END4 - ECOLI - GREMLIN Contacts

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END4 - Endonuclease 4

UniProt:	P0A6C1	Sequences: MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFKAACEKYHYTSAQILPHDSYLINLGHPVTEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEEDCLARIAESINIALDKTQGVTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPAECEKTFADFARTVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10651
Length:	285 (270)
Sequences:	2246 (1439)
Seq/√Len:	87.6

ECOLI - END4
BACSU - END4
HALSA - END4
SULSO - Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_K	232_H	4.125	1.00
127_A	167_G	4.058	1.00
223_T	238_N	3.057	1.00
195_E	198_K	2.998	1.00
54_A	58_K	2.825	1.00
113_H	118_S	2.726	1.00
85_E	89_D	2.725	1.00
162_A	166_D	2.646	1.00
141_T	213_R	2.619	1.00
178_I	183_A	2.581	1.00
21_A	26_A	2.580	1.00
146_N	183_A	2.568	1.00
80_V	83_A	2.504	1.00
159_E	206_T	2.487	1.00
201_A	205_R	2.399	1.00
219_D	235_G	2.371	1.00
27_T	276_K	2.361	1.00
123_L	163_A	2.234	1.00
84_L	129_S	2.209	1.00
196_C	250_D	2.151	1.00
119_E	160_H	2.145	1.00
156_F	160_H	2.071	1.00
120_E	163_A	2.047	1.00
99_E	139_G	2.021	1.00
67_L	259_I	1.996	1.00
184_F	238_N	1.968	1.00
241_H	274_W	1.949	1.00
189_D	192_T	1.943	1.00
18_A	55_A	1.935	1.00
22_A	59_Y	1.927	1.00
215_M	258_L	1.922	1.00
163_A	167_G	1.879	1.00
222_S	228_V	1.872	1.00
239_I	243_A	1.858	1.00
98_C	103_L	1.846	1.00
203_F	212_L	1.845	1.00
158_F	199_T	1.821	1.00
268_W	271_E	1.820	1.00
124_A	167_G	1.799	1.00
131_N	169_E	1.787	1.00
84_L	125_R	1.773	1.00
15_A	48_T	1.766	1.00
21_A	29_F	1.759	1.00
232_H	236_E	1.713	1.00
202_D	205_R	1.712	1.00
119_E	156_F	1.700	1.00
176_V	203_F	1.690	1.00
202_D	206_T	1.681	1.00
77_G	122_C	1.681	1.00
76_L	129_S	1.667	1.00
88_R	132_I	1.638	1.00
200_F	253_F	1.611	1.00
242_D	245_R	1.608	1.00
53_K	102_G	1.595	1.00
244_F	247_I	1.560	1.00
30_A	259_I	1.560	1.00
165_I	174_V	1.554	1.00
196_C	200_F	1.544	1.00
48_T	51_E	1.512	1.00
112_S	152_S	1.508	1.00
274_W	277_A	1.472	0.99
159_E	202_D	1.460	0.99
78_H	83_A	1.450	0.99
92_I	136_K	1.445	0.99
118_S	121_D	1.443	0.99
19_I	55_A	1.441	0.99
67_L	214_G	1.440	0.99
171_K	211_Y	1.437	0.99
16_N	20_R	1.386	0.99
168_V	174_V	1.372	0.99
185_A	222_S	1.371	0.99
184_F	224_F	1.365	0.99
105_L	213_R	1.362	0.99
157_K	160_H	1.352	0.99
3_Y	65_Q	1.345	0.99
50_D	54_A	1.345	0.99
115_M	118_S	1.343	0.99
191_R	195_E	1.328	0.99
269_A	273_A	1.316	0.99
112_S	153_N	1.305	0.99
165_I	211_Y	1.289	0.99
144_I	161_L	1.287	0.99
123_L	154_L	1.285	0.99
84_L	88_R	1.283	0.99
82_E	86_K	1.262	0.98
46_T	50_D	1.257	0.98
273_A	277_A	1.253	0.98
89_D	93_D	1.244	0.98
196_C	246_W	1.238	0.98
251_D	254_D	1.231	0.98
161_L	176_V	1.230	0.98
197_E	201_A	1.229	0.98
35_N	38_Q	1.218	0.98
98_C	106_L	1.218	0.98
113_H	122_C	1.215	0.98
157_K	202_D	1.213	0.98
53_K	57_E	1.206	0.98
46_T	100_Q	1.196	0.98
165_I	176_V	1.177	0.97
44_L	49_I	1.176	0.97
91_F	108_F	1.164	0.97
22_A	55_A	1.161	0.97
174_V	211_Y	1.156	0.97
10_A	31_L	1.144	0.97
18_A	29_F	1.143	0.97
18_A	22_A	1.141	0.97
81_T	85_E	1.140	0.97
163_A	166_D	1.123	0.97
131_N	168_V	1.121	0.96
15_A	51_E	1.113	0.96
124_A	163_A	1.110	0.96
84_L	128_E	1.104	0.96
113_H	119_E	1.104	0.96
118_S	122_C	1.102	0.96
68_P	103_L	1.101	0.96
226_S	238_N	1.100	0.96
107_N	177_C	1.093	0.96
15_A	55_A	1.090	0.96
125_R	128_E	1.087	0.96
130_I	142_A	1.082	0.96
121_D	124_A	1.075	0.96
183_A	190_L	1.072	0.95
55_A	58_K	1.067	0.95
131_N	171_K	1.066	0.95
52_F	56_C	1.064	0.95
67_L	107_N	1.055	0.95
3_Y	27_T	1.055	0.95
195_E	199_T	1.039	0.95
158_F	203_F	1.039	0.95
68_P	98_C	1.038	0.95
184_F	191_R	1.030	0.94
91_F	133_A	1.026	0.94
123_L	167_G	1.026	0.94
268_W	272_I	1.019	0.94
34_K	41_A	1.018	0.94
170_D	173_R	1.016	0.94
20_R	23_E	1.009	0.94
14_L	101_L	1.009	0.94
220_A	238_N	1.008	0.94
55_A	59_Y	1.006	0.94
33_T	68_P	1.006	0.94
123_L	164_I	1.003	0.94
137_T	173_R	0.985	0.93
253_F	258_L	0.984	0.93
245_R	275_L	0.984	0.93
270_E	273_A	0.983	0.93
171_K	174_V	0.983	0.93
28_A	65_Q	0.982	0.93
124_A	128_E	0.981	0.93
176_V	207_V	0.980	0.93
219_D	240_G	0.979	0.93
36_Q	71_S	0.959	0.92
32_F	72_Y	0.959	0.92
54_A	57_E	0.951	0.92
42_A	45_T	0.943	0.91
184_F	239_I	0.941	0.91
198_K	202_D	0.939	0.91
51_E	55_A	0.938	0.91
70_D	108_F	0.937	0.91
20_R	24_I	0.936	0.91
88_R	129_S	0.936	0.91
50_D	57_E	0.928	0.91
39_W	86_K	0.923	0.90
93_D	96_Q	0.921	0.90
56_C	66_I	0.918	0.90
236_E	270_E	0.916	0.90
212_L	253_F	0.906	0.90
34_K	71_S	0.905	0.90
4_I	248_M	0.887	0.89
175_G	213_R	0.881	0.88
121_D	125_R	0.881	0.88
15_A	19_I	0.878	0.88
271_E	274_W	0.877	0.88
126_I	164_I	0.871	0.88
95_M	106_L	0.869	0.88
113_H	152_S	0.868	0.87
3_Y	64_A	0.862	0.87
191_R	224_F	0.859	0.87
105_L	175_G	0.856	0.87
76_L	91_F	0.855	0.87
138_Q	173_R	0.852	0.86
83_A	86_K	0.850	0.86
143_V	175_G	0.846	0.86
39_W	73_L	0.844	0.86
49_I	100_Q	0.839	0.86
200_F	250_D	0.838	0.86
92_I	96_Q	0.834	0.85
92_I	137_T	0.834	0.85
12_G	20_R	0.833	0.85
34_K	90_A	0.827	0.85
192_T	195_E	0.825	0.85
247_I	253_F	0.822	0.84
3_Y	61_Y	0.822	0.84
14_L	17_A	0.820	0.84
105_L	143_V	0.816	0.84
79_P	114_L	0.813	0.84
70_D	91_F	0.812	0.84
219_D	237_G	0.809	0.84
81_T	125_R	0.809	0.84
26_A	272_I	0.807	0.83
51_E	54_A	0.806	0.83
143_V	214_G	0.806	0.83
201_A	252_R	0.805	0.83
74_I	90_A	0.803	0.83
184_F	226_S	0.801	0.83
234_L	248_M	0.800	0.83
96_Q	99_E	0.800	0.83
95_M	140_V	0.793	0.82
249_Q	277_A	0.791	0.82
28_A	259_I	0.791	0.82
244_F	275_L	0.790	0.82
49_I	53_K	0.788	0.82
214_G	259_I	0.788	0.82
4_I	272_I	0.780	0.81
33_T	97_R	0.780	0.81
130_I	174_V	0.779	0.81
204_A	207_V	0.778	0.81
156_F	227_R	0.771	0.80
132_I	135_D	0.771	0.80
197_E	250_D	0.768	0.80
31_L	101_L	0.767	0.80
122_C	154_L	0.763	0.80
233_S	263_I	0.763	0.80
233_S	236_E	0.759	0.79
105_L	141_T	0.759	0.79
191_R	238_N	0.758	0.79
159_E	162_A	0.754	0.79
241_H	245_R	0.752	0.79
203_F	208_G	0.751	0.79
70_D	106_L	0.751	0.79
148_A	185_A	0.744	0.78
120_E	124_A	0.744	0.78
196_C	243_A	0.743	0.78
8_V	20_R	0.743	0.78
61_Y	64_A	0.743	0.78
151_G	227_R	0.740	0.78
64_A	104_S	0.738	0.78
99_E	140_V	0.738	0.78
47_Q	51_E	0.737	0.77
45_T	48_T	0.735	0.77
233_S	267_I	0.734	0.77
160_H	207_V	0.734	0.77
6_A	24_I	0.732	0.77
147_T	153_N	0.731	0.77
234_L	275_L	0.730	0.77
29_F	56_C	0.730	0.77
94_E	106_L	0.730	0.77
134_L	142_A	0.728	0.77
135_D	170_D	0.723	0.76
235_G	240_G	0.722	0.76
204_A	209_F	0.722	0.76
233_S	264_N	0.721	0.76
38_Q	71_S	0.718	0.76
158_F	188_Y	0.715	0.75
158_F	206_T	0.714	0.75
77_G	125_R	0.709	0.75
77_G	126_I	0.709	0.75
233_S	271_E	0.708	0.75
203_F	207_V	0.707	0.74
217_L	247_I	0.704	0.74
8_V	17_A	0.700	0.74
223_T	226_S	0.698	0.73
76_L	87_S	0.697	0.73
162_A	206_T	0.696	0.73
3_Y	60_H	0.695	0.73
135_D	169_E	0.690	0.73
122_C	125_R	0.688	0.72
266_D	270_E	0.682	0.72
70_D	74_I	0.677	0.71
209_F	212_L	0.673	0.71
52_F	55_A	0.672	0.71
18_A	66_I	0.670	0.70
79_P	116_Q	0.667	0.70
125_R	129_S	0.666	0.70
215_M	247_I	0.664	0.70
71_S	90_A	0.663	0.70
84_L	132_I	0.663	0.70
232_H	263_I	0.660	0.69
77_G	233_S	0.658	0.69
26_A	271_E	0.657	0.69
178_I	199_T	0.656	0.69
183_A	186_A	0.654	0.69
8_V	21_A	0.653	0.68
34_K	38_Q	0.651	0.68
272_I	276_K	0.651	0.68
19_I	23_E	0.648	0.68
150_Q	153_N	0.648	0.68
88_R	136_K	0.643	0.67
21_A	24_I	0.641	0.67
8_V	29_F	0.640	0.67
132_I	136_K	0.640	0.67
42_A	48_T	0.639	0.67
119_E	157_K	0.639	0.67
130_I	134_L	0.638	0.67
99_E	138_Q	0.637	0.67
188_Y	202_D	0.633	0.66
217_L	248_M	0.632	0.66
92_I	133_A	0.629	0.66
24_I	268_W	0.629	0.66
65_Q	104_S	0.628	0.65
10_A	17_A	0.626	0.65
61_Y	65_Q	0.626	0.65
215_M	252_R	0.626	0.65
110_P	147_T	0.624	0.65
39_W	87_S	0.623	0.65
178_I	215_M	0.618	0.64
150_Q	228_V	0.618	0.64
184_F	244_F	0.617	0.64
243_A	246_W	0.617	0.64
241_H	277_A	0.615	0.64
128_E	132_I	0.613	0.64
56_C	59_Y	0.612	0.63
134_L	170_D	0.611	0.63
243_A	247_I	0.610	0.63
245_R	249_Q	0.610	0.63
234_L	244_F	0.610	0.63
95_M	142_A	0.605	0.63
196_C	253_F	0.605	0.63
185_A	224_F	0.604	0.62
190_L	195_E	0.602	0.62
34_K	93_D	0.601	0.62
212_L	215_M	0.598	0.62
135_D	138_Q	0.596	0.61
22_A	27_T	0.596	0.61
107_N	214_G	0.595	0.61
6_A	26_A	0.595	0.61
157_K	186_A	0.590	0.61
106_L	140_V	0.587	0.60
78_H	125_R	0.586	0.60
88_R	133_A	0.584	0.60
126_I	147_T	0.584	0.60
178_I	253_F	0.582	0.60
123_L	160_H	0.581	0.59
191_R	243_A	0.580	0.59
14_L	31_L	0.580	0.59
191_R	196_C	0.580	0.59
22_A	61_Y	0.580	0.59
151_G	228_V	0.578	0.59
67_L	105_L	0.573	0.58
140_V	145_E	0.573	0.58
30_A	67_L	0.573	0.58
89_D	96_Q	0.572	0.58
54_A	210_K	0.572	0.58
156_F	186_A	0.571	0.58
71_S	150_Q	0.570	0.58
18_A	52_F	0.568	0.58
191_R	246_W	0.567	0.58
11_A	16_N	0.561	0.57
76_L	161_L	0.560	0.57
200_F	215_M	0.560	0.57
234_L	260_L	0.560	0.57
93_D	97_R	0.559	0.57
158_F	207_V	0.558	0.56
155_G	161_L	0.556	0.56
69_H	109_H	0.553	0.56
184_F	243_A	0.553	0.56
234_L	243_A	0.553	0.56
190_L	196_C	0.551	0.56
233_S	268_W	0.550	0.55
8_V	24_I	0.547	0.55
8_V	268_W	0.547	0.55
130_I	164_I	0.545	0.55
146_N	207_V	0.544	0.55
73_L	87_S	0.544	0.55
9_S	13_G	0.542	0.54
239_I	244_F	0.542	0.54
210_K	273_A	0.542	0.54
31_L	103_L	0.541	0.54
38_Q	153_N	0.538	0.54
158_F	212_L	0.538	0.54
80_V	116_Q	0.536	0.54
115_M	152_S	0.532	0.53
69_H	182_H	0.532	0.53
109_H	182_H	0.529	0.53
250_D	253_F	0.527	0.52
80_V	114_L	0.522	0.52
244_F	258_L	0.522	0.52
30_A	143_V	0.521	0.51
209_F	252_R	0.521	0.51
39_W	90_A	0.521	0.51
83_A	91_F	0.519	0.51
127_A	163_A	0.518	0.51
196_C	256_I	0.517	0.51
186_A	225_G	0.516	0.51
53_K	56_C	0.515	0.51
195_E	224_F	0.515	0.51
223_T	228_V	0.514	0.51
10_A	14_L	0.513	0.50
10_A	13_G	0.511	0.50
116_Q	125_R	0.511	0.50
84_L	116_Q	0.509	0.50
46_T	49_I	0.509	0.50
141_T	175_G	0.509	0.50
247_I	258_L	0.508	0.50
155_G	160_H	0.508	0.50
4_I	258_L	0.506	0.49
76_L	88_R	0.506	0.49
38_Q	41_A	0.506	0.49
196_C	252_R	0.506	0.49
16_N	19_I	0.506	0.49
168_V	171_K	0.505	0.49
99_E	141_T	0.503	0.49
222_S	238_N	0.502	0.49
73_L	86_K	0.501	0.49
98_C	140_V	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qtwA	1	1	100	0.541	Contact Map
4hnoA	1	0.9965	100	0.554	Contact Map
3tc3A	1	0.8807	100	0.563	Contact Map
3aalA	1	0.9789	100	0.565	Contact Map
3aamA	1	0.9333	100	0.58	Contact Map
3wqoA	2	0.9193	100	0.672	Contact Map
3ayvA	2	0.8351	100	0.679	Contact Map
2zvrA	2	0.8667	100	0.682	Contact Map
2j6vA	1	0.8281	100	0.687	Contact Map
3p14A	2	0.9088	100	0.692	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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