_C125_R0.6880.72
266_D270_E0.6820.72
70_D74_I0.6770.71
209_F212_L0.6730.71
52_F55_A0.6720.71
18_A66_I0.6700.70
79_P116_Q0.6670.70
125_R129_S0.6660.70
215_M247_I0.6640.70
71_S90_A0.6630.70
84_L132_I0.6630.70
232_H263_I0.6600.69
77_G233_S0.6580.69
26_A271_E0.6570.69
178_I199_T0.6560.69
183_A186_A0.6540.69
8_V21_A0.6530.68
34_K38_Q0.6510.68
272_I276_K0.6510.68
19_I23_E0.6480.68
150_Q153_N0.6480.68
88_R136_K0.6430.67
21_A24_I0.6410.67
8_V29_F0.6400.67
132_I136_K0.6400.67
42_A48_T0.6390.67
119_E157_K0.6390.67
130_I134_L0.6380.67
99_E138_Q0.6370.67
188_Y202_D0.6330.66
217_L248_M0.6320.66
92_I133_A0.6290.66
24_I268_W0.6290.66
65_Q104_S0.6280.65
10_A17_A0.6260.65
61_Y65_Q0.6260.65
215_M252_R0.6260.65
110_P147_T0.6240.65
39_W87_S0.6230.65
178_I215_M0.6180.64
150_Q228_V0.6180.64
184_F244_F0.6170.64
243_A246_W0.6170.64
241_H277_A0.6150.64
128_E132_I0.6130.64
56_C59_Y0.6120.63
134_L170_D0.6110.63
243_A247_I0.6100.63
245_R249_Q0.6100.63
234_L244_F0.6100.63
95_M142_A0.6050.63
196_C253_F0.6050.63
185_A224_F0.6040.62
190_L195_E0.6020.62
34_K93_D0.6010.62
212_L215_M0.5980.62
135_D138_Q0.5960.61
22_A27_T0.5960.61
107_N214_G0.5950.61
6_A26_A0.5950.61
157_K186_A0.5900.61
106_L140_V0.5870.60
78_H125_R0.5860.60
88_R133_A0.5840.60
126_I147_T0.5840.60
178_I253_F0.5820.60
123_L160_H0.5810.59
191_R243_A0.5800.59
14_L31_L0.5800.59
191_R196_C0.5800.59
22_A61_Y0.5800.59
151_G228_V0.5780.59
67_L105_L0.5730.58
140_V145_E0.5730.58
30_A67_L0.5730.58
89_D96_Q0.5720.58
54_A210_K0.5720.58
156_F186_A0.5710.58
71_S150_Q0.5700.58
18_A52_F0.5680.58
191_R246_W0.5670.58
11_A16_N0.5610.57
76_L161_L0.5600.57
200_F215_M0.5600.57
234_L260_L0.5600.57
93_D97_R0.5590.57
158_F207_V0.5580.56
155_G161_L0.5560.56
69_H109_H0.5530.56
184_F243_A0.5530.56
234_L243_A0.5530.56
190_L196_C0.5510.56
233_S268_W0.5500.55
8_V24_I0.5470.55
8_V268_W0.5470.55
130_I164_I0.5450.55
146_N207_V0.5440.55
73_L87_S0.5440.55
9_S13_G0.5420.54
239_I244_F0.5420.54
210_K273_A0.5420.54
31_L103_L0.5410.54
38_Q153_N0.5380.54
158_F212_L0.5380.54
80_V116_Q0.5360.54
115_M152_S0.5320.53
69_H182_H0.5320.53
109_H182_H0.5290.53
250_D253_F0.5270.52
80_V114_L0.5220.52
244_F258_L0.5220.52
30_A143_V0.5210.51
209_F252_R0.5210.51
39_W90_A0.5210.51
83_A91_F0.5190.51
127_A163_A0.5180.51
196_C256_I0.5170.51
186_A225_G0.5160.51
53_K56_C0.5150.51
195_E224_F0.5150.51
223_T228_V0.5140.51
10_A14_L0.5130.50
10_A13_G0.5110.50
116_Q125_R0.5110.50
84_L116_Q0.5090.50
46_T49_I0.5090.50
141_T175_G0.5090.50
247_I258_L0.5080.50
155_G160_H0.5080.50
4_I258_L0.5060.49
76_L88_R0.5060.49
38_Q41_A0.5060.49
196_C252_R0.5060.49
16_N19_I0.5060.49
168_V171_K0.5050.49
99_E141_T0.5030.49
222_S238_N0.5020.49
73_L86_K0.5010.49
98_C140_V0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qtwA 1 1 100 0.541 Contact Map
4hnoA 1 0.9965 100 0.554 Contact Map
3tc3A 1 0.8807 100 0.563 Contact Map
3aalA 1 0.9789 100 0.565 Contact Map
3aamA 1 0.9333 100 0.58 Contact Map
3wqoA 2 0.9193 100 0.672 Contact Map
3ayvA 2 0.8351 100 0.679 Contact Map
2zvrA 2 0.8667 100 0.682 Contact Map
2j6vA 1 0.8281 100 0.687 Contact Map
3p14A 2 0.9088 100 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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